{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:57:27Z","timestamp":1790150247708,"version":"4.0.1"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,26]],"date-time":"2019-05-26T00:00:00Z","timestamp":1558828800000},"content-version":"am","delay-in-days":298,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["16H05333"],"award-info":[{"award-number":["16H05333"]}]},{"DOI":"10.13039\/501100003382","name":"AMED-CREST","doi-asserted-by":"publisher","award":["JP17gm0610016"],"award-info":[{"award-number":["JP17gm0610016"]}],"id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.neulet.2018.05.035","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T21:12:12Z","timestamp":1527109932000},"page":"50-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Analysis of peripheral ghrelin signaling via the vagus nerve in ghrelin receptor\u2013restored GHSR-null mice"],"prefix":"10.1016","volume":"681","author":[{"given":"Tadashi","family":"Okada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.M. Zaved","family":"Waise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Toshinai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Mita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Sakoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6511-1049","authenticated-orcid":false,"given":"Masamitsu","family":"Nakazato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2018.05.035_bib0005","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2018.05.035_bib0010","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1053\/gast.2002.35954","article-title":"The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats","volume":"123","author":"Date","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neulet.2018.05.035_bib0015","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.cmet.2006.09.004","article-title":"Peripheral ghrelin transmits orexigenic signals through the noradrenergic pathway from the hindbrain to the hypothalamus","volume":"4","author":"Date","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.neulet.2018.05.035_bib0020","doi-asserted-by":"crossref","first-page":"e44089","DOI":"10.1371\/journal.pone.0044089","article-title":"Hindbrain ghrelin receptor signaling is sufficient to maintain fasting glucose","volume":"7","author":"Scott","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2018.05.035_bib0025","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1172\/JCI26002","article-title":"Mice lacking ghrelin receptors resist the development of diet-induced obesity","volume":"115","author":"Zigman","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neulet.2018.05.035_bib0030","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.molmet.2015.01.002","article-title":"Genetic determination of the cellular basis of the ghrelin-dependent bone remodeling","volume":"21","author":"Ma","year":"2015","journal-title":"Mol. Metab."},{"key":"10.1016\/j.neulet.2018.05.035_bib0035","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1172\/JCI43703","article-title":"Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice","volume":"121","author":"Scott","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neulet.2018.05.035_bib0040","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ejphar.2016.11.028","article-title":"Canagliflozin a sodium glucose cotransporter 2 inhibitor, attenuates obesity-induced inflammation in the nodose ganglion, hypothalamus, and skeletal muscle of mice","volume":"794","author":"Naznin","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neulet.2018.05.035_bib0045","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.regpep.2008.03.011","article-title":"Improved insulin sensitivity and metabolic flexibility in ghrelin receptor knockout mice","volume":"150","author":"Longo","year":"2008","journal-title":"Regul. Pept."},{"key":"10.1016\/j.neulet.2018.05.035_bib0050","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/ejn.12390","article-title":"Ghrelin receptor-knockout mice display alterations in circadian rhythms of activity and feeding under constant lighting conditions","volume":"39","author":"Lamont","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neulet.2018.05.035_bib0055","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1210\/en.2003-1596","article-title":"Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein","volume":"145","author":"Chen","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.neulet.2018.05.035_bib0060","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.2337\/diabetes.52.9.2260","article-title":"Hyperphagic effects of brainstem ghrelin administration","volume":"52","author":"Faulconbridge","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.neulet.2018.05.035_bib0065","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1530\/JME-17-0192","article-title":"Restoration of metabolic inflammation-related ghrelin resistance by weight loss","volume":"60","author":"Naznin","year":"2018","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.neulet.2018.05.035_bib0070","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1093\/embo-reports\/kve064","article-title":"A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent","volume":"2","author":"Vooijs","year":"2001","journal-title":"EMBO Rep."},{"key":"10.1016\/j.neulet.2018.05.035_bib0075","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.cell.2005.02.012","article-title":"Mosaic analysis with double markers in mice","volume":"121","author":"Zong","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2018.05.035_bib0080","doi-asserted-by":"crossref","first-page":"e5435","DOI":"10.1371\/journal.pone.0005435","article-title":"Silencing inhibits Cre-mediated recombination of the Z\/AP and Z\/EG reporters in adult cells","volume":"4","author":"Long","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2018.05.035_bib0085","doi-asserted-by":"crossref","first-page":"3706","DOI":"10.1182\/blood-2014-02-555151","article-title":"A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII","volume":"123","author":"Fahs","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.neulet.2018.05.035_bib0090","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.cmet.2011.01.010","article-title":"Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis","volume":"13","author":"Rossi","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.neulet.2018.05.035_bib0095","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1038\/ijo.2013.48","article-title":"Vagal innervation patterns following Roux-en-Y gastric bypass in the mouse","volume":"37","author":"Gautron","year":"2013","journal-title":"Int. J. Obes. (Lond.)"},{"key":"10.1016\/j.neulet.2018.05.035_bib0100","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.cmet.2014.01.021","article-title":"PPAR\u03b3 in vagal neurons regulates high-fat diet induced thermogenesis","volume":"19","author":"Liu","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.neulet.2018.05.035_bib0105","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2337\/db15-0973","article-title":"Knockdown of GLP-1 receptors in vagal afferents affects normal food intake and glycemia","volume":"65","author":"Krieger","year":"2016","journal-title":"Diabetes"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394018303781?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394018303781?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:21:22Z","timestamp":1759609282000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394018303781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":21,"alternative-id":["S0304394018303781"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2018.05.035","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of peripheral ghrelin signaling via the vagus nerve in ghrelin receptor\u2013restored GHSR-null mice","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2018.05.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}