{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T08:02:14Z","timestamp":1772006534219,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601018"],"award-info":[{"award-number":["81601018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.neulet.2019.02.016","type":"journal-article","created":{"date-parts":[[2019,2,10]],"date-time":"2019-02-10T17:10:19Z","timestamp":1549818619000},"page":"177-183","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Fastigial nucleus electrostimulation promotes axonal regeneration after experimental stroke via cAMP\/PKA pathway"],"prefix":"10.1016","volume":"699","author":[{"given":"An-rong","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-zhe","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze-yu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2019.02.016_bib0005","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/nn.2674","article-title":"An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke","volume":"13","author":"Li","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neulet.2019.02.016_bib0010","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/jcbfm.2010.8","article-title":"Bone marrow stromal cells enhance inter- and intracortical axonal connections after ischemic stroke in adult rats","volume":"30","author":"Liu","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neulet.2019.02.016_bib0015","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nrn1195","article-title":"Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS","volume":"4","author":"Filbin","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2019.02.016_bib0020","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.conb.2003.09.006","article-title":"Signaling mechanisms of the myelin inhibitors of axon regeneration","volume":"13","author":"Yiu","year":"2003","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neulet.2019.02.016_bib0025","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1146\/annurev.neuro.27.070203.144340","article-title":"The nogo signaling pathway for regeneration block","volume":"27","author":"He","year":"2004","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2019.02.016_bib0030","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0896-6273(02)00702-X","article-title":"Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation","volume":"34","author":"Neumann","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2019.02.016_bib0035","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0896-6273(02)00730-4","article-title":"Spinal axon regeneration induced by elevation of cyclic AMP","volume":"34","author":"Qiu","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2019.02.016_bib0040","doi-asserted-by":"crossref","first-page":"22554","DOI":"10.1074\/jbc.273.35.22554","article-title":"cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho kinase ROK alpha","volume":"273","author":"Dong","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2019.02.016_bib0045","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/01616412.2016.1251710","article-title":"Electrical stimulation of cerebellar fastigial nucleus protects against cerebral ischemic injury by PPAR\u03b3 upregulation","volume":"39","author":"Liu","year":"2017","journal-title":"Neurol. Res."},{"key":"10.1016\/j.neulet.2019.02.016_bib0050","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/jnc.13094","article-title":"Fastigial nucleus stimulation regulates neuroprotection via induction of a novel microRNA, rno-miR-676-1, in middle cerebral artery occlusion rats","volume":"133","author":"Pang","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2019.02.016_bib0055","article-title":"The effect of pre-condition cerebella fastigial nucleus electrical stimulation within and beyond the time window of thrombolytic on ischemic stroke in the rats","volume":"10","author":"Tang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2019.02.016_bib0060","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/jcbfm.1991.139","article-title":"Electrical stimulation of cerebellar fastigial nucleus reduces ischemic infarction elicited by middle cerebral artery occlusion in rat","volume":"11","author":"Reis","year":"1991","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neulet.2019.02.016_bib0065","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/jcbfm.1993.128","article-title":"Reductions in focal ischemic infarctions elicited from cerebellar fastigial nucleus do not result from elevations in cerebral","volume":"13","author":"Yamamoto","year":"1993","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neulet.2019.02.016_bib0070","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1007\/s11064-012-0809-y","article-title":"Fastigial nucleus electrostimulation reduces the expression of repulsive guidance molecule, improves axonal growth following focal cerebral ischemia","volume":"37","author":"Jiang","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neulet.2019.02.016_bib0075","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/cns.12288","article-title":"Electrical stimulation of cerebellar fastigial nucleus: mechanism of neuroprotection and prospects for clinical application against cerebral ischemia","volume":"20","author":"Wang","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.neulet.2019.02.016_bib0080","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1161\/01.STR.27.9.1616","article-title":"Middle cerebral artery occlusion in the rat by intraluminal suture. Neurological and pathological evaluation of an improved model","volume":"27","author":"Belayev","year":"1996","journal-title":"Stroke"},{"key":"10.1016\/j.neulet.2019.02.016_bib0085","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neulet.2012.05.044","article-title":"Electrical stimulation of cerebellar fastigial nucleus promotes the expression of growth arrest and DNA damage inducible gene \u03b2 and motor function recovery in cerebral ischemia\/reperfusion rats","volume":"520","author":"Liu","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2019.02.016_bib0090","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.neulet.2019.02.016_bib0095","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/S0028-3908(99)00262-2","article-title":"Functional assessments in mice and rats after focal stroke","volume":"39","author":"Hunter","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neulet.2019.02.016_bib0100","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0165-0270(90)90154-8","article-title":"Beam-walking in rats: studies towards developing an animal model of functional recovery after brain injury","volume":"31","author":"Goldstein","year":"1990","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.neulet.2019.02.016_bib0105","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1517\/14656566.9.7.1071","article-title":"Recommendations and treatment strategies for the management of acute ischemic stroke","volume":"9","author":"Segura","year":"2008","journal-title":"Expert Opin. Pharmacother."},{"issue":"24","key":"10.1016\/j.neulet.2019.02.016_bib0110","doi-asserted-by":"crossref","first-page":"9356","DOI":"10.1128\/MCB.20.24.9356-9363.2000","article-title":"Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3beta","volume":"20","author":"Li","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.neulet.2019.02.016_bib0115","doi-asserted-by":"crossref","first-page":"8786","DOI":"10.1073\/pnas.0402595101","article-title":"The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery","volume":"101","author":"Nikulina","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2019.02.016_bib0120","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nm1056","article-title":"cAMP and Schwann cells promote axon growth and functional recovery after spinal cord injury","volume":"10","author":"Bretzner","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.neulet.2019.02.016_bib0125","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1523\/JNEUROSCI.21-13-04731.2001","article-title":"Neuronal cyclic AMP controls the developmental loss in ability of axons to regenerate","volume":"21","author":"Cai","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2019.02.016_bib0130","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nchembio.2298","article-title":"AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons","volume":"13","author":"Gorshkov","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.neulet.2019.02.016_bib0135","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neulet.2016.12.033","article-title":"The role of cAMP and its downstream targets in neurite growth in the adult nervous system","volume":"652","author":"Batty","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2019.02.016_bib0140","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.mcn.2009.06.005","article-title":"ROCK inhibition promotes adult retinal ganglion cell neurite outgrowth only in the presence of growth promoting factors","volume":"42","author":"Ahmed","year":"2009","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neulet.2019.02.016_bib0145","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.1007\/s12035-015-9397-6","article-title":"Inhibitory injury signaling represses axon regeneration after dorsal root injury","volume":"53","author":"Mar","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.neulet.2019.02.016_bib0150","first-page":"11","article-title":"Inhibition of the Rho signaling pathway improves neurite outgrowth and neuronal differentiation of mouse neural stem cells","volume":"5","author":"Gu","year":"2013","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"10.1016\/j.neulet.2019.02.016_bib0155","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.neuroscience.2012.09.025","article-title":"Exendin-4 improved rat cortical neuron survival under oxygen\/glucose deprivation through PKA pathway","volume":"226","author":"Wang","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2019.02.016_bib0160","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/336672a0","article-title":"Development of neuronal polarity: GAP43 distinguishes axonal from dendritic growth cones","volume":"336","author":"Goslin","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2019.02.016_bib0165","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1161\/01.STR.26.11.2135","article-title":"Neocortical neural sprouting, synaptogenesis, and behavioral recovery after neocortical infarction in rats","volume":"26","author":"Stroemer","year":"1995","journal-title":"Stroke"},{"key":"10.1016\/j.neulet.2019.02.016_bib0170","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0304-3940(93)90557-2","article-title":"Acute increase in expression of growth associated protein GAP43 following cortical ischemia in rat","volume":"162","author":"Stroemer","year":"1993","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2019.02.016_bib0175","doi-asserted-by":"crossref","first-page":"e5561","DOI":"10.1590\/1414-431x20175561","article-title":"Retinoic acid protects from experimental cerebral infarction by upregulating GAP-43 expression","volume":"50","author":"Li","year":"2017","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.neulet.2019.02.016_bib0180","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0079-6123(08)63182-9","article-title":"Genetics and biology of the Alzheimer amyloid precursor","volume":"86","author":"Neve","year":"1990","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.neulet.2019.02.016_bib0185","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1523\/JNEUROSCI.15-05-03594.1995","article-title":"The effects of a lesion or a peripheral nerve graft on GAP-43 upregulation in the adult rat brain: an in situ hybridization and immunocytochemical study","volume":"15","author":"Vaudano","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2019.02.016_bib0190","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.biopha.2018.04.125","article-title":"Investigation of Ginkgo biloba extract (EGb 761) promotes neurovascular restoration and axonal remodeling after embolic stroke in rat using magnetic resonance imaging and histopathological analysis","volume":"103","author":"Li","year":"2018","journal-title":"Biomed. Pharmacother."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394019300990?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394019300990?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:27:00Z","timestamp":1759609620000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394019300990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":38,"alternative-id":["S0304394019300990"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2019.02.016","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fastigial nucleus electrostimulation promotes axonal regeneration after experimental stroke via cAMP\/PKA pathway","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2019.02.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}