{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:47:13Z","timestamp":1780076833055,"version":"3.54.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671770"],"award-info":[{"award-number":["81671770"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771923"],"award-info":[{"award-number":["81771923"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005196","name":"Chinese Academy of Agricultural Sciences","doi-asserted-by":"publisher","award":["XDB32030200"],"award-info":[{"award-number":["XDB32030200"]}],"id":[{"id":"10.13039\/501100005196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.neulet.2019.134699","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T12:28:31Z","timestamp":1577104111000},"page":"134699","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Distinct relationships of amyloid-beta and tau deposition to cerebral glucose metabolic networks in Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"717","author":[{"given":"Xi","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7417-5063","authenticated-orcid":false,"given":"Baoci","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengxiang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guihong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.neulet.2019.134699_bib0005","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nrneurol.2018.9","article-title":"Imaging tau and amyloid-beta proteinopathies in Alzheimer disease and other conditions","volume":"14","author":"Villemagne","year":"2018","journal-title":"Nat. Rev. Neurol. (Review)"},{"issue":"10043","key":"10.1016\/j.neulet.2019.134699_bib0010","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0140-6736(15)01124-1","article-title":"Alzheimer\u2019s disease","volume":"388","author":"Scheltens","year":"2016","journal-title":"Lancet (Review)"},{"issue":"2","key":"10.1016\/j.neulet.2019.134699_bib0015","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer\u2019s disease: an updated hypothetical model of dynamic biomarkers","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet Neurol. (Article)"},{"issue":"3","key":"10.1016\/j.neulet.2019.134699_bib0020","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41593-018-0085-5","article-title":"Following the pathway to Alzheimer\u2019s disease","volume":"21","author":"Jagust","year":"2018","journal-title":"Nat. Neurosci. (Editorial Material)"},{"issue":"4","key":"10.1016\/j.neulet.2019.134699_bib0025","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1474-4422(17)30044-3","article-title":"Epileptic activity in Alzheimer\u2019s disease: causes and clinical relevance","volume":"16","author":"Vossel","year":"2017","journal-title":"Lancet Neurol. (Review)"},{"issue":"Suppl. 16","key":"10.1016\/j.neulet.2019.134699_bib0030","article-title":"Amyloid-beta and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer\u2019s disease","volume":"86","author":"Pascoal","year":"2016","journal-title":"Neurology (Meeting)"},{"issue":"6","key":"10.1016\/j.neulet.2019.134699_bib0035","first-page":"11","article-title":"Network analysis of intrinsic functional brain connectivity in Alzheimer\u2019s disease","volume":"4","author":"Supekar","year":"2008","journal-title":"PLoS Comput. Biol. (Article)"},{"issue":"1","key":"10.1016\/j.neulet.2019.134699_bib0040","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41380-018-0067-8","article-title":"Changes in functional and structural brain connectome along the Alzheimer\u2019s disease continuum","volume":"25","author":"Filippi","year":"2018","journal-title":"Mol. Psychiatr."},{"issue":"7","key":"10.1016\/j.neulet.2019.134699_bib0045","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1097\/JIM.0000000000000102","article-title":"Destruction of white matter integrity in patients with mild cognitive impairment and Alzheimer disease","volume":"62","author":"Sun","year":"2014","journal-title":"J. Invest. Med. (Article)"},{"key":"10.1016\/j.neulet.2019.134699_bib0050","first-page":"98","article-title":"Structural connectivity centrality changes mark the path toward Alzheimer\u2019s disease","volume":"11","author":"Peraza","year":"2019","journal-title":"Alzheimer\u2019s Dement. (Amsterdam, Netherlands)"},{"issue":"2","key":"10.1016\/j.neulet.2019.134699_bib0055","first-page":"22","article-title":"Changes in thalamic connectivity in the early and late stages of amnestic mild cognitive impairment: a resting-state functional magnetic resonance study from ADNI","volume":"10","author":"Cai","year":"2015","journal-title":"PLoS One (Article)"},{"issue":"7","key":"10.1016\/j.neulet.2019.134699_bib0060","first-page":"16","article-title":"A FDG-PET study of metabolic networks in apolipoprotein E epsilon 4 allele carriers","volume":"10","author":"Yao","year":"2015","journal-title":"PLoS One (Article)"},{"issue":"1","key":"10.1016\/j.neulet.2019.134699_bib0065","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jalz.2012.09.017","article-title":"AD dementia risk in late MCI, in early MCI, and in subjective memory impairment","volume":"10","author":"Jessen","year":"2014","journal-title":"Alzheimers Dement. (Article)"},{"issue":"6","key":"10.1016\/j.neulet.2019.134699_bib0070","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1093\/brain\/awz090","article-title":"A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer\u2019s disease dementia","volume":"142","author":"Pontecorvo","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.neulet.2019.134699_bib0075","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cortex.2017.09.018","article-title":"Tau, amyloid, and cascading network failure across the Alzheimer\u2019s disease spectrum","volume":"97","author":"Jones","year":"2017","journal-title":"Cortex (Article)"},{"issue":"3","key":"10.1016\/j.neulet.2019.134699_bib0080","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1148\/radiol.15141700","article-title":"Disrupted functional brain connectome in patients with posttraumatic stress disorder","volume":"276","author":"Lei","year":"2015","journal-title":"Radiology (Article)"},{"issue":"3","key":"10.1016\/j.neulet.2019.134699_bib0085","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1016\/j.neuroimage.2010.07.025","article-title":"Brain anatomical networks in early human brain development","volume":"54","author":"Fan","year":"2011","journal-title":"Neuroimage (Article)"},{"issue":"3","key":"10.1016\/j.neulet.2019.134699_bib0090","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/hbm.21232","article-title":"Age-related changes in topological organization of structural brain networks in healthy individuals","volume":"33","author":"Wu","year":"2012","journal-title":"Hum. Brain Mapp. (Article)"},{"issue":"5","key":"10.1016\/j.neulet.2019.134699_bib0095","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.semcdb.2011.03.011","article-title":"Amyloid in neurodegenerative diseases: friend or foe?","volume":"22","author":"Wolfe","year":"2011","journal-title":"Semin. Cell Dev. Biol. (Review)"},{"issue":"10","key":"10.1016\/j.neulet.2019.134699_bib0100","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/nn.3806","article-title":"Neural compensation in older people with brain amyloid-beta deposition","volume":"17","author":"Elman","year":"2014","journal-title":"Nat. Neurosci. (Article)"},{"key":"10.1016\/j.neulet.2019.134699_bib0105","series-title":"Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable","first-page":"1","article-title":"Challenging the amyloid cascade hypothesis - senile plaques and amyloid-beta as protective adaptations to Alzheimer disease","author":"Lee","year":"2004"},{"key":"10.1016\/j.neulet.2019.134699_bib0110","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.nbd.2015.08.024","article-title":"Protective properties of lysozyme on beta-amyloid pathology: implications for Alzheimer disease","volume":"83","author":"Helmfors","year":"2015","journal-title":"Neurobiol. Dis. (Article)"},{"issue":"9","key":"10.1016\/j.neulet.2019.134699_bib0115","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1056\/NEJM200308283490917","article-title":"Mechanisms of actions of inhaled anesthetics","volume":"349","author":"Seutin","year":"2003","journal-title":"N. Engl. J. Med. (Letter)"},{"issue":"12","key":"10.1016\/j.neulet.2019.134699_bib0120","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/j.jalz.2018.06.3040","article-title":"The antimicrobial protection hypothesis of Alzheimer\u2019s disease","volume":"14","author":"Moir","year":"2018","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neulet.2019.134699_bib0125","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fnagi.2019.00070","article-title":"Low evolutionary selection pressure in senescence does not explain the persistence of a beta in the vertebrate genome","volume":"11","author":"Moir","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neulet.2019.134699_bib0130","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1093\/brain\/aww163","article-title":"F-18-AV-1451 tau PET imaging correlates strongly with tau neuropathology in MAPT mutation carriers","volume":"139","author":"Smith","year":"2016","journal-title":"Brain"},{"issue":"11","key":"10.1016\/j.neulet.2019.134699_bib0135","first-page":"7","article-title":"Tau PET imaging in Alzheimer\u2019s disease","volume":"14","author":"Okamura","year":"2014","journal-title":"Curr. Neurol. Neurosci. Rep. (Review)"},{"issue":"3","key":"10.1016\/j.neulet.2019.134699_bib0140","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.neuroimage.2009.10.003","article-title":"Complex network measures of brain connectivity: uses and interpretations","volume":"52","author":"Rubinov","year":"2010","journal-title":"Neuroimage (Article)"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030439401930802X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030439401930802X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:30:20Z","timestamp":1759609820000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030439401930802X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":28,"alternative-id":["S030439401930802X"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2019.134699","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distinct relationships of amyloid-beta and tau deposition to cerebral glucose metabolic networks in Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2019.134699","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"134699"}}