{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T06:43:12Z","timestamp":1768804992823,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.neulet.2020.135504","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T11:25:05Z","timestamp":1605266705000},"page":"135504","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Effect of captopril, an angiotensin-converting enzyme inhibitor, on morphine analgesia and tolerance in rats, and elucidating the inflammation and endoplasmic reticulum stress pathway in this effect"],"prefix":"10.1016","volume":"741","author":[{"given":"Ahmet Sevki","family":"Taskiran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onur","family":"Avci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2020.135504_bib0005","doi-asserted-by":"crossref","first-page":"119","DOI":"10.17305\/bjbms.2013.2394","article-title":"Role of D1\/D2 dopamin receptors antagonist perphenazine in morphine analgesia and tolerance in rats","volume":"13","author":"Ozdemir","year":"2013","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"10.1016\/j.neulet.2020.135504_bib0010","doi-asserted-by":"crossref","first-page":"217","DOI":"10.18203\/2319-2003.ijbcp20170312","article-title":"The pathophysiological role of serotonin receptor systems in opioid analgesia and tolerance","volume":"6","author":"Ozdemir","year":"2017","journal-title":"Int. J. Basic Clin. Pharmacol."},{"key":"10.1016\/j.neulet.2020.135504_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-0115(98)00138-4","article-title":"Angiotensin II receptors in the human brain","volume":"79","author":"Allen","year":"1999","journal-title":"Regul. Pept."},{"key":"10.1016\/j.neulet.2020.135504_bib0020","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.brainres.2005.03.048","article-title":"Brain angiotensin and anxiety-related behavior: the transgenic rat TGR(ASrAOGEN)680","volume":"1046","author":"Voigt","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2020.135504_bib0025","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1159\/000074446","article-title":"Brain renin-angiotensin system","volume":"78","author":"Baltatu","year":"2003","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.neulet.2020.135504_bib0030","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1006\/phrs.1998.0407","article-title":"Bilateral transections of Temporo\u2013ENTORHINAL connections attenuate vasopressin improvement of memory in rats","volume":"39","author":"WINNICKA","year":"1999","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.neulet.2020.135504_bib0035","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0304-3959(99)00294-8","article-title":"Synergistic effect of cholecystokinin octapeptide and angiotensin II in reversal of morphine induced analgesia in rats","volume":"85","author":"Han","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.neulet.2020.135504_bib0040","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0091-3057(98)00116-6","article-title":"The role of angiotensin II and of its receptor subtypes in the acetic acid-induced abdominal constriction test","volume":"62","author":"Georgieva","year":"1999","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neulet.2020.135504_bib0045","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0167-0115(02)00285-9","article-title":"The effects of sarmesin, an Angiotensin II analogue on seizure susceptibility, memory retention and nociception","volume":"111","author":"Tchekalarova","year":"2003","journal-title":"Regul. Pept."},{"key":"10.1016\/j.neulet.2020.135504_bib0050","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1111\/j.1471-4159.2008.05723.x","article-title":"Angiotensin-converting enzyme 2 in the brain: properties and future directions","volume":"107","author":"Xia","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2020.135504_bib0055","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S1357-2725(02)00306-0","article-title":"The brain renin\u2013angiotensin system: location and physiological roles","volume":"35","author":"McKinley","year":"2003","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.neulet.2020.135504_bib0060","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1046\/j.1471-4159.1997.68031304.x","article-title":"Angiotensin-converting enzyme modulates dopamine turnover in the striatum","volume":"68","author":"Jenkins","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2020.135504_bib0065","first-page":"97","article-title":"Effects of lisinopril, captopril and losartan alone or in combination with morphine in light tail flick analgesic test","volume":"2","author":"Hajhashemi","year":"2014","journal-title":"Res. Pharm. Sci."},{"key":"10.1016\/j.neulet.2020.135504_bib0070","doi-asserted-by":"crossref","DOI":"10.3906\/sag-2005-256","article-title":"Anakinra, an interleukin-1 receptor antagonist, increases morphine analgesic effect and decreases morphine tolerance development by modulating oxidative stress and endoplasmic reticulum stress in rats","author":"Avci","year":"2020","journal-title":"Turkish J. Med. Sci."},{"key":"10.1016\/j.neulet.2020.135504_bib0075","doi-asserted-by":"crossref","first-page":"64","DOI":"10.30714\/j-ebr.2018339492","article-title":"Effects of the phosphodiesterase type-5 inhibitor tadalafil on nociception, morphine analgesia and tolerance in rats","volume":"1","author":"Taskiran","year":"2018","journal-title":"Exp. Biomed. Res"},{"key":"10.1016\/j.neulet.2020.135504_bib0080","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s10753-014-0015-y","article-title":"Attenuation of morphine analgesic tolerance by Rosuvastatin in na\u00efve and morphine tolerance rats","volume":"38","author":"Li","year":"2015","journal-title":"Inflammation."},{"key":"10.1016\/j.neulet.2020.135504_bib0085","doi-asserted-by":"crossref","first-page":"879","DOI":"10.2147\/JPR.S185873","article-title":"Resveratrol inhibits paclitaxel-induced neuropathic pain by the activation of PI3K\/Akt and SIRT1\/PGC1\u03b1 pathway","volume":"12","author":"Li","year":"2019","journal-title":"J. Pain Res."},{"key":"10.1016\/j.neulet.2020.135504_bib0090","series-title":"Protein Protoc. Handbook","first-page":"15","article-title":"The Bradford method for protein quantitation","author":"Kruger","year":"1994"},{"key":"10.1016\/j.neulet.2020.135504_bib0095","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0304-3959(03)00138-6","article-title":"Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines","volume":"104","author":"Raghavendra","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.neulet.2020.135504_bib0100","doi-asserted-by":"crossref","first-page":"8692","DOI":"10.1523\/JNEUROSCI.23-25-08692.2003","article-title":"Interleukin-1\u03b2 enhances NMDA receptor-mediated intracellular calcium increase through activation of the src family of kinases","volume":"23","author":"Viviani","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2020.135504_bib0105","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1523\/JNEUROSCI.4486-04.2005","article-title":"Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-","volume":"25","author":"Stellwagen","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2020.135504_bib0110","doi-asserted-by":"crossref","first-page":"9980","DOI":"10.1523\/JNEUROSCI.22-22-09980.2002","article-title":"The role of spinal neuroimmune activation in morphine Tolerance\/Hyperalgesia in neuropathic and sham-operated rats","volume":"22","author":"Raghavendra","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2020.135504_bib0115","first-page":"40","article-title":"Neuroimmune activation and neuroinflammation in chronic pain and opioid Tolerance\/Hyperalgesia","volume":"10","author":"Deleo","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2020.135504_bib0120","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1080\/15360280902901404","article-title":"Palliative care pharmacotherapy literature summaries and analyses","volume":"23","author":"Abernethy","year":"2009","journal-title":"J. Pain Palliat. Care Pharmacother."},{"key":"10.1016\/j.neulet.2020.135504_bib0125","doi-asserted-by":"crossref","first-page":"6325","DOI":"10.1073\/pnas.1200130109","article-title":"Morphine activates neuroinflammation in a manner parallel to endotoxin","volume":"109","author":"Wang","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2020.135504_bib0130","doi-asserted-by":"crossref","first-page":"7353","DOI":"10.1523\/JNEUROSCI.1850-04.2004","article-title":"A role for proinflammatory cytokines and fractalkine in Analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine","volume":"24","author":"Johnston","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2020.135504_bib0135","article-title":"Morphine activates neuroinflammation in a manner parallel to endotoxin","author":"Wang","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2020.135504_bib0140","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.2353\/ajpath.2006.050924","article-title":"Gangliosides trigger inflammatory responses via TLR4 in Brain Glia","volume":"168","author":"Jou","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neulet.2020.135504_bib0145","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.bbi.2009.08.004","article-title":"Evidence that opioids may have toll-like receptor 4 and MD-2 effects","volume":"24","author":"Hutchinson","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neulet.2020.135504_bib0150","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.neuroscience.2009.10.011","article-title":"Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4\/MD-2 and interleukin-1\u03b2","volume":"165","author":"Lewis","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2020.135504_bib0155","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s10571-005-4011-5","article-title":"Brain angiotensin II: new developments, unanswered questions and therapeutic opportunities","volume":"25","author":"Saavedra","year":"2005","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.neulet.2020.135504_bib0160","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0014-2999(82)90469-1","article-title":"Adrenal involvement in captopril-induced potentiation of morphine analgesia","volume":"85","author":"Das","year":"1982","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neulet.2020.135504_bib0165","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0014-2999(79)90350-9","article-title":"Potentiation by angiotensin converting enzyme inhibitor, SQ 14225, of the analgesic effect of morphine in mice","volume":"58","author":"T\u00fcrker","year":"1979","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neulet.2020.135504_bib0170","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1146\/annurev.biochem.73.011303.074134","article-title":"The mammalian unfolded protein response","volume":"74","author":"Schr\u00f6der","year":"2005","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.neulet.2020.135504_bib0175","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.neulet.2020.135504_bib0180","doi-asserted-by":"crossref","first-page":"11555","DOI":"10.1038\/srep11555","article-title":"Endoplasmic reticulum stress impairment in the spinal dorsal horn of a neuropathic pain model","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neulet.2020.135504_bib0185","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1089\/ars.2009.2485","article-title":"Role of the unfolded protein response regulator GRP78\/BiP in development, cancer, and neurological disorders","volume":"11","author":"Wang","year":"2009","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.neulet.2020.135504_bib0190","doi-asserted-by":"crossref","first-page":"7650","DOI":"10.1523\/JNEUROSCI.22-17-07650.2002","article-title":"Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism","volume":"22","author":"Mao","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2020.135504_bib0195","doi-asserted-by":"crossref","first-page":"9082","DOI":"10.1073\/pnas.1510137112","article-title":"Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain","volume":"112","author":"Inceoglu","year":"2015","journal-title":"Proc. Natl. Acad. Scii. U. S. A."},{"key":"10.1016\/j.neulet.2020.135504_bib0200","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2018.00072","article-title":"Endoplasmic reticulum stress in spinal cord contributes to the development of morphine tolerance","volume":"11","author":"Liu","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neulet.2020.135504_bib0205","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic reticulum stress and the inflammatory basis of metabolic disease","volume":"140","author":"Hotamisligil","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2020.135504_bib0210","doi-asserted-by":"crossref","first-page":"8481","DOI":"10.1038\/s41598-019-44834-8","article-title":"Angiotensin II increases endoplasmic reticulum stress in adipose tissue and adipocytes","volume":"9","author":"Menikdiwela","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neulet.2020.135504_bib0215","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0028-3908(02)00030-8","article-title":"Morphine induces apoptosis of human microglia and neurons","volume":"42","author":"Hu","year":"2002","journal-title":"Neuropharmacology"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394020307746?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394020307746?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:35:54Z","timestamp":1759610154000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394020307746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":43,"alternative-id":["S0304394020307746"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2020.135504","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of captopril, an angiotensin-converting enzyme inhibitor, on morphine analgesia and tolerance in rats, and elucidating the inflammation and endoplasmic reticulum stress pathway in this effect","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2020.135504","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"135504"}}