{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:26:13Z","timestamp":1790040373961,"version":"4.0.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Romanian National Authority for Scientific Research, CNCS \u2013 UEFISCDI","award":["PN-III- ID-PCE- 2016-4- 0864"],"award-info":[{"award-number":["PN-III- ID-PCE- 2016-4- 0864"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.neulet.2018.07.018","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T13:11:12Z","timestamp":1531314672000},"page":"7-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Childhood trauma and emotion regulation: The moderator role of BDNF Val66Met"],"prefix":"10.1016","volume":"685","author":[{"given":"Mirela I.","family":"B\u00eelc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romana","family":"Vulturar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adina","family":"Chi\u0219","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u0103d\u0103lina","family":"Buciuman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Nu\u0163u","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Bunea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Szent\u00e1gotai-T\u0103tar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6459-5010","authenticated-orcid":false,"given":"Andrei C.","family":"Miu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2018.07.018_bib0005","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1177\/2167702614536164","article-title":"Emotion, emotion regulation, and psychopathology: an affective science perspective","volume":"2","author":"Gross","year":"2014","journal-title":"Clin. Psychol. Sci."},{"key":"10.1016\/j.neulet.2018.07.018_bib0010","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1176\/appi.ajp.2010.09091379","article-title":"research domain criteria (RDoC): toward a new classification framework for research on mental disorders","volume":"167","author":"Insel","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neulet.2018.07.018_bib0015","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neuroscience.2009.06.049","article-title":"Genetics of emotion regulation","volume":"164","author":"Canli","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2018.07.018_bib0020","unstructured":"A.C. Miu, M.I. Bilc, Genetics of emotion regulation: a systematic review, in: A.C. Miu, J.R. Homberg, K.P. Lesch (Eds.), Genes, Brain and Emotions: Interdisciplinary and Translational Perspectives, Oxford University Press, Oxford, in press."},{"key":"10.1016\/j.neulet.2018.07.018_bib0025","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s10608-016-9772-2","article-title":"Emotion regulation: a transdiagnostic perspective on a new RDoC domain","volume":"40","author":"Fernandez","year":"2016","journal-title":"Cogn. Ther. Res."},{"key":"10.1016\/j.neulet.2018.07.018_bib0030","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrn1726","article-title":"The yin and yang of neurotrophin action","volume":"6","author":"Lu","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2018.07.018_bib0035","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.biopsych.2008.05.005","article-title":"Meta-analysis of serum brain-derived neurotrophic factor (BDNF) levels in depression and antidepressant treatment","volume":"63","author":"Sen","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2018.07.018_bib0040","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.biopsych.2006.02.013","article-title":"A neurotrophic model for stress-related mood disorders","volume":"59","author":"Duman","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2018.07.018_bib0045","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0092-8674(03)00035-7","article-title":"The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function","volume":"112","author":"Egan","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2018.07.018_bib0050","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3758\/CABN.6.1.79","article-title":"Variant BDNF (VAl66Met) impact on brain structure and function","volume":"6","author":"Bath","year":"2006","journal-title":"Cogn. Affect Behav. Neurosci."},{"key":"10.1016\/j.neulet.2018.07.018_bib0055","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1177\/1073858411431646","article-title":"Impact of the BDNF Val66Met polymorphism on cognition: implications for behavioral genetics","volume":"18","author":"Dincheva","year":"2012","journal-title":"Neuroscientist"},{"key":"10.1016\/j.neulet.2018.07.018_bib0060","doi-asserted-by":"crossref","DOI":"10.1186\/1741-7015-12-7","article-title":"Interaction between stress and the BDNF Val66Met polymorphism in depression: a systematic review and meta-analysis","volume":"12","author":"Hosang","year":"2014","journal-title":"BMC Med."},{"key":"10.1016\/j.neulet.2018.07.018_bib0065","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jad.2017.10.024","article-title":"BDNF Val66Met polymorphism, life stress and depression: a meta-analysis of gene-environment interaction","volume":"227","author":"Zhao","year":"2017","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neulet.2018.07.018_bib0070","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jpsychires.2017.07.020","article-title":"Exploring the association between BDNF Val66Met polymorphism and suicidal behavior: meta-analysis and systematic review","volume":"94","author":"Gonzalez-Castro","year":"2017","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neulet.2018.07.018_bib0075","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.euroneuro.2009.12.005","article-title":"Meta-analysis of BDNF Val66Met polymorphism association with treatment response in patients with major depressive disorder","volume":"20","author":"Zou","year":"2010","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neulet.2018.07.018_bib0080","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.360","article-title":"Genetic association of the transcription of neuroplasticity-related genes and variation in stress-coping style","volume":"5","author":"Aizawa","year":"2015","journal-title":"Brain Behav."},{"key":"10.1016\/j.neulet.2018.07.018_bib0085","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jpsychores.2014.04.008","article-title":"Influence of the BDNF Val66Met polymorphism on coping response to stress in patients with advanced gastric cancer","volume":"77","author":"Koh","year":"2014","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.neulet.2018.07.018_bib0090","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.psychres.2014.07.001","article-title":"Associations between avoidant focused coping strategies and polymorphisms in genes coding for brain-derived neurotrophic factor and vascular endothelial growth factor in suicide attempters: a preliminary study","volume":"220","author":"Ambrus","year":"2014","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.neulet.2018.07.018_bib0095","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/j.1601-183X.2011.00715.x","article-title":"5-HTTLPR and BDNF Val66Met polymorphisms moderate effects of stress on rumination","volume":"10","author":"Clasen","year":"2011","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.neulet.2018.07.018_bib0100","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1080\/02699931.2016.1168779","article-title":"Partial replication of two rumination-related candidate gene studies","volume":"31","author":"Van Hulle","year":"2017","journal-title":"Cogn. Emot."},{"key":"10.1016\/j.neulet.2018.07.018_bib0105","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.paid.2013.02.022","article-title":"Desirable responding mediates the relationship between emotion regulation and anxiety","volume":"55","author":"Arndt","year":"2013","journal-title":"Pers. Individ. Differ."},{"key":"10.1016\/j.neulet.2018.07.018_bib0110","series-title":"Handbook of Emotion Regulation","first-page":"3","article-title":"Emotion regulation: conceptual and empirical foundations","author":"Gross","year":"2014"},{"key":"10.1016\/j.neulet.2018.07.018_bib0115","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cpr.2009.11.004","article-title":"Emotion-regulation strategies across psychopathology: a meta-analytic review","volume":"30","author":"Aldao","year":"2010","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.neulet.2018.07.018_bib0120","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1037\/a0028555","article-title":"Cognitive reappraisal self-efficacy mediates the effects of individual cognitive-behavioral therapy for social anxiety disorder","volume":"80","author":"Goldin","year":"2012","journal-title":"J. Consult. Clin. Psychol."},{"key":"10.1016\/j.neulet.2018.07.018_bib0125","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/gbb.12366","article-title":"BDNF Val66Met polymorphism moderates the link between child maltreatment and reappraisal ability","volume":"16","author":"Miu","year":"2017","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.neulet.2018.07.018_bib0130","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/YPG.0b013e32833a2038","article-title":"Genotyping the BDNF rs6265 (val66met) polymorphism by one-step amplified refractory mutation system PCR","volume":"20","author":"Sheikh","year":"2010","journal-title":"Psychiatr. Genet."},{"key":"10.1016\/j.neulet.2018.07.018_bib0135","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1515\/tnsci-2016-0006","article-title":"Allelic distribution of BDNF Val66Met polymorphism in healthy Romanian volunteers","volume":"7","author":"Vulturar","year":"2016","journal-title":"Transl. Neurosci."},{"key":"10.1016\/j.neulet.2018.07.018_bib0140","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0277-9536(88)90397-8","article-title":"Disclosure of traumas and psychosomatic processes","volume":"26","author":"Pennebaker","year":"1988","journal-title":"Soc. Sci. Med."},{"key":"10.1016\/j.neulet.2018.07.018_bib0145","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.paid.2017.07.015","article-title":"Childhood trauma and sensitivity to reward and punishment: implications for depressive and anxiety symptoms","volume":"119","author":"Miu","year":"2017","journal-title":"Pers. Individ. Differ."},{"key":"10.1016\/j.neulet.2018.07.018_bib0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134716","article-title":"Shame and guilt-proneness in adolescents: gene-environment interactions","volume":"10","author":"Szentagotai-Tatar","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2018.07.018_bib0155","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.biopsych.2009.07.014","article-title":"Neural mechanisms of cognitive reappraisal of negative self-beliefs in social anxiety disorder","volume":"66","author":"Goldin","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2018.07.018_bib0160","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.neuroimage.2004.06.030","article-title":"For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion","volume":"23","author":"Ochsner","year":"2004","journal-title":"Neuroimage"},{"key":"10.1016\/j.neulet.2018.07.018_bib0165","doi-asserted-by":"crossref","first-page":"596","DOI":"10.3758\/s13428-013-0379-1","article-title":"The Nencki Affective Picture System (NAPS): introduction to a novel, standardized, wide-range, high-quality, realistic Picture database","volume":"46","author":"Marchewka","year":"2014","journal-title":"Behav. Res. Methods"},{"key":"10.1016\/j.neulet.2018.07.018_bib0170","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/aje\/kwn359","article-title":"Hardy-Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies","volume":"169","author":"Rodriguez","year":"2009","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.neulet.2018.07.018_bib0175","first-page":"1","volume":"vol. 3","author":"Cicchetti","year":"2015"},{"key":"10.1016\/j.neulet.2018.07.018_bib0180","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.biopsych.2013.09.006","article-title":"Gene x environment interaction studies have not properly controlled for potential confounders: the problem and the (simple) solution","volume":"75","author":"Keller","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2018.07.018_bib0185","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1037\/a0020262","article-title":"Seeing the silver lining: cognitive reappraisal ability moderates the relationship between stress and depressive symptoms","volume":"10","author":"Troy","year":"2010","journal-title":"Emotion"},{"key":"10.1016\/j.neulet.2018.07.018_bib0190","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.jaac.2015.06.010","article-title":"Child maltreatment and neural systems underlying emotion regulation","volume":"54","author":"McLaughlin","year":"2015","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.neulet.2018.07.018_bib0195","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1037\/0022-006X.68.5.782","article-title":"Depression and sensitization to stressors among young women as a function of childhood adversity","volume":"68","author":"Hammen","year":"2000","journal-title":"J. Consult. Clin. Psychol."},{"key":"10.1016\/j.neulet.2018.07.018_bib0200","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1017\/S0033291709992121","article-title":"Childhood adversity, adult stressful life events, and risk of past-year psychiatric disorder: a test of the stress sensitization hypothesis in a population-based sample of adults","volume":"40","author":"McLaughlin","year":"2010","journal-title":"Psychol. Med."},{"key":"10.1016\/j.neulet.2018.07.018_bib0205","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1192\/bjp.bp.113.131227","article-title":"Rates of post-traumatic stress disorder in trauma-exposed children and adolescents: meta-analysis","volume":"204","author":"Alisic","year":"2014","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.neulet.2018.07.018_bib0210","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nrn2639","article-title":"Effects of stress throughout the lifespan on the brain, behaviour and cognition","volume":"10","author":"Lupien","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2018.07.018_bib0215","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1176\/appi.ajp.2010.09101452","article-title":"Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits","volume":"167","author":"Caspi","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neulet.2018.07.018_bib0220","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1176\/appi.ajp.160.4.636","article-title":"The endophenotype concept in psychiatry: etymology and strategic intentions","volume":"160","author":"Gottesman","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neulet.2018.07.018_bib0225","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/mp.2009.44","article-title":"Vulnerability genes or plasticity genes?","volume":"14","author":"Belsky","year":"2009","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.neulet.2018.07.018_bib0230","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2045-5380-3-4","article-title":"Therapygenetics: using genetic markers to predict response to psychological treatment for mood and anxiety disorders","volume":"3","author":"Lester","year":"2013","journal-title":"Biol. Mood Anxiety Disord."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394018304877?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394018304877?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:21:36Z","timestamp":1759609296000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394018304877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":46,"alternative-id":["S0304394018304877"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2018.07.018","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Childhood trauma and emotion regulation: The moderator role of BDNF Val66Met","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2018.07.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}