{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T15:52:31Z","timestamp":1776268351268,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010815","name":"Stiftelsen For Gamla Tjanarinnor","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010815","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut Och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007464","name":"Torsten Soderbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007464","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.neulet.2021.135894","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T11:27:57Z","timestamp":1618313277000},"page":"135894","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Characterization of monomeric and soluble aggregated A\u03b2 in Down\u2019s syndrome and Alzheimer\u2019s disease brains"],"prefix":"10.1016","volume":"754","author":[{"given":"Eleni","family":"Gkanatsiou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Sahlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Portelius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malin","family":"Johannesson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"S\u00f6derberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"F\u00e4lting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Basun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christer","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Odergren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Lannfelt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6958-2393","authenticated-orcid":false,"given":"Gunnar","family":"Brinkmalm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.neulet.2021.135894_bib0005","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1073\/pnas.82.12.4245","article-title":"Amyloid plaque core protein in Alzheimer disease and Down syndrome","volume":"82","author":"Masters","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.neulet.2021.135894_bib0010","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nrn3983","article-title":"A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome","volume":"16","author":"Wiseman","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"issue":"2","key":"10.1016\/j.neulet.2021.135894_bib0015","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1365-2559.1988.tb02018.x","article-title":"Alzheimer\u2019s disease and Down\u2019s syndrome","volume":"13","author":"Mann","year":"1988","journal-title":"Histopathology"},{"issue":"1","key":"10.1016\/j.neulet.2021.135894_bib0020","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/jir.12074","article-title":"A prospective 14-year longitudinal follow-up of dementia in persons with Down syndrome","volume":"58","author":"McCarron","year":"2014","journal-title":"J. Intellect. Disabil. Res."},{"issue":"4959","key":"10.1016\/j.neulet.2021.135894_bib0025","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1126\/science.2111583","article-title":"Cleavage of amyloid beta peptide during constitutive processing of its precursor","volume":"248","author":"Esch","year":"1990","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.neulet.2021.135894_bib0030","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","article-title":"Alzheimer\u2019s disease: genes, proteins, and therapy","volume":"81","author":"Selkoe","year":"2001","journal-title":"Physiol. Rev."},{"issue":"6","key":"10.1016\/j.neulet.2021.135894_bib0035","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.neurobiolaging.2009.06.002","article-title":"A novel pathway for amyloid precursor protein processing","volume":"32","author":"Portelius","year":"2011","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.neulet.2021.135894_bib0040","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0896-6273(03)00205-8","article-title":"Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex","volume":"38","author":"De Strooper","year":"2003","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.neulet.2021.135894_bib0045","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006270","article-title":"Trafficking and proteolytic processing of APP","volume":"2","author":"Haass","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"5","key":"10.1016\/j.neulet.2021.135894_bib0050","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1046\/j.1471-4159.2002.00908.x","article-title":"A non-amyloidogenic function of BACE-2 in the secretory pathway","volume":"81","author":"Fluhrer","year":"2002","journal-title":"J. Neurochem."},{"issue":"23","key":"10.1016\/j.neulet.2021.135894_bib0055","doi-asserted-by":"crossref","first-page":"21286","DOI":"10.1074\/jbc.M209859200","article-title":"Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity","volume":"278","author":"Shi","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.neulet.2021.135894_bib0060","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1096\/fj.05-5632com","article-title":"BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer\u2019s disease in Down syndrome","volume":"20","author":"Sun","year":"2006","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.neulet.2021.135894_bib0065","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/0006-291X(84)91209-9","article-title":"Alzheimer\u2019s disease and Down\u2019s syndrome: sharing of a unique cerebrovascular amyloid fibril protein","volume":"122","author":"Glenner","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"Suppl. 3","key":"10.1016\/j.neulet.2021.135894_bib0070","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3233\/JAD-2006-9S317","article-title":"Alzheimer\u2019s disease: the amyloid cascade hypothesis: an update and reappraisal","volume":"9","author":"Hardy","year":"2006","journal-title":"J. Alzheimers Dis."},{"issue":"43","key":"10.1016\/j.neulet.2021.135894_bib0075","doi-asserted-by":"crossref","first-page":"14411","DOI":"10.1523\/JNEUROSCI.3537-10.2010","article-title":"Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils","volume":"30","author":"O\u2019Nuallain","year":"2010","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.neulet.2021.135894_bib0080","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1515\/revneuro-2017-0063","article-title":"Amyloid toxicity in Alzheimer\u2019s disease","volume":"29","author":"Reiss","year":"2018","journal-title":"Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.neulet.2021.135894_bib0085","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s40478-016-0380-x","article-title":"pGluAbeta increases accumulation of Abeta in vivo and exacerbates its toxicity","volume":"4","author":"Sofola-Adesakin","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"issue":"3","key":"10.1016\/j.neulet.2021.135894_bib0090","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41582-018-0132-6","article-title":"Dementia in Down syndrome: unique insights for Alzheimer disease research","volume":"15","author":"Lott","year":"2019","journal-title":"Nat. Rev. Neurol."},{"issue":"5","key":"10.1016\/j.neulet.2021.135894_bib0095","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jalz.2015.07.490","article-title":"The pattern of amyloid accumulation in the brains of adults with Down syndrome","volume":"12","author":"Annus","year":"2016","journal-title":"Alzheimers Dement."},{"issue":"6","key":"10.1016\/j.neulet.2021.135894_bib0100","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jalz.2011.09.229","article-title":"Imaging brain amyloid in nondemented young adults with Down syndrome using Pittsburgh compound B","volume":"8","author":"Handen","year":"2012","journal-title":"Alzheimers Dement."},{"issue":"4","key":"10.1016\/j.neulet.2021.135894_bib0105","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jalz.2015.05.013","article-title":"The effects of normal aging on amyloid-beta deposition in nondemented adults with Down syndrome as imaged by carbon 11-labeled Pittsburgh compound B","volume":"12","author":"Lao","year":"2016","journal-title":"Alzheimers Dement."},{"issue":"4","key":"10.1016\/j.neulet.2021.135894_bib0110","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1001\/archneur.1995.00540280065020","article-title":"Age-related distribution of neuropathologic changes in the cerebral cortex of patients with Down\u2019s syndrome. Quantitative regional analysis and comparison with Alzheimer\u2019s disease","volume":"52","author":"Hof","year":"1995","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neulet.2021.135894_bib0115","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neulet.2019.02.033","article-title":"A distinct brain beta amyloid signature in cerebral amyloid angiopathy compared to Alzheimer\u2019s disease","volume":"701","author":"Gkanatsiou","year":"2019","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.neulet.2021.135894_bib0120","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1471-4159.2007.04759.x","article-title":"Sensitive ELISA detection of amyloid-beta protofibrils in biological samples","volume":"103","author":"Englund","year":"2007","journal-title":"J. Neurochem."},{"issue":"11","key":"10.1016\/j.neulet.2021.135894_bib0125","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1021\/pr0703627","article-title":"Characterization of amyloid beta peptides in cerebrospinal fluid by an automated immunoprecipitation procedure followed by mass spectrometry","volume":"6","author":"Portelius","year":"2007","journal-title":"J. Proteome Res."},{"issue":"5","key":"10.1016\/j.neulet.2021.135894_bib0130","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/jms.2987","article-title":"An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid beta and amyloid precursor protein in human and cat cerebrospinal fluid","volume":"47","author":"Brinkmalm","year":"2012","journal-title":"J. Mass Spectrom."},{"issue":"5","key":"10.1016\/j.neulet.2021.135894_bib0135","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1093\/brain\/awz066","article-title":"Identification of neurotoxic cross-linked amyloid-beta dimers in the Alzheimer\u2019s brain","volume":"142","author":"Brinkmalm","year":"2019","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.neulet.2021.135894_bib0140","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jneumeth.2010.12.001","article-title":"Specificity and sensitivity of the Abeta oligomer ELISA","volume":"195","author":"Klaver","year":"2011","journal-title":"J. Neurosci. Methods"},{"issue":"3","key":"10.1016\/j.neulet.2021.135894_bib0145","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/ajmg.c.30098","article-title":"The proteins of human chromosome 21","volume":"142C","author":"Gardiner","year":"2006","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"issue":"2","key":"10.1016\/j.neulet.2021.135894_bib0150","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1586\/14789450.5.2.225","article-title":"Targeted proteomics in Alzheimer\u2019s disease: focus on amyloid-beta","volume":"5","author":"Portelius","year":"2008","journal-title":"Expert Rev. Proteomics"},{"key":"10.1016\/j.neulet.2021.135894_bib0155","article-title":"Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain","author":"Alic","year":"2020","journal-title":"Mol. Psychiatry"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030439402100272X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030439402100272X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:39:21Z","timestamp":1759610361000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030439402100272X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":31,"alternative-id":["S030439402100272X"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2021.135894","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of monomeric and soluble aggregated A\u03b2 in Down\u2019s syndrome and Alzheimer\u2019s disease brains","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2021.135894","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"135894"}}