{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:42:20Z","timestamp":1791355340686,"version":"4.3.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.neulet.2020.135292","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T21:44:32Z","timestamp":1596577472000},"page":"135292","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Association of the TLR4 gene with depressive symptoms and antidepressant efficacy in major depressive disorder"],"prefix":"10.1016","volume":"736","author":[{"given":"Jizhi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7397-2738","authenticated-orcid":false,"given":"Kerang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2020.135292_bib0005","series-title":"Depression and Other Common Mental Disorders Global Health Estimates","year":"2017"},{"key":"10.1016\/j.neulet.2020.135292_bib0010","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","article-title":"A meta-analysis of cytokines in major depression","volume":"67","author":"Dowlati","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2020.135292_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2020.02.010","article-title":"Inflammatory markers in depression: a meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls","author":"Osimo","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neulet.2020.135292_bib0020","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/672395","article-title":"DAMPening inflammation by modulating TLR signalling","volume":"2010","author":"Piccinini","year":"2010","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.neulet.2020.135292_bib0025","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/sj.cdd.4401850","article-title":"TLR signaling","volume":"13","author":"Kawai","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.neulet.2020.135292_bib0030","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.psychres.2014.07.074","article-title":"Association between toll-like receptors expression and major depressive disorder","volume":"220","author":"Hung","year":"2014","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.neulet.2020.135292_bib0035","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.bbi.2014.03.020","article-title":"Expression of Toll-Like Receptors in peripheral blood mononuclear cells and response to cognitive-behavioral therapy in major depressive disorder","volume":"40","author":"K\u00e9ri","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neulet.2020.135292_bib0040","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jpsychires.2014.01.021","article-title":"Toll-like receptors in the depressed and suicide brain","volume":"53","author":"Pandey","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neulet.2020.135292_bib0045","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1742-2094-11-8","article-title":"Toll-like 4 receptor inhibitor TAK-242 decreases neuroinflammation in rat brain frontal cortex after stress","volume":"11","author":"Garate","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neulet.2020.135292_bib0050","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1007\/s00213-015-4087-7","article-title":"Antidepressants normalize elevated Toll-like receptor profile in major depressive disorder","volume":"233","author":"Hung","year":"2016","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neulet.2020.135292_bib0055","first-page":"6","article-title":"The association study of CLOCK gene polymorphisms with antidepressant effect in Chinese with MDD","author":"Ma","year":"2019","journal-title":"Shanxi Medical University"},{"key":"10.1016\/j.neulet.2020.135292_bib0060","doi-asserted-by":"crossref","first-page":"940","DOI":"10.30773\/pi.2019.0117","article-title":"C-reactive protein gene variants in depressive symptoms & antidepressants efficacy","volume":"16","author":"Li","year":"2019","journal-title":"Psychiatry Investig."},{"key":"10.1016\/j.neulet.2020.135292_bib0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpsychires.2017.02.020","article-title":"Clinical characteristics and treatment outcomes of patients with major depressive disorder and comorbid anxiety disorders - results from a European multicenter study","volume":"91","author":"Dold","year":"2017","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neulet.2020.135292_bib0070","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.euroneuro.2009.11.011","article-title":"Outcomes of 1014 naturalistically treated inpatients with major depressive episode","volume":"20","author":"Seemuller","year":"2010","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neulet.2020.135292_bib0075","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1017\/S003329170400412X","article-title":"The co-morbidity of anxiety and depression in the perspective of genetic epidemiology. A review of twin and family studies","volume":"35","author":"Middeldorp","year":"2005","journal-title":"Psychol. Med. (Paris)"},{"key":"10.1016\/j.neulet.2020.135292_bib0080","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.chc.2005.05.007","article-title":"A genetic epidemiologic perspective on comorbidity of depression and anxiety","volume":"14","author":"Williamson","year":"2005","journal-title":"Child Adolesc. Psychiatr. Clin. N. Am."},{"key":"10.1016\/j.neulet.2020.135292_bib0085","first-page":"1853","article-title":"Association between toll-like receptor 4 expression and symptoms of major depressive disorder","volume":"11","author":"Wu","year":"2015","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.neulet.2020.135292_bib0090","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.biopsych.2008.05.035","article-title":"Elevated neuroimmune biomarkers in sweat patches and plasma of premenopausal women with major depressive disorder in remission: the POWER study","volume":"64","author":"Cizza","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2020.135292_bib0095","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1001\/jamapsychiatry.2014.1332","article-title":"Association of serum interleukin 6 and C-reactive protein in childhood with depression and psychosis in young adult life: a population-based longitudinal study","volume":"71","author":"Khandaker","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.neulet.2020.135292_bib0100","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neulet.2009.03.068","article-title":"Interleukin-1 receptor null mutant mice show decreased anxiety-like behavior and enhanced fear memory","volume":"456","author":"Koo","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2020.135292_bib0105","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0306-4530(98)00077-8","article-title":"Central injection of IL-10 antagonizes the behavioural effects of lipopolysaccharide in rats","volume":"24","author":"Bluthe","year":"1999","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neulet.2020.135292_bib0110","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.bbi.2017.11.022","article-title":"Toll-like receptor-4 regulates anxiety-like behavior and DARPP-32 phosphorylation","volume":"69","author":"Femenia","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neulet.2020.135292_bib0115","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.tins.2011.02.005","article-title":"Toll-like receptor signaling in neural plasticity and disease","volume":"34","author":"Okun","year":"2011","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neulet.2020.135292_bib0120","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1001\/archpsyc.58.9.844","article-title":"Excess mortality in bipolar and unipolar disorder in Sweden","volume":"58","author":"Osby","year":"2001","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neulet.2020.135292_bib0125","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1093\/ije\/dyq112","article-title":"Acute stress reaction and completed suicide","volume":"39","author":"Gradus","year":"2010","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.neulet.2020.135292_bib0130","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.psychres.2019.01.013","article-title":"Low serum brain-derived neurotrophic factor is associated with suicidal ideation in major depressive disorder","volume":"273","author":"Khan","year":"2019","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.neulet.2020.135292_bib0135","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.cyto.2018.07.036","article-title":"Interleukin (IL)-8 polymorphisms contribute in suicide behavior","volume":"111","author":"Noroozi","year":"2018","journal-title":"Cytokine"},{"key":"10.1016\/j.neulet.2020.135292_bib0140","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ejphar.2009.08.046","article-title":"Cognitive impairment in major depression","volume":"626","author":"Marazziti","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neulet.2020.135292_bib0145","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1016\/j.euroneuro.2014.07.013","article-title":"Psychomotor retardation is a scar of past depressive episodes, revealed by simple cognitive tests","volume":"24","author":"Gorwood","year":"2014","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neulet.2020.135292_bib0150","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jad.2003.10.009","article-title":"Evidence for continuing neuropsychological impairments in depression","volume":"82","author":"Weiland-Fiedler","year":"2004","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neulet.2020.135292_bib0155","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.phrs.2003.07.016","article-title":"Studies on the anti-inflammatory effect of fluoxetine in the rat","volume":"49","author":"Abdel-Salam","year":"2004","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.neulet.2020.135292_bib0160","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/hup.717","article-title":"IL-6 levels decrease with SSRI treatment in patients with major depression","volume":"20","author":"Basterzi","year":"2005","journal-title":"Hum. Psychopharmacol."},{"key":"10.1016\/j.neulet.2020.135292_bib0165","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.bbi.2011.12.011","article-title":"A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia","volume":"26","author":"Tynan","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neulet.2020.135292_bib0170","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.pbb.2012.12.003","article-title":"Effects of antidepressants on alternations in serum cytokines and depressive-like behavior in mice after lipopolysaccharide administration","volume":"103","author":"Ohgi","year":"2013","journal-title":"Pharmacol. Biochem. Behav."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394020305620?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394020305620?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:37:22Z","timestamp":1759610242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394020305620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":34,"alternative-id":["S0304394020305620"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2020.135292","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of the TLR4 gene with depressive symptoms and antidepressant efficacy in major depressive disorder","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2020.135292","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"135292"}}