{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:54:22Z","timestamp":1792623262869,"version":"4.5.0"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.neulet.2021.135873","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T20:57:37Z","timestamp":1617310657000},"page":"135873","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":160,"special_numbering":"C","title":["Metals associated neurodegeneration in Parkinson\u2019s disease: Insight to physiological, pathological mechanisms and management"],"prefix":"10.1016","volume":"753","author":[{"given":"Khadga","family":"Raj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawandeep","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.D.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamsher","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2021.135873_bib0005","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/jnc.13691","article-title":"The clinical symptoms of Parkinson\u2019s disease","volume":"139","author":"Sveinbjornsdottir","year":"2016","journal-title":"J. Neurochem."},{"issue":"16","key":"10.1016\/j.neulet.2021.135873_bib0010","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1503\/cmaj.151179","article-title":"An update on the diagnosis and treatment of Parkinson disease","volume":"188","author":"Rizek","year":"2016","journal-title":"CMAJ"},{"issue":"3","key":"10.1016\/j.neulet.2021.135873_bib0015","doi-asserted-by":"crossref","first-page":"259","DOI":"10.31887\/DCNS.2004.6.3\/galexander","article-title":"Biology of Parkinson\u2019s disease: pathogenesis and pathophysiology of a multisystem neurodegenerative disorder","volume":"6","author":"Alexander","year":"2004","journal-title":"Dialogues Clin. Neurosci."},{"issue":"3","key":"10.1016\/j.neulet.2021.135873_bib0020","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.neubiorev.2006.11.005","article-title":"From symphony to cacophony: pathophysiology of the human basal ganglia in Parkinson disease","volume":"32","author":"Gale","year":"2008","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"2","key":"10.1016\/j.neulet.2021.135873_bib0025","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0278-5846(03)00019-8","article-title":"Apoptosis and Parkinson\u2019s disease","volume":"27","author":"Lev","year":"2003","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"1\u20132","key":"10.1016\/j.neulet.2021.135873_bib0030","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11010-010-0563-x","article-title":"Metals, oxidative stress and neurodegenerative disorders","volume":"345","author":"Jomova","year":"2010","journal-title":"Mol. Cell. Biochem."},{"issue":"11","key":"10.1016\/j.neulet.2021.135873_bib0035","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.3390\/ijerph13111047","article-title":"Heavy metal pollution from gold mines: environmental effects and bacterial strategies for resistance","volume":"13","author":"Fashola","year":"2016","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.neulet.2021.135873_bib0040","first-page":"1","article-title":"Heavy-metal-induced reactive oxygen species: phytotoxicity and physicochemical changes in plants","volume":"232","author":"Shahid","year":"2014","journal-title":"Rev. Environ. Contam. Toxicol."},{"issue":"4","key":"10.1016\/j.neulet.2021.135873_bib0045","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3233\/JPD-130230","article-title":"The role of oxidative stress in Parkinson\u2019s disease","volume":"3","author":"Dias","year":"2013","journal-title":"J. Parkinson\u2019s Dis."},{"key":"10.1016\/j.neulet.2021.135873_bib0050","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pneurobio.2013.04.004","article-title":"Mitochondrial dysfunction and oxidative stress in Parkinson\u2019s disease","volume":"106","author":"Subramaniam","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neulet.2021.135873_bib0055","series-title":"Molecular, Clinical and Environmental Toxicology","first-page":"133","article-title":"Heavy metal toxicity and the environment","author":"Tchounwou","year":"2012"},{"issue":"2","key":"10.1016\/j.neulet.2021.135873_bib0060","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00244-016-0349-6","article-title":"Heavy metals in liver and brain of waterfowl from the Evros Delta, Greece","volume":"72","author":"Aloupi","year":"2017","journal-title":"Arch. Environ. Contam. Toxicol."},{"issue":"3","key":"10.1016\/j.neulet.2021.135873_bib0065","first-page":"280","article-title":"Neurological and neuropsychological features in Parkinsonian patients exposed to neurotoxic metals","volume":"29","author":"Lucchini","year":"2007","journal-title":"G. Ital. Med. Lav. Ergon."},{"issue":"1","key":"10.1016\/j.neulet.2021.135873_bib0070","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.chemosphere.2011.02.088","article-title":"Probability of intellectual disability is associated with soil concentrations of arsenic and lead","volume":"84","author":"McDermott","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.neulet.2021.135873_bib0075","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3389\/fneur.2019.00218","article-title":"Parkinson\u2019s disease and the environment","volume":"10","author":"Ball","year":"2019","journal-title":"Front. Neurol."},{"issue":"10","key":"10.1016\/j.neulet.2021.135873_bib0080","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S1474-4422(14)70117-6","article-title":"The role of iron in brain ageing and neurodegenerative disorders","volume":"13","author":"Ward","year":"2014","journal-title":"Lancet Neurol."},{"issue":"3","key":"10.1016\/j.neulet.2021.135873_bib0085","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1159\/000314341","article-title":"Gestational and neonatal iron deficiency alters apical dendrite structure of CA1 pyramidal neurons in adult rat hippocampus","volume":"32","author":"Brunette","year":"2010","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.neulet.2021.135873_bib0090","series-title":"Neurocognitive Dysfunctions in Iron Deficiency Patients","first-page":"83","author":"Zhukovskaya","year":"2019"},{"issue":"18","key":"10.1016\/j.neulet.2021.135873_bib0095","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1089\/ars.2017.7272","article-title":"Neurotoxicity linked to dysfunctional metal ion homeostasis and xenobiotic metal exposure: redox signaling and oxidative stress","volume":"28","author":"Garza-Lomb\u00f3","year":"2018","journal-title":"Antioxid. Redox Signal."},{"issue":"1","key":"10.1016\/j.neulet.2021.135873_bib0100","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/17474086.2016.1268047","article-title":"Mitochondria and Iron: current questions","volume":"10","author":"Paul","year":"2017","journal-title":"Expert Rev. Hematol."},{"issue":"7","key":"10.1016\/j.neulet.2021.135873_bib0105","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.freeradbiomed.2004.06.005","article-title":"Progressive iron accumulation induces a biphasic change in the glutathione content of neuroblastoma cells","volume":"37","author":"N\u00fa\u00f1ez","year":"2004","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.neulet.2021.135873_bib0110","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1089\/ars.2007.1893","article-title":"Intracellular iron transport and storage: from molecular mechanisms to health implications","volume":"10","author":"Mackenzie","year":"2008","journal-title":"Antioxid. Redox Signal."},{"issue":"1","key":"10.1016\/j.neulet.2021.135873_bib0115","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2174\/157015909787602814","article-title":"Targeting the progression of Parkinson\u2019s disease","volume":"7","author":"George","year":"2009","journal-title":"Curr. Neuropharmacol."},{"issue":"51","key":"10.1016\/j.neulet.2021.135873_bib0120","doi-asserted-by":"crossref","first-page":"16233","DOI":"10.1021\/bi048453u","article-title":"Impact of the acidic C-terminal region comprising amino acids 109\u2212 140 on \u03b1-synuclein aggregation in vitro","volume":"43","author":"Hoyer","year":"2004","journal-title":"Biochemistry"},{"issue":"3","key":"10.1016\/j.neulet.2021.135873_bib0125","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1089\/ars.2008.2228","article-title":"Parkinson-linked genes and toxins that affect neuronal cell death through the Bcl-2 family","volume":"11","author":"Ethell","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.neulet.2021.135873_bib0130","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3389\/fnagi.2017.00300","article-title":"Serum copper, zinc, and iron levels in patients with Alzheimer\u2019s disease: a meta-analysis of case-control studies","volume":"9","author":"Li","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neulet.2021.135873_bib0135","article-title":"Is aluminum exposure a risk factor for neurological disorders?","volume":"23","author":"Inan-Eroglu","year":"2018","journal-title":"J. Res. Med. Sci."},{"issue":"9","key":"10.1016\/j.neulet.2021.135873_bib0140","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/j.jinorgbio.2005.04.021","article-title":"Nanomolar aluminum induces pro-inflammatory and pro-apoptotic gene expression in human brain cells in primary culture","volume":"99","author":"Lukiw","year":"2005","journal-title":"J. Inorg. Biochem."},{"issue":"3","key":"10.1016\/j.neulet.2021.135873_bib0145","first-page":"593","article-title":"Calcium, magnesium and aluminum concentrations in Parkinson\u2019s disease","volume":"13","author":"Yasui","year":"1992","journal-title":"Neurotoxicology"},{"issue":"1","key":"10.1016\/j.neulet.2021.135873_bib0150","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1054\/mehy.1997.0701","article-title":"Aluminum-containing antacids as a cause of idiopathic Parkinson\u2019s disease","volume":"53","author":"Altschuler","year":"1999","journal-title":"Med. Hypotheses"},{"issue":"2","key":"10.1016\/j.neulet.2021.135873_bib0155","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3961\/jpmph.2014.47.2.74","article-title":"Environmental mercury and its toxic effects","volume":"47","author":"Rice","year":"2014","journal-title":"J. Prev. Med. Public Health"},{"issue":"12","key":"10.1016\/j.neulet.2021.135873_bib0160","doi-asserted-by":"crossref","first-page":"29592","DOI":"10.3390\/ijms161226183","article-title":"Heavy metals and human health: mechanistic insight into toxicity and counter defense system of anti-oxidants","volume":"16","author":"Jan","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neulet.2021.135873_bib0165","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/640754","article-title":"Biomedical implications of heavy metals induced imbalances in redox systems","volume":"2014","author":"Sharma","year":"2014","journal-title":"Biomed Res. Int."},{"issue":"8","key":"10.1016\/j.neulet.2021.135873_bib0170","doi-asserted-by":"crossref","first-page":"5752","DOI":"10.1007\/s12035-016-0101-2","article-title":"Neurotoxicity of methylmercury in isolated astrocytes and neurons: the cytoskeleton as a main target","volume":"54","author":"Pierozan","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"8","key":"10.1016\/j.neulet.2021.135873_bib0175","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1042\/CS20150153","article-title":"Copper dyshomoeostasis in Parkinson\u2019s disease: implications for pathogenesis and indications for novel therapeutics","volume":"130","author":"Davies","year":"2016","journal-title":"Clin. Sci."},{"issue":"12","key":"10.1016\/j.neulet.2021.135873_bib0180","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1111\/febs.12817","article-title":"Cu (II) and dopamine bind to \u03b1-synuclein and cause large conformational changes","volume":"281","author":"Tavassoly","year":"2014","journal-title":"FEBS J."},{"issue":"21\u201322","key":"10.1016\/j.neulet.2021.135873_bib0185","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1016\/j.ccr.2009.05.011","article-title":"Copper, iron, and zinc ions homeostasis and their role in neurodegenerative disorders (metal uptake, transport, distribution and regulation)","volume":"253","author":"Kozlowski","year":"2009","journal-title":"Coord. Chem. Rev."},{"issue":"3","key":"10.1016\/j.neulet.2021.135873_bib0190","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0304-3940(99)00221-9","article-title":"Reduced ferroxidase activity in the cerebrospinal fluid from patients with Parkinson\u2019s disease","volume":"265","author":"Boll","year":"1999","journal-title":"Neurosci. Lett."},{"issue":"11","key":"10.1016\/j.neulet.2021.135873_bib0195","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1289\/ehp.1002339","article-title":"Association of cumulative lead exposure with Parkinson\u2019s disease","volume":"118","author":"Weisskopf","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.neulet.2021.135873_bib0200","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/457327","article-title":"Oxidative stress in lead and cadmium toxicity and its amelioration","volume":"2011","author":"Patra","year":"2011","journal-title":"Vet. Med. Int."},{"key":"10.1016\/j.neulet.2021.135873_bib0205","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.chemosphere.2015.10.078","article-title":"Children with health impairments by heavy metals in an e-waste recycling area","volume":"148","author":"Zeng","year":"2016","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.neulet.2021.135873_bib0210","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0891-5849(97)00219-0","article-title":"Modification of glutamate-induced oxidative stress by lead: the role of extracellular calcium","volume":"24","author":"Loikkanen","year":"1998","journal-title":"Free Radic. Biol. Med."},{"issue":"7","key":"10.1016\/j.neulet.2021.135873_bib0215","doi-asserted-by":"crossref","first-page":"935","DOI":"10.7150\/ijbs.4499","article-title":"The role of \u03b1-synuclein and tau hyperphosphorylation-mediated autophagy and apoptosis in lead-induced learning and memory injury","volume":"8","author":"Zhang","year":"2012","journal-title":"Int. J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.neulet.2021.135873_bib0220","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/jnc.13671","article-title":"A role for amyloid precursor protein translation to restore iron homeostasis and ameliorate lead (Pb) neurotoxicity","volume":"138","author":"Rogers","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2021.135873_bib0225","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.neulet.2016.02.001","article-title":"Tannic acid alleviates lead acetate-induced neurochemical perturbations in rat brain","volume":"617","author":"Ashafaq","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2021.135873_bib0230","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.neuroscience.2018.10.006","article-title":"Regulated necrosis orchestrates microglial cell death in manganese-induced toxicity","volume":"393","author":"Alcon","year":"2018","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.neulet.2021.135873_bib0235","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/jnc.13442","article-title":"Manganese neurotoxicity: behavioral disorders associated with dysfunctions in the basal ganglia and neurochemical transmission","volume":"136","author":"Bouabid","year":"2016","journal-title":"J. Neurochem."},{"issue":"8","key":"10.1016\/j.neulet.2021.135873_bib0240","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1289\/ehp.0901748","article-title":"Manganese and Parkinson\u2019s disease: a critical review and new findings","volume":"118","author":"Guilarte","year":"2010","journal-title":"Environ. Health Perspect."},{"issue":"4","key":"10.1016\/j.neulet.2021.135873_bib0245","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s12017-009-8088-8","article-title":"Are there common biochemical and molecular mechanisms controlling manganism and parkisonism","volume":"11","author":"Roth","year":"2009","journal-title":"Neuromolecular Med."},{"key":"10.1016\/j.neulet.2021.135873_bib0250","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.freeradbiomed.2013.01.032","article-title":"Manganese neurotoxicity and the role of reactive oxygen species","volume":"62","author":"Martinez-Finley","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neulet.2021.135873_bib0255","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.neuro.2017.05.009","article-title":"Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes","volume":"64","author":"Sarkar","year":"2018","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neulet.2021.135873_bib0260","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2020.00381","article-title":"Associations among monoamine neurotransmitter pathways, personality traits, and major depressive disorder","volume":"11","author":"Shao","year":"2020","journal-title":"Front. Psychiatry"},{"issue":"5","key":"10.1016\/j.neulet.2021.135873_bib0265","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3961\/jpmph.14.036","article-title":"Environmental source of arsenic exposure","volume":"47","author":"Chung","year":"2014","journal-title":"J. Prev. Med. Public Health"},{"issue":"2","key":"10.1016\/j.neulet.2021.135873_bib0270","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4103\/0971-6580.84258","article-title":"Mechanisms pertaining to arsenic toxicity","volume":"18","author":"Singh","year":"2011","journal-title":"Toxicol. Int."},{"issue":"14","key":"10.1016\/j.neulet.2021.135873_bib0275","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.3390\/ijms20143418","article-title":"Arsenic neurotoxicity in humans","volume":"20","author":"Mochizuki","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.neulet.2021.135873_bib0280","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s40572-014-0012-1","article-title":"The effects of arsenic exposure on neurological and cognitive dysfunction in human and rodent studies: a review","volume":"1","author":"Tyler","year":"2014","journal-title":"Curr. Environ. Health Rep."},{"issue":"2","key":"10.1016\/j.neulet.2021.135873_bib0285","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/jat.3256","article-title":"Mitochondrial oxidative stress and dysfunction in arsenic neurotoxicity: a review","volume":"36","author":"Prakash","year":"2016","journal-title":"J. Appl. Toxicol."},{"issue":"2","key":"10.1016\/j.neulet.2021.135873_bib0290","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2478\/intox-2014-0009","article-title":"Toxicity, mechanism and health effects of some heavy metals","volume":"7","author":"Jaishankar","year":"2014","journal-title":"Interdiscip. Toxicol."},{"issue":"4","key":"10.1016\/j.neulet.2021.135873_bib0295","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.3892\/ijo.2014.2558","article-title":"Cadmium induces urokinase-type plasminogen activator receptor expression and the cell invasiveness of human gastric cancer cells via the ERK-1\/2, NF-\u03baB, and AP-1 signaling pathways","volume":"45","author":"Khoi","year":"2014","journal-title":"Int. J. Oncol."},{"issue":"2","key":"10.1016\/j.neulet.2021.135873_bib0300","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3390\/toxics2020258","article-title":"Effects of lead and cadmium on brain endothelial cell survival, monolayer permeability, and crucial oxidative stress markers in an in vitro model of the blood-brain barrier","volume":"2","author":"Tobwala","year":"2014","journal-title":"Toxics"},{"issue":"23","key":"10.1016\/j.neulet.2021.135873_bib0305","doi-asserted-by":"crossref","first-page":"6010","DOI":"10.3390\/ijms20236010","article-title":"Effects of cadmium on ZO-1 tight junction integrity of the blood brain barrier","volume":"20","author":"Branca","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.neulet.2021.135873_bib0310","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s12199-007-0019-4","article-title":"Selenium: its role as anti-oxidant in human health","volume":"13","author":"Tinggi","year":"2008","journal-title":"Environ. Health Prev. Med."},{"issue":"3\u20134","key":"10.1016\/j.neulet.2021.135873_bib0315","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0753-3322(03)00035-0","article-title":"The anti-oxidant role of selenium and seleno-compounds","volume":"57","author":"Tapiero","year":"2003","journal-title":"Biomed. Pharmacother."},{"issue":"5","key":"10.1016\/j.neulet.2021.135873_bib0320","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.neuro.2012.04.019","article-title":"Selenium induces cholinergic motor neuron degeneration in Caenorhabditis elegans","volume":"33","author":"Estevez","year":"2012","journal-title":"Neurotoxicology"},{"issue":"8","key":"10.1016\/j.neulet.2021.135873_bib0325","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1096\/fj.14-252874","article-title":"Selenoprotein P and apolipoprotein E receptor-2 interact at the blood-brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration","volume":"28","author":"Burk","year":"2014","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.neulet.2021.135873_bib0330","doi-asserted-by":"crossref","first-page":"e1005383","DOI":"10.1371\/journal.pcbi.1005383","article-title":"Computational identification of the selenocysteine tRNA (tRNASec) in genomes","volume":"13","author":"Santesmasses","year":"2017","journal-title":"PLoS Comput. Biol."},{"issue":"4","key":"10.1016\/j.neulet.2021.135873_bib0335","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1515\/bmc-2013-0007","article-title":"The molecular biology of selenocysteine","volume":"4","author":"Gonzalez-Flores","year":"2013","journal-title":"Biomol. Concepts"},{"issue":"5","key":"10.1016\/j.neulet.2021.135873_bib0340","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3390\/antiox7050066","article-title":"Selenium-dependent anti-oxidant enzymes: actions and properties of selenoproteins","volume":"7","author":"Zoidis","year":"2018","journal-title":"Antioxidants"},{"issue":"8","key":"10.1016\/j.neulet.2021.135873_bib0345","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1136\/jnnp-2019-322338","article-title":"Parkinson\u2019s disease: etiopathogenesis and treatment","volume":"91","author":"Jankovic","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatr."},{"issue":"23","key":"10.1016\/j.neulet.2021.135873_bib0350","doi-asserted-by":"crossref","first-page":"5981","DOI":"10.1111\/febs.12335","article-title":"The hallmarks of Parkinson\u2019s disease","volume":"280","author":"Antony","year":"2013","journal-title":"FEBS J."},{"issue":"1","key":"10.1016\/j.neulet.2021.135873_bib0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00204-015-1579-5","article-title":"Redox-and non-redox-metal-induced formation of free radicals and their role in human disease","volume":"90","author":"Valko","year":"2016","journal-title":"Arch. Toxicol."},{"issue":"10","key":"10.1016\/j.neulet.2021.135873_bib0360","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1002\/chem.201803176","article-title":"Beyond biological chelation: coordination of f-block elements by polyhydroxamate ligands","volume":"25","author":"Sockwell","year":"2019","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.neulet.2021.135873_bib0365","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.expneurol.2016.03.016","article-title":"Deferoxamine-mediated up-regulation of HIF-1\u03b1 prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice","volume":"280","author":"Guo","year":"2016","journal-title":"Exp. Neurol."},{"issue":"7","key":"10.1016\/j.neulet.2021.135873_bib0370","doi-asserted-by":"crossref","first-page":"7519","DOI":"10.3390\/ijerph120707519","article-title":"Manganese-induced parkinsonism and Parkinson\u2019s disease: shared and distinguishable features","volume":"12","author":"Kwakye","year":"2015","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"7","key":"10.1016\/j.neulet.2021.135873_bib0375","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.3390\/ijerph7072745","article-title":"Chelation in metal intoxication","volume":"7","author":"Flora","year":"2010","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.neulet.2021.135873_bib0380","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/983245","article-title":"Chelators in the treatment of iron accumulation in Parkinson\u2019s disease","volume":"2012","author":"Mounsey","year":"2012","journal-title":"Int. J. Cell Biol."},{"issue":"2","key":"10.1016\/j.neulet.2021.135873_bib0385","first-page":"164","article-title":"Review on iron and its importance for human health","volume":"19","author":"Abbaspour","year":"2014","journal-title":"J. Res. Med. Sci."},{"issue":"6","key":"10.1016\/j.neulet.2021.135873_bib0390","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s40495-016-0068-8","article-title":"Chelators in iron and copper toxicity","volume":"2","author":"Lawson","year":"2016","journal-title":"Curr. Pharmacol. Rep."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394021002512?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394021002512?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:39:37Z","timestamp":1759610377000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394021002512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":78,"alternative-id":["S0304394021002512"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2021.135873","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metals associated neurodegeneration in Parkinson\u2019s disease: Insight to physiological, pathological mechanisms and management","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2021.135873","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"135873"}}