{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:20:28Z","timestamp":1789759228956,"version":"4.0.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003790","name":"Hiroshima University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004330","name":"Smoking Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23890130"],"award-info":[{"award-number":["JP23890130"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.neulet.2018.10.020","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T14:09:59Z","timestamp":1539266999000},"page":"145-150","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Synphilin-1 has neuroprotective effects on MPP+-induced Parkinson\u2019s disease model cells by inhibiting ROS production and apoptosis"],"prefix":"10.1016","volume":"690","author":[{"given":"Takeo","family":"Shishido","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Nagano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutsuko","family":"Araki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5206-5979","authenticated-orcid":false,"given":"Takashi","family":"Kurashige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitomi","family":"Obayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayasu","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2018.10.020_bib0005","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"Alpha-synuclein in Lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2018.10.020_bib0010","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.neulet.2018.10.020_bib0015","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neuroscience.2011.10.057","article-title":"Neurotoxin-based models of Parkinson\u2019s disease","volume":"211","author":"Bov\u00e9","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2018.10.020_bib0020","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/8820","article-title":"Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions","volume":"22","author":"Engelender","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neulet.2018.10.020_bib0025","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00441-004-0953-z","article-title":"The role of synphilin-1 in synaptic function and protein degradation","volume":"318","author":"Kr\u00fcger","year":"2004","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.neulet.2018.10.020_bib0030","doi-asserted-by":"crossref","first-page":"23927","DOI":"10.1074\/jbc.M201115200","article-title":"Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein","volume":"277","author":"Ribeiro","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2018.10.020_bib0035","doi-asserted-by":"crossref","first-page":"51504","DOI":"10.1074\/jbc.M306347200","article-title":"Siah-1 facilitates ubiquitination and degradation of synphilin-1","volume":"278","author":"Nagano","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2018.10.020_bib0040","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/1531-8249(200004)47:4<521::AID-ANA18>3.0.CO;2-B","article-title":"Synphilin-1 is present in Lewy bodies in Parkinson\u2019s disease","volume":"47","author":"Wakabayashi","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neulet.2018.10.020_bib0045","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s004010100451","article-title":"Immunocytochemical localization of synphilin-1, an \u03b1-synuclein-associated protein, in neurodegenerative disorders","volume":"103","author":"Wakabayashi","year":"2002","journal-title":"Acta. Neuropathol."},{"key":"10.1016\/j.neulet.2018.10.020_bib0050","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s00018-007-7343-0","article-title":"Synphilin-1 isoforms in Parkinson\u2019s disease:\u3000regulation by phosphorylation and ubiquitylation","volume":"65","author":"Szargel","year":"2008","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.neulet.2018.10.020_bib0055","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.neuroscience.2009.10.042","article-title":"Synphilin-1 exhibits trophic and protective effects against rotenone toxicity","volume":"165","author":"Li","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2018.10.020_bib0060","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1093\/hmg\/ddq086","article-title":"Synphilin-1 attenuates neuronal degeneration in the A53T \u03b1-synuclein transgenic mouse model","volume":"19","author":"Smith","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neulet.2018.10.020_bib0065","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/hmg\/ddt467","article-title":"Overexpression of synpahilin-1 promotes clearance of soluble and misfoleded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice","volume":"23","author":"Casadei","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neulet.2018.10.020_bib0070","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1093\/hmg\/ddv504","article-title":"Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson\u2019s disease models","volume":"25","author":"Liu","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neulet.2018.10.020_bib0075","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0306-4522(01)00295-0","article-title":"Mouse model of parkinsonism:a comparison between subacute MPTP and chronic MPTP\/probenecid treatment","volume":"106","author":"Petroske","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2018.10.020_bib0080","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0304-3940(94)90271-2","article-title":"Apoptosis is induced by 1-methyl-4-phenylpyridinium ion(MPP+) in ventral mesencephalic-striatal co culture in rat","volume":"170","author":"Mochizuki","year":"1994","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2018.10.020_bib0085","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0925-4439(98)00083-0","article-title":"The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism","volume":"1453","author":"Cassarino","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neulet.2018.10.020_bib0090","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1074\/jbc.M207880200","article-title":"14-3-3 interacts directly with and negatively regulates pro-apoptotic bax","volume":"278","author":"Nomura","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2018.10.020_bib0095","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s12264-016-0047-4","article-title":"Echinacoside protects against MPP+-induced neuronal apoptosis via ROS\/ATF3\/CHOP pathway regulation","volume":"32","author":"Zhao","year":"2016","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.neulet.2018.10.020_bib0100","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.neulet.2018.10.020_bib0105","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1046\/j.1471-4159.2002.01136.x","article-title":"Synphilin-1 degradation by the ubiquitin-proteasome pathway and effects on cell survival","volume":"83","author":"Lee","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2018.10.020_bib0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013700","article-title":"Synphilin-1 enhances \u03b1-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner","volume":"5","author":"B\u00fcttner","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2018.10.020_bib0115","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neulet.2008.08.073","article-title":"Synphilin-1 transgenic mice exhibit mild motor impairments","volume":"445","author":"Jin","year":"2008","journal-title":"Neurosci. Lett."},{"issue":"2010","key":"10.1016\/j.neulet.2018.10.020_bib0120","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10048-009-0212-2","article-title":"Transgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice","volume":"11","author":"Nuber","year":"2010","journal-title":"Neurogenetics"},{"key":"10.1016\/j.neulet.2018.10.020_bib0125","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/dvg.20740","article-title":"Synphilin suppresses \u03b1-synuclein neurotoxicity in a Parkinson\u2019s disease Drosophila model","volume":"49","author":"Hern\u00e1ndez-Vargas","year":"2011","journal-title":"Genesis"},{"key":"10.1016\/j.neulet.2018.10.020_bib0130","doi-asserted-by":"crossref","first-page":"4625","DOI":"10.1074\/jbc.M310994200","article-title":"Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective","volume":"279","author":"Tanaka","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2018.10.020_bib0135","doi-asserted-by":"crossref","first-page":"11515","DOI":"10.1074\/jbc.M508619200","article-title":"Caspase-3-derived C-terminal product of synphilin-1 displays antiapoptotic function via modulation of the p53-dependent cell death pathway","volume":"281","author":"Giaime","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2018.10.020_bib0140","first-page":"35","article-title":"Mechanisms of MPTP toxicity","volume":"13","author":"Przedborski","year":"1998","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neulet.2018.10.020_bib0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115233","article-title":"Synphilin-1 binds ATP and regulates intracellular energy status","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2018.10.020_bib0150","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4161\/auto.7.1.13909","article-title":"Binding preference of p62 towards LC3-ll during dopaminergic neurotoxin-induced impairment of autophagic flux","volume":"7","author":"Lim","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.neulet.2018.10.020_bib0155","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neulet.2016.12.017","article-title":"Valproic acid protects against MPP+-mediated neurotoxicity in SH-SY5Y cells through autophagy","volume":"638","author":"Zhang","year":"2017","journal-title":"Neurosci Lett."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394018306967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394018306967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:25:04Z","timestamp":1759609504000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394018306967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":31,"alternative-id":["S0304394018306967"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2018.10.020","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synphilin-1 has neuroprotective effects on MPP+-induced Parkinson\u2019s disease model cells by inhibiting ROS production and apoptosis","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2018.10.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}