{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:08:37Z","timestamp":1768313317120,"version":"3.49.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005001","name":"Ahvaz Jundishapur University of Medical Sciences","doi-asserted-by":"publisher","award":["IR.AJUMS.ABHC.REC.1398.023"],"award-info":[{"award-number":["IR.AJUMS.ABHC.REC.1398.023"]}],"id":[{"id":"10.13039\/501100005001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.neulet.2021.135675","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T18:27:09Z","timestamp":1611858429000},"page":"135675","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["FTY720 administration following hypoxia-induced neonatal seizure reverse cognitive impairments and severity of seizures in male and female adult rats: The role of inflammation"],"prefix":"10.1016","volume":"748","author":[{"given":"Seyed Ahmad","family":"Najafian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaghoob","family":"Farbood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Sarkaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samireh","family":"Ghafouri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.neulet.2021.135675_bib0005","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/ana.21167","article-title":"Neonatal seizures","volume":"62","author":"Silverstein","year":"2007","journal-title":"Ann. Neurol."},{"issue":"19","key":"10.1016\/j.neulet.2021.135675_bib0010","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1212\/01.wnl.0000279335.85797.2c","article-title":"Long-term prognosis in children with neonatal seizures: a population-based study","volume":"69","author":"Ronen","year":"2007","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.neulet.2021.135675_bib0015","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/j.1528-1157.1992.tb01746.x","article-title":"Age-dependent changes in long-term seizure susceptibility and behavior after hypoxia in rats","volume":"33","author":"Jensen","year":"1992","journal-title":"Epilepsia"},{"issue":"7","key":"10.1016\/j.neulet.2021.135675_bib0020","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nrneurol.2009.80","article-title":"Epileptogenesis in the immature brain: emerging mechanisms","volume":"5","author":"Rakhade","year":"2009","journal-title":"Nat. Rev. Neurol."},{"issue":"50","key":"10.1016\/j.neulet.2021.135675_bib0025","doi-asserted-by":"crossref","first-page":"18211","DOI":"10.1523\/JNEUROSCI.4838-11.2011","article-title":"Hypoxia-induced neonatal seizures diminish silent synapses and long-term potentiation in hippocampal CA1 neurons","volume":"31","author":"Zhou","year":"2011","journal-title":"J. Neurosci."},{"issue":"7","key":"10.1016\/j.neulet.2021.135675_bib0030","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nrneurol.2009.80","article-title":"Epileptogenesis in the immature brain: emerging mechanisms","volume":"5","author":"Rakhade","year":"2009","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neulet.2021.135675_bib0035","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/neuro.08.014.2009","article-title":"Early-life programming of later-life brain and behavior: a critical role for the immune system","volume":"3","author":"Bilbo","year":"2009","journal-title":"Front. Behav. Neurosci."},{"issue":"5","key":"10.1016\/j.neulet.2021.135675_bib0040","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1093\/brain\/awv066","article-title":"Roles of microglia in brain development, tissue maintenance and repair","volume":"138","author":"Michell-Robinson","year":"2015","journal-title":"Brain."},{"issue":"2","key":"10.1016\/j.neulet.2021.135675_bib0045","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1440-1789.2003.00539.x","article-title":"Expression of glial fibrillary acidic protein in developing rat brain after intrauterine infection","volume":"24","author":"Yu","year":"2004","journal-title":"Neuropathology"},{"key":"10.1016\/j.neulet.2021.135675_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2015.11.003","article-title":"Functional polarization of neuroglia: implications in neuroinflammation and neurological disorders","volume":"103","author":"Jha","year":"2016","journal-title":"Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.neulet.2021.135675_bib0055","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/0167-5699(93)90281-O","article-title":"Interleukin 1 receptors in the brain and endocrine tissues","volume":"14","author":"Cunningham","year":"1993","journal-title":"Immunol. Today"},{"issue":"7","key":"10.1016\/j.neulet.2021.135675_bib0060","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1056\/NEJM199908123410704","article-title":"Phenobarbital compared with phenytoin for the treatment of neonatal seizures","volume":"341","author":"Painter","year":"1999","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.neulet.2021.135675_bib0065","doi-asserted-by":"crossref","first-page":"F165","DOI":"10.1136\/fn.86.3.F165","article-title":"Phenobarbitone, neonatal seizures, and video-EEG","volume":"86","author":"Boylan","year":"2002","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"issue":"2","key":"10.1016\/j.neulet.2021.135675_bib0070","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/apa.12812","article-title":"Systematic review of neonatal seizure management strategies provides guidance on anti-epileptic treatment","volume":"104","author":"Hellstrom-Westas","year":"2015","journal-title":"Acta Paediatr."},{"issue":"7","key":"10.1016\/j.neulet.2021.135675_bib0075","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1016\/j.neuropharm.2012.02.001","article-title":"Neonatal exposure to phenobarbital potentiates schizophrenia-like behavioral outcomes in the rat","volume":"62","author":"Bhardwaj","year":"2012","journal-title":"Neuropharmacology"},{"issue":"8 Suppl 3","key":"10.1016\/j.neulet.2021.135675_bib0080","first-page":"S20","article-title":"Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis","volume":"76","author":"Mehling","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2021.135675_bib0085","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ejps.2016.09.016","article-title":"Fingolimod enhances myelin repair of hippocampus in pentylenetetrazol-induced kindling model","volume":"96","author":"Gol","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"issue":"11","key":"10.1016\/j.neulet.2021.135675_bib0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0188748","article-title":"Fingolimod suppresses neuronal autophagy through the mTOR\/p70S6K pathway and alleviates ischemic brain damage in mice","volume":"12","author":"Li","year":"2017","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.neulet.2021.135675_bib0095","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1161\/STROKEAHA.117.018505","article-title":"Fingolimod protects against ischemic white matter damage by modulating microglia toward M2 polarization via STAT3 pathway","volume":"48","author":"Qin","year":"2017","journal-title":"Stroke"},{"issue":"8","key":"10.1016\/j.neulet.2021.135675_bib0100","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.neuint.2012.10.003","article-title":"Interactions between age, sex, and hormones in experimental ischemic stroke","volume":"61","author":"Liu","year":"2012","journal-title":"Neurochem. Int."},{"issue":"8","key":"10.1016\/j.neulet.2021.135675_bib0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042622","article-title":"Early-life stress is associated with gender-based vulnerability to epileptogenesis in rat pups","volume":"7","author":"Desgent","year":"2012","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.neulet.2021.135675_bib0110","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1212\/WNL.55.10.1479","article-title":"Men may be more vulnerable to seizure-associated brain damage","volume":"55","author":"Briellmann","year":"2000","journal-title":"Neurology."},{"issue":"1\u20132","key":"10.1016\/j.neulet.2021.135675_bib0115","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0006-8993(94)90631-9","article-title":"Sex differences in the anticonvulsant efficacy of phenytoin in amygdala-kindled rats","volume":"638","author":"Ebert","year":"1994","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.neulet.2021.135675_bib0120","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1528-1167.2011.02992.x","article-title":"Development of later life spontaneous seizures in a rodent model of hypoxia-induced neonatal seizures","volume":"52","author":"Rakhade","year":"2011","journal-title":"Epilepsia."},{"key":"10.1016\/j.neulet.2021.135675_bib0125","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.eplepsyres.2016.06.010","article-title":"Effect of low frequency stimulation on impaired spontaneous alternation behavior of kindled rats in Y-maze test","volume":"126","author":"Ghafouri","year":"2016","journal-title":"Epilepsy Res."},{"issue":"2","key":"10.1016\/j.neulet.2021.135675_bib0130","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10339-011-0430-z","article-title":"The novel object recognition memory: neurobiology, test procedure, and its modifications","volume":"13","author":"Antunes","year":"2012","journal-title":"Cogn. Process."},{"issue":"6","key":"10.1016\/j.neulet.2021.135675_bib0135","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s12576-018-0594-8","article-title":"Litter size reduction accentuates maternal care and alters behavioral and physiological phenotypes in rat adult offspring","volume":"68","author":"Enes-Marques","year":"2018","journal-title":"J. Physiol. Sci."},{"issue":"2\u20133","key":"10.1016\/j.neulet.2021.135675_bib0140","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ejphar.2011.11.010","article-title":"Age dependent learning and memory deficit in Pentylenetetrazol kindled mice","volume":"674","author":"Mishra","year":"2012","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.neulet.2021.135675_bib0145","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0028-3908(99)00073-8","article-title":"Cocaine-induced kindling is associated with elevated NMDA receptor binding in discrete mouse brain regions","volume":"39","author":"Itzhak","year":"2000","journal-title":"Neuropharmacology."},{"issue":"1\u20132","key":"10.1016\/j.neulet.2021.135675_bib0150","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11010-016-2678-1","article-title":"Neurochemical modulation involved in the beneficial effect of liraglutide, GLP-1 agonist on PTZ kindling epilepsy-induced comorbidities in mice","volume":"415","author":"Koshal","year":"2016","journal-title":"Mol. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.neulet.2021.135675_bib0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-28044-2","article-title":"Complex spectrum of phenobarbital effects in a mouse model of neonatal hypoxia-induced seizures","volume":"8","author":"Quinlan","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neulet.2021.135675_bib0160","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.3389\/fimmu.2019.01752","article-title":"The anti-inflammatory compound candesartan cilexitil improves neurological outcomes in a mouse model of neonatal hypoxia","volume":"10","author":"Quinlan","year":"2019","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.neulet.2021.135675_bib0165","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.devbrainres.2005.03.007","article-title":"Long-term effects of acute and of chronic hypoxia on behavior and on hippocampal histology in the developing brain","volume":"157","author":"Mikati","year":"2005","journal-title":"Brain Res. Dev. Brain Res."},{"issue":"9","key":"10.1016\/j.neulet.2021.135675_bib0170","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1111\/j.1528-1167.2007.01135.x","article-title":"Glial activation links early\u2010life seizures and long\u2010term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation","volume":"48","author":"Somera\u2010Molina","year":"2007","journal-title":"Epilepsia."},{"issue":"2","key":"10.1016\/j.neulet.2021.135675_bib0175","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.pbb.2012.08.025","article-title":"Fingolimod (FTY720) inhibits neuroinflammation and attenuates spontaneous convulsions in lithium-pilocarpine induced status epilepticus in rat model","volume":"103","author":"Gao","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"4","key":"10.1016\/j.neulet.2021.135675_bib0180","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1007\/s13311-017-0550-y","article-title":"Fingolimod exerts only temporary antiepileptogenic effects but longer-lasting positive effects on behavior in the WAG\/Rij rat absence epilepsy model","volume":"14","author":"Leo","year":"2017","journal-title":"Neurotherapeutics."},{"issue":"3","key":"10.1016\/j.neulet.2021.135675_bib0185","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0966-3274(00)00025-3","article-title":"The novel immunosuppressant FTY720 induces peripheral lymphodepletion of both T- and B-cells in cynomolgus monkeys when given alone, with Cyclosporine Neoral or with RAD","volume":"8","author":"Quesniaux","year":"2000","journal-title":"Transpl. Immunol."},{"issue":"8","key":"10.1016\/j.neulet.2021.135675_bib0190","doi-asserted-by":"crossref","first-page":"5562","DOI":"10.1074\/jbc.M111.305359","article-title":"FTY720 normalizes hyperglycemia by stimulating beta-cell in vivo regeneration in db\/db mice through regulation of cyclin D3 and p57(KIP2)","volume":"287","author":"Zhao","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.neulet.2021.135675_bib0195","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3858\/emm.2012.44.10.069","article-title":"Antiobesity activity of a sphingosine 1-phosphate analogue FTY720 observed in adipocytes and obese mouse model","volume":"44","author":"Moon","year":"2012","journal-title":"Exp. Mol. Med."},{"issue":"6","key":"10.1016\/j.neulet.2021.135675_bib0200","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/17843286.1975.11717044","article-title":"Effects of long-term anticonvulsant therapy on calcium metabolism in adult epileptics: influence of age and sex","volume":"30","author":"Dequeker","year":"1975","journal-title":"Acta Clin. Belg."},{"key":"10.1016\/j.neulet.2021.135675_bib0205","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.nbd.2015.08.023","article-title":"Effects of hypoxia-induced neonatal seizures on acute hippocampal injury and later-life seizure susceptibility and anxiety-related behavior in mice","volume":"83","author":"Rodriguez-Alvarez","year":"2015","journal-title":"Neurobiol. Dis."},{"issue":"5","key":"10.1016\/j.neulet.2021.135675_bib0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1000781","article-title":"Impact of dendritic size and dendritic topology on burst firing in pyramidal cells","volume":"6","author":"van Elburg","year":"2010","journal-title":"PLoS Comput. Biol."},{"issue":"1\u20132","key":"10.1016\/j.neulet.2021.135675_bib0215","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/jnr.23828","article-title":"Sex-dependent consequences of neonatal brain hypoxia-ischemia in the rat","volume":"95","author":"Netto","year":"2017","journal-title":"J. Neurosci. Res."},{"issue":"1","key":"10.1016\/j.neulet.2021.135675_bib0220","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19010061","article-title":"Sexually dimorphic outcomes after neonatal stroke and hypoxia-ischemia","volume":"19","author":"Charriaut-Marlangue","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.neulet.2021.135675_bib0225","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1523\/JNEUROSCI.5180-07.2008","article-title":"Dissociated gender-specific effects of recurrent seizures on GABA signaling in CA1 pyramidal neurons: role of GABA(A) receptors","volume":"28","author":"Galanopoulou","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2021.135675_bib0230","article-title":"Sex differences in mechanisms and outcome of neonatal hypoxia-ischemia in rodent models: implications for sex-specific neuroprotection in clinical neonatal practice","volume":"2012","author":"Hill","year":"2012","journal-title":"Neurol. Res. Int."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394021000537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394021000537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:38:49Z","timestamp":1759610329000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394021000537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":46,"alternative-id":["S0304394021000537"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2021.135675","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FTY720 administration following hypoxia-induced neonatal seizure reverse cognitive impairments and severity of seizures in male and female adult rats: The role of inflammation","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2021.135675","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"135675"}}