{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T05:46:00Z","timestamp":1778305560303,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002865","name":"Chongqing Science and Technology Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.neulet.2020.134922","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T12:22:35Z","timestamp":1584706955000},"page":"134922","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Vitamin A regulates neural stem cell proliferation in rats after hypoxic-ischemic brain damage via RAR\u0251-mediated modulation of the \u03b2-catenin pathway"],"prefix":"10.1016","volume":"727","author":[{"given":"Min","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao-lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2020.134922_bib0005","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1001\/archpediatrics.2011.1772","article-title":"Hypothermia for neonatal hypoxic ischemic encephalopathy: an updated systematic review and meta-analysis","volume":"166","author":"Tagin","year":"2012","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"10.1016\/j.neulet.2020.134922_bib0010","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fncel.2017.00078","article-title":"Neonatal hypoxia ischaemia: mechanisms, models, and therapeutic challenges","volume":"11","author":"Millar","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neulet.2020.134922_bib0015","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.earlhumdev.2010.05.010","article-title":"Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy","volume":"86","author":"Kurinczuk","year":"2010","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.neulet.2020.134922_bib0020","doi-asserted-by":"crossref","first-page":"1816S","DOI":"10.3945\/jn.115.229708","article-title":"Biomarkers of nutrition for development (BOND)\u2014vitamin A review","volume":"146","author":"Tanumihardjo","year":"2016","journal-title":"J. Nutr."},{"key":"10.1016\/j.neulet.2020.134922_bib0025","first-page":"71","article-title":"Vitamin A - functions, dietary requirements and safety in humans","volume":"67","author":"Gerster","year":"1997","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"10.1016\/j.neulet.2020.134922_bib0030","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1242\/dev.065938","article-title":"Retinoic acid signalling during development","volume":"139","author":"Rhinn","year":"2012","journal-title":"Development."},{"key":"10.1016\/j.neulet.2020.134922_bib0035","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.brainres.2011.01.027","article-title":"The pattern of retinoic acid receptor expression and subcellular, anatomic and functional area translocation during the postnatal development of the rat cerebral cortex and white matter","volume":"1382","author":"Jiang","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2020.134922_bib0040","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1046\/j.1460-9568.1999.00444.x","article-title":"Role of retinpids in the CMS: differential expression of retinoid binding proteins and receptors and evidence for presence of retinoic acid","volume":"11","author":"Zetterstr\u00f6m","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neulet.2020.134922_bib0045","doi-asserted-by":"crossref","first-page":"dev167502","DOI":"10.1242\/dev.167502","article-title":"Retinoic acid signaling pathways","volume":"146","author":"Ghyselinck","year":"2019","journal-title":"Development."},{"key":"10.1016\/j.neulet.2020.134922_bib0050","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1007\/s00018-014-1815-9","article-title":"Retinoic acid signaling and neuronal differentiation","volume":"72","author":"Janesick","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neulet.2020.134922_bib0055","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/jnr.23843","article-title":"All-trans retinoic acid improved impaired proliferation of neural stem cells and suppressed microglial activation in the hippocampus in an Alzheimer\u2019s mouse model","volume":"95","author":"Takamura","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neulet.2020.134922_bib0060","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.ydbio.2007.04.010","article-title":"Wnt signaling is required for antero-posterior patterning of the planarian brain","volume":"306","author":"Kobayashi","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.neulet.2020.134922_bib0065","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1159\/000016696","article-title":"An in vitro pathway from embryonic stem cells to neurons and glia","volume":"165","author":"Gottlieb","year":"1999","journal-title":"Cells Tissues Organs."},{"key":"10.1016\/j.neulet.2020.134922_bib0070","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00441-014-1996-4","article-title":"Wnt signalling in neuronal differentiation and development","volume":"359","author":"Inestrosa","year":"2015","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.neulet.2020.134922_bib0075","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature08602","article-title":"Designing materials to direct stem-cell fate","volume":"462","author":"Lutolf","year":"2009","journal-title":"Nature."},{"key":"10.1016\/j.neulet.2020.134922_bib0080","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.bbrc.2003.12.023","article-title":"Wnt proteins promote neuronal differentiation in neural stem cell culture","volume":"313","author":"Muroyama","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neulet.2020.134922_bib0085","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/ncb2313","article-title":"Notch post-translationally regulates \u03b2-catenin protein in stem and progenitor cells","volume":"13","author":"Kwon","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neulet.2020.134922_bib0090","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10571-010-9559-z","article-title":"The role of \u03b2-catenin signaling pathway on proliferation of rats neural stem cells after hyperbaric oxygen therapy in vitro","volume":"31","author":"Zhang","year":"2011","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.neulet.2020.134922_bib0095","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/cns.12683","article-title":"GSK-3\u03b2 inhibitor TDZD-8 reduces neonatal hypoxic-ischemic brain injury in mice","volume":"23","author":"Huang","year":"2017","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.neulet.2020.134922_bib0100","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13041-018-0360-0","article-title":"Vitamin A bio-modulates apoptosis via the mitochondrial pathway after hypoxic-ischemic brain damage","volume":"11","author":"Jiang","year":"2018","journal-title":"Mol. Brain"},{"key":"10.1016\/j.neulet.2020.134922_bib0105","series-title":"Indicators for Asssessing Vitamin A Deficiency and Their Application in Monitoring and Evaluating Intervention Programmes","first-page":"66","author":"WHO","year":"1996"},{"key":"10.1016\/j.neulet.2020.134922_bib0110","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ana.410090206","article-title":"The influence of immaturity on hypoxic\u2010ischemic brain damage in the rat","volume":"9","author":"Rice","year":"1981","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neulet.2020.134922_bib0115","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neuroscience.2014.02.034","article-title":"Red photon treatment inhibits apoptosis via regulation of bcl-2 proteins and ROS levels, alleviating hypoxic-ischemic brain damage","volume":"268","author":"Jiang","year":"2014","journal-title":"Neuroscience."},{"key":"10.1016\/j.neulet.2020.134922_bib0120","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/j.1556-4029.2006.00174.x","article-title":"Cerebral hypoxia and ischemia: the forensic point of view: a review","volume":"51","author":"Oechmichen","year":"2006","journal-title":"J. Forensic Sci."},{"key":"10.1016\/j.neulet.2020.134922_bib0125","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.brainres.2008.05.016","article-title":"Therapeutic window of hyperbaric oxygen therapy for hypoxic-ischemic brain damage in newborn rats","volume":"1222","author":"Wang","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2020.134922_bib0130","first-page":"3525","article-title":"Retinoic acid receptor \u03b1 expression exerts an anti-apoptosis effect on PC12 cells following oxygen-glucose deprivation","volume":"16","author":"Dong","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.neulet.2020.134922_bib0135","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3390\/children5070099","article-title":"Current and emerging therapies in the management of hypoxic ischemic encephalopathy in neonates","volume":"5","author":"Nair","year":"2018","journal-title":"Children."},{"key":"10.1016\/j.neulet.2020.134922_bib0140","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1001\/jamapediatrics.2014.3269","article-title":"Hypoxic-ischemic encephalopathy a review for the clinician","volume":"169","author":"Douglas-Escobar","year":"2015","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.neulet.2020.134922_bib0145","doi-asserted-by":"crossref","first-page":"562","DOI":"10.2174\/1567205013666161223162110","article-title":"Marginal vitamin a deficiency exacerbates memory deficits following a?1-42 injection in rats","volume":"14","author":"Zeng","year":"2017","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.neulet.2020.134922_bib0150","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201700754","article-title":"Vitamin A deficiency induces autistic-like behaviors in rats by regulating the RAR\u03b2-CD38-oxytocin axis in the hypothalamus","volume":"62","author":"Lai","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.neulet.2020.134922_bib0155","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jnutbio.2017.05.007","article-title":"The change in retinoic acid receptor signaling induced by prenatal marginal vitamin A deficiency and its effects on learning and memory","volume":"47","author":"Zhang","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.neulet.2020.134922_bib0160","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.nbd.2009.09.018","article-title":"A retinoic acid receptor \u03b2 agonist (CD2019) overcomes inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord","volume":"37","author":"Agudo","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neulet.2020.134922_bib0165","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/3305","article-title":"Neurogenesis in the adult human hippocampus","volume":"4","author":"Eriksson","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.neulet.2020.134922_bib0170","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.gendis.2015.12.004","article-title":"Wnt\/\u03b2-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance","volume":"3","author":"Mohammed","year":"2016","journal-title":"Genes Dis."},{"key":"10.1016\/j.neulet.2020.134922_bib0175","first-page":"781","article-title":"Development and disease","volume":"20","author":"Logan","year":"2004","journal-title":"Rev. Lit. Arts Am."},{"key":"10.1016\/j.neulet.2020.134922_bib0180","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.diff.2016.11.002","article-title":"Beta-catenin and estrogen signaling collaborate to drive cyclin D1 expression in developing mouse prostate","volume":"93","author":"Mulligan","year":"2017","journal-title":"Differentiation"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394020301920?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394020301920?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:31:54Z","timestamp":1759609914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394020301920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":36,"alternative-id":["S0304394020301920"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2020.134922","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin A regulates neural stem cell proliferation in rats after hypoxic-ischemic brain damage via RAR\u0251-mediated modulation of the \u03b2-catenin pathway","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2020.134922","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"134922"}}