{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:26:44Z","timestamp":1786994804107,"version":"build-2736575974"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001673","name":"J\u00e9r\u00f4me Lejeune Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001673","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Kent State University Innovation Research"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.neulet.2019.134569","type":"journal-article","created":{"date-parts":[[2019,10,20]],"date-time":"2019-10-20T09:56:19Z","timestamp":1571565379000},"page":"134569","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Neurodevelopmental wiring deficits in the Ts65Dn mouse model of Down syndrome"],"prefix":"10.1016","volume":"714","author":[{"given":"Shruti","family":"Jain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina A.","family":"Watts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson C.J.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6624-4719","authenticated-orcid":false,"given":"Kristy","family":"Welshhans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2019.134569_bib0005","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/ajmg.a.37001","article-title":"Estimates of the live births, natural losses, and elective terminations with Down syndrome in the United States","volume":"167A","author":"de Graaf","year":"2015","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.neulet.2019.134569_bib0010","first-page":"181","article-title":"Brain growth in Down syndrome subjects 15 to 22 weeks of gestational age and birth to 60 months","volume":"9","author":"Schmidt-Sidor","year":"1990","journal-title":"Clin. Neuropathol."},{"key":"10.1016\/j.neulet.2019.134569_bib0015","first-page":"274","article-title":"Down-syndrome children often have brain with maturation delay, retardation of growth, and cortical dysgenesis","author":"Wisniewski","year":"1990","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.neulet.2019.134569_bib0020","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/hipo.20308","article-title":"Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice","volume":"17","author":"Contestabile","year":"2007","journal-title":"Hippocampus"},{"key":"10.1016\/j.neulet.2019.134569_bib0025","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1176\/appi.ajp.160.10.1870","article-title":"Relation of corpus callosum and hippocampal size to age in nondemented adults with Down\u2019s syndrome","volume":"160","author":"Teipel","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neulet.2019.134569_bib0030","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1001\/archneur.1992.00530280101029","article-title":"Callosal morphology concurs with neurobehavioral and neuropathological findings in two neurodevelopmental disorders","volume":"49","author":"Wang","year":"1992","journal-title":"Arch. Neurol."},{"issue":"Pt. 1","key":"10.1016\/j.neulet.2019.134569_bib0035","first-page":"19","article-title":"The anterior commissure in Down\u2019s syndrome","volume":"30","author":"Sylvester","year":"1986","journal-title":"J. Ment. Defic. Res."},{"key":"10.1016\/j.neulet.2019.134569_bib0040","first-page":"117","article-title":"Segmental trisomy as a mouse model for Down syndrome","volume":"384","author":"Davisson","year":"1993","journal-title":"Prog. Clin. Biol. Res."},{"key":"10.1016\/j.neulet.2019.134569_bib0045","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1242\/dmm.007716","article-title":"The use of mouse models to understand and improve cognitive deficits in Down syndrome","volume":"4","author":"Das","year":"2011","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.neulet.2019.134569_bib0050","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1007\/s00335-016-9661-8","article-title":"Mouse models of Down syndrome: gene content and consequences","volume":"27","author":"Gupta","year":"2016","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.neulet.2019.134569_bib0055","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/s00335-011-9356-0","article-title":"Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome","volume":"22","author":"Duchon","year":"2011","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.neulet.2019.134569_bib0060","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/ajmg.c.30280","article-title":"Mouse models of cognitive disabilities in trisomy 21 (Down syndrome)","volume":"154C","author":"Roubertoux","year":"2010","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"10.1016\/j.neulet.2019.134569_bib0065","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/nrn3314","article-title":"Down syndrome: the brain in trisomic mode","volume":"13","author":"Dierssen","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2019.134569_bib0070","doi-asserted-by":"crossref","first-page":"11483","DOI":"10.1523\/JNEUROSCI.3406-07.2007","article-title":"Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome","volume":"27","author":"Chakrabarti","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2019.134569_bib0075","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1750-3639.2007.00113.x","article-title":"Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with Down syndrome","volume":"18","author":"Guidi","year":"2008","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neulet.2019.134569_bib0080","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1093\/brain\/awt340","article-title":"Prenatal pharmacotherapy rescues brain development in a Down\u2019s syndrome mouse model","volume":"137","author":"Guidi","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.neulet.2019.134569_bib0085","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.brainres.2006.05.022","article-title":"Hippocampal hypocellularity in the Ts65Dn mouse originates early in development","volume":"1104","author":"Lorenzi","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2019.134569_bib0090","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3005983","article-title":"Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model","volume":"5","author":"Das","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neulet.2019.134569_bib0095","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00335-011-9357-z","article-title":"Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn","volume":"22","author":"Reinholdt","year":"2011","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.neulet.2019.134569_bib0100","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/dneu.22360","article-title":"Netrin-1 induces local translation of down syndrome cell adhesion molecule in axonal growth cones","volume":"76","author":"Jain","year":"2016","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.neulet.2019.134569_bib0105","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1038\/nprot.2006.356","article-title":"Culturing hippocampal neurons","volume":"1","author":"Kaech","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neulet.2019.134569_bib0110","doi-asserted-by":"crossref","first-page":"9800","DOI":"10.1523\/JNEUROSCI.0166-11.2011","article-title":"Netrin-1-induced local beta-actin synthesis and growth cone guidance requires zipcode binding protein 1","volume":"31","author":"Welshhans","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2019.134569_bib0115","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.neuroscience.2008.08.071","article-title":"Effects of ethanol on axon outgrowth and branching in developing rat cortical neurons","volume":"157","author":"Hoffman","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2019.134569_bib0120","doi-asserted-by":"crossref","first-page":"5873","DOI":"10.1523\/JNEUROSCI.0183-09.2009","article-title":"Wnt5a induces simultaneous cortical axon outgrowth and repulsive axon guidance through distinct signaling mechanisms","volume":"29","author":"Li","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2019.134569_bib0125","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12868-017-0392-x","article-title":"Shift in the function of netrin-1 from axon outgrowth to axon branching in developing cerebral cortical neurons","volume":"18","author":"Matsumoto","year":"2017","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.neulet.2019.134569_bib0130","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jchemneu.2011.09.002","article-title":"Alterations of brain circuits in Down syndrome murine models","volume":"42","author":"Gotti","year":"2011","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.neulet.2019.134569_bib0135","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/B978-0-444-54299-1.00006-6","article-title":"Neurological phenotypes for Down syndrome across the life span","volume":"197","author":"Lott","year":"2012","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.neulet.2019.134569_bib0140","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1096\/fj.13-232686","article-title":"Dosage of amyloid precursor protein affects axonal contact guidance in Down syndrome","volume":"28","author":"Sosa","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.neulet.2019.134569_bib0145","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S0140-6736(02)07497-4","article-title":"Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down\u2019s syndrome: a gene expression study","volume":"359","author":"Bahn","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.neulet.2019.134569_bib0150","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.stemcr.2018.02.001","article-title":"Modeling down syndrome with patient iPSCs reveals cellular and migration deficits of GABAergic neurons","volume":"10","author":"Huo","year":"2018","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.neulet.2019.134569_bib0155","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0169-328X(00)00108-X","article-title":"Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesion","volume":"79","author":"Agarwala","year":"2000","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.neulet.2019.134569_bib0160","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/jnr.1226","article-title":"Dscam is associated with axonal and dendritic features of neuronal cells","volume":"66","author":"Agarwala","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neulet.2019.134569_bib0165","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000048808","article-title":"Down Syndrome Cell Adhesion Molecule is conserved in mouse and highly expressed in the adult mouse brain","volume":"94","author":"Barlow","year":"2001","journal-title":"Cytogenet. Cell Genet."},{"key":"10.1016\/j.neulet.2019.134569_bib0170","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/hmg\/7.2.227","article-title":"DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system","volume":"7","author":"Yamakawa","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neulet.2019.134569_bib0175","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1007\/s004010000230","article-title":"The developmental and aging changes of Down\u2019s syndrome cell adhesion molecule expression in normal and Down\u2019s syndrome brains","volume":"100","author":"Saito","year":"2000","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neulet.2019.134569_bib0180","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/00005072-199409000-00011","article-title":"Development of the superior temporal neocortex is anomalous in trisomy 21","volume":"53","author":"Golden","year":"1994","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neulet.2019.134569_bib0185","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF02361154","article-title":"Behavioral assessment of the Ts65Dn mouse, a model for Down syndrome: altered behavior in the elevated plus maze and open field","volume":"26","author":"Coussons-Read","year":"1996","journal-title":"Behav. Genet."},{"key":"10.1016\/j.neulet.2019.134569_bib0190","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0304-3940(95)12052-6","article-title":"A behavioral-assessment of Ts65dn mice - a putative down-syndrome model","volume":"199","author":"Escorihuela","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2019.134569_bib0195","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.nbd.2011.04.011","article-title":"Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of beta1-adrenergic receptor by xamoterol as a potential cognitive enhancer","volume":"43","author":"Faizi","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neulet.2019.134569_bib0200","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/ng1095-177","article-title":"A mouse model for Down syndrome exhibits learning and behaviour deficits","volume":"11","author":"Reeves","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neulet.2019.134569_bib0205","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000082142","article-title":"Concurrent generation of subplate and cortical plate neurons in developing trisomy 16 mouse cortex","volume":"26","author":"Cheng","year":"2004","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.neulet.2019.134569_bib0210","doi-asserted-by":"crossref","first-page":"13333","DOI":"10.1073\/pnas.93.23.13333","article-title":"Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome","volume":"93","author":"Holtzman","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2019.134569_bib0215","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/463909","article-title":"Age-related neurodegeneration and memory loss in down syndrome","volume":"2012","author":"Lockrow","year":"2012","journal-title":"Curr. Gerontol. Geriatr. Res."},{"key":"10.1016\/j.neulet.2019.134569_bib0220","first-page":"133","article-title":"Growth and development of the brain in Down syndrome","volume":"373","author":"Becker","year":"1991","journal-title":"Prog. Clin. Biol. Res."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030439401930672X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030439401930672X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T20:14:43Z","timestamp":1577391283000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030439401930672X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":44,"alternative-id":["S030439401930672X"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2019.134569","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/784314","asserted-by":"object"}]},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurodevelopmental wiring deficits in the Ts65Dn mouse model of Down syndrome","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2019.134569","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"134569"}}