{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:28:06Z","timestamp":1792801686302,"version":"4.5.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T00:00:00Z","timestamp":1590105600000},"content-version":"vor","delay-in-days":326,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","award":["16\/2551-0000526-5"],"award-info":[{"award-number":["16\/2551-0000526-5"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","award":["16\/2251-0000183-9"],"award-info":[{"award-number":["16\/2251-0000183-9"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.neulet.2019.05.036","type":"journal-article","created":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T11:22:46Z","timestamp":1558351366000},"page":"158-163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Chrysin protects against behavioral, cognitive and neurochemical alterations in a 6-hydroxydopamine model of Parkinson's disease"],"prefix":"10.1016","volume":"706","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3613-4134","authenticated-orcid":false,"given":"Lucian","family":"Del Fabbro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Rossito Goes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano Ricardo","family":"Jesse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9017-5979","authenticated-orcid":false,"given":"Marcelo Gomes","family":"de Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro","family":"Cattelan Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando V.","family":"Lobo Ladd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliny A.B.","family":"Lobo Ladd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0145-7718","authenticated-orcid":false,"given":"Ricardo Vinicius","family":"Nunes Arantes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astor","family":"Reis Simionato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Schneider","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Flavia","family":"Furian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana Peterini","family":"Boeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2019.05.036_bib0005","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1365-2796.2006.01745.x","article-title":"New roles for an old enzyme: Na,K-ATPase emerges as an interesting drug target","volume":"261","author":"Aperia","year":"2007","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.neulet.2019.05.036_bib0010","first-page":"4240","article-title":"Effect of intrastriatal 6-OHDA lesions on extrastriatal brain structures in the mouse","volume":"55","author":"Becker","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neulet.2019.05.036_bib0015","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.neulet.2019.05.036_bib0020","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/sj.cdd.4401261","article-title":"Nitric oxide: NO apoptosis or turning it ON?","volume":"10","author":"Brune","year":"2003","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.neulet.2019.05.036_bib0025","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S1474-4422(09)70068-7","article-title":"Non-motor symptoms of Parkinson\u2019s disease: dopaminergic pathophysiology and treatment","volume":"8","author":"Chaudhuri","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neulet.2019.05.036_bib0030","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.expneurol.2006.08.008","article-title":"Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in mice","volume":"203","author":"Dall\u2019Igna","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neulet.2019.05.036_bib0035","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1023\/A:1006928927480","article-title":"Na\/K-ATPase under oxidative stress: molecular mechanisms of injury","volume":"19","author":"Dobrota","year":"1999","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.neulet.2019.05.036_bib0040","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.brainresbull.2014.03.004","article-title":"Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: possible role of l-arginine-NO-cGMP pathway and BDNF levels","volume":"104","author":"Donato","year":"2014","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neulet.2019.05.036_bib0045","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.bbi.2012.02.007","article-title":"MyD88 deficiency results in both cognitive and motor impairments in mice","volume":"26","author":"Drouin-Ouellet","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neulet.2019.05.036_bib0050","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1007\/s11064-007-9575-7","article-title":"Evaluation of estrogen neuroprotective effect on nigrostriatal dopaminergic neurons following 6-hydroxydopamine injection into the substantia nigra pars compacta or the medial forebrain bundle","volume":"33","author":"Ferraz","year":"2008","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neulet.2019.05.036_bib0055","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.neuint.2013.09.012","article-title":"The effect of NADPH-oxidase inhibitor apocynin on cognitive impairment induced by moderate lateral fluid percussion injury: role of inflammatory and oxidative brain damage","volume":"63","author":"Ferreira","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neulet.2019.05.036_bib0060","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.neuroscience.2014.12.048","article-title":"Chronic unpredictable mild stress decreases BDNF and NGF levels and Na(+),K(+)-ATPase activity in the hippocampus and prefrontal cortex of mice: antidepressant effect of chrysin","volume":"289","author":"Filho","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2019.05.036_bib0065","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cbi.2017.10.019","article-title":"Protective role of chrysin on 6-hydroxydopamine-induced neurodegeneration a mouse model of Parkinson\u2019s disease: involvement of neuroinflammation and neurotrophins","volume":"279","author":"Goes","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.neulet.2019.05.036_bib0070","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0003-2697(76)90326-2","article-title":"A fluorometric method for determination of oxidized and reduced glutathione in tissues","volume":"74","author":"Hissin","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.neulet.2019.05.036_bib0075","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1742-7843.2007.00145.x","article-title":"Comparison of the effects of deramciclane, ritanserin and buspirone on extracellular dopamine and its metabolites in striatum and nucleus accumbens of freely moving rats","volume":"102","author":"Kaariainen","year":"2008","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.neulet.2019.05.036_bib0080","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.niox.2006.07.003","article-title":"Nitric oxide synthase regulation and diversity: implications in Parkinson\u2019s disease","volume":"15","author":"Kavya","year":"2006","journal-title":"Nitric oxide: biology and chemistry"},{"key":"10.1016\/j.neulet.2019.05.036_bib0085","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1080\/19390211.2016.1275916","article-title":"Neuroprotective and therapeutic effect of caffeine on the rat model of parkinson\u2019s disease induced by rotenone","volume":"14","author":"Khadrawy","year":"2017","journal-title":"J. Diet. Suppl."},{"key":"10.1016\/j.neulet.2019.05.036_bib0090","article-title":"Chrysin attenuates VCAM-1 expression and monocyte adhesion in lipopolysaccharide-stimulated brain endothelial cells by preventing NF-kappaB signaling","volume":"18","author":"Lee","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neulet.2019.05.036_bib0095","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1248\/bpb.34.1291","article-title":"Neuroprotective effect of kaempferol against a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson\u2019s disease","volume":"34","author":"Li","year":"2011","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.neulet.2019.05.036_bib0100","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1196\/annals.1332.007","article-title":"Inflammation and the degenerative diseases of aging","volume":"1035","author":"McGeer","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neulet.2019.05.036_bib0105","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.bcp.2004.09.018","article-title":"Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures","volume":"69","author":"Mercer","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neulet.2019.05.036_bib0110","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/ana.23687","article-title":"Meta-analysis of early nonmotor features and risk factors for Parkinson disease","volume":"72","author":"Noyce","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neulet.2019.05.036_bib0115","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s13238-015-0230-9","article-title":"Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson\u2019s disease","volume":"7","author":"Song","year":"2016","journal-title":"Protein Cell"},{"key":"10.1016\/j.neulet.2019.05.036_bib0120","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.pbb.2015.04.010","article-title":"Flavonoid Chrysin prevents age-related cognitive decline via attenuation of oxidative stress and modulation of BDNF levels in aged mouse brain","volume":"134","author":"Souza","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neulet.2019.05.036_bib0125","doi-asserted-by":"crossref","first-page":"717","DOI":"10.3109\/00207454.2014.982795","article-title":"Neuroinflammation in Parkinson\u2019s disease: role in neurodegeneration and tissue repair","volume":"125","author":"Vivekanantham","year":"2015","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.neulet.2019.05.036_bib0130","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.tiv.2018.04.005","article-title":"Neuroprotective effect of angiotensin-(1-7) against rotenone-induced oxidative damage in CATH.a neurons","volume":"50","author":"Zhou","year":"2018","journal-title":"Toxicol. In Vitro"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394019303544?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394019303544?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T15:10:38Z","timestamp":1778685038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394019303544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":26,"alternative-id":["S0304394019303544"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2019.05.036","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chrysin protects against behavioral, cognitive and neurochemical alterations in a 6-hydroxydopamine model of Parkinson's disease","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2019.05.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}