{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:13:42Z","timestamp":1789161222094,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Innovation Team Project of the Department of Education of Liaoning Province","award":["LT2015010"],"award-info":[{"award-number":["LT2015010"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.neulet.2018.12.008","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T12:22:27Z","timestamp":1544012547000},"page":"67-73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Fenamates inhibit human sodium channel Nav1.7 and Nav1.8"],"prefix":"10.1016","volume":"696","author":[{"given":"Jian-Fang","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hua","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan-You","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2018.12.008_bib0005","doi-asserted-by":"crossref","first-page":"7093","DOI":"10.1021\/jm501981g","article-title":"Voltage-gated sodium channels: structure, function, pharmacology, and clinical indications","volume":"58","author":"de Lera Ruiz","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.neulet.2018.12.008_bib0010","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1093\/brain\/aws225","article-title":"Neurological perspectives on voltage-gated sodium channels","volume":"135","author":"Eijkelkamp","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.neulet.2018.12.008_bib0015","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/S1474-4422(14)70150-4","article-title":"Sodium channel genes in pain-related disorders: phenotypegenotype associations and recommendations for clinical use","volume":"13","author":"Waxman","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neulet.2018.12.008_bib0020","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.pain.2003.12.035","article-title":"Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain","volume":"108","author":"Black","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.neulet.2018.12.008_bib0025","doi-asserted-by":"crossref","first-page":"12706","DOI":"10.1073\/pnas.0404915101","article-title":"Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain","volume":"101","author":"Nassar","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2018.12.008_bib0030","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/ncomms1795","article-title":"Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons","volume":"3","author":"Minett","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neulet.2018.12.008_bib0035","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/379257a0","article-title":"A tetrodotoxin resistant voltage-gated sodium channel expressed by sensory neurons","volume":"379","author":"Akopian","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2018.12.008_bib0040","doi-asserted-by":"crossref","first-page":"5953","DOI":"10.1074\/jbc.271.11.5953","article-title":"Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specific to sensory neurons","volume":"271","author":"Sangameswaran","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2018.12.008_bib0045","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.pain.2006.02.011","article-title":"Involvement of the TTX-resistant sodium channel Nav1.8 in inflammatory and neuropathic, but not post-operative, pain states","volume":"123","author":"Joshi","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.neulet.2018.12.008_bib0050","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.bcp.2012.01.014","article-title":"Effect of non-steroidal anti-inflammatory drugs and new fenamate analogues on TRPC4 and TRPC5 channels","volume":"83","author":"Jiang","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neulet.2018.12.008_bib0055","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/newbio238104a0","article-title":"Effects of anti-inflammatory drugs on prostaglandin biosynthesis","volume":"238","author":"Flower","year":"1972","journal-title":"Nat. New Biol."},{"key":"10.1016\/j.neulet.2018.12.008_bib0060","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1365-2125.1979.tb01030.x","article-title":"Fenamates may antagonize the actions of prostaglandin endoperoxides in human myometrium","volume":"8","author":"Sanger","year":"1979","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.neulet.2018.12.008_bib0065","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/S0026-895X(25)10907-3","article-title":"Niflumic and flufenamic acids are potent reversible blockers of Ca2+-activated Cl\u2212 channels in Xenopus oocytes","volume":"37","author":"White","year":"1990","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neulet.2018.12.008_bib0070","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1111\/j.1476-5381.1995.tb15948.x","article-title":"Comparison of the effects of fenamates on Ca-activated chloride and potassium currents in rabbit portal vein smooth muscle cells","volume":"116","author":"Greenwood","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neulet.2018.12.008_bib0075","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/S0022-3565(25)38739-2","article-title":"The cardioprotective and electrophysiological effects of cromakalim are attenuated by meclofenamate through a cyclooxygenase-independent mechanism","volume":"269","author":"Grover","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neulet.2018.12.008_bib0080","first-page":"G873","article-title":"Potassium current in circular smooth muscle of human jejunum activated by fenamates","volume":"265","author":"Farrugia","year":"1993","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.neulet.2018.12.008_bib0085","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1016\/S0006-3495(94)80712-X","article-title":"Potentiation of large conductance KCa channels by niflumic, flufenamic, and mefenamic acids","volume":"67","author":"Ottolia","year":"1994","journal-title":"Biophys. J."},{"key":"10.1016\/j.neulet.2018.12.008_bib0090","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0026-895X(25)09145-X","article-title":"Effects of channel modulators on cloned large-conductance calcium-activated potassium channels","volume":"50","author":"Gribkoff","year":"1996","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neulet.2018.12.008_bib0095","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1124\/mol.112.079194","article-title":"Structure-activity relationship of fenamates as Slo2.1 channel activators","volume":"82","author":"Garg","year":"2012","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neulet.2018.12.008_bib0100","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00424-009-0749-9","article-title":"Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs","volume":"459","author":"Hu","year":"2010","journal-title":"Pflug. Arch."},{"key":"10.1016\/j.neulet.2018.12.008_bib0105","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1124\/mol.111.073726","article-title":"The pharmacological profile of brain liver intestine Na channel: inhibition by diarylamidines and activation by fenamates","volume":"80","author":"Wiemuth","year":"2011","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neulet.2018.12.008_bib0110","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1161\/01.RES.81.5.711","article-title":"Unexpected and differential effects of Cl\u2212 channel blockers on the Kv4.3 and Kv4.2\u2009K channels. Implications for the study of the I (to2) current","volume":"81","author":"Wang","year":"1997","journal-title":"Circ. Res."},{"key":"10.1016\/j.neulet.2018.12.008_bib0115","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/S0026-895X(25)09808-6","article-title":"Positive regulation by chloride channel blockers of IsK channels expressed in Xenopus oocytes","volume":"46","author":"Busch","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neulet.2018.12.008_bib0120","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1124\/mol.104.007112","article-title":"Meclofenamic acid and diclofenac, novel templates of KCNQ2\/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties","volume":"67","author":"Peretz","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neulet.2018.12.008_bib0125","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0014-2999(02)02330-0","article-title":"Fenamate-induced enhancement of heterologously expressed HERG currents in Xenopus oocytes","volume":"452","author":"Malykhina","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neulet.2018.12.008_bib0130","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1124\/mol.107.043505","article-title":"Structural basis for ether-a-go-go-related gene K channel subtype-dependent activation by niflumic acid","volume":"73","author":"Fernandez","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neulet.2018.12.008_bib0135","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1113\/jphysiol.2010.193037","article-title":"Flufenamic acid decreases neuronal excitability through modulation of voltage-gated sodium channel gating","volume":"588","author":"Yau","year":"2010","journal-title":"J. Physiol."},{"key":"10.1016\/j.neulet.2018.12.008_bib0140","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.brainres.2003.08.048","article-title":"Diclofenac inhibition of sodium currents in rat dorsal root ganglion neurons","volume":"992","author":"Lee","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2018.12.008_bib0145","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1111\/j.1476-5381.2010.00976.x","article-title":"Ranolazine selectively blocks persistent current evoked by epilepsy-associated Nav1.1 mutations","volume":"161","author":"Kahlig","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neulet.2018.12.008_bib0150","doi-asserted-by":"crossref","first-page":"18270","DOI":"10.1074\/jbc.M117.792697","article-title":"A mutant of the Buthus martensii Karsch antitumor-analgesic peptide exhibits reduced inhibition to hNav1.4 and hNav1.5 channels while retaining analgesic activity","volume":"292","author":"Xu","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2018.12.008_bib0155","doi-asserted-by":"crossref","first-page":"17534","DOI":"10.1073\/pnas.1306285110","article-title":"Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models","volume":"110","author":"Yang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2018.12.008_bib0160","doi-asserted-by":"crossref","first-page":"5856","DOI":"10.1073\/pnas.1603486113","article-title":"Mutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of hNaV1.7","volume":"113","author":"Thomas-Tran","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2018.12.008_bib0165","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.pharmthera.2016.11.015","article-title":"NaV1.7 as a pain target \u2013 from gene to pharmacology","volume":"172","author":"Vetter","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.neulet.2018.12.008_bib0170","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrn3404","article-title":"The Na(v)1.7 sodium channel: from molecule to man","volume":"14","author":"Dib-Hajj","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2018.12.008_bib0175","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature05413","article-title":"An SCN9A channelopathy causes congenital inability to experience pain","volume":"444","author":"Cox","year":"2006","journal-title":"Nature"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030439401830853X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030439401830853X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T09:21:37Z","timestamp":1775294497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030439401830853X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":35,"alternative-id":["S030439401830853X"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2018.12.008","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fenamates inhibit human sodium channel Nav1.7 and Nav1.8","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2018.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}