{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:41:39Z","timestamp":1793421699928,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"onsejo Nacional de Ciencia y Tecnolog\u00eda","award":["602756. Supported by the S"],"award-info":[{"award-number":["602756. Supported by the S"]}]},{"name":"panish Ministry of Economy and Competitiveness","award":["BFU2017-82375-R"],"award-info":[{"award-number":["BFU2017-82375-R"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.neulet.2020.135439","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T07:35:18Z","timestamp":1603438518000},"page":"135439","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Recovery of sciatic nerve with complete transection in rats treated with leuprolide acetate: A gonadotropin-releasing hormone agonist"],"prefix":"10.1016","volume":"739","author":[{"given":"Irma","family":"Hern\u00e1ndez-Jasso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Dom\u00ednguez-del-Toro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Delgado-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Luis","family":"Quintanar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2020.135439_bib0005","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s12013-013-9742-1","article-title":"Peripheral nerve injuries treatment: a systematic review","volume":"68","author":"Li","year":"2014","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.neulet.2020.135439_bib0010","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3944\/AOTT.2010.2172","article-title":"The results of surgical repair of sciatic nerve injuries","volume":"44","author":"Aydin","year":"2010","journal-title":"Acta Orthop. Traumatol. Turc."},{"key":"10.1016\/j.neulet.2020.135439_bib0015","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jneumeth.2015.01.021","article-title":"The sciatic nerve injury model in pre-clinical research","volume":"243","author":"Geuna","year":"2015","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.neulet.2020.135439_bib0020","doi-asserted-by":"crossref","first-page":"939","DOI":"10.4103\/1673-5374.250566","article-title":"Gene expression changes in dorsal root ganglia following peripheral nerve injury: roles in inflammation, cell death and nociception","volume":"14","author":"Martin","year":"2019","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.neulet.2020.135439_bib0025","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1590\/S0102-36162011000600004","article-title":"Peripheral nerve regeneration: cell therapy and neurotrophic factors","volume":"46","author":"Sebben","year":"2011","journal-title":"Rev. Bras. Ortop."},{"key":"10.1016\/j.neulet.2020.135439_bib0030","doi-asserted-by":"crossref","first-page":"698256","DOI":"10.1155\/2014\/698256","article-title":"Peripheral nerve reconstruction after injury: a review of clinical and experimental therapies","volume":"2014","author":"Grinsell","year":"2014","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.neulet.2020.135439_bib0035","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.addr.2014.11.010","article-title":"Peripheral nerve regeneration: experimental strategies and future perspectives","volume":"82\u201383","author":"Faroni","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.neulet.2020.135439_bib0040","doi-asserted-by":"crossref","first-page":"e141","DOI":"10.3928\/01477447-20161019-01","article-title":"The present and future for peripheral nerve regeneration","volume":"40","author":"Panagopoulos","year":"2017","journal-title":"Orthopedics"},{"key":"10.1016\/j.neulet.2020.135439_bib0045","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/mus.22303","article-title":"Growth hormone treatment enhances the functional recovery of sciatic nerves after transection and repair","volume":"45","author":"Devesa","year":"2012","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.neulet.2020.135439_bib0050","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1007\/s11064-016-1983-0","article-title":"Effects of GnRH on neurite outgrowth, neurofilament and spinophilin proteins expression in cultured spinal cord neurons of rat embryos","volume":"41","author":"Quintanar","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neulet.2020.135439_bib0055","first-page":"104","article-title":"The effect of short-term treatments of a gonadotropinreleasing hormone analog (buserelin) on sciatic nerve regeneration","volume":"15","author":"Farjah","year":"2014","journal-title":"Iran. J. Vet. Res."},{"key":"10.1016\/j.neulet.2020.135439_bib0060","doi-asserted-by":"crossref","DOI":"10.1007\/s11064-012-0842-x","article-title":"Leuprolide acetate, a GnRH agonist, improves experimental autoimmune encephalomyelitis: a possible therapy for multiple sclerosis","volume":"37","author":"Guzm\u00e1n-Soto","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neulet.2020.135439_bib0065","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.4103\/1673-5374.170311","article-title":"Leuprolide acetate induces structural and functional recovery of injured spinal cord in rats","volume":"10","author":"D\u00edaz Galindo","year":"2015","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.neulet.2020.135439_bib0070","doi-asserted-by":"crossref","first-page":"352","DOI":"10.21307\/ane-2018-034","article-title":"Neurological improvement in patients with chronic spinal cord injury treated with leuprolide acetate, an agonist of GnRH","volume":"78","author":"Quintanar","year":"2018","journal-title":"Acta Neurobiol. Exp."},{"key":"10.1016\/j.neulet.2020.135439_bib0075","doi-asserted-by":"crossref","first-page":"151","DOI":"10.5405\/jmbe.902","article-title":"Review: bioengineering approaches for guided peripheral nerve regeneration","volume":"31","author":"Wang","year":"2011","journal-title":"J. Med. Biol. Eng."},{"key":"10.1016\/j.neulet.2020.135439_bib0080","series-title":"Principles of Regenerative Medicine","first-page":"1223","article-title":"Peripheral nerve regeneration","author":"Dodla","year":"2019"},{"key":"10.1016\/j.neulet.2020.135439_bib0085","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0006-8993(88)90613-0","article-title":"Effects of growth hormone treatment on the regeneration of rat sciatic nerve","volume":"475","author":"Kanje","year":"1988","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2020.135439_bib0090","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1097\/PRS.0000000000002188","article-title":"Growth hormone therapy accelerates axonal regeneration, promotes motor reinnervation, and reduces muscle atrophy following peripheral nerve injury","volume":"137","author":"Tuffaha","year":"2016","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.neulet.2020.135439_bib0095","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s11064-014-1486-9","article-title":"Functional and structural recovery of the injured spinal cord in rats treated with gonadotropin-releasing hormone","volume":"40","author":"Calder\u00f3n-Vallejo","year":"2015","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neulet.2020.135439_bib0100","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/j.clinph.2008.03.018","article-title":"Evaluation and management of peripheral nerve injury","volume":"119","author":"Campbell","year":"2008","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.neulet.2020.135439_bib0105","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0074-7742(09)87004-9","article-title":"Chapter 4: Methods and protocols in peripheral nerve regeneration experimental research: part I-experimental models","volume":"87","author":"Tos","year":"2009","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.neulet.2020.135439_bib0110","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1055\/s-2007-1006472","article-title":"Ankle stance angle: a functional index for the evaluation of sciatic nerve recovery after complete transection","volume":"12","author":"Lin","year":"1996","journal-title":"J. Reconstr. Microsurg."},{"key":"10.1016\/j.neulet.2020.135439_bib0115","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0304-3940(03)00594-9","article-title":"Expression of gonadotropin-releasing hormone and gonadotropin-releasing hormone receptor in sheep spinal cord","volume":"346","author":"Dolan","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2020.135439_bib0120","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neulet.2009.06.028","article-title":"Gonadotropin-releasing hormone receptor in spinal cord neurons of embryos and adult rats","volume":"461","author":"Quintanar","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2020.135439_bib0125","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1073\/pnas.84.10.3472","article-title":"Neurofilament gene expression: a major determinant of axonal caliber","volume":"84","author":"Hoffman","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2020.135439_bib0130","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0304-3940(93)90078-Y","article-title":"Reduced diameter and conduction velocity of myelinated fibers in the sciatic nerve of a neurofilament-deficient mutant quail","volume":"153","author":"Sakaguchi","year":"1993","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2020.135439_bib0135","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.pneurobio.2007.06.005","article-title":"Neural plasticity after peripheral nerve injury and regeneration","volume":"82","author":"Navarro","year":"2007","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neulet.2020.135439_bib0140","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.neulet.2012.03.052","article-title":"Gonadotropin-releasing hormone treatment improves locomotor activity, urinary function and neurofilament protein expression after spinal cord injury in ovariectomized rats","volume":"515","author":"Calder\u00f3n-Vallejo","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2020.135439_bib0145","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nrn1746","article-title":"The origin and development of glial cells in peripheral nerves","volume":"6","author":"Jessen","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2020.135439_bib0150","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/jnr.490330402","article-title":"The role of microtubule-associated protein 2 (MAP-2) in neuronal growth, plasticity, and degeneration","volume":"33","author":"Johnson","year":"1992","journal-title":"J. Neurosci. Res."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394020307096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394020307096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:36:14Z","timestamp":1759610174000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394020307096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":30,"alternative-id":["S0304394020307096"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2020.135439","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recovery of sciatic nerve with complete transection in rats treated with leuprolide acetate: A gonadotropin-releasing hormone agonist","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2020.135439","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"135439"}}