{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:26:59Z","timestamp":1777868819707,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007108","name":"George Washington University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P40 OD010440"],"award-info":[{"award-number":["P40 OD010440"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.neulet.2019.04.016","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T11:34:39Z","timestamp":1554723279000},"page":"212-219","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["An inducible model of human amylin overexpression reveals diverse transcriptional changes"],"prefix":"10.1016","volume":"704","author":[{"given":"Yoseph","family":"Aldras","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanghamitra","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Bode","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diti Chatterjee","family":"Bhowmick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandar","family":"Jeremic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5752-2131","authenticated-orcid":false,"given":"Damien M.","family":"O\u2019Halloran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.neulet.2019.04.016_bib0005","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol."},{"issue":"2","key":"10.1016\/j.neulet.2019.04.016_bib0010","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.neulet.2019.04.016_bib0015","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"issue":"2\u20133","key":"10.1016\/j.neulet.2019.04.016_bib0020","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jmb.2012.01.024","article-title":"A molecular history of the amyloidoses","volume":"421","author":"Buxbaum","year":"2012","journal-title":"J. Mol. Biol."},{"issue":"9","key":"10.1016\/j.neulet.2019.04.016_bib0025","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.2337\/db07-0178","article-title":"Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic beta-cell apoptosis","volume":"56","author":"Casas","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.neulet.2019.04.016_bib0030","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.RA118.002414","article-title":"Functional proteasome complex is required for turnover of islet amyloid polypeptide in pancreatic beta-cells","author":"Chatterjee Bhowmick","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.neulet.2019.04.016_bib0035","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1046\/j.1471-4159.2002.01137.x","article-title":"Proteasomal degradation of tau protein","volume":"83","author":"David","year":"2002","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.neulet.2019.04.016_bib0040","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molcel.2011.05.012","article-title":"A diversity of assembly mechanisms of a generic amyloid fold","volume":"43","author":"Eichner","year":"2011","journal-title":"Mol. Cell"},{"issue":"7","key":"10.1016\/j.neulet.2019.04.016_bib0045","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1210\/en.2012-2172","article-title":"Amylin acts in the central nervous system to increase sympathetic nerve activity","volume":"154","author":"Fernandes-Santos","year":"2013","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.neulet.2019.04.016_bib0050","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1001\/archneurol.2008.582","article-title":"Midlife and late-life obesity and the risk of dementia: cardiovascular health study","volume":"66","author":"Fitzpatrick","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neulet.2019.04.016_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2013.08.011","article-title":"Nuclear PKG localization is regulated by G alpha and is necessary in the AWB neurons to mediate avoidance in Caenorhabditis elegans","author":"He","year":"2013","journal-title":"Neurosci. Lett."},{"issue":"4","key":"10.1016\/j.neulet.2019.04.016_bib0060","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/ana.23956","article-title":"Amylin deposition in the brain: A second amyloid in Alzheimer disease?","volume":"74","author":"Jackson","year":"2013","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.neulet.2019.04.016_bib0065","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10495-011-0656-3","article-title":"beta-Amyloid protein (Abeta) and human amylin regulation of apoptotic genes occurs through the amylin receptor","volume":"17","author":"Jhamandas","year":"2012","journal-title":"Apoptosis"},{"issue":"8","key":"10.1016\/j.neulet.2019.04.016_bib0070","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.2337\/diab.43.8.1066","article-title":"Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes","volume":"43","author":"Kahn","year":"1994","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.neulet.2019.04.016_bib0075","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2013-14-4-r36","article-title":"TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions","volume":"14","author":"Kim","year":"2013","journal-title":"Genome Biol."},{"issue":"18","key":"10.1016\/j.neulet.2019.04.016_bib0080","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.12968\/bjon.2003.12.18.11775","article-title":"A history of diabetes: from antiquity to discovering insulin","volume":"12","author":"King","year":"2003","journal-title":"Br J Nurs"},{"issue":"5","key":"10.1016\/j.neulet.2019.04.016_bib0085","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2000-1-5-reviews3002","article-title":"The F-box protein family","volume":"1","author":"Kipreos","year":"2000","journal-title":"Genome Biol."},{"issue":"4","key":"10.1016\/j.neulet.2019.04.016_bib0090","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"issue":"3","key":"10.1016\/j.neulet.2019.04.016_bib0095","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol."},{"issue":"6","key":"10.1016\/j.neulet.2019.04.016_bib0100","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.cmet.2015.10.012","article-title":"Hypothalamic amylin acts in concert with leptin to regulate food intake","volume":"22","author":"Li","year":"2015","journal-title":"Cell Metab."},{"issue":"8","key":"10.1016\/j.neulet.2019.04.016_bib0105","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1002\/pmic.200900651","article-title":"Abeta and human amylin share a common toxicity pathway via mitochondrial dysfunction","volume":"10","author":"Lim","year":"2010","journal-title":"Proteomics"},{"issue":"22","key":"10.1016\/j.neulet.2019.04.016_bib0110","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1242\/dev.02648","article-title":"The Caenorhabditis elegans P21-activated kinases are differentially required for UNC-6\/netrin-mediated commissural motor axon guidance","volume":"133","author":"Lucanic","year":"2006","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.neulet.2019.04.016_bib0115","doi-asserted-by":"crossref","first-page":"723","DOI":"10.3233\/JAD-2010-091687","article-title":"Type 2 diabetes, related conditions, in relation and dementia: an opportunity for prevention?","volume":"20","author":"Luchsinger","year":"2010","journal-title":"J. Alzheimers Dis."},{"issue":"12","key":"10.1016\/j.neulet.2019.04.016_bib0120","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1007\/s00018-011-0905-1","article-title":"Control of energy homeostasis by amylin","volume":"69","author":"Lutz","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"issue":"Database issue","key":"10.1016\/j.neulet.2019.04.016_bib0125","doi-asserted-by":"crossref","first-page":"D284","DOI":"10.1093\/nar\/gki078","article-title":"The PANTHER database of protein families, subfamilies, functions and pathways","volume":"33","author":"Mi","year":"2005","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.neulet.2019.04.016_bib0130","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0168-8227(92)90060-5","article-title":"Islet amyloid polypeptide (IAPP) and pancreatic islet amyloid deposition in diabetic and non-diabetic patients","volume":"15","author":"Narita","year":"1992","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"4","key":"10.1016\/j.neulet.2019.04.016_bib0135","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1177\/030098589303000401","article-title":"Islet amyloid polypeptide: a review of its biology and potential roles in the pathogenesis of diabetes mellitus","volume":"30","author":"O\u2019Brien","year":"1993","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.neulet.2019.04.016_bib0140","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.molbiopara.2018.12.001","article-title":"Genome aware CRISPR gRNA target prediction for parasitic nematodes","volume":"227","author":"O\u2019Halloran","year":"2019","journal-title":"Mol. Biochem. Parasitol."},{"issue":"8","key":"10.1016\/j.neulet.2019.04.016_bib0145","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1172\/JCI71981","article-title":"Autophagy defends pancreatic beta cells from human islet amyloid polypeptide-induced toxicity","volume":"124","author":"Rivera","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.neulet.2019.04.016_bib0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0149409","article-title":"Hsp72 (HSPA1A) prevents human islet amyloid polypeptide aggregation and toxicity: a new approach for type 2 diabetes treatment","volume":"11","author":"Rosas","year":"2016","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.neulet.2019.04.016_bib0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020221","article-title":"Drosophila melanogaster as a model system for studies of islet amyloid polypeptide aggregation","volume":"6","author":"Schultz","year":"2011","journal-title":"PLoS One"},{"issue":"13","key":"10.1016\/j.neulet.2019.04.016_bib0160","doi-asserted-by":"crossref","first-page":"5364","DOI":"10.1074\/jbc.M116.758953","article-title":"The NCLX-type Na+\/Ca2+ Exchanger NCX-9 Is Required for Patterning of Neural Circuits in Caenorhabditis elegans","volume":"292","author":"Sharma","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.neulet.2019.04.016_bib0165","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.diabres.2009.10.007","article-title":"Global estimates of the prevalence of diabetes for 2010 and 2030","volume":"87","author":"Shaw","year":"2010","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"8","key":"10.1016\/j.neulet.2019.04.016_bib0170","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1172\/JCI69866","article-title":"Human IAPP-induced pancreatic beta cell toxicity and its regulation by autophagy","volume":"124","author":"Shigihara","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neulet.2019.04.016_bib0175","doi-asserted-by":"crossref","DOI":"10.1186\/1750-1326-9-30","article-title":"Neuroinflammation and neurologic deficits in diabetes linked to brain accumulation of amylin","volume":"9","author":"Srodulski","year":"2014","journal-title":"Mol. Neurodegener."},{"issue":"9","key":"10.1016\/j.neulet.2019.04.016_bib0180","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1101\/gr.772403","article-title":"PANTHER: a library of protein families and subfamilies indexed by function","volume":"13","author":"Thomas","year":"2003","journal-title":"Genome Res."},{"issue":"2","key":"10.1016\/j.neulet.2019.04.016_bib0185","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0092-8674(00)80399-2","article-title":"Reprogramming chemotaxis responses: sensory neurons define olfactory preferences in C. elegans","volume":"91","author":"Troemel","year":"1997","journal-title":"Cell"},{"issue":"27","key":"10.1016\/j.neulet.2019.04.016_bib0190","doi-asserted-by":"crossref","first-page":"25009","DOI":"10.1074\/jbc.M300227200","article-title":"Alpha-Synuclein is degraded by both autophagy and the proteasome","volume":"278","author":"Webb","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.neulet.2019.04.016_bib0195","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1152\/physrev.00042.2009","article-title":"Islet amyloid polypeptide, islet amyloid, and diabetes mellitus","volume":"91","author":"Westermark","year":"2011","journal-title":"Physiol. Rev."},{"issue":"11","key":"10.1016\/j.neulet.2019.04.016_bib0200","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.1073\/pnas.84.11.3881","article-title":"Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells","volume":"84","author":"Westermark","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"11","key":"10.1016\/j.neulet.2019.04.016_bib0205","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.2337\/diabetes.52.11.2759","article-title":"Prevalence and clinicopathological characteristics of islet amyloid in chinese patients with type 2 diabetes","volume":"52","author":"Zhao","year":"2003","journal-title":"Diabetes"},{"issue":"6865","key":"10.1016\/j.neulet.2019.04.016_bib0210","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/414782a","article-title":"Global and societal implications of the diabetes epidemic","volume":"414","author":"Zimmet","year":"2001","journal-title":"Nature"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394019302502?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394019302502?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:44:25Z","timestamp":1777553065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394019302502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":42,"alternative-id":["S0304394019302502"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2019.04.016","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An inducible model of human amylin overexpression reveals diverse transcriptional changes","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2019.04.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}