{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:06:06Z","timestamp":1788347166817,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T00:00:00Z","timestamp":1629676800000},"content-version":"am","delay-in-days":326,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005924","name":"International Association for the Study of Pain","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PD\/BD\/114117\/2015"],"award-info":[{"award-number":["PD\/BD\/114117\/2015"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/ 109111\/2015"],"award-info":[{"award-number":["SFRH\/BD\/ 109111\/2015"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/NEU-SCC\/5301\/2014"],"award-info":[{"award-number":["PTDC\/NEU-SCC\/5301\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-007038"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007038"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010854","name":"International Association for Suicide Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010854","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.neulet.2020.135309","type":"journal-article","created":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T12:01:29Z","timestamp":1597665689000},"page":"135309","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Mesocorticolimbic monoamines in a rodent model of chronic neuropathic pain"],"prefix":"10.1016","volume":"737","author":[{"given":"Ana Margarida","family":"Cunha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Rafael","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5081-3382","authenticated-orcid":false,"given":"Nikolaos","family":"Kokras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Sotiropoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7528-0487","authenticated-orcid":false,"given":"Christina","family":"Dalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5566-0386","authenticated-orcid":false,"given":"Hugo","family":"Leite-Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2020.135309_bib0005","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.expneurol.2007.03.010","article-title":"Striatal dopamine D(2) receptors attenuate neuropathic hypersensitivity in the rat","volume":"205","author":"Ansah","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neulet.2020.135309_bib0010","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1001\/archinte.163.20.2433","article-title":"Depression and pain comorbidity: a literature review","volume":"163","author":"Bair","year":"2003","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.neulet.2020.135309_bib0015","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nn.3153","article-title":"Corticostriatal functional connectivity predicts transition to chronic back pain","volume":"15","author":"Baliki","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neulet.2020.135309_bib0020","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000435933","article-title":"Biogenic amines and the amino acids GABA and glutamate: relationships with pain and depression","volume":"30","author":"Benson","year":"2015","journal-title":"Mod. Trends Pharmacopsychiatry"},{"key":"10.1016\/j.neulet.2020.135309_bib0025","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ejpain.2005.06.009","article-title":"Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment","volume":"10","author":"Breivik","year":"2006","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.neulet.2020.135309_bib0030","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.neulet.2020.135309_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynpai.2019.100042","article-title":"High trait impulsivity potentiates the effects of chronic pain on impulsive behavior","volume":"7","author":"Cunha","year":"2020","journal-title":"Neurobiol Pain"},{"key":"10.1016\/j.neulet.2020.135309_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113221","article-title":"Unilateral accumbal dopamine depletion affects decision-making in a side-specific manner","volume":"327","author":"Cunha","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neulet.2020.135309_bib0045","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-3959(00)00276-1","article-title":"Spared nerve injury: an animal model of persistent peripheral neuropathic pain","volume":"87","author":"Decosterd","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.neulet.2020.135309_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2019.05.013","article-title":"MORPhA Scale: Behavioral and electroencephalographic validation of a rodent anesthesia scale","volume":"324","author":"Esteves","year":"2019","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.neulet.2020.135309_bib0055","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/00002508-199509000-00007","article-title":"Differential consequences of left- and right-sided chronic pain","volume":"11","author":"Gagliese","year":"1995","journal-title":"Clin. J. Pain"},{"key":"10.1016\/j.neulet.2020.135309_bib0060","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1111\/ejn.14518","article-title":"Altered monoamine levels in the dorsal striatum of the rat are associated with alterations in behavioural selection and motivation following peripheral nerve injury and acute stress","volume":"50","author":"Gemikonakli","year":"2019","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neulet.2020.135309_bib0065","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neuroscience.2016.03.068","article-title":"Gestational stress and fluoxetine treatment differentially affect plasticity, methylation and serotonin levels in the PFC and hippocampus of rat dams","volume":"327","author":"Gemmel","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2020.135309_bib0070","doi-asserted-by":"crossref","DOI":"10.1111\/gbb.12542","article-title":"Evidence for lack of direct causality between pain and affective disturbances in a rat peripheral neuropathy model","volume":"18","author":"Guimaraes","year":"2019","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.neulet.2020.135309_bib0075","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0304-3959(00)00409-7","article-title":"Role of the dopaminergic system in chronic pain -- a fluorodopa-PET study","volume":"90","author":"Jaaskelainen","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.neulet.2020.135309_bib0080","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.jpain.2014.05.009","article-title":"Prevalence of persistent pain in the U.S. Adult population: new data from the 2010 national health interview survey","volume":"15","author":"Kennedy","year":"2014","journal-title":"J. Pain"},{"key":"10.1016\/j.neulet.2020.135309_bib0085","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1743-6109.2012.03000.x","article-title":"Experimental evidence for sildenafil\u2019s action in the central nervous system: dopamine and serotonin changes in the medial preoptic area and nucleus accumbens during sexual arousal","volume":"10","author":"Kyratsas","year":"2013","journal-title":"J. Sex. Med."},{"key":"10.1016\/j.neulet.2020.135309_bib0090","doi-asserted-by":"crossref","first-page":"5247","DOI":"10.1523\/JNEUROSCI.3494-14.2015","article-title":"Activation of corticostriatal circuitry relieves chronic neuropathic pain","volume":"35","author":"Lee","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2020.135309_bib0095","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1016\/j.pain.2012.07.007","article-title":"Differential effects of left\/right neuropathy on rats\u2019 anxiety and cognitive behavior","volume":"153","author":"Leite-Almeida","year":"2012","journal-title":"Pain"},{"key":"10.1016\/j.neulet.2020.135309_bib0100","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1744-8069-10-41","article-title":"Asymmetric c-fos expression in the ventral orbital cortex is associated with impaired reversal learning in a right-sided neuropathy","volume":"10","author":"Leite-Almeida","year":"2014","journal-title":"Mol. Pain"},{"key":"10.1016\/j.neulet.2020.135309_bib0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000435929","article-title":"Animal models for the study of comorbid pain and psychiatric disorders","volume":"30","author":"Leite-Almeida","year":"2015","journal-title":"Mod. Trends Pharmacopsychiatry"},{"key":"10.1016\/j.neulet.2020.135309_bib0110","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.physbeh.2012.06.016","article-title":"Sertraline behavioral response associates closer and dose-dependently with cortical rather than hippocampal serotonergic activity in the rat forced swim stress","volume":"107","author":"Mikail","year":"2012","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neulet.2020.135309_bib0115","doi-asserted-by":"crossref","first-page":"466","DOI":"10.3389\/fnmol.2018.00466","article-title":"Changes in Monoaminergic Neurotransmission in an animal model of osteoarthritis: the role of endocannabinoid signaling","volume":"11","author":"Mlost","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neulet.2020.135309_bib0120","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/j.euroneuro.2015.07.003","article-title":"Stress induced risk-aversion is reverted by D2\/D3 agonist in the rat","volume":"25","author":"Morgado","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neulet.2020.135309_bib0125","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.pneurobio.2011.01.002","article-title":"The effect of pain on cognitive function: a review of clinical and preclinical research","volume":"93","author":"Moriarty","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neulet.2020.135309_bib0130","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.neuroscience.2009.04.011","article-title":"Cognitive impairment of prefrontal-dependent decision-making in rats after the onset of chronic pain","volume":"161","author":"Pais-Vieira","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2020.135309_bib0135","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2007"},{"key":"10.1016\/j.neulet.2020.135309_bib0140","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nrn3381","article-title":"The brain reward circuitry in mood disorders","volume":"14","author":"Russo","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2020.135309_bib0145","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.neuropharm.2015.06.003","article-title":"Enhanced serotonin and mesolimbic dopamine transmissions in a rat model of neuropathic pain","volume":"97","author":"Sagheddu","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neulet.2020.135309_bib0150","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0010-9452(13)80197-9","article-title":"The consequences of experimentally induced and chronic unilateral pain: reflections of hemispheric lateralization of emotion","volume":"30","author":"Schiff","year":"1994","journal-title":"Cortex"},{"key":"10.1016\/j.neulet.2020.135309_bib0155","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.pnpbp.2014.05.002","article-title":"Mesocortical dopamine depletion and anxiety-related behavior in the rat: sex and hemisphere differences","volume":"54","author":"Sullivan","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2020.135309_bib0160","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1097\/j.pain.0000000000000494","article-title":"Mesolimbic dopamine signaling in acute and chronic pain: implications for motivation, analgesia, and addiction","volume":"157","author":"Taylor","year":"2016","journal-title":"Pain"},{"key":"10.1016\/j.neulet.2020.135309_bib0165","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.jpain.2014.05.006","article-title":"Correlation between ventral striatal catecholamine content and nociceptive thresholds in neuropathic mice","volume":"15","author":"Taylor","year":"2014","journal-title":"J. Pain"},{"key":"10.1016\/j.neulet.2020.135309_bib0170","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jpain.2006.05.014","article-title":"Reduced presynaptic dopamine activity in fibromyalgia syndrome demonstrated with positron emission tomography: a pilot study","volume":"8","author":"Wood","year":"2007","journal-title":"J. Pain"},{"key":"10.1016\/j.neulet.2020.135309_bib0175","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.pain.2014.05.018","article-title":"Activation of mesocorticolimbic reward circuits for assessment of relief of ongoing pain: a potential biomarker of efficacy","volume":"155","author":"Xie","year":"2014","journal-title":"Pain"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394020305796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394020305796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:46:09Z","timestamp":1777553169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394020305796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":35,"alternative-id":["S0304394020305796"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2020.135309","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mesocorticolimbic monoamines in a rodent model of chronic neuropathic pain","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2020.135309","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"135309"}}