{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:44:47Z","timestamp":1789055087817,"version":"build-2803163510"},"reference-count":173,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.neulet.2020.135505","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T11:25:20Z","timestamp":1605266720000},"page":"135505","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Molecular identity, anatomy, gene expression and function of neural crest vs. placode-derived nociceptors in the lower airways"],"prefix":"10.1016","volume":"742","author":[{"given":"Thomas E.","family":"Taylor-Clark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2020.135505_bib0005","first-page":"1","article-title":"Afferent vagal C fibre innervation of the lungs and airways and its functional significance","volume":"99","author":"Coleridge","year":"1984","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"issue":"Pt 2","key":"10.1016\/j.neulet.2020.135505_bib0010","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1113\/jphysiol.1996.sp021703","article-title":"Interganglionic segregation of distinct vagal afferent fibre phenotypes in guinea-pig airways","volume":"496","author":"Ricco","year":"1996","journal-title":"J. Physiol."},{"issue":"2\u20133","key":"10.1016\/j.neulet.2020.135505_bib0015","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0034-5687(01)00241-9","article-title":"Sensitivity of vagal afferent endings to chemical irritants in the rat lung","volume":"127","author":"Ho","year":"2001","journal-title":"Respir. Physiol."},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0020","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.resp.2004.08.001","article-title":"Substance P expression in TRPV1 and trkA-positive dorsal root ganglion neurons innervating the mouse lung","volume":"144","author":"Dinh","year":"2004","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"Pt 3","key":"10.1016\/j.neulet.2020.135505_bib0025","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1113\/jphysiol.2003.060079","article-title":"Subtypes of vagal afferent C-fibres in guinea-pig lungs","volume":"556","author":"Undem","year":"2004","journal-title":"J. Physiol."},{"issue":"2","key":"10.1016\/j.neulet.2020.135505_bib0030","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1152\/japplphysiol.00252.2006","article-title":"Central pathways of pulmonary and lower airway vagal afferents","volume":"101","author":"Kubin","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.neulet.2020.135505_bib0035","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.neuroscience.2012.01.029","article-title":"Transneuronal tracing of airways-related sensory circuitry using herpes simplex virus 1, strain H129","volume":"207","author":"McGovern","year":"2012","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.neulet.2020.135505_bib0040","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.cell.2015.03.022","article-title":"Vagal sensory neuron subtypes that differentially control breathing","volume":"161","author":"Chang","year":"2015","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.neulet.2020.135505_bib0045","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.cell.2020.03.004","article-title":"An airway protection program revealed by sweeping genetic control of vagal afferents","volume":"181","author":"Prescott","year":"2020","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.neulet.2020.135505_bib0050","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1152\/physrev.00039.2015","article-title":"Vagal afferent innervation of the airways in health and disease","volume":"96","author":"Mazzone","year":"2016","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/dbio.2001.0156","article-title":"Vertebrate cranial placodes I. Embryonic induction","volume":"232","author":"Baker","year":"2001","journal-title":"Dev. Biol."},{"issue":"2","key":"10.1016\/j.neulet.2020.135505_bib0060","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/cne.901930216","article-title":"Substance P in the vagal sensory ganglia: localization in cell bodies and pericellular arborizations","volume":"193","author":"Katz","year":"1980","journal-title":"J. Comp. Neurol."},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0065","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0361-9230(85)90181-9","article-title":"Innervation of the posterior fossa dura of the cat","volume":"14","author":"Keller","year":"1985","journal-title":"Brain Res. Bull."},{"issue":"6","key":"10.1016\/j.neulet.2020.135505_bib0070","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s10571-014-0062-9","article-title":"Distribution of TRPVs, P2X3, and parvalbumin in the human nodose ganglion","volume":"34","author":"Sato","year":"2014","journal-title":"Cell. Mol. Neurobiol."},{"issue":"8","key":"10.1016\/j.neulet.2020.135505_bib0075","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1097\/WNR.0000000000001231","article-title":"Phenotypic distinctions between the nodose and jugular TRPV1-positive vagal sensory neurons in the cynomolgus monkey","volume":"30","author":"Kollarik","year":"2019","journal-title":"Neuroreport"},{"key":"10.1016\/j.neulet.2020.135505_bib0080","doi-asserted-by":"crossref","first-page":"101344","DOI":"10.1016\/j.tice.2020.101344","article-title":"Sensory neurons in the human jugular ganglion","volume":"64","author":"Atsumi","year":"2020","journal-title":"Tissue Cell"},{"issue":"2","key":"10.1016\/j.neulet.2020.135505_bib0085","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/0306-4522(88)90166-2","article-title":"Immunohistochemical study of neuropeptides in vagal and glossopharyngeal afferent neurons in the rat","volume":"26","author":"Helke","year":"1988","journal-title":"Neuroscience"},{"issue":"Pt 23","key":"10.1016\/j.neulet.2020.135505_bib0090","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1113\/jphysiol.2010.195339","article-title":"Phenotypic distinctions between neural crest and placodal derived vagal C-fibres in mouse lungs","volume":"588","author":"Nassenstein","year":"2010","journal-title":"J. Physiol."},{"issue":"18","key":"10.1016\/j.neulet.2020.135505_bib0095","doi-asserted-by":"crossref","first-page":"7041","DOI":"10.1523\/JNEUROSCI.5128-14.2015","article-title":"Distinct brainstem and forebrain circuits receiving tracheal sensory neuron inputs revealed using a novel conditional anterograde transsynaptic viral tracing system","volume":"35","author":"McGovern","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2020.135505_bib0100","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0494-19.2020","article-title":"Mapping of sensory nerve subsets within the vagal ganglia and the brainstem using reporter mice for Pirt, TRPV1, 5HT3 and Tac1 expression","author":"Kim","year":"2020","journal-title":"eNeuro"},{"issue":"Pt 2","key":"10.1016\/j.neulet.2020.135505_bib0105","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1113\/jphysiol.2003.057885","article-title":"Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigs","volume":"557","author":"Canning","year":"2004","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0110","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/ar.1091960108","article-title":"Neural crest and placodal contributions in the development of the glossopharyngeal-vagal complex in the chick","volume":"196","author":"Narayanan","year":"1980","journal-title":"Anat. Rec."},{"issue":"2","key":"10.1016\/j.neulet.2020.135505_bib0115","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0012-1606(82)90349-9","article-title":"The early development of cranial sensory ganglia and the potentialities of their component cells studied in quail-chick chimeras","volume":"94","author":"Ayer-Le Lievre","year":"1982","journal-title":"Dev. Biol."},{"issue":"5660","key":"10.1016\/j.neulet.2020.135505_bib0120","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1126\/science.1091611","article-title":"Instructive role of Wnt\/beta-catenin in sensory fate specification in neural crest stem cells","volume":"303","author":"Lee","year":"2004","journal-title":"Science"},{"issue":"50","key":"10.1016\/j.neulet.2020.135505_bib0125","doi-asserted-by":"crossref","first-page":"20018","DOI":"10.1073\/pnas.1110416108","article-title":"Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways","volume":"108","author":"D\u2019Autr\u00e9aux","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.neulet.2020.135505_bib0130","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/ng.3308","article-title":"Transcriptional regulator PRDM12 is essential for human pain perception","volume":"47","author":"Chen","year":"2015","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0135","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nn.3881","article-title":"Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing","volume":"18","author":"Usoskin","year":"2015","journal-title":"Nat. Neurosci."},{"issue":"10","key":"10.1016\/j.neulet.2020.135505_bib0140","doi-asserted-by":"crossref","first-page":"e0185985","DOI":"10.1371\/journal.pone.0185985","article-title":"Distinct and common expression of receptors for inflammatory mediators in vagal nodose versus jugular capsaicin-sensitive\/TRPV1-positive neurons detected by low input RNA sequencing","volume":"12","author":"Wang","year":"2017","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.neulet.2020.135505_bib0145","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1016\/j.celrep.2019.04.096","article-title":"An atlas of vagal sensory neurons and their molecular specialization","volume":"27","author":"Kupari","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.neulet.2020.135505_bib0150","article-title":"Transcriptional profiling of individual airway projecting vagal sensory neurons","author":"Mazzone","year":"2019","journal-title":"Mol. Neurobiol."},{"issue":"20","key":"10.1016\/j.neulet.2020.135505_bib0155","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.1242\/dev.124.20.4065","article-title":"Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis","volume":"124","author":"Pattyn","year":"1997","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.neulet.2020.135505_bib0160","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0896-6273(00)81242-8","article-title":"Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a","volume":"18","author":"Morin","year":"1997","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.neulet.2020.135505_bib0165","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1152\/japplphysiol.00944.2015","article-title":"Characterization of cardiovascular reflexes evoked by airway stimulation with allylisothiocyanate, capsaicin, and ATP in Sprague-Dawley rats","volume":"120","author":"Hooper","year":"2016","journal-title":"J. Appl. Physiol."},{"issue":"6653","key":"10.1016\/j.neulet.2020.135505_bib0170","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: a heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"issue":"5464","key":"10.1016\/j.neulet.2020.135505_bib0175","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1126\/science.288.5464.306","article-title":"Impaired nociception and pain sensation in mice lacking the capsaicin receptor","volume":"288","author":"Caterina","year":"2000","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.neulet.2020.135505_bib0180","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1152\/jappl.1995.79.4.1082","article-title":"Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs","volume":"79","author":"Lalloo","year":"1995","journal-title":"J. Appl. Physiol."},{"issue":"2","key":"10.1016\/j.neulet.2020.135505_bib0185","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/sj.bjp.0701111","article-title":"Central antitussive activity of the NK1 and NK2 tachykinin receptor antagonists, CP-99,994 and SR 48968, in the guinea-pig and cat","volume":"121","author":"Bolser","year":"1997","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0190","doi-asserted-by":"crossref","first-page":"R86","DOI":"10.1152\/ajpregu.00007.2002","article-title":"Synergistic interactions between airway afferent nerve subtypes mediating reflex bronchospasm in guinea pigs","volume":"283","author":"Mazzone","year":"2002","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"5","key":"10.1016\/j.neulet.2020.135505_bib0195","doi-asserted-by":"crossref","first-page":"R1572","DOI":"10.1152\/ajpregu.90382.2008","article-title":"Differential effects of airway afferent nerve subtypes on cough and respiration in anesthetized guinea pigs","volume":"295","author":"Chou","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"1\u20133","key":"10.1016\/j.neulet.2020.135505_bib0200","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ejphar.2012.05.048","article-title":"Comparison of TRPA1-versus TRPV1-mediated cough in guinea pigs","volume":"689","author":"Brozmanova","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neulet.2020.135505_bib0205","series-title":"The Integrative Action of the Nervous System","author":"Sherrington","year":"1906"},{"issue":"Pt 3","key":"10.1016\/j.neulet.2020.135505_bib0210","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1113\/jphysiol.2003.042028","article-title":"Capsaicin-sensitive and -insensitive vagal bronchopulmonary C-fibres in the mouse","volume":"551","author":"Kollarik","year":"2003","journal-title":"J. Physiol."},{"issue":"5","key":"10.1016\/j.neulet.2020.135505_bib0215","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.jaci.2007.07.007","article-title":"Neuroimmune crosstalk in asthma: dual role of the neurotrophin receptor p75NTR","volume":"120","author":"Nassenstein","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"issue":"2","key":"10.1016\/j.neulet.2020.135505_bib0220","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1165\/rcmb.2016-0228OC","article-title":"Mechanistic studies of capsaicin-induced apnea in rodents","volume":"56","author":"Ren","year":"2017","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"2","key":"10.1016\/j.neulet.2020.135505_bib0225","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/S0022-3565(24)38188-1","article-title":"Characterization of vagal afferent subtypes stimulated by bradykinin in guinea pig trachea","volume":"289","author":"Kajekar","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"Pt 1","key":"10.1016\/j.neulet.2020.135505_bib0230","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1113\/jphysiol.2005.087577","article-title":"Role of chloride channels in bradykinin-induced guinea pig airway vagal C-fibre activation","volume":"566","author":"Lee","year":"2005","journal-title":"J. Physiol."},{"issue":"6","key":"10.1016\/j.neulet.2020.135505_bib0235","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1113\/jphysiol.2007.148379","article-title":"Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs","volume":"586","author":"Nassenstein","year":"2008","journal-title":"J. Physiol."},{"key":"10.1016\/j.neulet.2020.135505_bib0240","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1113\/jphysiol.1982.sp014041","article-title":"The brain-stem projections of pulmonary stretch afferent neurones in cats and rabbits","volume":"322","author":"Donoghue","year":"1982","journal-title":"J. Physiol."},{"issue":"4","key":"10.1016\/j.neulet.2020.135505_bib0245","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1161\/01.RES.51.4.525","article-title":"Responses to inflation of vagal afferents with endings in the lung of dogs","volume":"51","author":"Kaufman","year":"1982","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0250","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1152\/japplphysiol.00137.2003","article-title":"Structure of slowly adapting pulmonary stretch receptors in the lung periphery","volume":"95","author":"Yu","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.neulet.2020.135505_bib0255","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1113\/jphysiol.1986.sp016035","article-title":"Projection of pulmonary rapidly adapting receptors to the medulla of the cat: an antidromic mapping study","volume":"373","author":"Davies","year":"1986","journal-title":"J. Physiol."},{"key":"10.1016\/j.neulet.2020.135505_bib0260","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1113\/jphysiol.1987.sp016429","article-title":"Pulmonary stretch receptor relay neurones of the cat: location and contralateral medullary projections","volume":"383","author":"Davies","year":"1987","journal-title":"J. Physiol."},{"issue":"9","key":"10.1016\/j.neulet.2020.135505_bib0265","doi-asserted-by":"crossref","first-page":"L941","DOI":"10.1152\/ajplung.00366.2011","article-title":"TRPV1 induction in airway vagal low-threshold mechanosensory neurons by allergen challenge and neurotrophic factors","volume":"302","author":"Lieu","year":"2012","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"43","key":"10.1016\/j.neulet.2020.135505_bib0270","doi-asserted-by":"crossref","first-page":"13662","DOI":"10.1523\/JNEUROSCI.4354-08.2009","article-title":"Selective expression of a sodium pump isozyme by cough receptors and evidence for its essential role in regulating cough","volume":"29","author":"Mazzone","year":"2009","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.neulet.2020.135505_bib0275","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jaci.2005.04.005","article-title":"Allergen-induced substance P synthesis in large-diameter sensory neurons innervating the lungs","volume":"116","author":"Chuaychoo","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.neulet.2020.135505_bib0280","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1745-9974-4-9","article-title":"Immunohistochemical characterization of nodose cough receptor neurons projecting to the trachea of guinea pigs","volume":"4","author":"Mazzone","year":"2008","journal-title":"Cough"},{"issue":"5","key":"10.1016\/j.neulet.2020.135505_bib0285","doi-asserted-by":"crossref","first-page":"L858","DOI":"10.1152\/ajplung.90360.2008","article-title":"P2X2 receptors differentiate placodal vs neural crest C-fiber phenotypes innervating guinea pig lungs and esophagus","volume":"295","author":"Kwong","year":"2008","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.neulet.2020.135505_bib0290","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0203-20.2020","article-title":"Development of a mouse reporter strain for the purinergic P2X(2) receptor","author":"Kim","year":"2020","journal-title":"eNeuro"},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0295","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0031-6997(24)01482-0","article-title":"International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits","volume":"53","author":"Khakh","year":"2001","journal-title":"Pharmacol. Rev."},{"issue":"Pt 2","key":"10.1016\/j.neulet.2020.135505_bib0300","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1113\/jphysiol.2006.109371","article-title":"Evidence for both adenosine A1 and A2A receptors activating single vagal sensory C-fibres in guinea pig lungs","volume":"575","author":"Chuaychoo","year":"2006","journal-title":"J. Physiol."},{"issue":"4","key":"10.1016\/j.neulet.2020.135505_bib0305","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.pupt.2004.12.010","article-title":"Effect of 5-hydroxytryptamine on vagal C-fiber subtypes in guinea pig lungs","volume":"18","author":"Chuaychoo","year":"2005","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.neulet.2020.135505_bib0310","doi-asserted-by":"crossref","DOI":"10.1113\/jphysiol.2012.237115","article-title":"Activation of mouse bronchopulmonary C-fibers by serotonin and allergen-ovalbumin challenge","author":"Potenzieri","year":"2012","journal-title":"J. Physiol."},{"issue":"2","key":"10.1016\/j.neulet.2020.135505_bib0315","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1748-1716.1984.tb00127.x","article-title":"Vascular permeability changes and smooth muscle contraction in relation to capsaicin-sensitive substance P afferents in the guinea-pig","volume":"120","author":"Lundberg","year":"1984","journal-title":"Acta Physiol. Scand."},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0320","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0022-3565(25)39576-5","article-title":"Pharmacological examination of receptors mediating contractile responses to tachykinins in airways isolated from human, guinea pig and hamster","volume":"267","author":"Ellis","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"2","key":"10.1016\/j.neulet.2020.135505_bib0325","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0301-0082(97)00003-8","article-title":"Neurochemistry of the nodose ganglion","volume":"52","author":"Zhuo","year":"1997","journal-title":"Prog. Neurobiol."},{"issue":"6","key":"10.1016\/j.neulet.2020.135505_bib0330","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1164\/ajrccm.159.6.9808078","article-title":"Identification and substance P content of vagal afferent neurons innervating the epithelium of the guinea pig trachea","volume":"159","author":"Hunter","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.neulet.2020.135505_bib0335","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1523\/JNEUROSCI.19-05-01844.1999","article-title":"Differential expression of the mRNA for the vanilloid receptor subtype 1 in cells of the adult rat dorsal root and nodose ganglia and its downregulation by axotomy","volume":"19","author":"Michael","year":"1999","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0340","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0169-328X(02)00584-3","article-title":"Distribution and colocalization of NGF and GDNF family ligand receptor mRNAs in dorsal root and nodose ganglion neurons of adult rats","volume":"110","author":"Kashiba","year":"2003","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"5","key":"10.1016\/j.neulet.2020.135505_bib0345","doi-asserted-by":"crossref","first-page":"L790","DOI":"10.1152\/ajplung.00449.2010","article-title":"Neurotrophin and GDNF family ligand receptor expression in vagal sensory nerve subtypes innervating the adult guinea pig respiratory tract","volume":"300","author":"Lieu","year":"2011","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"1338","key":"10.1016\/j.neulet.2020.135505_bib0350","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1098\/rstb.1996.0030","article-title":"Role of neurotrophins and trk receptors in the development and maintenance of sensory neurons: an overview","volume":"351","author":"Lindsay","year":"1996","journal-title":"Philos. Trans. R. Soc. Lond., B, Biol. Sci."},{"issue":"2","key":"10.1016\/j.neulet.2020.135505_bib0355","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1165\/ajrcmb.18.2.2803m","article-title":"Hyperinnervation of the airways in transgenic mice overexpressing nerve growth factor","volume":"18","author":"Hoyle","year":"1998","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"6","key":"10.1016\/j.neulet.2020.135505_bib0360","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1164\/ajrccm.161.6.9908051","article-title":"Nerve growth factor-induced phenotypic switch in guinea pig airway sensory neurons","volume":"161","author":"Hunter","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"9","key":"10.1016\/j.neulet.2020.135505_bib0365","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1111\/j.1365-2222.2004.02066.x","article-title":"Nerve growth factor-induced substance P in capsaicin-insensitive vagal neurons innervating the lower mouse airway","volume":"34","author":"Dinh","year":"2004","journal-title":"Clin. Exp. Allergy"},{"issue":"3","key":"10.1016\/j.neulet.2020.135505_bib0370","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/sj.bjp.0705638","article-title":"Brain-derived neurotrophic factor (BDNF) contributes to neuronal dysfunction in a model of allergic airway inflammation","volume":"141","author":"Braun","year":"2004","journal-title":"Br. J. Pharmacol."},{"issue":"Pt 23","key":"10.1016\/j.neulet.2020.135505_bib0375","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.1113\/jphysiol.2008.161042","article-title":"Altered expression of TRPV1 and sensitivity to capsaicin in pulmonary myelinated afferents following chronic airway inflammation in the rat","volume":"586","author":"Zhang","year":"2008","journal-title":"J. Physiol."},{"issue":"9","key":"10.1016\/j.neulet.2020.135505_bib0380","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1111\/j.1365-2222.2006.02549.x","article-title":"Airway hyper-responsiveness in allergic asthma in guinea-pigs is mediated by nerve growth factor via the induction of substance P: a potential role for trkA","volume":"36","author":"de Vries","year":"2006","journal-title":"Clin. Exp. Allergy"},{"issue":"8","key":"10.1016\/j.neulet.2020.135505_bib0385","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1164\/ajrccm.165.8.2108065","article-title":"Expression of tachykinins in nonnociceptive vagal afferent neurons during respiratory viral infection in guinea pigs","volume":"165","author":"Carr","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1\u20133","key":"10.1016\/j.neulet.2020.135505_bib0390","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000053711","article-title":"Nerve growth factor induces airway hyperresponsiveness in mice","volume":"124","author":"Braun","year":"2001","journal-title":"Int. Arch. Allergy Immunol."},{"issue":"3","key":"10.1016\/j.neulet.2020.135505_bib0395","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/0306-4522(92)90239-X","article-title":"The sensory and sympathetic innervation of guinea-pig lung and trachea as studied by retrograde neuronal tracing and double-labelling immunohistochemistry","volume":"49","author":"Kummer","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2020.135505_bib0400","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1465-9921-7-96","article-title":"Spinal afferent neurons projecting to the rat lung and pleura express acid sensitive channels","volume":"7","author":"Groth","year":"2006","journal-title":"Respir. Res."},{"issue":"Pt 2","key":"10.1016\/j.neulet.2020.135505_bib0405","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1113\/jphysiol.2005.104661","article-title":"Reflex regulation of airway sympathetic nerves in guinea-pigs","volume":"573","author":"Oh","year":"2006","journal-title":"J. Physiol."},{"issue":"9","key":"10.1016\/j.neulet.2020.135505_bib0410","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1007\/s00429-018-1732-z","article-title":"Reflex regulation of breathing by the paratrigeminal nucleus via multiple bulbar circuits","volume":"223","author":"Driessen","year":"2018","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.neulet.2020.135505_bib0415","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1113\/jphysiol.1991.sp018506","article-title":"The medullary projections of afferent bronchopulmonary C fibres in the cat as shown by antidromic mapping","volume":"435","author":"Kubin","year":"1991","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.neulet.2020.135505_bib0420","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/cne.902110304","article-title":"Brainstem projections of sensory and motor components of the vagus nerve in the rat","volume":"211","author":"Kalia","year":"1982","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neulet.2020.135505_bib0425","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3389\/fphys.2015.00378","article-title":"The role of the paratrigeminal nucleus in vagal afferent evoked respiratory reflexes: a neuroanatomical and functional study in Guinea Pigs","volume":"6","author":"Driessen","year":"2015","journal-title":"Front. Physiol."},{"issue":"3","key":"10.1016\/j.neulet.2020.135505_bib0430","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0306-4522(83)90196-3","article-title":"Substance P neurones in medullary baroreflex areas and baroreflex function of capsaicin-treated rats. Comparison with other primary afferent systems","volume":"8","author":"Lorez","year":"1983","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0435","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0306-4522(84)90148-9","article-title":"Autoradiographic localization of substance P receptors in rat medulla: effect of vagotomy and nodose ganglionectomy","volume":"12","author":"Helke","year":"1984","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0440","first-page":"188","article-title":"Well-maintained reflex responses of sympathetic nerve activity to stimulation of baroreceptor, chemoreceptor and cutaneous mechanoreceptors in neonatal capsaicin-treated rats","volume":"445","author":"Takano","year":"1988","journal-title":"Brain Res."},{"issue":"Pt 2","key":"10.1016\/j.neulet.2020.135505_bib0445","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1113\/jphysiol.2005.093153","article-title":"Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea-pigs","volume":"569","author":"Mazzone","year":"2005","journal-title":"J. Physiol."},{"issue":"2","key":"10.1016\/j.neulet.2020.135505_bib0450","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/sj.bjp.0702522","article-title":"Respiratory action of capsaicin microinjected into the nucleus of the solitary tract: involvement of vanilloid and tachykinin receptors","volume":"127","author":"Mazzone","year":"1999","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.neulet.2020.135505_bib0455","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1164\/rccm.200308-1139OC","article-title":"Passive smoke effects on cough and airways in young guinea pigs: role of brainstem substance P","volume":"169","author":"Joad","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"6","key":"10.1016\/j.neulet.2020.135505_bib0460","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/sj.bjp.0703172","article-title":"Respiratory actions of tachykinins in the nucleus of the solitary tract: characterization of receptors using selective agonists and antagonists","volume":"129","author":"Mazzone","year":"2000","journal-title":"Br. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.neulet.2020.135505_bib0465","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1046\/j.1460-9568.1998.00238.x","article-title":"Importance of neurokinin-1 receptors in the nucleus tractus solitarii of mice for the integration of cardiac vagal inputs","volume":"10","author":"Paton","year":"1998","journal-title":"Eur. J. Neurosci."},{"issue":"20","key":"10.1016\/j.neulet.2020.135505_bib0470","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1523\/JNEUROSCI.0753-04.2004","article-title":"Purinergic and vanilloid receptor activation releases glutamate from separate cranial afferent terminals in nucleus tractus solitarius","volume":"24","author":"Jin","year":"2004","journal-title":"J. Neurosci."},{"issue":"18","key":"10.1016\/j.neulet.2020.135505_bib0475","doi-asserted-by":"crossref","first-page":"8222","DOI":"10.1523\/JNEUROSCI.22-18-08222.2002","article-title":"Vanilloid receptors presynaptically modulate cranial visceral afferent synaptic transmission in nucleus tractus solitarius","volume":"22","author":"Doyle","year":"2002","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0480","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jneumeth.2012.05.035","article-title":"Anterograde neuronal circuit tracing using a genetically modified herpes simplex virus expressing EGFP","volume":"209","author":"McGovern","year":"2012","journal-title":"J. Neurosci. Methods"},{"issue":"6","key":"10.1016\/j.neulet.2020.135505_bib0485","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1007\/s00429-014-0883-9","article-title":"Evidence for multiple sensory circuits in the brain arising from the respiratory system: an anterograde viral tract tracing study in rodents","volume":"220","author":"McGovern","year":"2015","journal-title":"Brain Struct. Funct."},{"issue":"10","key":"10.1016\/j.neulet.2020.135505_bib0490","doi-asserted-by":"crossref","first-page":"3916","DOI":"10.1096\/fj.09-151068","article-title":"An essential component to brainstem cough gating identified in anesthetized guinea pigs","volume":"24","author":"Canning","year":"2010","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.neulet.2020.135505_bib0495","doi-asserted-by":"crossref","first-page":"R369","DOI":"10.1152\/ajpregu.00044.2010","article-title":"Encoding of the cough reflex in anesthetized guinea pigs","volume":"300","author":"Canning","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.neulet.2020.135505_bib0500","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1113\/jphysiol.1993.sp019660","article-title":"Pulmonary stretch receptor afferents activate excitatory amino acid receptors in the nucleus tractus solitarii in rats","volume":"464","author":"Bonham","year":"1993","journal-title":"J. Physiol."},{"issue":"1\u20132","key":"10.1016\/j.neulet.2020.135505_bib0505","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.brainresbull.2009.05.022","article-title":"Role of excitatory amino acids in the mediation of tracheobronchial cough induced by citric acid inhalation in the rabbit","volume":"80","author":"Mutolo","year":"2009","journal-title":"Brain Res. Bull."},{"issue":"11","key":"10.1016\/j.neulet.2020.135505_bib0510","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1113\/JP279644","article-title":"A role for neurokinin 1 receptor expressing neurons in the paratrigeminal nucleus in bradykinin-evoked cough in guinea-pigs","volume":"598","author":"Driessen","year":"2020","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0515","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1165\/rcmb.2013-0284OC","article-title":"Tissue optical clearing, three-dimensional imaging, and computer morphometry in whole mouse lungs and human airways","volume":"51","author":"Scott","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0520","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1164\/rccm.201412-2293OC","article-title":"Morphologic characterization of nerves in Whole-Mount Airway Biopsies","volume":"192","author":"West","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.neulet.2020.135505_bib0525","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1165\/rcmb.4889","article-title":"The three-dimensional distribution of nerves along the entire intrapulmonary airway tree of the adult rat and the anatomical relationship between nerves and neuroepithelial bodies","volume":"28","author":"Larson","year":"2003","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0530","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1165\/rcmb.2003-0097OC","article-title":"Quantification of neuroepithelial bodies and their innervation in fawn-hooded and Wistar rat lungs","volume":"30","author":"Van Genechten","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"3","key":"10.1016\/j.neulet.2020.135505_bib0535","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s004410051131","article-title":"Pulmonary intraepithelial vagal nodose afferent nerve terminals are confined to neuroepithelial bodies: an anterograde tracing and confocal microscopy study in adult rats","volume":"293","author":"Adriaensen","year":"1998","journal-title":"Cell Tissue Res."},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0540","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00418-008-0495-7","article-title":"Neurochemical pattern of the complex innervation of neuroepithelial bodies in mouse lungs","volume":"131","author":"Brouns","year":"2009","journal-title":"Histochem. Cell Biol."},{"issue":"3","key":"10.1016\/j.neulet.2020.135505_bib0545","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1165\/rcmb.2002-0117OC","article-title":"Dual sensory innervation of pulmonary neuroepithelial bodies","volume":"28","author":"Brouns","year":"2003","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"6393","key":"10.1016\/j.neulet.2020.135505_bib0550","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan8546","article-title":"Pulmonary neuroendocrine cells amplify allergic asthma responses","volume":"360","author":"Sui","year":"2018","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.neulet.2020.135505_bib0555","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00418-005-0078-9","article-title":"Neurochemical characterisation of sensory receptors in airway smooth muscle: comparison with pulmonary neuroepithelial bodies","volume":"125","author":"Brouns","year":"2006","journal-title":"Histochem. Cell Biol."},{"issue":"5","key":"10.1016\/j.neulet.2020.135505_bib0560","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1152\/japplphysiol.00632.2010","article-title":"Sympathetic nerve-dependent regulation of mucosal vascular tone modifies airway smooth muscle reactivity","volume":"109","author":"Mazzone","year":"2010","journal-title":"J. Appl. Physiol."},{"issue":"4 Pt 1","key":"10.1016\/j.neulet.2020.135505_bib0565","first-page":"L731","article-title":"Localization of cholinergic nerves in lower airways of guinea pigs using antisera to choline acetyltransferase","volume":"272","author":"Canning","year":"1997","journal-title":"Am. J. Physiol."},{"issue":"4","key":"10.1016\/j.neulet.2020.135505_bib0570","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/(SICI)1096-9861(20000417)419:4<439::AID-CNE3>3.0.CO;2-3","article-title":"Anatomical characteristics of tonic and phasic postganglionic neurons in guinea pig bronchial parasympathetic ganglia","volume":"419","author":"Myers","year":"2000","journal-title":"J. Comp. Neurol."},{"issue":"3","key":"10.1016\/j.neulet.2020.135505_bib0575","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.pupt.2004.12.002","article-title":"Immunohistochemical localization of vanilloid receptor subtype 1 (TRPV1) in the guinea pig respiratory system","volume":"18","author":"Watanabe","year":"2005","journal-title":"Pulm. Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.neulet.2020.135505_bib0580","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.neuroscience.2006.04.073","article-title":"Immunohistochemical co-localization of transient receptor potential vanilloid (TRPV)1 and sensory neuropeptides in the guinea-pig respiratory system","volume":"141","author":"Watanabe","year":"2006","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.neulet.2020.135505_bib0585","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/j.1469-7580.2007.00821.x","article-title":"Distribution of TRPV1- and TRPV2-immunoreactive afferent nerve endings in rat trachea","volume":"211","author":"Yamamoto","year":"2007","journal-title":"J. Anat."},{"issue":"3","key":"10.1016\/j.neulet.2020.135505_bib0590","first-page":"155","article-title":"Distribution of peptidergic nerve fibers in rat bronchus-associated lymphoid tissue: light microscopic observations","volume":"23","author":"Inoue","year":"1990","journal-title":"Lymphology"},{"issue":"2","key":"10.1016\/j.neulet.2020.135505_bib0595","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1152\/jappl.1990.68.2.770","article-title":"Origin and colocalization of CGRP- and SP-reactive nerves in cat airway epithelium","volume":"68","author":"Dey","year":"1990","journal-title":"J. Appl. Physiol."},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0600","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF00185838","article-title":"Afferent nerve endings in the tracheal muscle of guinea-pigs and rats","volume":"183","author":"Baluk","year":"1991","journal-title":"Anat. Embryol. (Berl.)"},{"issue":"4","key":"10.1016\/j.neulet.2020.135505_bib0605","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/cne.903190408","article-title":"Substance P-immunoreactive sensory axons in the rat respiratory tract: a quantitative study of their distribution and role in neurogenic inflammation","volume":"319","author":"Baluk","year":"1992","journal-title":"J. Comp. Neurol."},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0610","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0034-5288(96)90135-6","article-title":"Distribution of calcitonin gene-related peptide, vasoactive intestinal polypeptide, neuropeptide Y, substance P and dopamine beta-hydroxylase immunoreactive nerve fibres in the trachea of sheep","volume":"60","author":"Corcoran","year":"1996","journal-title":"Res. Vet. Sci."},{"issue":"2","key":"10.1016\/j.neulet.2020.135505_bib0615","doi-asserted-by":"crossref","first-page":"R320","DOI":"10.1152\/ajpregu.00001.2002","article-title":"Endogenous neurokinins facilitate synaptic transmission in guinea pig airway parasympathetic ganglia","volume":"283","author":"Canning","year":"2002","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"9","key":"10.1016\/j.neulet.2020.135505_bib0620","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1164\/rccm.2112018","article-title":"Three-dimensional mapping of sensory innervation with substance p in porcine bronchial mucosa: comparison with human airways","volume":"166","author":"Lamb","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0625","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.resp.2007.07.010","article-title":"Calcitonin gene-related peptide affects synaptic and membrane properties of bronchial parasympathetic neurons","volume":"160","author":"Kajekar","year":"2008","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"2","key":"10.1016\/j.neulet.2020.135505_bib0630","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00418-015-1371-x","article-title":"Morphology of P2X3-immunoreactive nerve endings in the rat laryngeal mucosa","volume":"145","author":"Takahashi","year":"2016","journal-title":"Histochem. Cell Biol."},{"issue":"7636","key":"10.1016\/j.neulet.2020.135505_bib0635","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nature20793","article-title":"Piezo2 senses airway stretch and mediates lung inflation-induced apnoea","volume":"541","author":"Nonomura","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0640","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.resp.2004.07.022","article-title":"Neuroepithelial bodies not connected to pulmonary slowly adapting stretch receptors","volume":"144","author":"Yu","year":"2004","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"13","key":"10.1016\/j.neulet.2020.135505_bib0645","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1113\/JP278085","article-title":"Nociceptive pulmonary-cardiac reflexes are altered in the spontaneously Hypertensive rat","volume":"597","author":"Hooper","year":"2019","journal-title":"J. Physiol."},{"issue":"2","key":"10.1016\/j.neulet.2020.135505_bib0650","doi-asserted-by":"crossref","first-page":"R454","DOI":"10.1152\/ajpregu.00862.2005","article-title":"Mechanistic studies of acid-evoked coughing in anesthetized guinea pigs","volume":"291","author":"Canning","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"11","key":"10.1016\/j.neulet.2020.135505_bib0655","doi-asserted-by":"crossref","first-page":"R1017","DOI":"10.1152\/ajpregu.00028.2013","article-title":"Selective inhibition of vagal afferent nerve pathways regulating cough using Nav 1.7 shRNA silencing in guinea pig nodose ganglia","volume":"304","author":"Muroi","year":"2013","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"2","key":"10.1016\/j.neulet.2020.135505_bib0660","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0304-3940(91)90536-3","article-title":"Ruthenium red decreases capsaicin and citric acid-induced cough in guinea pigs","volume":"126","author":"Bolser","year":"1991","journal-title":"Neurosci. Lett."},{"issue":"3","key":"10.1016\/j.neulet.2020.135505_bib0665","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/pulp.1993.1023","article-title":"A comparative study of the effects of citric acid, capsaicin and resiniferatoxin on the cough challenge in guinea-pig and man","volume":"6","author":"Laude","year":"1993","journal-title":"Pulm. Pharmacol."},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0670","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1254\/jphs.FPJ05014X","article-title":"Mechanisms of capsaicin- and citric-acid-induced cough reflexes in guinea pigs","volume":"99","author":"Tanaka","year":"2005","journal-title":"J. Pharmacol. Sci."},{"issue":"6","key":"10.1016\/j.neulet.2020.135505_bib0675","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1111\/j.1476-5381.2009.00438.x","article-title":"Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents","volume":"158","author":"Andre","year":"2009","journal-title":"Br. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.neulet.2020.135505_bib0680","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1164\/rccm.200905-0665OC","article-title":"TRPA1 agonists evoke coughing in guinea-pig and human volunteers","volume":"180","author":"Birrell","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"10","key":"10.1016\/j.neulet.2020.135505_bib0685","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1136\/thoraxjnl-2011-201443","article-title":"Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin","volume":"67","author":"Grace","year":"2012","journal-title":"Thorax"},{"issue":"3","key":"10.1016\/j.neulet.2020.135505_bib0690","doi-asserted-by":"crossref","first-page":"R489","DOI":"10.1152\/ajpregu.00313.2017","article-title":"Opposing effects of bronchopulmonary C-fiber subtypes on cough in guinea pigs","volume":"314","author":"Chou","year":"2018","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"4","key":"10.1016\/j.neulet.2020.135505_bib0695","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1152\/jappl.1989.67.4.1428","article-title":"Reflex responses to capsaicin: intravenous, aerosol, and intratracheal administration","volume":"67","author":"Palecek","year":"1989","journal-title":"J. Appl. Physiol."},{"issue":"2 Pt 2","key":"10.1016\/j.neulet.2020.135505_bib0700","first-page":"R394","article-title":"Pulmonary depressor reflex elicited by capsaicin in conscious intact and lung-denervated dogs","volume":"252","author":"Clifford","year":"1987","journal-title":"Am. J. Physiol."},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0705","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1152\/physrev.1973.53.1.159","article-title":"Vagal sensory receptors and their reflex effects","volume":"53","author":"Paintal","year":"1973","journal-title":"Physiol. Rev."},{"issue":"4","key":"10.1016\/j.neulet.2020.135505_bib0710","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1161\/01.RES.58.4.512","article-title":"Stimulation of pulmonary vagal afferent C-fibers by lung edema in dogs","volume":"58","author":"Roberts","year":"1986","journal-title":"Circ. Res."},{"key":"10.1016\/j.neulet.2020.135505_bib0715","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2013.07.024","article-title":"Isoflurane inhibits bronchopulmonary C-fiber-mediated apneic response to phenylbiguanide by depressing 5-HT3 receptor function in anesthetized rats","volume":"552","author":"Zhang","year":"2013","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2020.135505_bib0720","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3389\/fphys.2019.00642","article-title":"Stimulatory effect of 5-Hydroxytryptamine (5-HT) on rat capsaicin-sensitive lung vagal sensory neurons via activation of 5-HT(3) receptors","volume":"10","author":"Hsu","year":"2019","journal-title":"Front. Physiol."},{"issue":"3","key":"10.1016\/j.neulet.2020.135505_bib0725","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1152\/japplphysiol.00161.2006","article-title":"Pulmonary sensory and reflex responses in the mouse","volume":"101","author":"Zhang","year":"2006","journal-title":"J. Appl. Physiol."},{"issue":"3","key":"10.1016\/j.neulet.2020.135505_bib0730","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/s41593-018-0074-8","article-title":"Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness","volume":"21","author":"Han","year":"2018","journal-title":"Nat. Neurosci."},{"issue":"4440","key":"10.1016\/j.neulet.2020.135505_bib0735","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1126\/science.7361114","article-title":"A nonadrenergic vagal inhibitory pathway to feline airways","volume":"208","author":"Diamond","year":"1980","journal-title":"Science"},{"key":"10.1016\/j.neulet.2020.135505_bib0740","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1113\/jphysiol.1993.sp019889","article-title":"Evidence that distinct neural pathways mediate parasympathetic contractions and relaxations of guinea-pig trachealis","volume":"471","author":"Canning","year":"1993","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0745","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0163-7258(89)90021-1","article-title":"Afferent pathways involved in reflex regulation of airway smooth muscle","volume":"42","author":"Coleridge","year":"1989","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.neulet.2020.135505_bib0750","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1152\/japplphysiol.00313.2006","article-title":"Reflex regulation of airway smooth muscle tone","volume":"101","author":"Canning","year":"2006","journal-title":"J. Appl. Physiol."},{"issue":"6","key":"10.1016\/j.neulet.2020.135505_bib0755","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1152\/jappl.2001.91.6.2642","article-title":"Multiple mechanisms of reflex bronchospasm in guinea pigs","volume":"91","author":"Canning","year":"2001","journal-title":"J. Appl. Physiol."},{"issue":"2","key":"10.1016\/j.neulet.2020.135505_bib0760","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1113\/jphysiol.1969.sp008755","article-title":"The role of the vagus nerves in the respiratory and circulatory responses to intravenous histamine and phenyl diguanide in rabbits","volume":"201","author":"Karczewski","year":"1969","journal-title":"J. Physiol."},{"issue":"2","key":"10.1016\/j.neulet.2020.135505_bib0765","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1113\/jphysiol.1972.sp009908","article-title":"Reflex effects of laryngeal irritation on the pattern of breathing and total lung resistance","volume":"224","author":"Boushey","year":"1972","journal-title":"J. Physiol."},{"issue":"6","key":"10.1016\/j.neulet.2020.135505_bib0770","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/pulp.1995.1037","article-title":"Mechanisms of 5-hydroxytryptamine-induced contraction of isolated rat intrapulmonary bronchi","volume":"8","author":"Szarek","year":"1995","journal-title":"Pulm. Pharmacol."},{"issue":"2 Suppl","key":"10.1016\/j.neulet.2020.135505_bib0775","first-page":"176","article-title":"The effect of tachykinins on the conducting airways of the rat","volume":"280","author":"Joos","year":"1986","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"issue":"2","key":"10.1016\/j.neulet.2020.135505_bib0780","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1164\/ajrccm.155.2.9032224","article-title":"Tachykinin-independent effects of capsaicin on smooth muscle in human isolated bronchi","volume":"155","author":"Ellis","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"4","key":"10.1016\/j.neulet.2020.135505_bib0785","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1111\/j.1476-5381.1990.tb14174.x","article-title":"Non-adrenergic, non-cholinergic contractions in the electrically field stimulated guinea-pig trachea","volume":"101","author":"Ellis","year":"1990","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.neulet.2020.135505_bib0790","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0022-3565(25)38506-X","article-title":"Inhibition by capsazepine of resiniferatoxin- and capsaicin-induced contractions of guinea pig trachea","volume":"268","author":"Ellis","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"Pt 3","key":"10.1016\/j.neulet.2020.135505_bib0795","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1113\/jphysiol.1994.sp020388","article-title":"Evidence that antidromically stimulated vagal afferents activate inhibitory neurones innervating guinea-pig trachealis","volume":"480","author":"Canning","year":"1994","journal-title":"J. Physiol."},{"issue":"8644","key":"10.1016\/j.neulet.2020.135505_bib0800","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/S0140-6736(89)92509-9","article-title":"Opioid inhibition of neurally mediated mucus secretion in human bronchi","volume":"1","author":"Rogers","year":"1989","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.neulet.2020.135505_bib0805","first-page":"985","article-title":"Reflex tracheal gland secretion evoked by stimulation of bronchial C-fibers in dogs","volume":"53","author":"Davis","year":"1982","journal-title":"J. Appl. Physiol. Respir. Environ. Exerc. Physiol."},{"issue":"3","key":"10.1016\/j.neulet.2020.135505_bib0810","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1152\/jappl.1985.58.3.907","article-title":"Pulmonary C-fibers reflexly increase secretion by tracheal submucosal glands in dogs","volume":"58","author":"Schultz","year":"1985","journal-title":"J. Appl. Physiol."},{"issue":"3","key":"10.1016\/j.neulet.2020.135505_bib0815","doi-asserted-by":"crossref","first-page":"L370","DOI":"10.1152\/ajplung.00372.2010","article-title":"Properties of substance P-stimulated mucus secretion from porcine tracheal submucosal glands","volume":"300","author":"Khansaheb","year":"2011","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"8","key":"10.1016\/j.neulet.2020.135505_bib0820","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/sj.bjp.0707168","article-title":"Capsaicin-induced mucus secretion in rat airways assessed in vivo and non-invasively by magnetic resonance imaging","volume":"150","author":"Karmouty-Quintana","year":"2007","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.neulet.2020.135505_bib0825","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1111\/j.1476-5381.1994.tb17122.x","article-title":"\u2019SEnsory-efferent\u2019 neural control of mucus secretion: characterization using tachykinin receptor antagonists in ferret trachea in vitro","volume":"113","author":"Ramnarine","year":"1994","journal-title":"Br. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.neulet.2020.135505_bib0830","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1139\/y95-129","article-title":"Neurokinin receptors subserving airways secretion","volume":"73","author":"Rogers","year":"1995","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"12","key":"10.1016\/j.neulet.2020.135505_bib0835","doi-asserted-by":"crossref","first-page":"e13742","DOI":"10.14814\/phy2.13742","article-title":"Sympatho-excitatory response to pulmonary chemosensitive spinal afferent activation in anesthetized, vagotomized rats","volume":"6","author":"Shanks","year":"2018","journal-title":"Physiol. Rep."},{"issue":"4","key":"10.1016\/j.neulet.2020.135505_bib0840","doi-asserted-by":"crossref","first-page":"H862","DOI":"10.1152\/ajpheart.00696.2018","article-title":"Sympathoexcitation in response to cardiac and pulmonary afferent stimulation of TRPA1 channels is attenuated in rats with chronic heart failure","volume":"316","author":"Adam","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"31","key":"10.1016\/j.neulet.2020.135505_bib0845","doi-asserted-by":"crossref","first-page":"11515","DOI":"10.1073\/pnas.1411032111","article-title":"Population of sensory neurons essential for asthmatic hyperreactivity of inflamed airways","volume":"111","author":"Trankner","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2020.135505_bib0850","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.resp.2015.03.007","article-title":"Vagotomy reverses established allergen-induced airway hyperreactivity to methacholine in the mouse","volume":"212-214","author":"McAlexander","year":"2015","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"21","key":"10.1016\/j.neulet.2020.135505_bib0855","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1161\/CIR.0b013e3181dbece1","article-title":"Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association","volume":"121","author":"Brook","year":"2010","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.neulet.2020.135505_bib0860","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.jaci.2017.04.038","article-title":"Mechanistic link between diesel exhaust particles and respiratory reflexes","volume":"141","author":"Robinson","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.neulet.2020.135505_bib0865","doi-asserted-by":"crossref","DOI":"10.1021\/acs.chemrestox.8b00375","article-title":"Differential activation of TRPA1 by diesel exhaust particles: relationships between chemical composition, potency, and lung toxicity","author":"Deering-Rice","year":"2019","journal-title":"Chem. Res. Toxicol."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394020307758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394020307758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:36:56Z","timestamp":1759610216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394020307758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":173,"alternative-id":["S0304394020307758"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2020.135505","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular identity, anatomy, gene expression and function of neural crest vs. placode-derived nociceptors in the lower airways","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2020.135505","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"135505"}}