{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:17:31Z","timestamp":1792894651456,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002449","name":"Jeju National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.neulet.2019.134619","type":"journal-article","created":{"date-parts":[[2019,11,9]],"date-time":"2019-11-09T02:21:52Z","timestamp":1573266112000},"page":"134619","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Hesperidin improves motor disability in rat spinal cord injury through anti-inflammatory and antioxidant mechanism via Nrf-2\/HO-1 pathway"],"prefix":"10.1016","volume":"715","author":[{"given":"Seung-Dam","family":"Heo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongtae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuna","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poornima","family":"Ekanayake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meejung","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9851-4354","authenticated-orcid":false,"given":"Taekyun","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2019.134619_bib0005","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.brainres.2012.01.045","article-title":"Immunohistochemical study of arginase-1 in the spinal cords of rats with clip compression injury","volume":"1445","author":"Ahn","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2019.134619_bib0010","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.acthis.2014.11.001","article-title":"Transient activation of an adaptor protein, disabled-2, in rat spinal cord injury","volume":"117","author":"Ahn","year":"2015","journal-title":"Acta Histochem."},{"key":"10.1016\/j.neulet.2019.134619_bib0015","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ejphar.2016.07.042","article-title":"Hesperidin reverses cognitive and depressive disturbances induced by olfactory bulbectomy in mice by modulating hippocampal neurotrophins and cytokine levels and acetylcholinesterase activity","volume":"789","author":"Antunes","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neulet.2019.134619_bib0020","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.redox.2013.07.004","article-title":"Mitochondria-targeted heme oxygenase-1 induces oxidative stress and mitochondrial dysfunction in macrophages, kidney fibroblasts and in chronic alcohol hepatotoxicity","volume":"2","author":"Bansal","year":"2014","journal-title":"Redox Biol."},{"key":"10.1016\/j.neulet.2019.134619_bib0025","doi-asserted-by":"crossref","first-page":"H643","DOI":"10.1152\/ajpheart.2000.278.2.H643","article-title":"Heme oxygenase-1-derived bilirubin ameliorates postischemic myocardial dysfunction","volume":"278","author":"Clark","year":"2000","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.neulet.2019.134619_bib0030","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.expneurol.2007.06.009","article-title":"Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury","volume":"209","author":"Donnelly","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neulet.2019.134619_bib0035","first-page":"4067","article-title":"The effects of oxyresveratrol abrogates inflammation and oxidative stress in rat model of spinal cord injury","volume":"17","author":"Du","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.neulet.2019.134619_bib0040","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/sc.2014.178","article-title":"Oxidative stress and antioxidative parameters in patients with spinal cord injury: implications in the pathogenesis of disease","volume":"53","author":"Fatima","year":"2015","journal-title":"Spinal Cord"},{"key":"10.1016\/j.neulet.2019.134619_bib0045","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fnmol.2019.00042","article-title":"Natrium benzoate alleviates neuronal apoptosis via the DJ-1-related anti-oxidative stress pathway involving Akt phosphorylation in a rat model of traumatic spinal cord injury","volume":"12","author":"Gao","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neulet.2019.134619_bib0050","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S1734-1140(10)70321-2","article-title":"Hesperidin pre-treatment attenuates NO-mediated cerebral ischemic reperfusion injury and memory dysfunction","volume":"62","author":"Gaur","year":"2010","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.neulet.2019.134619_bib0055","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1111\/j.1471-4159.2009.06395.x","article-title":"Acrolein scavenging: a potential novel mechanism of attenuating oxidative stress following spinal cord injury","volume":"111","author":"Hamann","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2019.134619_bib0060","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.lfs.2015.07.014","article-title":"Protective effects of flavonoids against microbes and toxins: the cases of hesperidin and hesperetin","volume":"137","author":"Iranshahi","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.neulet.2019.134619_bib0065","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00011-010-0295-0","article-title":"Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation","volume":"60","author":"Jain","year":"2011","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.neulet.2019.134619_bib0070","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/sc.2015.227","article-title":"Quercetin suppresses NLRP3 inflammasome activation and attenuates histopathology in a rat model of spinal cord injury","volume":"54","author":"Jiang","year":"2016","journal-title":"Spinal Cord"},{"key":"10.1016\/j.neulet.2019.134619_bib0075","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s12640-018-9904-4","article-title":"Attenuation of aluminum chloride-induced neuroinflammation and caspase activation through the AKT\/GSK-3beta pathway by hesperidin in wistar rats","volume":"34","author":"Justin-Thenmozhi","year":"2018","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.neulet.2019.134619_bib0080","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s11064-015-1525-1","article-title":"Neuroprotective effect of hesperidin on aluminium chloride induced Alzheimer\u2019s disease in Wistar rats","volume":"40","author":"Justin Thenmozhi","year":"2015","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neulet.2019.134619_bib0085","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1292\/jvms.17-0637","article-title":"Allyl isothiocyanate reduces liver fibrosis by regulating Kupffer cell activation in rats","volume":"80","author":"Kim","year":"2018","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.neulet.2019.134619_bib0090","doi-asserted-by":"crossref","first-page":"207","DOI":"10.5115\/acb.2017.50.3.207","article-title":"Lithium ameliorates rat spinal cord injury by suppressing glycogen synthase kinase-3beta and activating heme oxygenase-1","volume":"50","author":"Kim","year":"2017","journal-title":"Anat. Cell Biol."},{"key":"10.1016\/j.neulet.2019.134619_bib0095","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1242\/dmm.025833","article-title":"Rat models of spinal cord injury: from pathology to potential therapies","volume":"9","author":"Kjell","year":"2016","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.neulet.2019.134619_bib0100","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.freeradbiomed.2008.10.044","article-title":"Amplifying the fluorescence of bilirubin enables the real-time detection of heme oxygenase activity","volume":"46","author":"Klemz","year":"2009","journal-title":"Free Radic. Biol. Med."},{"issue":"Suppl. 1","key":"10.1016\/j.neulet.2019.134619_bib0105","first-page":"S71","article-title":"Hesperidin suppresses adjuvant arthritis in rats by inhibiting synoviocyte activity","volume":"24","author":"Li","year":"2010","journal-title":"Phytother. Res."},{"key":"10.1016\/j.neulet.2019.134619_bib0110","first-page":"659","article-title":"Eugenol promotes functional recovery and alleviates inflammation, oxidative stress, and neural apoptosis in a rat model of spinal cord injury","volume":"36","author":"Ma","year":"2018","journal-title":"Restor. Neurol. Neurosci."},{"key":"10.1016\/j.neulet.2019.134619_bib0115","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cbi.2017.09.015","article-title":"Hesperidin protects against chemically induced hepatocarcinogenesis via modulation of Nrf2\/ARE\/HO-1, PPARgamma and TGF-beta1\/Smad3 signaling, and amelioration of oxidative stress and inflammation","volume":"277","author":"Mahmoud","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.neulet.2019.134619_bib0120","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/74680","article-title":"Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway","volume":"6","author":"Otterbein","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.neulet.2019.134619_bib0125","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1007\/s12035-015-9292-1","article-title":"Hypericum perforatum attenuates spinal cord injury-induced oxidative stress and apoptosis in the dorsal root ganglion of rats: involvement of TRPM2 and TRPV1 channels","volume":"53","author":"Ozdemir","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neulet.2019.134619_bib0130","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/ptr.5256","article-title":"Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models","volume":"29","author":"Parhiz","year":"2015","journal-title":"Phytother. Res."},{"key":"10.1016\/j.neulet.2019.134619_bib0135","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1080\/1028415X.2015.1103460","article-title":"Spinal cord injury effectively ameliorated by neuroprotective effects of rosmarinic acid","volume":"20","author":"Shang","year":"2017","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.neulet.2019.134619_bib0140","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s12035-013-8398-6","article-title":"Alternatively activated macrophages in spinal cord injury and remission: another mechanism for repair?","volume":"47","author":"Shin","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neulet.2019.134619_bib0145","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.3029864","article-title":"Bilirubin is an antioxidant of possible physiological importance","volume":"235","author":"Stocker","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.neulet.2019.134619_bib0150","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21060708","article-title":"Antioxidative and antidiabetic effects of natural polyphenols and isoflavones","volume":"21","author":"Umeno","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.neulet.2019.134619_bib0155","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neuroscience.2017.09.056","article-title":"Ketogenic metabolism inhibits Histone Deacetylase (HDAC) and reduces oxidative stress after spinal cord injury in rats","volume":"366","author":"Wang","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2019.134619_bib0160","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.phymed.2009.02.021","article-title":"Modulating effect of Hesperidin on experimental murine colitis induced by dextran sulfate sodium","volume":"16","author":"Xu","year":"2009","journal-title":"Phytomedicine"},{"key":"10.1016\/j.neulet.2019.134619_bib0165","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1248\/bpb.b16-00332","article-title":"Epalrestat upregulates heme oxygenase-1, superoxide dismutase, and catalase in cells of the nervous system","volume":"39","author":"Yama","year":"2016","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.neulet.2019.134619_bib0170","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/j.lfs.2007.01.052","article-title":"The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro","volume":"80","author":"Yeh","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.neulet.2019.134619_bib0175","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.intimp.2018.05.022","article-title":"Protective role of beta-carotene against oxidative stress and neuroinflammation in a rat model of spinal cord injury","volume":"61","author":"Zhou","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.neulet.2019.134619_bib0180","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.3748\/wjg.v17.i38.4283","article-title":"Heme oxygenase-1 system and gastrointestinal inflammation: a short review","volume":"17","author":"Zhu","year":"2011","journal-title":"World J. Gastroenterol."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394019307220?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394019307220?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:33:00Z","timestamp":1759609980000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394019307220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":36,"alternative-id":["S0304394019307220"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2019.134619","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hesperidin improves motor disability in rat spinal cord injury through anti-inflammatory and antioxidant mechanism via Nrf-2\/HO-1 pathway","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2019.134619","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"134619"}}