{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T20:04:31Z","timestamp":1769457871756,"version":"3.49.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T00:00:00Z","timestamp":1636243200000},"content-version":"vor","delay-in-days":310,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordination for the Improvement of Higher Education Personnel","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004612","name":"Funda\u00e7\u00e3o Arauc\u00e1ria","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004612","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.neulet.2020.135487","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T10:24:02Z","timestamp":1604571842000},"page":"135487","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Association of -94 ATTG insertion\/deletion NFkB1 and c.*126G>A NFkBIA genetic polymorphisms with oxidative and nitrosative stress biomarkers in Brazilian subjects with Parkinson\u2019s Disease"],"prefix":"10.1016","volume":"740","author":[{"given":"Thiago Hissnauer Leal","family":"Baltus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7183-4668","authenticated-orcid":false,"given":"Nayara Rampazzo","family":"Morelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carine Coneglian","family":"de Farias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kleber Paiva","family":"Trugilo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2131-6800","authenticated-orcid":false,"given":"N\u00e1dia Calvo Martins","family":"Okuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9666-6963","authenticated-orcid":false,"given":"Karen Braj\u00e3o","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucio Baena","family":"de Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhaila Mahmoud","family":"Smaili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9cio Sabbatini","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"612","key":"10.1016\/j.neulet.2020.135487_bib0005","first-page":"1","article-title":"Parkinson\u2019s disease: biomarkers, treatment, and risk factors","volume":"12","author":"Emamzadeh","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neulet.2020.135487_bib0010","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s00018-015-2101-1","article-title":"Current disease modifying approaches to treat Parkinson\u2019s disease","volume":"73","author":"Lindholm","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neulet.2020.135487_bib0015","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.3390\/molecules23071531","article-title":"\u0391-synuclein and polyunsaturated fatty acids: molecular basis of the interaction and implication in neurodegeneration","volume":"23","author":"Fecchio","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.neulet.2020.135487_bib0020","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00702-010-0401-z","article-title":"No increased chromosomal damage in L-DOPA-treated patients with Parkinson\u2019s disease: a pilot study","volume":"117","author":"Oli","year":"2010","journal-title":"J. Neural Transm. (Vienna)"},{"key":"10.1016\/j.neulet.2020.135487_bib0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0146129","article-title":"Iron and oxidative stress in Parkinson\u2019s disease: an observational study of injury biomarkers","volume":"11","author":"Medeiros","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2020.135487_bib0030","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neulet.2016.02.011","article-title":"Highly specific changes in antioxidant levels and lipid peroxidation in Parkinson\u2019s disease and its progression: disease and staging biomarkers and new drug targets","volume":"617","author":"de Farias","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2020.135487_bib0035","first-page":"1221","article-title":"Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence","volume":"6","author":"Mowla","year":"2013","journal-title":"Onco. Targets. Ther."},{"key":"10.1016\/j.neulet.2020.135487_bib0040","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.canep.2013.05.007","article-title":"The functional -94 insertion\/deletion ATTG polymorphism in the promoter region of NFKB1 gene increases the risk of sporadic colorectal cancer","volume":"37","author":"Mohd Suzairi","year":"2013","journal-title":"Cancer Epidemiol."},{"key":"10.1016\/j.neulet.2020.135487_bib0045","first-page":"21487","article-title":"Association between genetic polymorphism in NFKB1 and NFKBIA and coronary artery disease in a Chinese Han population","volume":"8","author":"Lai","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.neulet.2020.135487_bib0050","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.imbio.2014.03.009","article-title":"Polymorphism of the NFKB1 affects the serum inflammatory levels of IL-6 in Hashimoto thyroiditis in a Turkish population","volume":"219","author":"Koc","year":"2014","journal-title":"Immunobiology"},{"key":"10.1016\/j.neulet.2020.135487_bib0055","first-page":"8153","article-title":"The association between NFKB1-94ins\/del ATTG polymorphism and non-small cell lung cancer risk in a Chinese Han population","volume":"8","author":"Wang","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.neulet.2020.135487_bib0060","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/sji.12251","article-title":"Association of NFKB1 and NFKBIA polymorphisms in relation to susceptibility of Beh\u00e7et\u2019s disease","volume":"81","author":"Yenmis","year":"2015","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.neulet.2020.135487_bib0065","first-page":"48","article-title":"Single nucleotide polymorphism rs696 in miR449a binding site of NFKBIA gene is correlated with risk of colorectal cancer","volume":"11","author":"Simonian","year":"2018","journal-title":"Gastroenterol. Hepatol. Bed Bench"},{"key":"10.1016\/j.neulet.2020.135487_bib0070","doi-asserted-by":"crossref","first-page":"6265","DOI":"10.1007\/s13277-015-3312-7","article-title":"NFKB1\/NFKBIa polymorphisms are associated with the progression of cervical carcinoma in HPV-infected postmenopausal women from rural area","volume":"36","author":"Pallavi","year":"2015","journal-title":"Tumour Biol."},{"issue":"1","key":"10.1016\/j.neulet.2020.135487_bib0075","first-page":"14","article-title":"Sample size calculation in medical studies","volume":"6","author":"Pourhoseingholi","year":"2013","journal-title":"Gastroenterol. Hepatol. Bed Bench"},{"key":"10.1016\/j.neulet.2020.135487_bib0080","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","article-title":"Accuracy of clinical diagnosis of idiopathic Parkinson\u2019s disease: a clinico-pathological study of 100 cases","volume":"55","author":"Hughes","year":"1992","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neulet.2020.135487_bib0085","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/530381","article-title":"Investigation of NF-\u03baB1 and NF-\u03baBIA gene polymorphism in non-small cell lung cancer","author":"Oltulu","year":"2014","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.neulet.2020.135487_bib0090","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.cca.2012.01.038","article-title":"Improved detection of advanced oxidation protein products in plasma","volume":"413","author":"Hanasand","year":"2012","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.neulet.2020.135487_bib0095","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0891-5849(91)90002-K","article-title":"Hydroperoxide-initiated chemiluminescence: an assay for oxidative stress in biopsies of heart, liver, and muscle","volume":"10","author":"Gonzalez Flecha","year":"1991","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neulet.2020.135487_bib0100","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1093\/clinchem\/44.3.679","article-title":"Semiautomated measurement of nitrate in biological fluids","volume":"44","author":"Navarro-Gonz\u00e1lvez","year":"1998","journal-title":"Clin. Chem."},{"key":"10.1016\/j.neulet.2020.135487_bib0105","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0009-8981(96)06394-2","article-title":"Oxidative stress in blood of HIV infected patients","volume":"255","author":"Repetto","year":"1996","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.neulet.2020.135487_bib0110","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1161\/CIRCGENETICS.108.811638","article-title":"Determination of paraoxonase 1 statuswithout the use of toxic organophosphate substrates","volume":"1","author":"Richter","year":"2008","journal-title":"Circ. Cardiovasc. Genet."},{"key":"10.1016\/j.neulet.2020.135487_bib0115","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0076-6879(94)33044-1","article-title":"Measurement of protein thiol groups and glutathione in plasma","volume":"233","author":"Hu","year":"1994","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.neulet.2020.135487_bib0120","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin. Chem."},{"key":"10.1016\/j.neulet.2020.135487_bib0125","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.critrevonc.2017.11.001","article-title":"The role of Nuclear Factor-kappa B signaling in human cervical cancer","volume":"120","author":"Tilborghs","year":"2017","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.neulet.2020.135487_bib0130","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.00417","article-title":"Toll-like receptor 2 signaling and current approaches for therapeutic modulation in Synucleinopathies","volume":"9","author":"Caplan","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neulet.2020.135487_bib0135","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1055\/s-2007-949589","article-title":"HLA, NFKB1 and NFKBIA gene polymorphism profile in autoimmune diabetes mellitus patients","volume":"2","author":"Katarina","year":"2007","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.neulet.2020.135487_bib0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021726","article-title":"NF\u03baB1 and NF\u03baBIA polymorphisms are associated with increased risk for sporadic colorectal cancer in a southern Chinese population","volume":"6","author":"Song","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2020.135487_bib0145","first-page":"137","article-title":"Oxidative stress-related biomarkers in Parkinson\u2019s disease: a systematic review and meta-analysis","volume":"17","author":"Khan","year":"2018","journal-title":"Iran. J. Neurol."},{"key":"10.1016\/j.neulet.2020.135487_bib0150","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00204-015-1496-7","article-title":"Sulfhydryl-mediated redox signaling in inflammation: role in neurodegenerative diseases","volume":"89","author":"Miller","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.neulet.2020.135487_bib0155","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/eci.12430","article-title":"The contribution of NF-\u03baB signalling to immune regulation and tolerance","volume":"45","author":"van Delft","year":"2015","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.neulet.2020.135487_bib0160","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/cr.2010.177","article-title":"Non-canonical NF-\u03baB signaling pathway","volume":"21","author":"Sun","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.neulet.2020.135487_bib0165","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.humimm.2012.08.008","article-title":"The nuclear factor-kB functional promoter polymorphism is associated with endometriosis and infertility","volume":"73","author":"Bianco","year":"2012","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.neulet.2020.135487_bib0170","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.meegid.2016.01.023","article-title":"The -94Ins\/DelATTG polymorphism in NF\u03baB1 promoter modulates chronic hepatitis C and liver disease progression","volume":"39","author":"Fakhir","year":"2016","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.neulet.2020.135487_bib0175","doi-asserted-by":"crossref","first-page":"140","DOI":"10.2174\/1570159X11666131120230309","article-title":"Oxidative stress and psychological disorders","volume":"12","author":"Salim","year":"2014","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.neulet.2020.135487_bib0180","doi-asserted-by":"crossref","first-page":"5472","DOI":"10.3390\/ijms20215472","article-title":"The blood-brain barrier and its intercellular junctions in age-related brain disorders","volume":"20","author":"Costea","year":"2019","journal-title":"Int. J. Mol. Sci."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394020307576?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394020307576?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:35:07Z","timestamp":1759610107000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394020307576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":36,"alternative-id":["S0304394020307576"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2020.135487","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of -94 ATTG insertion\/deletion NFkB1 and c.*126G>A NFkBIA genetic polymorphisms with oxidative and nitrosative stress biomarkers in Brazilian subjects with Parkinson\u2019s Disease","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2020.135487","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"135487"}}