{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:38:54Z","timestamp":1790771934104,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"CurePSP foundation (PI Dugger), Alzheimer\u2019s Association","award":["AARG-16-441221"],"award-info":[{"award-number":["AARG-16-441221"]}]},{"name":"Arizona Alzheimer\u2019s Research Consortium"},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the National Institute on Aging"},{"DOI":"10.13039\/100007306","name":"the Arizona Department of Health Services","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007306","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008335","name":"the Arizona Biomedical Research Commission","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008335","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000864","name":"the Michael J. Fox Foundation for Parkinson\u2019s Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.neulet.2018.12.031","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T21:07:43Z","timestamp":1545340063000},"page":"132-139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Tau immunoreactivity in peripheral tissues of human aging and select tauopathies"],"prefix":"10.1016","volume":"696","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2141-8855","authenticated-orcid":false,"given":"Brittany N.","family":"Dugger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany R.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Scroggins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geidy E.","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"Adler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly A.","family":"Shill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Belden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwan N.","family":"Sabbagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N.","family":"Caviness","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Driver Dunckley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Beach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2018.12.031_bib0005","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/mds.26476","article-title":"Peripheral synucleinopathy in early Parkinson\u2019s disease: submandibular gland needle biopsy findings","volume":"31","author":"Adler","year":"2016","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neulet.2018.12.031_bib0010","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1212\/WNL.0000000000000204","article-title":"Submandibular gland needle biopsy for the diagnosis of Parkinson disease","volume":"82","author":"Adler","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2018.12.031_bib0015","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s004010100423","article-title":"Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer\u2019s disease","volume":"103","author":"Augustinack","year":"2002","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neulet.2018.12.031_bib0020","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3233\/JPD-150680","article-title":"Parkinson\u2019s Disease, prevalence of submandibular gland Synucleinopathy in Parkinson\u2019s disease, dementia with Lewy bodies and other Lewy body disorders","volume":"6","author":"Beach","year":"2016","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.neulet.2018.12.031_bib0025","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/neup.12189","article-title":"Arizona study of aging and neurodegenerative disorders and brain and body donation program","volume":"35","author":"Beach","year":"2015","journal-title":"Neuropathology"},{"key":"10.1016\/j.neulet.2018.12.031_bib0030","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00401-010-0664-3","article-title":"Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders","volume":"119","author":"Beach","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neulet.2018.12.031_bib0035","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s10561-008-9067-2","article-title":"The sun health research institute brain donation program: description and experience, 1987-2007","volume":"9","author":"Beach","year":"2008","journal-title":"Cell Tissue Bank"},{"key":"10.1016\/j.neulet.2018.12.031_bib0040","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/cne.903580209","article-title":"Distribution of Big tau in the central nervous system of the adult and developing rat","volume":"358","author":"Boyne","year":"1995","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neulet.2018.12.031_bib0045","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neulet.2005.11.012","article-title":"Gastric alpha-synuclein immunoreactive inclusions in Meissner\u2019s and Auerbach\u2019s plexuses in cases staged for Parkinson\u2019s disease-related brain pathology","volume":"396","author":"Braak","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2018.12.031_bib0050","first-page":"89","article-title":"Neurofibrillary tangles of Alzheimer\u2019s disease: an immunohistochemical study","volume":"17","author":"Brion","year":"1985","journal-title":"J. Submicrosc. Cytol."},{"key":"10.1016\/j.neulet.2018.12.031_bib0055","series-title":"Salivary Gland Pathology: Diagnosis and Management. p. 1 Online Resource","author":"Carlson","year":"2018"},{"key":"10.1016\/j.neulet.2018.12.031_bib0060","doi-asserted-by":"crossref","first-page":"7751","DOI":"10.1073\/pnas.112194599","article-title":"A polymorphic gene nested within an intron of the tau gene: implications for Alzheimer\u2019s disease","volume":"99","author":"Conrad","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2018.12.031_bib0065","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a028035","article-title":"Pathology of neurodegenerative diseases","author":"Dugger","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.neulet.2018.12.031_bib0070","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3233\/JAD-121864","article-title":"The distribution of phosphorylated tau in spinal cords of Alzheimer\u2019s disease and non-demented individuals","volume":"34","author":"Dugger","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neulet.2018.12.031_bib0075","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3233\/JAD-150859","article-title":"The presence of select tau species in human peripheral tissues and their relation to alzheimer\u2019s disease","volume":"51","author":"Dugger","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neulet.2018.12.031_bib0080","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1073\/pnas.89.5.1983","article-title":"Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system","volume":"89","author":"Goedert","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2018.12.031_bib0085","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1046\/j.1471-4159.1996.67031235.x","article-title":"Tau is widely expressed in rat tissues","volume":"67","author":"Gu","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2018.12.031_bib0090","series-title":"Ham\u2019s Histology","first-page":"732","author":"Ham","year":"1987"},{"key":"10.1016\/j.neulet.2018.12.031_bib0095","doi-asserted-by":"crossref","first-page":"M64","DOI":"10.1093\/gerona\/57.1.M64","article-title":"The tau protein of oral epithelium increases in Alzheimer\u2019s disease","volume":"57","author":"Hattori","year":"2002","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.neulet.2018.12.031_bib0100","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1440-1789.2007.00787.x","article-title":"Widespread spinal cord involvement in progressive supranuclear palsy","volume":"27","author":"Iwasaki","year":"2007","journal-title":"Neuropathology"},{"key":"10.1016\/j.neulet.2018.12.031_bib0105","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1007\/s00401-005-1017-5","article-title":"Widespread spinal cord involvement in corticobasal degeneration","volume":"109","author":"Iwasaki","year":"2005","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neulet.2018.12.031_bib0110","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s004010051033","article-title":"Preferential neurodegeneration in the cervical spinal cord of progressive supranuclear palsy","volume":"97","author":"Kikuchi","year":"1999","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neulet.2018.12.031_bib0115","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1006\/exnr.1993.1074","article-title":"Tau proteins are abnormally expressed in olfactory epithelium of Alzheimer patients and developmentally regulated in human fetal spinal cord","volume":"121","author":"Lee","year":"1993","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neulet.2018.12.031_bib0120","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00401-015-1507-z","article-title":"Propagation of tau pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies","volume":"131","author":"Lewis","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neulet.2018.12.031_bib0125","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0168-0102(95)00897-2","article-title":"Tau protein immunolocalization in fetal and adult human spinal cord","volume":"22","author":"Liberini","year":"1995","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neulet.2018.12.031_bib0130","doi-asserted-by":"crossref","first-page":"8422","DOI":"10.1073\/pnas.87.21.8422","article-title":"Identification of nuclear tau isoforms in human neuroblastoma cells","volume":"87","author":"Loomis","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2018.12.031_bib0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050393","article-title":"Identification of biomarkers of human skin ageing in both genders. Wnt signalling - a label of skin ageing?","volume":"7","author":"Makrantonaki","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2018.12.031_bib0140","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006247","article-title":"Biochemistry and cell biology of tau protein in neurofibrillary degeneration","volume":"2","author":"Mandelkow","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.neulet.2018.12.031_bib0145","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.neuint.2010.12.023","article-title":"Post-translational modifications of tau protein: implications for Alzheimer\u2019s disease","volume":"58","author":"Martin","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neulet.2018.12.031_bib0150","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1097\/00005072-199908000-00003","article-title":"Alzheimer disease: curly fibers and tangles in organs other than brain","volume":"58","author":"Miklossy","year":"1999","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neulet.2018.12.031_bib0155","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF00294503","article-title":"Corticobasal degeneration: a disease with widespread appearance of abnormal tau and neurofibrillary tangles, and its relation to progressive supranuclear palsy","volume":"88","author":"Mori","year":"1994","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neulet.2018.12.031_bib0160","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-017-0488-7","article-title":"What is the evidence that tau pathology spreads through prion-like propagation?","volume":"5","author":"Mudher","year":"2017","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.neulet.2018.12.031_bib0165","first-page":"005","article-title":"Presence of phosphorylated tau protein in the skin of alzheimer\u00b4s disease patients","volume":"S6","author":"Rodr\u00edguez-Leyva","year":"2015","journal-title":"J. Mol. Biomark. Diagn."},{"key":"10.1016\/j.neulet.2018.12.031_bib0170","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/acn3.285","article-title":"Parkinson disease and progressive supranuclear palsy: protein expression in skin","volume":"3","author":"Rodriguez-Leyva","year":"2016","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.neulet.2018.12.031_bib0175","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.4161\/cc.7.12.6012","article-title":"A new function of microtubule-associated protein tau: involvement in chromosome stability","volume":"7","author":"Rossi","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.neulet.2018.12.031_bib0180","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3233\/JAD-2011-110731","article-title":"Salivary tau species are potential biomarkers of Alzheimer\u2019s disease","volume":"27","author":"Shi","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neulet.2018.12.031_bib0185","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/BF02510035","article-title":"Tau as a nucleolar protein in human nonneural cells in vitro and in vivo","volume":"105","author":"Thurston","year":"1996","journal-title":"Chromosoma"},{"key":"10.1016\/j.neulet.2018.12.031_bib0190","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1093\/hmg\/dds238","article-title":"MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies","volume":"21","author":"Trabzuni","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neulet.2018.12.031_bib0195","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/jnen\/61.3.268","article-title":"The pathology of the spinal cord in progressive supranuclear palsy","volume":"61","author":"Vitaliani","year":"2002","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neulet.2018.12.031_bib0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-010-0706-x","article-title":"Involvement of the peripheral nervous system in synucleinopathies, tauopathies and other neurodegenerative proteinopathies of the brain","volume":"120","author":"Wakabayashi","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neulet.2018.12.031_bib0205","first-page":"1005","article-title":"Inflammation in Alzheimer disease: driving force, bystander or beneficial response?","volume":"12","author":"Wyss-Coray","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.neulet.2018.12.031_bib0210","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0304-3940(92)90145-W","article-title":"Appearance of paired nucleated, Tau-positive glia in patients with progressive supranuclear palsy brain tissue","volume":"135","author":"Yamada","year":"1992","journal-title":"Neurosci. Lett."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394018308760?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394018308760?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T00:09:20Z","timestamp":1551139760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394018308760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":42,"alternative-id":["S0304394018308760"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2018.12.031","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tau immunoreactivity in peripheral tissues of human aging and select tauopathies","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2018.12.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}