{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T06:03:01Z","timestamp":1778220181169,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Nature Science Foundation of China to Lili Hou","award":["81300020"],"award-info":[{"award-number":["81300020"]}]},{"name":"Young Physician Assistant Training Program of Shanghai"},{"name":"Excellent Young Physician Assistant Training Program of Shanghai General Hospital affiliated to Shanghai Jiao Tong University to Lili Hou"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.neulet.2018.11.024","type":"journal-article","created":{"date-parts":[[2018,11,17]],"date-time":"2018-11-17T07:18:55Z","timestamp":1542439135000},"page":"231-237","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Central inspiratory activity rhythmically activates synaptic currents of airway vagal preganglionic neurons in neonatal rats"],"prefix":"10.1016","volume":"694","author":[{"given":"Lili","family":"Hou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark C.","family":"Bellingham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2018.11.024_bib0005","doi-asserted-by":"crossref","DOI":"10.1038\/sdata.2017.97","article-title":"Morphology of Dbx1 respiratory neurons in the preBotzinger complex and reticular formation of neonatal mice","volume":"4","author":"Akins","year":"2017","journal-title":"Sci. Data"},{"key":"10.1016\/j.neulet.2018.11.024_bib0010","doi-asserted-by":"crossref","first-page":"139","DOI":"10.12688\/f1000research.10193.1","article-title":"Respiratory rhythm generation: triple oscillator hypothesis","volume":"6","author":"Anderson","year":"2017","journal-title":"F1000Research"},{"key":"10.1016\/j.neulet.2018.11.024_bib0015","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0034-5687(00)00208-5","article-title":"Neural regulation of airway smooth muscle tone","volume":"125","author":"Canning","year":"2001","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.neulet.2018.11.024_bib0020","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0306-4522(02)00454-2","article-title":"Nicotinic excitation of rat hypoglossal motoneurons","volume":"115","author":"Chamberlin","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2018.11.024_bib0025","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.resp.2011.12.014","article-title":"Inspiratory-activated and inspiratory-inhibited airway vagal preganglionic neurons in the ventrolateral medulla of neonatal rat are different in intrinsic electrophysiological properties","volume":"180","author":"Chen","year":"2012","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.neulet.2018.11.024_bib0030","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1113\/expphysiol.2006.036079","article-title":"The airway-related parasympathetic motoneurones in the ventrolateral medulla of newborn rats were dissociated anatomically and in functional control","volume":"92","author":"Chen","year":"2007","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.neulet.2018.11.024_bib0035","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.neuroscience.2012.01.047","article-title":"Agonist of 5-HT1A\/7 receptors but not that of 5-HT2 receptors disinhibits tracheobronchial-projecting airway vagal preganglionic neurons of rats","volume":"207","author":"Chen","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2018.11.024_bib0040","first-page":"770","article-title":"Selective revealing of gap junction currents in single inspiratory tracheal motor neurons","volume":"59","author":"Chen","year":"2007","journal-title":"Sheng li xue bao : [Acta physiologica Sinica]"},{"key":"10.1016\/j.neulet.2018.11.024_bib0045","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.neuron.2016.07.003","article-title":"Defining preBotzinger complex rhythm- and pattern-generating neural microcircuits in vivo","volume":"91","author":"Cui","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2018.11.024_bib0050","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.autneu.2006.02.023","article-title":"Airway-related vagal preganglionic neurons express multiple nicotinic acetylcholine receptor subunits","volume":"128","author":"Dehkordi","year":"2006","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.neulet.2018.11.024_bib0055","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1152\/jn.2001.86.1.59","article-title":"Models of respiratory rhythm generation in the pre-Botzinger complex. III. Experimental tests of model predictions","volume":"86","author":"Del Negro","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neulet.2018.11.024_bib0060","doi-asserted-by":"crossref","first-page":"6325","DOI":"10.1523\/JNEUROSCI.17-16-06325.1997","article-title":"P2 receptor excitation of rodent hypoglossal motoneuron activity in vitro and in vivo: a molecular physiological analysis","volume":"17","author":"Funk","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2018.11.024_bib0065","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0165-1838(99)00020-X","article-title":"CNS innervation of vagal preganglionic neurons controlling peripheral airways: a transneuronal labeling study using pseudorabies virus","volume":"76","author":"Hadziefendic","year":"1999","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.neulet.2018.11.024_bib0070","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.brainres.2016.02.020","article-title":"CNQX facilitates inhibitory synaptic transmission in rat hypoglossal nucleus","volume":"1637","author":"Han","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2018.11.024_bib0075","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1152\/jappl.1992.73.3.1122","article-title":"Bronchomotor vagal preganglionic cell bodies in the dog: an anatomic and functional study","volume":"73","author":"Haselton","year":"1992","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.neulet.2018.11.024_bib0080","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1152\/jappl.1987.63.3.1268","article-title":"Effect of N-methyl-D-aspartate applied to the ventral surface of the medulla on the trachea","volume":"63","author":"Haxhiu","year":"1987","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.neulet.2018.11.024_bib0085","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0034-5687(86)90128-3","article-title":"Medullary effects of nicotine and GABA on tracheal smooth muscle tone","volume":"64","author":"Haxhiu","year":"1986","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.neulet.2018.11.024_bib0090","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0165-1838(97)00110-0","article-title":"The role of excitatory amino acids in airway reflex responses in anesthetized dogs","volume":"67","author":"Haxhiu","year":"1997","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.neulet.2018.11.024_bib0095","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1152\/japplphysiol.01340.2004","article-title":"Brain stem excitatory and inhibitory signaling pathways regulating bronchoconstrictive responses","volume":"98","author":"Haxhiu","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.neulet.2018.11.024_bib0100","doi-asserted-by":"crossref","first-page":"881","DOI":"10.3389\/fphys.2018.00881","article-title":"Inspiratory-activated airway vagal preganglionic neurones excited by thyrotropin-releasing hormone via multiple mechanisms in neonatal rats","volume":"9","author":"Hou","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.neulet.2018.11.024_bib0105","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.neuroscience.2011.12.003","article-title":"Thyrotropin-releasing hormone causes a tonic excitatory postsynaptic current and inhibits the phasic inspiratory inhibitory inputs in inspiratory-inhibited airway vagal preganglionic neurons","volume":"202","author":"Hou","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2018.11.024_bib0110","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1159\/000475638","article-title":"Participation of antidiuretic hormone (ADH) in asthma exacerbations induced by psychological stress via PKA\/PKC signal pathway in Airway-Related vagal preganglionic neurons (AVPNs)","volume":"41","author":"Hou","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.neulet.2018.11.024_bib0115","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.1523\/JNEUROSCI.6027-09.2010","article-title":"Glia contribute to the purinergic modulation of inspiratory rhythm-generating networks","volume":"30","author":"Huxtable","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2018.11.024_bib0120","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1113\/jphysiol.2007.150532","article-title":"Distinct receptors underlie glutamatergic signalling in inspiratory rhythm-generating networks and motor output pathways in neonatal rat","volume":"586","author":"Ireland","year":"2008","journal-title":"J. Physiol."},{"key":"10.1016\/j.neulet.2018.11.024_bib0125","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0011-16.2016","article-title":"Perturbations of respiratory rhythm and pattern by disrupting synaptic inhibition within pre-Botzinger and Botzinger complexes","volume":"3","author":"Marchenko","year":"2016","journal-title":"eNeuro"},{"key":"10.1016\/j.neulet.2018.11.024_bib0130","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1126\/science.1146317","article-title":"TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists","volume":"318","author":"Menuz","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.neulet.2018.11.024_bib0135","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1152\/japplphysiol.00475.2001","article-title":"Modulation of phrenic motoneuron excitability by ATP: consequences for respiratory-related output in vitro","volume":"92","author":"Miles","year":"2002","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.neulet.2018.11.024_bib0140","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1152\/jappl.1985.58.3.911","article-title":"Inspiratory rhythm in airway smooth muscle tone","volume":"58","author":"Mitchell","year":"1985","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.neulet.2018.11.024_bib0145","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0169-328X(99)00004-2","article-title":"Developmental changes in nicotinic receptor mRNAs and responses to nicotine in the suprachiasmatic nucleus and other brain regions, Brain research","volume":"66","author":"O\u2019Hara","year":"1999","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.neulet.2018.11.024_bib0150","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.resp.2011.05.010","article-title":"Beta-asarone inhibits synaptic inputs to airway preganglionic parasympathetic motoneurons","volume":"177","author":"Qiu","year":"2011","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.neulet.2018.11.024_bib0155","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.20-23-j0003.2000","article-title":"Electrical coupling and excitatory synaptic transmission between rhythmogenic respiratory neurons in the preBotzinger complex","volume":"20","author":"Rekling","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2018.11.024_bib0160","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.neulet.2003.12.061","article-title":"S 18986, a positive modulator of AMPA receptors with cognition-enhancing properties, increases ACh release in the hippocampus of young and aged rat","volume":"361","author":"Rosi","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2018.11.024_bib0165","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.30005","article-title":"Synaptic up-scaling preserves motor circuit output after chronic, natural inactivity","volume":"6","author":"Santin","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.neulet.2018.11.024_bib0170","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1111\/j.0953-816X.2004.03347.x","article-title":"AMPA receptor-mediated presynaptic inhibition at cerebellar GABAergic synapses: a characterization of molecular mechanisms","volume":"19","author":"Satake","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neulet.2018.11.024_bib0175","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1152\/jn.2002.88.4.1851","article-title":"Pharmacology of nicotinic receptors in preBotzinger complex that mediate modulation of respiratory pattern","volume":"88","author":"Shao","year":"2002","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neulet.2018.11.024_bib0180","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1113\/jphysiol.2002.031005","article-title":"Modulation of AMPA receptors by cAMP-dependent protein kinase in preBotzinger complex inspiratory neurons regulates respiratory rhythm in the rat","volume":"547","author":"Shao","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.neulet.2018.11.024_bib0185","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/75768","article-title":"Motor coordination without action potentials in the mammalian spinal cord","volume":"3","author":"Tresch","year":"2000","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neulet.2018.11.024_bib0190","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0304-3940(02)00957-6","article-title":"Synaptic activation of hypoglossal respiratory motorneurons during inspiration in rats","volume":"332","author":"Wang","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2018.11.024_bib0195","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fncel.2017.00012","article-title":"Arginine vasopressin alters both spontaneous and phase-locked synaptic inputs to airway vagal preganglionic neuron via activation of V1a receptor: insights into stress-related airway vagal excitation","volume":"11","author":"Yan","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neulet.2018.11.024_bib0200","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1113\/expphysiol.2012.066589","article-title":"Nicotine enhances both excitatory and inhibitory synaptic inputs to inspiratory-activated airway vagal preganglionic neurons","volume":"98","author":"Zhou","year":"2013","journal-title":"Exp. Physiol."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394018308115?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394018308115?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T20:10:27Z","timestamp":1560024627000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394018308115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":40,"alternative-id":["S0304394018308115"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2018.11.024","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Central inspiratory activity rhythmically activates synaptic currents of airway vagal preganglionic neurons in neonatal rats","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2018.11.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2018 Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}