{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:17:37Z","timestamp":1791339457556,"version":"4.3.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.neulet.2020.135076","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T21:34:29Z","timestamp":1590096869000},"page":"135076","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Investigation of functional variability and connectivity in temporal lobe epilepsy: A resting state fMRI study"],"prefix":"10.1016","volume":"733","author":[{"given":"Seda Nilg\u00fcn","family":"Dumlu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Ademo\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.neulet.2020.135076_bib0005","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.1528-1157.2002.26901.x","article-title":"Neural networks in human epilepsy: evidence of and implications for treatment","volume":"43","author":"Spencer","year":"2002","journal-title":"Epilepsia"},{"issue":"11","key":"10.1016\/j.neulet.2020.135076_bib0010","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1111\/epi.13133","article-title":"Connectomics and graph theory analyses: novel insights into network abnormalities in epilepsy","volume":"56","author":"Gleichgerrcht","year":"2015","journal-title":"Epilepsia"},{"key":"10.1016\/j.neulet.2020.135076_bib0015","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fneur.2014.00093","article-title":"Network connectivity in epilepsy: resting state fMRI and EEG\u2013fMRI contributions","volume":"5","author":"Centeno","year":"2014","journal-title":"Front. Neurol."},{"key":"10.1016\/j.neulet.2020.135076_bib0020","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jns.2017.08.007","article-title":"Neuroimaging and cognitive functions in temporal lobe epilepsy: a review of the literature","volume":"381","author":"Allone","year":"2017","journal-title":"J. Neurol. Sci."},{"issue":"12","key":"10.1016\/j.neulet.2020.135076_bib0025","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1111\/epi.12400","article-title":"Resting state networks in temporal lobe epilepsy","volume":"54","author":"Cataldi","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.neulet.2020.135076_bib0030","series-title":"Movie-driven fMRI Reveals Network Asynchrony and Connectivity Alterations in Temporal Lobe Epilepsy (master\u2019s thesis)","author":"Bullen","year":"2017"},{"issue":"4","key":"10.1016\/j.neulet.2020.135076_bib0035","doi-asserted-by":"crossref","first-page":"374","DOI":"10.4103\/0972-2327.144003","article-title":"Neuropsychological deficits in temporal lobe epilepsy: a comprehensive review","volume":"17","author":"Zhao","year":"2014","journal-title":"Ann. Indian Acad. Neurol."},{"issue":"4","key":"10.1016\/j.neulet.2020.135076_bib0040","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/j.1528-1167.2009.02508.x","article-title":"Altered white matter integrity in temporal lobe epilepsy: association with cognitive and clinical profiles","volume":"51","author":"Riley","year":"2010","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.neulet.2020.135076_bib0045","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/nrneurol.2011.3","article-title":"The neurobiology of cognitive disorders in temporal lobe epilepsy","volume":"7","author":"Bell","year":"2011","journal-title":"Nat. Rev. Neurol."},{"issue":"4","key":"10.1016\/j.neulet.2020.135076_bib0050","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1001\/archneur.1997.00550160019010","article-title":"Neuropsychological characteristics of the syndrome of mesial temporal lobe epilepsy","volume":"54","author":"Hermann","year":"1997","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neulet.2020.135076_bib0055","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.seizure.2016.10.003","article-title":"Functional MRI-based connectivity analysis: A promising tool for the investigation of the pathophysiology and comorbidity of epilepsy","volume":"44","author":"Xiao","year":"2017","journal-title":"Seizure-Eur. J. Epilepsy"},{"issue":"3","key":"10.1016\/j.neulet.2020.135076_bib0060","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.4172\/Neuropsychiatry.1000429","article-title":"Abnormal brain network in epilepsy and associated comorbidites","volume":"8","author":"Yang","year":"2018","journal-title":"Neuropsychiatry"},{"issue":"11","key":"10.1016\/j.neulet.2020.135076_bib0065","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1001\/jamapsychiatry.2017.2663","article-title":"Heterogeneity and homogeneity of regional brain structure in schizophrenia a meta-analysis","volume":"74","author":"Brugger","year":"2017","journal-title":"JAMA Psychiatry"},{"issue":"2","key":"10.1016\/j.neulet.2020.135076_bib0070","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.clinph.2018.11.016","article-title":"Resting state connectivity in neocortical epilepsy: the epilepsy network as a patient-specific biomarker","volume":"130","author":"Marino","year":"2019","journal-title":"Clin. Neurophysiol."},{"issue":"9","key":"10.1016\/j.neulet.2020.135076_bib0075","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nrn2201","article-title":"Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging","volume":"8","author":"Fox","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.neulet.2020.135076_bib0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1440.011","article-title":"The brain\u2019s default network","volume":"1124","author":"Buckner","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"1","key":"10.1016\/j.neulet.2020.135076_bib0085","doi-asserted-by":"crossref","first-page":"e8525","DOI":"10.1371\/journal.pone.0008525","article-title":"Altered functional connectivity and small-world in mesial temporal lobe epilepsy","volume":"5","author":"Liao","year":"2010","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.neulet.2020.135076_bib0090","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1136\/jnnp-2011-301944","article-title":"Large scale brain models of epilepsy: dynamics meets connectomics","volume":"83","author":"Richardson","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"10.1016\/j.neulet.2020.135076_bib0095","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neuroimage.2009.06.060","article-title":"Accurate and robust brain image alignment using boundary-based registration","volume":"48","author":"Greve","year":"2009","journal-title":"Neuroimage"},{"issue":"3","key":"10.1016\/j.neulet.2020.135076_bib0100","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"Yeo","year":"2011","journal-title":"J. Neurophysiol."},{"issue":"3","key":"10.1016\/j.neulet.2020.135076_bib0105","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.neuron.2012.12.028","article-title":"Individual variability in functional connectivity architecture of the human brain","volume":"77","author":"Mueller","year":"2013","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.neulet.2020.135076_bib0110","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1001\/jamapsychiatry.2013.3469","article-title":"Disruption of cortical association networks in schizophrenia and psychotic bipolar disorder","volume":"71","author":"Baker","year":"2014","journal-title":"JAMA Psychiatry"},{"issue":"1","key":"10.1016\/j.neulet.2020.135076_bib0115","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. Royal Stat. Soc. Ser. B"},{"issue":"10","key":"10.1016\/j.neulet.2020.135076_bib0120","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1007\/s00415-009-5187-2","article-title":"Impaired perceptual networks in temporal lobe epilepsy revealed by resting fMRI","volume":"256","author":"Zhang","year":"2009","journal-title":"J. Neurol."},{"issue":"3","key":"10.1016\/j.neulet.2020.135076_bib0125","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.neulet.2009.04.040","article-title":"Impaired attention network in temporal lobe epilepsy: a resting FMRI study","volume":"458","author":"Zhang","year":"2009","journal-title":"Neurosci. Lett."},{"issue":"8","key":"10.1016\/j.neulet.2020.135076_bib0130","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.3174\/ajnr.A4346","article-title":"Influence of resting-state network on lateralization of functional connectivity in mesial temporal lobe epilepsy","volume":"36","author":"Su","year":"2015","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.neulet.2020.135076_bib0135","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.nicl.2013.06.011","article-title":"Impaired and facilitated functional networks in temporal lobe epilepsy","volume":"2","author":"Maccotta","year":"2013","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.neulet.2020.135076_bib0140","article-title":"Genetics of temporal lobe epilepsy: a review","volume":"2012","author":"Salzmann","year":"2012","journal-title":"Epilepsy Res. Treat."},{"issue":"3","key":"10.1016\/j.neulet.2020.135076_bib0145","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.neuroimage.2012.01.126","article-title":"Neural correlates of working memory in Temporal Lobe Epilepsy--an fMRI study","volume":"60","author":"Stretton","year":"2012","journal-title":"NeuroImage"},{"key":"10.1016\/j.neulet.2020.135076_bib0150","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.eplepsyres.2018.11.002","article-title":"Resting state functional connectivity patterns associated with pharmacological treatment resistance in temporal lobe epilepsy","volume":"149","author":"Pressl","year":"2019","journal-title":"Epilepsy Res."},{"issue":"3","key":"10.1016\/j.neulet.2020.135076_bib0155","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3171\/2018.3.PEDS17701","article-title":"Changes in resting-state connectivity in pediatric temporal lobe epilepsy","volume":"22","author":"Grassia","year":"2018","journal-title":"J. Neurosurg. Pediatr."},{"issue":"3","key":"10.1016\/j.neulet.2020.135076_bib0160","doi-asserted-by":"crossref","first-page":"351","DOI":"10.31887\/DCNS.2013.15.3\/rbuckner","article-title":"The brain\u2019s default network: origins and implications for the study of psychosis","volume":"15","author":"Buckner","year":"2013","journal-title":"Dialogues Clin. Neurosci."},{"issue":"7","key":"10.1016\/j.neulet.2020.135076_bib0165","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/nn.3423","article-title":"Opportunities and limitations of intrinsic functional connectivity MRI","volume":"16","author":"Buckner","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neulet.2020.135076_bib0170","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3389\/fnhum.2017.00609","article-title":"Characteristics of resting-state functional connectivity in intractable unilateral temporal lobe epilepsy patients with impaired executive control function","volume":"11","author":"Zhang","year":"2017","journal-title":"Front. Hum. Neurosci."},{"issue":"9","key":"10.1016\/j.neulet.2020.135076_bib0175","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1002\/hbm.23231","article-title":"Large\u2010scale brain networks are distinctly affected in right and left mesial temporal lobe epilepsy","volume":"37","author":"de Campos","year":"2016","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neulet.2020.135076_bib0180","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.eplepsyres.2017.09.001","article-title":"Altered functional connectivity in mesial temporal lobe epilepsy","volume":"137","author":"Burianov\u00e1","year":"2017","journal-title":"Epilepsy Res."},{"issue":"3","key":"10.1016\/j.neulet.2020.135076_bib0185","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1002\/hbm.23910","article-title":"Differential patterns of dynamic functional connectivity variability of striato\u2013cortical circuitry in children with benign epilepsy with centrotemporal spikes","volume":"39","author":"Li","year":"2018","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.neulet.2020.135076_bib0190","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.seizure.2015.06.011","article-title":"Variability in clinical assessment of neuroimaging in temporal lobe epilepsy","volume":"30","author":"Struck","year":"2015","journal-title":"Seizure"},{"issue":"6","key":"10.1016\/j.neulet.2020.135076_bib0195","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/j.1528-1167.2012.03464.x","article-title":"Patterns of altered functional connectivity in mesial temporal lobe epilepsy","volume":"53","author":"Pittau","year":"2012","journal-title":"Epilepsia"},{"issue":"9","key":"10.1016\/j.neulet.2020.135076_bib0200","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1046\/j.1528-1157.2002.49901.x","article-title":"The neurodevelopmental impact of childhood\u2010onset temporal lobe epilepsy on brain structure and function","volume":"43","author":"Hermann","year":"2002","journal-title":"Epilepsia"},{"issue":"8","key":"10.1016\/j.neulet.2020.135076_bib0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134944","article-title":"Functional connectivity alterations in epilepsy from resting-state functional MRI","volume":"10","author":"Rajpoot","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.neulet.2020.135076_bib0210","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1152\/jn.90355.2008","article-title":"Evidence for a frontoparietal control system revealed by intrinsic functional connectivity","volume":"100","author":"Vincent","year":"2008","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neulet.2020.135076_bib0215","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.cobeha.2014.08.003","article-title":"Functions of the human frontoparietal attention network: evidence from neuroimaging","volume":"1","author":"Scolari","year":"2015","journal-title":"Curr. Opin. Behav. Sci."},{"issue":"1","key":"10.1016\/j.neulet.2020.135076_bib0220","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1162\/jocn_a_00281","article-title":"Intrinsic architecture underlying the relations among the default, dorsal attention, and frontoparietal control networks of the human brain","volume":"25","author":"Spreng","year":"2013","journal-title":"J. Cogn. Neurosci."},{"issue":"1","key":"10.1016\/j.neulet.2020.135076_bib0225","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1155\/2011\/912720","article-title":"The default mode network and altered consciousness in epilepsy","volume":"24","author":"Danielson","year":"2011","journal-title":"Behav. Neurol."},{"issue":"3","key":"10.1016\/j.neulet.2020.135076_bib0230","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/brain\/awl004","article-title":"The precuneus: a review of its functional anatomy and behavioural correlates","volume":"129","author":"Cavanna","year":"2006","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.neulet.2020.135076_bib0235","doi-asserted-by":"crossref","first-page":"552","DOI":"10.3174\/ajnr.A3265","article-title":"Impaired default mode network on resting-state fMRI in children with medically refractory epilepsy","volume":"34","author":"Widjaja","year":"2013","journal-title":"Am. J. Neuroradiol."},{"issue":"1","key":"10.1016\/j.neulet.2020.135076_bib0240","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/epi.12476","article-title":"Functional connectivity of hippocampal networks in temporal lobe epilepsy","volume":"55","author":"Haneef","year":"2014","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.neulet.2020.135076_bib0245","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nrn2575","article-title":"Complex brain networks: graph theoretical analysis of structural and functional systems","volume":"10","author":"Bullmore","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"issue":"9","key":"10.1016\/j.neulet.2020.135076_bib0250","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1136\/jnnp-2012-302476","article-title":"Medial temporal lobe epilepsy is associated with neuronal fibre loss and paradoxical increase in structural connectivity of limbic structures","volume":"83","author":"Bonilha","year":"2012","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"7","key":"10.1016\/j.neulet.2020.135076_bib0255","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1002\/hbm.20666","article-title":"Attention impairment in temporal lobe epilepsy: a neurophysiological approach via analysis of the P300 wave","volume":"30","author":"Bocquillon","year":"2009","journal-title":"Hum. Brain Mapp."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394020303463?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394020303463?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:33:35Z","timestamp":1759610015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394020303463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":51,"alternative-id":["S0304394020303463"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2020.135076","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigation of functional variability and connectivity in temporal lobe epilepsy: A resting state fMRI study","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2020.135076","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"135076"}}