{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:51:25Z","timestamp":1792900285631,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.neulet.2020.135604","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T01:56:06Z","timestamp":1609293366000},"page":"135604","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Mini Review: Central Organization of Airway Afferent Nerve Circuits"],"prefix":"10.1016","volume":"744","author":[{"given":"Robert","family":"Behrens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice E.","family":"McGovern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4126-8911","authenticated-orcid":false,"given":"Michael J.","family":"Farrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9629-7923","authenticated-orcid":false,"given":"Aung Aung Kywe","family":"Moe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart B.","family":"Mazzone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2020.135604_bib0005","article-title":"Molecular identity, anatomy, gene expression and function of neural crest vs. placode-derived nociceptors in the lower airways","author":"Taylor-Clark","year":"2020","journal-title":"Neurosci Lett."},{"issue":"3","key":"10.1016\/j.neulet.2020.135604_bib0010","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1152\/physrev.00039.2015","article-title":"Vagal afferent innervation of the airways in health and disease","volume":"96","author":"Mazzone","year":"2016","journal-title":"Physiol Rev."},{"issue":"6","key":"10.1016\/j.neulet.2020.135604_bib0015","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1007\/s00429-014-0883-9","article-title":"Evidence for multiple sensory circuits in the brain arising from the respiratory system: an anterograde viral tract tracing study in rodents","volume":"220","author":"McGovern","year":"2015","journal-title":"Brain Struct Funct."},{"issue":"18","key":"10.1016\/j.neulet.2020.135604_bib0020","doi-asserted-by":"crossref","first-page":"7041","DOI":"10.1523\/JNEUROSCI.5128-14.2015","article-title":"Distinct brainstem and forebrain circuits receiving tracheal sensory neuron inputs revealed using a novel conditional anterograde transsynaptic viral tracing system","volume":"35","author":"McGovern","year":"2015","journal-title":"J Neurosci."},{"issue":"Pt 2","key":"10.1016\/j.neulet.2020.135604_bib0025","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1113\/jphysiol.2005.104661","article-title":"Reflex regulation of airway sympathetic nerves in guinea-pigs","volume":"573","author":"Oh","year":"2006","journal-title":"J Physiol."},{"key":"10.1016\/j.neulet.2020.135604_bib0030","series-title":"Advances in Vagal Afferent Neurobiology","first-page":"3","article-title":"The embryology of vagal sensory neurons","author":"Baker","year":"2005"},{"issue":"31","key":"10.1016\/j.neulet.2020.135604_bib0035","doi-asserted-by":"crossref","first-page":"11515","DOI":"10.1073\/pnas.1411032111","article-title":"Population of sensory neurons essential for asthmatic hyperreactivity of inflamed airways","volume":"111","author":"Tr\u00e4nkner","year":"2014","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"3","key":"10.1016\/j.neulet.2020.135604_bib0040","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.cell.2015.03.022","article-title":"Vagal Sensory Neuron Subtypes that Differentially Control Breathing","volume":"161","author":"Chang","year":"2015","journal-title":"Cell"},{"issue":"7636","key":"10.1016\/j.neulet.2020.135604_bib0045","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nature20793","article-title":"Piezo2 senses airway stretch and mediates lung inflation-induced apnoea","volume":"541","author":"Nonomura","year":"2017","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.neulet.2020.135604_bib0050","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.cell.2020.03.004","article-title":"An Airway Protection Program Revealed by Sweeping Genetic Control of Vagal Afferents","volume":"181","author":"Prescott","year":"2020","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.neulet.2020.135604_bib0055","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/0306-4522(92)90239-X","article-title":"The sensory and sympathetic innervation of guinea-pig lung and trachea as studied by retrograde neuronal tracing and double-labelling immunohistochemistry","volume":"49","author":"Kummer","year":"1992","journal-title":"Neuroscience."},{"issue":"Pt 23","key":"10.1016\/j.neulet.2020.135604_bib0060","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1113\/jphysiol.2010.195339","article-title":"Phenotypic distinctions between neural crest and placodal derived vagal C-fibres in mouse lungs","volume":"588","author":"Nassenstein","year":"2010","journal-title":"J Physiol."},{"issue":"5","key":"10.1016\/j.neulet.2020.135604_bib0065","doi-asserted-by":"crossref","first-page":"L858","DOI":"10.1152\/ajplung.90360.2008","article-title":"P2X2 receptors differentiate placodal vs. neural crest C-fiber phenotypes innervating guinea pig lungs and esophagus","volume":"295","author":"Kwong","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol."},{"issue":"6","key":"10.1016\/j.neulet.2020.135604_bib0070","first-page":"378","article-title":"The Role of the Paratrigeminal Nucleus in Vagal Afferent Evoked Respiratory Reflexes: A Neuroanatomical and Functional Study in Guinea Pigs","volume":"21","author":"Driessen","year":"2015","journal-title":"Front Physiol."},{"issue":"3","key":"10.1016\/j.neulet.2020.135604_bib0075","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.neulet.2005.10.078","article-title":"Structural and neurochemical comparison of vagal and spinal afferent neurons projecting to the rat lung","volume":"395","author":"Plato","year":"2006","journal-title":"Neurosci Lett."},{"issue":"1","key":"10.1016\/j.neulet.2020.135604_bib0080","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1465-9921-7-96","article-title":"Spinal afferent neurons projecting to the rat lung and pleura express acid sensitive channels","volume":"7","author":"Groth","year":"2006","journal-title":"Respir Res."},{"issue":"12","key":"10.1016\/j.neulet.2020.135604_bib0085","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13742","article-title":"Sympatho-excitatory response to pulmonary chemosensitive spinal afferent activation in anesthetized, vagotomized rats","volume":"6","author":"Shanks","year":"2018","journal-title":"Physiol Rep."},{"issue":"50","key":"10.1016\/j.neulet.2020.135604_bib0090","doi-asserted-by":"crossref","first-page":"20018","DOI":"10.1073\/pnas.1110416108","article-title":"Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways","volume":"108","author":"D\u2019Autr\u00e9aux","year":"2011","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"9","key":"10.1016\/j.neulet.2020.135604_bib0095","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1007\/s00429-018-1732-z","article-title":"Reflex regulation of breathing by the paratrigeminal nucleus via multiple bulbar circuits","volume":"223","author":"Driessen","year":"2018","journal-title":"Brain Struct Funct."},{"issue":"11","key":"10.1016\/j.neulet.2020.135604_bib0100","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1113\/JP279644","article-title":"A role for neurokinin 1 receptor expressing neurons in the paratrigeminal nucleus in bradykinin-evoked cough in guinea-pigs","volume":"598","author":"Driessen","year":"2020","journal-title":"J Physiol."},{"issue":"4","key":"10.1016\/j.neulet.2020.135604_bib0105","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1152\/jn.00547.2018","article-title":"Regional brain stem activations during capsaicin inhalation using functional magnetic resonance imaging in humans","volume":"121","author":"Bautista","year":"2019","journal-title":"J Neurophysiol."},{"issue":"24","key":"10.1016\/j.neulet.2020.135604_bib0110","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.1113\/JP280220","article-title":"Evidence for multiple bulbar and higher brain circuits processing sensory inputs from the respiratory system in humans","volume":"598","author":"Farrell","year":"2020","journal-title":"J Physiol."},{"issue":"2","key":"10.1016\/j.neulet.2020.135604_bib0115","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.neuroscience.2004.05.032","article-title":"GABA, in some cases together with glycine, is used as the inhibitory transmitter by pump cells in the Hering-Breuer reflex pathway of the rat","volume":"127","author":"Ezure","year":"2004","journal-title":"Neuroscience."},{"issue":"1","key":"10.1016\/j.neulet.2020.135604_bib0120","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0306-4522(99)00098-6","article-title":"Reflex response and convergence of pharyngoesophageal and peripheral chemoreceptors in the nucleus of the solitary tract","volume":"93","author":"Paton","year":"1999","journal-title":"Neuroscience."},{"issue":"4 Pt 2","key":"10.1016\/j.neulet.2020.135604_bib0125","first-page":"R870","article-title":"Convergent carotid sinus nerve and superior laryngeal nerve afferent inputs to neurons in the NTS","volume":"271","author":"Mifflin","year":"1996","journal-title":"Am J Physiol."},{"issue":"2","key":"10.1016\/j.neulet.2020.135604_bib0130","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1152\/jn.00726.2012","article-title":"Independent transmission of convergent visceral primary afferents in the solitary tract nucleus","volume":"109","author":"McDougall","year":"2013","journal-title":"J Neurophysiol."},{"issue":"8","key":"10.1016\/j.neulet.2020.135604_bib0135","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1038\/sj.npp.1301570","article-title":"Induction of c-Fos and DeltaFosB immunoreactivity in rat brain by Vagal nerve stimulation","volume":"33","author":"Cunningham","year":"2008","journal-title":"Neuropsychopharmacology."},{"key":"10.1016\/j.neulet.2020.135604_bib0140","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.3389\/fphys.2019.01110","article-title":"Vagal Afferent Processing by the Paratrigeminal Nucleus","volume":"10","author":"Driessen","year":"2019","journal-title":"Front Physiol"},{"issue":"1","key":"10.1016\/j.neulet.2020.135604_bib0145","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/cne.902620104","article-title":"Evidence for a viscerotopic sensory representation in the cortex and thalamus in the rat","volume":"262","author":"Cechetto","year":"1987","journal-title":"J Comp Neurol."},{"issue":"1","key":"10.1016\/j.neulet.2020.135604_bib0150","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/cne.10120","article-title":"Visceral region in the rat primary somatosensory cortex identified by vagal evoked potential","volume":"444","author":"Ito","year":"2002","journal-title":"J Comp Neurol."},{"issue":"4","key":"10.1016\/j.neulet.2020.135604_bib0155","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.neuroimage.2012.03.030","article-title":"Neural correlates coding stimulus level and perception of capsaicin-evoked urge-to-cough in humans","volume":"61","author":"Farrell","year":"2012","journal-title":"Neuroimage."},{"issue":"8","key":"10.1016\/j.neulet.2020.135604_bib0160","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1523\/JNEUROSCI.4597-10.2011","article-title":"Investigation of the neural control of cough and cough suppression in humans using functional brain imaging","volume":"31","author":"Mazzone","year":"2011","journal-title":"J Neurosci."},{"issue":"4","key":"10.1016\/j.neulet.2020.135604_bib0165","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1164\/rccm.200612-1856OC","article-title":"Representation of capsaicin-evoked urge-to-cough in the human brain using functional magnetic resonance imaging","volume":"176","author":"Mazzone","year":"2007","journal-title":"Am J Respir Crit Care Med."},{"key":"10.1016\/j.neulet.2020.135604_bib0170","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.pupt.2017.01.010","article-title":"Central mechanisms of airway sensation and cough hypersensitivity","volume":"47","author":"Driessen","year":"2017","journal-title":"Pulm Pharmacol Ther."},{"key":"10.1016\/j.neulet.2020.135604_bib0175","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.resp.2015.09.017","article-title":"Multiple neural circuits mediating airway sensations: Recent advances in the neurobiology of the urge-to-cough","volume":"226","author":"Driessen","year":"2016","journal-title":"Respir Physiol Neurobiol."},{"issue":"2","key":"10.1016\/j.neulet.2020.135604_bib0180","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s12035-019-01782-8","article-title":"Transcriptional Profiling of Individual Airway Projecting Vagal Sensory Neurons","volume":"57","author":"Mazzone","year":"2020","journal-title":"Mol Neurobiol."},{"issue":"8","key":"10.1016\/j.neulet.2020.135604_bib0185","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1016\/j.celrep.2019.04.096","article-title":"An Atlas of Vagal Sensory Neurons and Their Molecular Specialization","volume":"27","author":"Kupari","year":"2019","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.neulet.2020.135604_bib0190","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0494-19.2020","article-title":"Mapping of Sensory Nerve Subsets within the Vagal Ganglia and the Brainstem Using Reporter Mice for Pirt, TRPV1, 5-HT3, and Tac1 Expression","volume":"7","author":"Kim","year":"2020","journal-title":"ENeuro"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394020308740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394020308740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:38:19Z","timestamp":1759610299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394020308740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":38,"alternative-id":["S0304394020308740"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2020.135604","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mini Review: Central Organization of Airway Afferent Nerve Circuits","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2020.135604","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"135604"}}