{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:20:00Z","timestamp":1793751600209,"version":"4.6.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.neulet.2021.135918","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T11:58:32Z","timestamp":1619783912000},"page":"135918","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Association of 5-HTR2A -1438A\/G polymorphism with anorexia nervosa and bulimia nervosa: A meta-analysis"],"prefix":"10.1016","volume":"755","author":[{"given":"Pan","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengdong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2655-4899","authenticated-orcid":false,"given":"Mingfen","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2021.135918_bib0005","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/00041444-200109000-00008","article-title":"5-HT2A promoter polymorphism is not associated with anorexia nervosa in Japanese patients","volume":"11","author":"Ando","year":"2001","journal-title":"Psychiatr. Genet."},{"key":"10.1016\/j.neulet.2021.135918_bib0010","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neubiorev.2016.02.008","article-title":"The 5-HT2A serotonin receptor in executive function: implications for neuropsychiatric and neurodegenerative diseases","volume":"64","author":"Aznar","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neulet.2021.135918_bib0015","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s11920-017-0842-2","article-title":"Genetics of anorexia nervosa","volume":"19","author":"Baker","year":"2017","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.neulet.2021.135918_bib0020","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"Begg","year":"1994","journal-title":"Biometrics"},{"key":"10.1016\/j.neulet.2021.135918_bib0025","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/ajmg.b.30205","article-title":"Young, Association of the promoter polymorphism -1438G\/A of the 5-HT2A receptor gene with behavioral impulsiveness and serotonin function in women with bulimia nervosa","volume":"137B","author":"Bruce","year":"2005","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.neulet.2021.135918_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1098-108X(200001)27:1<1::AID-EAT1>3.0.CO;2-Q","article-title":"Twin studies of eating disorders: a review","volume":"27","author":"Bulik","year":"2000","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.neulet.2021.135918_bib0035","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.biopsych.2009.08.010","article-title":"Understanding the relation between anorexia nervosa and bulimia nervosa in a Swedish national twin sample","volume":"67","author":"Bulik","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2021.135918_bib0040","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0140-6736(05)78688-8","article-title":"Lack of association between 5-HT2A gene promoter polymorphism and susceptibility to anorexia nervosa","volume":"351","author":"Campbell","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.neulet.2021.135918_bib0045","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/ajmg.b.32771","article-title":"5-HT2AR and BDNF gene variants in eating disorders susceptibility","volume":"183","author":"Ceccarini","year":"2019","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.neulet.2021.135918_bib0050","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/S0140-6736(05)64135-9","article-title":"Association between 5-HT2A gene promoter polymorphism and anorexia nervosa","volume":"350","author":"Collier","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.neulet.2021.135918_bib0055","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/S0140-6736(05)78746-8","article-title":"5-HT2A promoter polymorphism -1438G\/A, anorexia nervosa, and obsessive-compulsive disorder","volume":"351","author":"Enoch","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.neulet.2021.135918_bib0060","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/01.ypg.0000107933.32051.55","article-title":"Analysis of the -1438 G\/A polymorphism of the 5-HT2A serotonin receptor gene in bulimia nervosa patients with or without a history of anorexia nervosa","volume":"14","author":"Fuentes","year":"2004","journal-title":"Psychiatr. Genet."},{"key":"10.1016\/j.neulet.2021.135918_bib0065","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/WNN.0000000000000028","article-title":"Serotonin 2A receptor gene (HTR2A) regulatory variants: possible association with severity of depression symptoms in children with autism spectrum disorder","volume":"27","author":"Gadow","year":"2014","journal-title":"Cogn. Behav. Neurol."},{"key":"10.1016\/j.neulet.2021.135918_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpsychires.2014.09.014","article-title":"Specific and common genes implicated across major mental disorders: a review of meta-analysis studies","volume":"60","author":"Gatt","year":"2015","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neulet.2021.135918_bib0075","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-244X-13-25","article-title":"Association of the 5HTR2A gene with suicidal behavior: case-control study and updated meta-analysis","volume":"13","author":"Gonzalez-Castro","year":"2013","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.neulet.2021.135918_bib0080","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/sj.mp.4000938","article-title":"The 5-HT(2A) -1438G\/A polymorphism in anorexia nervosa: a combined analysis of 316 trios from six European centres","volume":"7","author":"Gorwood","year":"2002","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neulet.2021.135918_bib0085","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ejphar.2003.08.103","article-title":"The human genetics of anorexia nervosa","volume":"480","author":"Gorwood","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neulet.2021.135918_bib0090","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/S0140-6736(05)62485-3","article-title":"5-HT2A receptor gene polymorphisms, anorexia nervosa, and obesity","volume":"350","author":"Hinney","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.neulet.2021.135918_bib0095","article-title":"Association of the 5-HT2A receptor gene promoter polymorphism-1438G\/A with anorexia nervosa and psychopathological traits in the Chinese Han population: a preliminary study","volume":"9","author":"Kang","year":"2017","journal-title":"Asia. Pac."},{"key":"10.1016\/j.neulet.2021.135918_bib0100","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1002\/eat.20109","article-title":"Neurobiology of anorexia nervosa: clinical implications of alterations of the function of serotonin and other neuronal systems","volume":"37","author":"Kaye","year":"2005","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.neulet.2021.135918_bib0105","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0924-9338(02)00657-0","article-title":"5-HT(2A) gene promoter polymorphism as a modifying rather than a vulnerability factor in anorexia nervosa","volume":"17","author":"Kipman","year":"2002","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.neulet.2021.135918_bib0110","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel","year":"1959","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.neulet.2021.135918_bib0115","doi-asserted-by":"crossref","first-page":"192","DOI":"10.14712\/fb2009055050192","article-title":"Polymorphisms in serotonin-related genes in anorexia nervosa. The first study in Czech population and metaanalyses with previously performed studies","volume":"55","author":"Martaskova","year":"2009","journal-title":"Folia Biol (Praha)"},{"key":"10.1016\/j.neulet.2021.135918_bib0120","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1159\/000484525","article-title":"An evolutionary genetic perspective of eating disorders","volume":"106","author":"Mayhew","year":"2018","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.neulet.2021.135918_bib0125","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0304-3940(99)00859-9","article-title":"5-HT2A receptor gene polymorphisms in anorexia nervosa and bulimia nervosa","volume":"277","author":"Nacmias","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2021.135918_bib0130","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0006-3223(00)01107-0","article-title":"Association between 5HT2A receptor gene promoter region polymorphism and eating disorders in Japanese patients","volume":"50","author":"Nishiguchi","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2021.135918_bib0135","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.biopsych.2004.06.020","article-title":"The -1438A\/G polymorphism in the 5-hydroxytryptamine type 2A receptor gene affects promoter activity","volume":"56","author":"Parsons","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2021.135918_bib0140","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.psychres.2018.12.019","article-title":"Genetic variability in the serotoninergic system and age of onset in anorexia nervosa and obsessive-compulsive disorder","volume":"271","author":"Plana","year":"2019","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.neulet.2021.135918_bib0145","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.brainresrev.2009.10.007","article-title":"Molecular mechanisms underlying anorexia nervosa: focus on human gene association studies and systems controlling food intake","volume":"62","author":"Rask-Andersen","year":"2010","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.neulet.2021.135918_bib0150","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neulet.2004.04.057","article-title":"Psychopathological traits and 5-HT2A receptor promoter polymorphism (-1438 G\/A) in patients suffering from Anorexia Nervosa and Bulimia Nervosa","volume":"365","author":"Ricca","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2021.135918_bib0155","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0304-3940(02)00088-5","article-title":"5-HT2A receptor gene polymorphism and eating disorders","volume":"323","author":"Ricca","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2021.135918_bib0160","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000090701","article-title":"The 5-HT2A -1438 A\/G and 5-HTTLPR polymorphisms and personality dimensions in adolescent anorexia nervosa: association study","volume":"53","author":"Rybakowski","year":"2006","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.neulet.2021.135918_bib0165","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/YPG.0b013e3283050ada","article-title":"Association between the A-1438G polymorphism of the serotonin 2A receptor gene and nonimpulsive suicide attempts","volume":"18","author":"Saiz","year":"2008","journal-title":"Psychiatr. Genet."},{"key":"10.1016\/j.neulet.2021.135918_bib0170","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00787-009-0085-9","article-title":"Eating disorders: the current status of molecular genetic research","volume":"19","author":"Scherag","year":"2010","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.neulet.2021.135918_bib0175","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0166-4328(96)00066-6","article-title":"Serotonergic control of the organization of feeding and satiety","volume":"73","author":"Simansky","year":"1996","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neulet.2021.135918_bib0180","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/S0140-6736(05)78745-6","article-title":"5-HT2A promoter polymorphism in anorexia nervosa","volume":"351","author":"Sorbi","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.neulet.2021.135918_bib0185","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.neulet.2021.135918_bib0190","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/7854_2010_88","article-title":"Neural circuits, neurotransmitters, and behavior: serotonin and temperament in bulimic syndromes","volume":"6","author":"Steiger","year":"2011","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"10.1016\/j.neulet.2021.135918_bib0195","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/7854_2010_91","article-title":"The heritability of eating disorders: methods and current findings","volume":"6","author":"Thornton","year":"2011","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"10.1016\/j.neulet.2021.135918_bib0200","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1146\/annurev-clinpsy-050212-185546","article-title":"The genetics of eating disorders","volume":"9","author":"Trace","year":"2013","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"10.1016\/j.neulet.2021.135918_bib0205","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0140-6736(20)30059-3","article-title":"Eating disorders","volume":"395","author":"Treasure","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.neulet.2021.135918_bib0210","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1176\/ajp.156.9.1456","article-title":"Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide","volume":"156","author":"Turecki","year":"1999","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neulet.2021.135918_bib0215","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.psc.2018.10.002","article-title":"Recent research on bulimia nervosa","volume":"42","author":"Wade","year":"2019","journal-title":"Psychiatr. Clin. North Am."},{"key":"10.1016\/j.neulet.2021.135918_bib0220","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00702-011-0699-1","article-title":"Pilot study on HTR2A promoter polymorphism, -1438G\/A (rs6311) and a nearby copy number variation showed association with onset and severity in early onset obsessive-compulsive disorder","volume":"119","author":"Walitza","year":"2012","journal-title":"J. Neural Transm. Vienna (Vienna)"},{"key":"10.1016\/j.neulet.2021.135918_bib0225","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3389\/fncel.2017.00277","article-title":"Serotonergic control of metabolic homeostasis","volume":"11","author":"Wyler","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neulet.2021.135918_bib0230","first-page":"131","article-title":"Genetics and epigenetics of eating disorders","volume":"5","author":"Yilmaz","year":"2015","journal-title":"Adv. Genomics Genet."},{"key":"10.1016\/j.neulet.2021.135918_bib0235","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1007\/s10072-014-1970-7","article-title":"Association of HTR2A T102C and A-1438G polymorphisms with susceptibility to major depressive disorder: a meta-analysis","volume":"35","author":"Zhao","year":"2014","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.neulet.2021.135918_bib0240","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/070674370204700302","article-title":"Pharmacologic treatment of eating disorders","volume":"47","author":"Zhu","year":"2002","journal-title":"Can. J. Psychiatry"},{"key":"10.1016\/j.neulet.2021.135918_bib0245","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/sj.mp.4000561","article-title":"Further lack of association between the 5-HT2A gene promoter polymorphism and susceptibility to eating disorders and a meta-analysis pertaining to anorexia nervosa","volume":"4","author":"Ziegler","year":"1999","journal-title":"Mol. Psychiatry"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394021002962?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394021002962?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:43:14Z","timestamp":1759610594000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394021002962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":49,"alternative-id":["S0304394021002962"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2021.135918","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of 5-HTR2A -1438A\/G polymorphism with anorexia nervosa and bulimia nervosa: A meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2021.135918","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"135918"}}