{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:51:24Z","timestamp":1790693484177,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Albany Medical College"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.neulet.2019.134697","type":"journal-article","created":{"date-parts":[[2019,12,14]],"date-time":"2019-12-14T20:52:53Z","timestamp":1576356773000},"page":"134697","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Selective effects of dorsal raph\u00e9 nucleus glucocorticoid receptor deletion on depression-like behavior in female C57BL\/6J mice"],"prefix":"10.1016","volume":"717","author":[{"given":"Ankit","family":"Juneja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Barenboim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0406-703X","authenticated-orcid":false,"given":"Lauren","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2019.134697_bib0005","series-title":"Diagnostic and Statistical Manual of Mental Disorders V","year":"2013"},{"key":"10.1016\/j.neulet.2019.134697_bib0010","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.tins.2018.08.007","article-title":"Hormonal cycles, brain network connectivity, and windows of vulnerability to affective disorder","volume":"41","author":"Andreano","year":"2018","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neulet.2019.134697_bib0015","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/0896-6273(88)90136-5","article-title":"The neuronal mineralocorticoid receptor as a mediator of glucocorticoid response","volume":"1","author":"Arriza","year":"1988","journal-title":"Neuron"},{"issue":"Pt. B","key":"10.1016\/j.neulet.2019.134697_bib0020","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.brainres.2015.11.021","article-title":"Sex differences in the locus coeruleus-norepinephrine system and its regulation by stress","volume":"1641","author":"Bangasser","year":"2016","journal-title":"Brain Res."},{"issue":"Suppl. B","key":"10.1016\/j.neulet.2019.134697_bib0025","doi-asserted-by":"crossref","first-page":"S178","DOI":"10.1016\/S1550-8579(07)80057-X","article-title":"Anxiety disorders: sex differences in prevalence, degree, and background, but gender-neutral treatment","volume":"4","author":"Bekker","year":"2007","journal-title":"Gend. Med."},{"key":"10.1016\/j.neulet.2019.134697_bib0030","first-page":"8","article-title":"Effects of indomethacin and buprenorphine analgesia on postoperative recovery of mice","volume":"47","author":"Blaha","year":"2008","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"key":"10.1016\/j.neulet.2019.134697_bib0035","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1021\/acschemneuro.7b00042","article-title":"The rodent forced swim test measures stress-coping strategy, not depression-like behavior","volume":"8","author":"Commons","year":"2017","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.neulet.2019.134697_bib0040","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/BF02245592","article-title":"Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants","volume":"12","author":"Detke","year":"1995","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neulet.2019.134697_bib0045","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.physbeh.2003.07.012","article-title":"Sex differences in serotonergic activity in dorsal and median raphe nucleus","volume":"80","author":"Dom\u00ednguez","year":"2003","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neulet.2019.134697_bib0050","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00424-013-1271-7","article-title":"Sex differences in anxiety and emotional behavior","volume":"465","author":"Donner","year":"2013","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.neulet.2019.134697_bib0055","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.neuropharm.2017.11.022","article-title":"Behavioral and biochemical sensitivity to low doses of ketamine: influence of estrous cycle in C57BL\/6 mice","volume":"130","author":"Dossat","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neulet.2019.134697_bib0060","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0165-0270(80)90012-6","article-title":"The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs","volume":"2","author":"File","year":"1980","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.neulet.2019.134697_bib0065","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Franklin","year":"2007"},{"key":"10.1016\/j.neulet.2019.134697_bib0070","first-page":"1209","article-title":"Introducing genes into mammalian cells: viral vectors","volume":"2","author":"Gao","year":"2012"},{"key":"10.1016\/j.neulet.2019.134697_bib0075","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.psyneuen.2013.11.020","article-title":"Sex differences in serotonin (5-HT) 1A receptor regulation of HPA axis and dorsal raphe responses to acute restraint","volume":"40","author":"Goel","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neulet.2019.134697_bib0080","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.pnpbp.2013.04.009","article-title":"Monoamine neurocircuitry in depression and strategies for new treatments","volume":"45","author":"Hamon","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2019.134697_bib0085","doi-asserted-by":"crossref","first-page":"9779","DOI":"10.1073\/pnas.83.24.9779","article-title":"Glucocorticoid receptor immunoreactivity in monoaminergic neurons of rat brain","volume":"83","author":"Harfstrand","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2019.134697_bib0090","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.brainres.2009.06.082","article-title":"Glucocorticoid status affects antidepressant regulation of locus coeruleus tyrosine hydroxylase and dorsal raph\u00e9 tryptophan hydroxylase gene expression","volume":"1288","author":"Heydendael","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2019.134697_bib0095","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1111\/j.1460-9568.2010.07131.x","article-title":"Widespread hypothalamic-pituitary-adrenocortical axis-relevant and mood-relevant effects of chronic fluoxetine treatment on glucocorticoid receptor gene expression in mice","volume":"31","author":"Heydendael","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neulet.2019.134697_bib0100","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0028-3908(94)90064-7","article-title":"Contrasting behavioural effects of 8-OH DPAT in the dorsal raph\u00e9 nucleus and ventral hippocampus","volume":"33","author":"Hogg","year":"1994","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neulet.2019.134697_bib0105","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.biopsych.2013.10.013","article-title":"Sex differences in corticotropin-releasing factor receptor-1 action within the dorsal raphe nucleus in stress responsivity","volume":"75","author":"Howerton","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2019.134697_bib0110","series-title":"Guide for the Care and Use of Laboratory Animals","author":"Institute of Laboratory Animal Resources","year":"2010"},{"key":"10.1016\/j.neulet.2019.134697_bib0115","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.biopsych.2006.07.039","article-title":"Combined dexamethasone\/corticotropin releasing hormone test predicts treatment response in major depression\u2014a potential biomarker?","volume":"62","author":"Ising","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2019.134697_bib0120","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.brainres.2018.12.026","article-title":"Glucocorticoid receptor deletion from locus coeruleus norepinephrine neurons promotes depression-like social withdrawal in female but not male mice","volume":"1710","author":"Jacobson","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2019.134697_bib0125","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/j.2040-4603.2014.tb00561.x","article-title":"The hypothalamic-pituitary-adrenocortical axis: neuropsychiatric aspects","volume":"4","author":"Jacobson","year":"2014","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.neulet.2019.134697_bib0130","doi-asserted-by":"crossref","first-page":"T49","DOI":"10.1530\/JOE-16-0660","article-title":"30 Years of the mineralocorticoid receptor: the brain mineralocorticoid receptor: a saga in three episodes","volume":"234","author":"Jo\u00ebls","year":"2017","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.neulet.2019.134697_bib0135","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1176\/appi.ajp.2014.13091264","article-title":"Adverse consequences of glucocorticoid medication: psychological, cognitive, and behavioral effects","volume":"171","author":"Judd","year":"2014","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neulet.2019.134697_bib0140","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1440-1819.2011.02260.x","article-title":"Psychiatric complications of treatment with corticosteroids: review with case report","volume":"65","author":"Kenna","year":"2011","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.neulet.2019.134697_bib0145","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1210\/en.2004-0650","article-title":"Chronic treatment with the monoamine oxidase inhibitor phenelzine increases hypothalamic-pituitary-adrenocortical activity in male C57BL\/6 mice: relevance to atypical depression","volume":"146","author":"Kier","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.neulet.2019.134697_bib0150","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.cell.2019.05.022","article-title":"Correlated neural activity and encoding of behavior across brains of socially interacting animals","volume":"178","author":"Kingsbury","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2019.134697_bib0155","doi-asserted-by":"crossref","first-page":"4595","DOI":"10.1111\/bph.12710","article-title":"Sex differences in animal models of psychiatric disorders","volume":"171","author":"Kokras","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neulet.2019.134697_bib0160","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cell.2007.09.018","article-title":"Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions","volume":"131","author":"Krishnan","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2019.134697_bib0165","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.neubiorev.2008.04.006","article-title":"Corticosteroid-serotonin interactions in the neurobiological mechanisms of stress-related disorders","volume":"32","author":"Lanfumey","year":"2008","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neulet.2019.134697_bib0170","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1210\/me.2013-1187","article-title":"Disrupting hypothalamic glucocorticoid receptors causes HPA axis hyperactivity and excess adiposity","volume":"27","author":"Laryea","year":"2013","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.neulet.2019.134697_bib0175","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.comppsych.2007.06.012","article-title":"Sex differences in depression symptoms in treatment-seeking adults: confirmatory analyses from the Sequenced Treatment Alternatives to relieve Depression study","volume":"49","author":"Marcus","year":"2008","journal-title":"Compr. Psychiatry"},{"key":"10.1016\/j.neulet.2019.134697_bib0180","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.neubiorev.2003.11.005","article-title":"Aggression and defeat: persistent effects on cocaine self-administration and gene expression in peptidergic and aminergic mesocorticolimbic circuits","volume":"27","author":"Miczek","year":"2004","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neulet.2019.134697_bib0185","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1037\/0735-7044.105.6.798","article-title":"Effects of corticosterone on response consolidation and retrieval in the forced swim test","volume":"105","author":"Mitchell","year":"1991","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.neulet.2019.134697_bib0190","first-page":"95","article-title":"The distribution of dopamine-beta-hydroxylase, neuropeptide Y and galanin in locus coeruleus neurons","volume":"2","author":"Moore","year":"1989","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.neulet.2019.134697_bib0195","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.cbpa.2009.04.617","article-title":"Emerging targets for antidepressant therapies","volume":"13","author":"Rakofsky","year":"2009","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.neulet.2019.134697_bib0200","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1177\/000992289002900704","article-title":"Mental status changes in children receiving glucocorticoids","volume":"29","author":"Satel","year":"1990","journal-title":"Clin. Pediatr."},{"key":"10.1016\/j.neulet.2019.134697_bib0205","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jad.2013.12.011","article-title":"Gender differences in major depressive disorder: results from the Netherlands study of depression and anxiety","volume":"156","author":"Schuch","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neulet.2019.134697_bib0210","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.neures.2004.02.011","article-title":"Expression of estrogen receptors (alpha, beta) and androgen receptor in serotonin neurons of the rat and mouse dorsal raphe nuclei; sex and species differences","volume":"49","author":"Sheng","year":"2004","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neulet.2019.134697_bib0215","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1007\/s00213-017-4552-6","article-title":"Modelling depression in animals: at the interface of reward and stress pathways","volume":"234","author":"Slattery","year":"2017","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neulet.2019.134697_bib0220","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/mp.2012.62","article-title":"Involvement of estrogen receptor \u03b2 in maintenance of serotonergic neurons of the dorsal raphe","volume":"18","author":"Suzuki","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neulet.2019.134697_bib0225","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neulet.2017.11.041","article-title":"Dorsal raph\u00e9 nucleus glucocorticoid receptors inhibit tph2 gene expression in male C57BL\/6J mice","volume":"665","author":"Vincent","year":"2018","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2019.134697_bib0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2013.05.031","article-title":"Sensitivity of depression-like behavior to glucocorticoids and antidepressants is independent of forebrain glucocorticoid receptors","volume":"1525","author":"Vincent","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2019.134697_bib0235","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1111\/ejn.12538","article-title":"Glucocorticoid receptor deletion from the dorsal raph\u00e9 nucleus of mice reduces dysphoria-like behavior and impairs hypothalamic-pituitary-adrenocortical axis feedback inhibition","volume":"39","author":"Vincent","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neulet.2019.134697_bib0240","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/sj.npp.1301067","article-title":"A review and update of mechanisms of estrogen in the hippocampus and amygdala for anxiety and depression behavior","volume":"31","author":"Walf","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neulet.2019.134697_bib0245","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/S0006-2952(03)00556-2","article-title":"A unique central tryptophan hydroxylase isoform","volume":"66","author":"Walther","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neulet.2019.134697_bib0250","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.4065\/81.10.1361","article-title":"Psychiatric adverse effects of corticosteroids","volume":"81","author":"Warrington","year":"2006","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.neulet.2019.134697_bib0255","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1017\/S1461145708009474","article-title":"Antidepressant drugs with differing pharmacological actions decrease activity of locus coeruleus neurons","volume":"12","author":"West","year":"2009","journal-title":"Int. J. Neuropsychopharmacol."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394019308006?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394019308006?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:30:51Z","timestamp":1759609851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394019308006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":51,"alternative-id":["S0304394019308006"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2019.134697","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selective effects of dorsal raph\u00e9 nucleus glucocorticoid receptor deletion on depression-like behavior in female C57BL\/6J mice","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2019.134697","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"134697"}}