{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:18:19Z","timestamp":1776399499360,"version":"3.51.2"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004048","name":"Kashan University of Medical Sciences","doi-asserted-by":"publisher","award":["96126"],"award-info":[{"award-number":["96126"]}],"id":[{"id":"10.13039\/501100004048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.neulet.2021.136137","type":"journal-article","created":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T02:55:01Z","timestamp":1627095301000},"page":"136137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Blockade of the orexin 1 receptors in the nucleus accumbens\u2019 shell reversed the reduction effect of olanzapine on motivation for positive reinforcers"],"prefix":"10.1016","volume":"762","author":[{"given":"Saeedeh","family":"Nasrollahi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3626-8936","authenticated-orcid":false,"given":"Sara","family":"Karimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gholamali","family":"Hamidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monireh","family":"Naderitehrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Abed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.neulet.2021.136137_b0005","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/nn1923","article-title":"Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbens","volume":"10","author":"Day","year":"2007","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.neulet.2021.136137_b0010","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.neuro.30.051606.094341","article-title":"Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement","volume":"30","author":"Fields","year":"2007","journal-title":"Annu. Rev. Neurosci."},{"issue":"6","key":"10.1016\/j.neulet.2021.136137_b0015","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.conb.2012.06.004","article-title":"Pavlovian valuation systems in learning and decision making","volume":"22","author":"Clark","year":"2012","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neulet.2021.136137_b0020","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.npep.2017.08.003","article-title":"Role of orexin receptors in the ventral tegmental area on acquisition and expression of morphine-induced conditioned place preference in the rats","volume":"66","author":"Farahimanesh","year":"2017","journal-title":"Neuropeptides"},{"issue":"1","key":"10.1016\/j.neulet.2021.136137_b0025","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0306-4522(91)90202-Y","article-title":"Specificity in the projection patterns of accumbal core and shell in the rat","volume":"41","author":"Heimer","year":"1991","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.neulet.2021.136137_b0030","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/0306-4522(92)90202-D","article-title":"On the significance of subterritories in the \u201caccumbens\u201d part of the rat ventral striatum","volume":"50","author":"Zahm","year":"1992","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.neulet.2021.136137_b0035","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/cne.903270205","article-title":"Specificity in the efferent projections of the nucleus accumbens in the rat: comparison of the rostral pole projection patterns with those of the core and shell","volume":"327","author":"Zahm","year":"1993","journal-title":"J. Comparative Neurol."},{"issue":"8","key":"10.1016\/j.neulet.2021.136137_b0040","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1111\/j.1460-9568.1994.tb00315.x","article-title":"Immunohistochemical characterization of the shell and core territories of the nucleus accumbens in the rat","volume":"6","author":"Jongen-R\u00ealo","year":"1994","journal-title":"Eur. J. Neurosci."},{"issue":"9","key":"10.1016\/j.neulet.2021.136137_b0045","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1523\/JNEUROSCI.21-09-03251.2001","article-title":"The role of the nucleus accumbens in instrumental conditioning: evidence of a functional dissociation between accumbens core and shell","volume":"21","author":"Corbit","year":"2001","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.neulet.2021.136137_b0050","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.brainresrev.2007.05.004","article-title":"Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens\u2013olfactory tubercle complex","volume":"56","author":"Ikemoto","year":"2007","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.neulet.2021.136137_b0055","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.neuropharm.2004.07.017","article-title":"Nucleus accumbens cell firing and rapid dopamine signaling during goal-directed behaviors in rats","volume":"47","author":"Carelli","year":"2004","journal-title":"Neuropharmacology"},{"issue":"8","key":"10.1016\/j.neulet.2021.136137_b0060","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.neubiorev.2003.11.015","article-title":"Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning","volume":"27","author":"Kelley","year":"2004","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neulet.2021.136137_b0065","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2741\/E615","article-title":"Rapid dopamine dynamics in the accumbens core and shell: learning and action","volume":"5","author":"Saddoris","year":"2013","journal-title":"Front. Biosci. (Elite Ed.)"},{"issue":"9","key":"10.1016\/j.neulet.2021.136137_b0070","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.neubiorev.2012.11.019","article-title":"Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley","volume":"37","author":"Zorrilla","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neulet.2021.136137_b0075","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fnsys.2015.00090","article-title":"Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry","volume":"9","author":"Castro","year":"2015","journal-title":"Front. Syst. Neurosci."},{"issue":"4","key":"10.1016\/j.neulet.2021.136137_b0080","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/j.neuroscience.2010.06.047","article-title":"Cue-evoked dopamine release in the nucleus accumbens shell tracks reinforcer magnitude during intracranial self-stimulation","volume":"169","author":"Beyene","year":"2010","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.neulet.2021.136137_b0085","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3758\/s13415-010-0015-9","article-title":"Contributions of the nucleus accumbens and its subregions to different aspects of risk-based decision making","volume":"11","author":"Stopper","year":"2011","journal-title":"Cogn. Affect. Behav. Neurosci."},{"issue":"13","key":"10.1016\/j.neulet.2021.136137_b0090","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1073\/pnas.1017732108","article-title":"Risk preference following adolescent alcohol use is associated with corrupted encoding of costs but not rewards by mesolimbic dopamine","volume":"108","author":"Nasrallah","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"5715","key":"10.1016\/j.neulet.2021.136137_b0095","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1126\/science.1105370","article-title":"Adaptive coding of reward value by dopamine neurons","volume":"307","author":"Tobler","year":"2005","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.neulet.2021.136137_b0100","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1038\/nn2013","article-title":"Dopamine neurons encode the better option in rats deciding between differently delayed or sized rewards","volume":"10","author":"Roesch","year":"2007","journal-title":"Nat. Neurosci."},{"issue":"4","key":"10.1016\/j.neulet.2021.136137_b0105","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/01.wco.0000173463.24758.f6","article-title":"Functional magnetic resonance imaging of reward prediction","volume":"18","author":"Knutson","year":"2005","journal-title":"Curr. Opin. Neurol."},{"issue":"3","key":"10.1016\/j.neulet.2021.136137_b0110","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1177\/1073858404263526","article-title":"The neural substrates of reward processing in humans: the modern role of FMRI","volume":"10","author":"McClure","year":"2004","journal-title":"Neuroscientist"},{"issue":"3","key":"10.1016\/j.neulet.2021.136137_b0115","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0896-6273(00)80374-8","article-title":"Acute effects of cocaine on human brain activity and emotion","volume":"19","author":"Breiter","year":"1997","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.neulet.2021.136137_b0120","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0166-4328(94)90108-2","article-title":"Anhedonia or anergia? Effects of haloperidol and nucleus accumbens dopamine depletion on instrumental response selection in a T-maze cost\/benefit procedure","volume":"65","author":"Salamone","year":"1994","journal-title":"Behav. Brain Res."},{"issue":"3","key":"10.1016\/j.neulet.2021.136137_b0125","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0149-7634(96)00017-6","article-title":"Behavioral functions of nucleus accumbens dopamine: empirical and conceptual problems with the anhedonia hypothesis","volume":"21","author":"Salamone","year":"1997","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.neulet.2021.136137_b0130","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1037\/0735-7044.119.1.323","article-title":"The mesocortical dopamine projection to anterior cingulate cortex plays no role in guiding effort-related decisions","volume":"119","author":"Walton","year":"2005","journal-title":"Behav. Neurosci."},{"issue":"3","key":"10.1016\/j.neulet.2021.136137_b0135","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/npp.2009.187","article-title":"Separable roles of the nucleus accumbens core and shell in context-and cue-induced alcohol-seeking","volume":"35","author":"Chaudhri","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neulet.2021.136137_b0140","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/7854_2015_388","article-title":"Learning and motivational processes contributing to Pavlovian\u2013instrumental transfer and their neural bases: dopamine and beyond","author":"Corbit","year":"2015","journal-title":"Behav. Neurosci. Motivation"},{"issue":"3","key":"10.1016\/j.neulet.2021.136137_b0145","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1037\/bne0000050","article-title":"A critical role of nucleus accumbens dopamine D1-family receptors in renewal of alcohol seeking after punishment-imposed abstinence","volume":"129","author":"Marchant","year":"2015","journal-title":"Behav. Neurosci."},{"issue":"11","key":"10.1016\/j.neulet.2021.136137_b0150","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1038\/npp.2015.102","article-title":"Nucleus accumbens and posterior amygdala mediate cue-triggered alcohol seeking and suppress behavior during the omission of alcohol-predictive cues","volume":"40","author":"Millan","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neulet.2021.136137_b0155","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3389\/fncir.2013.00152","article-title":"Dopamine signaling in reward-related behaviors","volume":"7","author":"Baik","year":"2013","journal-title":"Front. Neural Circuits"},{"issue":"1","key":"10.1016\/j.neulet.2021.136137_b0160","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/acer.12216","article-title":"Selectively bred crossed high-alcohol-preferring mice drink to intoxication and develop functional tolerance, but not locomotor sensitization during free-choice ethanol access","volume":"38","author":"Matson","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neulet.2021.136137_b0165","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.neuropharm.2014.01.024","article-title":"mGluR1 within the nucleus accumbens regulates alcohol intake in mice under limited-access conditions","volume":"79","author":"Lum","year":"2014","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.neulet.2021.136137_b0170","doi-asserted-by":"crossref","first-page":"997","DOI":"10.3171\/2013.12.JNS13205","article-title":"Reduced ethanol consumption by alcohol-preferring (P) rats following pharmacological silencing and deep brain stimulation of the nucleus accumbens shell","volume":"120","author":"Wilden","year":"2014","journal-title":"J. Neurosurg."},{"issue":"11","key":"10.1016\/j.neulet.2021.136137_b0175","doi-asserted-by":"crossref","first-page":"871","DOI":"10.2165\/00023210-200115110-00005","article-title":"Olanzapine: a review of its use in the treatment of bipolar I disorder","volume":"15","author":"Bhana","year":"2001","journal-title":"CNS Drugs."},{"issue":"2","key":"10.1016\/j.neulet.2021.136137_b0180","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0893-133X(94)00129-N","article-title":"Radioreceptor binding profile of the atypical antipsychotic olanzapine","volume":"14","author":"Bymaster","year":"1996","journal-title":"Neuropsychopharmacology"},{"issue":"10","key":"10.1016\/j.neulet.2021.136137_b0185","first-page":"28","article-title":"In vitro and in vivo biochemistry of olanzapine: a novel, atypical antipsychotic drug","volume":"58","author":"Bymaster","year":"1997","journal-title":"J. Clin. Psychiatry"},{"issue":"10","key":"10.1016\/j.neulet.2021.136137_b0190","first-page":"37","article-title":"Behavioral pharmacology of olanzapine: a novel antipsychotic drug","volume":"58","author":"Moore","year":"1997","journal-title":"J. Clin. Psychiatry"},{"issue":"2","key":"10.1016\/j.neulet.2021.136137_b0195","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s002130050877","article-title":"Differential effects of olanzapine at dopamine D1 and D2 receptors in dopamine depleted animals","volume":"142","author":"Ninan","year":"1999","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neulet.2021.136137_b0200","doi-asserted-by":"crossref","first-page":"114946","DOI":"10.1016\/j.jelechem.2020.114946","article-title":"The chemical interaction between the neurotransmitter dopamine and the antipsychotic drugs olanzapine and quetiapine","volume":"881","author":"Bacil","year":"2021","journal-title":"J. Electroanal. Chem."},{"issue":"4","key":"10.1016\/j.neulet.2021.136137_b0205","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1139\/jpn.0336","article-title":"Actigraphic measurement of the effects of single-dose haloperidol and olanzapine on spontaneous motor activity in normal subjects","volume":"28","author":"Kiang","year":"2003","journal-title":"J. Psychiatry Neurosci."},{"issue":"1","key":"10.1016\/j.neulet.2021.136137_b0210","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/schbul\/23.1.29","article-title":"A cognitive neuroscience view of schizophrenic thought disorder","volume":"23","author":"Spitzer","year":"1997","journal-title":"Schizophr. Bull."},{"issue":"S37","key":"10.1016\/j.neulet.2021.136137_b0215","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1192\/S0007125000293653","article-title":"Olanzapine: a basic science update","volume":"174","author":"Bymaster","year":"1999","journal-title":"British J. Psychiatr."},{"issue":"1","key":"10.1016\/j.neulet.2021.136137_b0220","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1073\/pnas.95.1.322","article-title":"The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity","volume":"95","author":"de Lecea","year":"1998","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.neulet.2021.136137_b0225","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/bph.12415","article-title":"The hypocretins\/orexins: integrators of multiple physiological functions","volume":"171","author":"Li","year":"2014","journal-title":"Br. J. Pharmacol."},{"issue":"23","key":"10.1016\/j.neulet.2021.136137_b0230","doi-asserted-by":"crossref","first-page":"9996","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998","article-title":"Neurons containing hypocretin (orexin) project to multiple neuronal systems","volume":"18","author":"Peyron","year":"1998","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.neulet.2021.136137_b0235","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1523\/JNEUROSCI.2761-05.2006","article-title":"Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine","volume":"26","author":"Narita","year":"2006","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.neulet.2021.136137_b0240","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/sj.npp.1300807","article-title":"Hypocretin\/orexin selectively increases dopamine efflux within the prefrontal cortex: involvement of the ventral tegmental area","volume":"31","author":"Vittoz","year":"2006","journal-title":"Neuropsychopharmacology"},{"issue":"8","key":"10.1016\/j.neulet.2021.136137_b0245","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1111\/j.1460-9568.2008.06453.x","article-title":"Hypocretin \/orexin preferentially activates caudomedial ventral tegmental area dopamine neurons","volume":"28","author":"Vittoz","year":"2008","journal-title":"Eur. J. Neurosci."},{"issue":"2","key":"10.1016\/j.neulet.2021.136137_b0250","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1460-9568.2009.07065.x","article-title":"The hypocretin\u2013orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system","volume":"31","author":"Espa\u00f1a","year":"2010","journal-title":"Eur. J. Neurosci."},{"issue":"2","key":"10.1016\/j.neulet.2021.136137_b0255","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00213-010-2048-8","article-title":"Hypocretin 1\/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self-administration","volume":"214","author":"Espa\u00f1a","year":"2011","journal-title":"Psychopharmacology"},{"issue":"1-2","key":"10.1016\/j.neulet.2021.136137_b0260","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0920-9964(97)88740-3","article-title":"Effects of atypical antipsychotic drugs on dopamine output in the shell and the core of the nucleus accumbens: Role of 5-HT2A and \u03b1 1-adrenoceptor antagonism","volume":"29","author":"Marcus","year":"1998","journal-title":"Schizophr. Res."},{"issue":"15","key":"10.1016\/j.neulet.2021.136137_b0265","doi-asserted-by":"crossref","first-page":"6742","DOI":"10.1523\/JNEUROSCI.22-15-06742.2002","article-title":"Differential activation of orexin neurons by antipsychotic drugs associated with weight gain","volume":"22","author":"Fadel","year":"2002","journal-title":"J. Neurosci."},{"issue":"7","key":"10.1016\/j.neulet.2021.136137_b0270","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1017\/S1461145712001642","article-title":"Olanzapine treatment of adolescent rats alters adult reward behaviour and nucleus accumbens function","volume":"16","author":"Vinish","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"4","key":"10.1016\/j.neulet.2021.136137_b0275","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/sj.npp.1301239","article-title":"The orexin-1 receptor antagonist SB-334867 blocks the effects of antipsychotics on the activity of A9 and A10 dopamine neurons: implications for antipsychotic therapy","volume":"32","author":"Rasmussen","year":"2007","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/j.neulet.2021.136137_b0280","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00213-004-2059-4","article-title":"Differential involvement of serotonin and dopamine systems in cost-benefit decisions about delay or effort","volume":"179","author":"Denk","year":"2005","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neulet.2021.136137_b0285","article-title":"The rat brain in stereotaxic coordinates","volume":"32","author":"George","year":"2007","journal-title":"Qingchuan Zhuge Translate"},{"issue":"1","key":"10.1016\/j.neulet.2021.136137_b0290","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.pbb.2010.05.009","article-title":"Olanzapine affects locomotor activity and meal size in male rats","volume":"97","author":"van der Zwaal","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neulet.2021.136137_b0295","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0079-6123(08)00910-2","article-title":"Neuropharmacology of second-generation antipsychotic drugs: a validity of the serotonin\u2013dopamine hypothesis","volume":"172","author":"Kuroki","year":"2008","journal-title":"Prog. Brain Res."},{"issue":"2","key":"10.1016\/j.neulet.2021.136137_b0300","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0014-2999(85)90728-9","article-title":"SCH 23390 and SK&F 83566 are antagonists at vascular dopamine and serotonin receptors","volume":"108","author":"Ohlstein","year":"1985","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.neulet.2021.136137_b0305","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00213-006-0668-9","article-title":"Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits","volume":"191","author":"Salamone","year":"2007","journal-title":"Psychopharmacology"},{"issue":"3","key":"10.1016\/j.neulet.2021.136137_b0310","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.neuroscience.2008.04.004","article-title":"Opposing roles for the nucleus accumbens core and shell in cue-induced reinstatement of food-seeking behavior","volume":"154","author":"Floresco","year":"2008","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.neulet.2021.136137_b0315","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-neuro-061010-113641","article-title":"Modulation of striatal projection systems by dopamine","volume":"34","author":"Gerfen","year":"2011","journal-title":"Annu. Rev. Neurosci."},{"issue":"3","key":"10.1016\/j.neulet.2021.136137_b0320","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0306-4522(97)00327-8","article-title":"Expression of D1 receptor, D2 receptor, substance P and enkephalin messenger RNAs in the neurons projecting from the nucleus accumbens","volume":"82","author":"Lu","year":"1997","journal-title":"Neuroscience"},{"issue":"9","key":"10.1016\/j.neulet.2021.136137_b0325","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1038\/nn.4068","article-title":"Coding the direct\/indirect pathways by D1 and D2 receptors is not valid for accumbens projections","volume":"18","author":"Kupchik","year":"2015","journal-title":"Nat. Neurosci."},{"issue":"6002","key":"10.1016\/j.neulet.2021.136137_b0330","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1126\/science.1188472","article-title":"Cell type\u2013specific loss of BDNF signaling mimics optogenetic control of cocaine reward","volume":"330","author":"Lobo","year":"2010","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.neulet.2021.136137_b0335","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/nn.3100","article-title":"Distinct roles for direct and indirect pathway striatal neurons in reinforcement","volume":"15","author":"Kravitz","year":"2012","journal-title":"Nat. Neurosci."},{"issue":"10","key":"10.1016\/j.neulet.2021.136137_b0340","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1073\/pnas.1521238113","article-title":"In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward","volume":"113","author":"Calipari","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"5","key":"10.1016\/j.neulet.2021.136137_b0345","doi-asserted-by":"crossref","first-page":"488","DOI":"10.2174\/138161210790361461","article-title":"Third generation antipsychotic drugs: partial agonism or receptor functional selectivity?","volume":"16","author":"Mailman","year":"2010","journal-title":"Curr. Pharm. Des."},{"issue":"6","key":"10.1016\/j.neulet.2021.136137_b0350","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1111\/j.1743-6109.2009.01309.x","article-title":"Reviews: pathways of sexual desire","volume":"6","author":"Pfaus","year":"2009","journal-title":"J. Sexual Med."},{"issue":"1","key":"10.1016\/j.neulet.2021.136137_b0355","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1006\/appe.2000.0373","article-title":"The control of ingestive behavior by the median raphe nucleus","volume":"36","author":"Wirtshafter","year":"2001","journal-title":"Appetite"},{"issue":"3","key":"10.1016\/j.neulet.2021.136137_b0360","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/cne.901790311","article-title":"An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat","volume":"179","author":"Azmitia","year":"1978","journal-title":"J. Comparative Neurol."},{"issue":"2","key":"10.1016\/j.neulet.2021.136137_b0365","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neubiorev.2005.06.007","article-title":"Serotonergic modulation of the limbic system","volume":"30","author":"Hensler","year":"2006","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"2","key":"10.1016\/j.neulet.2021.136137_b0370","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.neubiorev.2010.02.001","article-title":"Brain reward circuitry beyond the mesolimbic dopamine system: a neurobiological theory","volume":"35","author":"Ikemoto","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"4","key":"10.1016\/j.neulet.2021.136137_b0375","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.pnpbp.2005.11.025","article-title":"Dorsal raphe vs. median raphe serotonergic antagonism. Anatomical, physiological, behavioral, neuroendocrinological, neuropharmacological and clinical evidences: relevance for neuropharmacological therapy","volume":"30","author":"Lechin","year":"2006","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.neulet.2021.136137_b0380","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1124\/pr.59.07103","article-title":"5-HT receptor regulation of neurotransmitter release","volume":"59","author":"Fink","year":"2007","journal-title":"Pharmacol. Rev."},{"issue":"2","key":"10.1016\/j.neulet.2021.136137_b0385","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.pharmthera.2006.08.004","article-title":"Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission","volume":"113","author":"Alex","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.neulet.2021.136137_b0390","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2018.00640","article-title":"Systemic administration of orexin A loaded liposomes potentiates nucleus accumbens shell dopamine release by sucrose feeding","volume":"9","author":"Lai","year":"2018","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.neulet.2021.136137_b0395","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fnbeh.2012.00082","article-title":"Local hypocretin-1 modulates terminal dopamine concentration in the nucleus accumbens shell","volume":"6","author":"Patyal","year":"2012","journal-title":"Front. Behav. Neurosci."},{"issue":"1","key":"10.1016\/j.neulet.2021.136137_b0400","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bbr.2010.10.007","article-title":"Chemical stimulation of the lateral hypothalamus induces conditioned place preference in rats: involvement of OX1 and CB1 receptors in the ventral tegmental area","volume":"217","author":"Taslimi","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neulet.2021.136137_b0405","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.nlm.2015.02.001","article-title":"The electrical activity of hippocampal pyramidal neuron is subjected to descending control by the brain orexin\/hypocretin system","volume":"119","author":"Riahi","year":"2015","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.neulet.2021.136137_b0410","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.brainres.2009.10.068","article-title":"Convergent actions of orexin\/hypocretin and CRF on dopamine neurons: emerging players in addiction","volume":"1314","author":"Borgland","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2021.136137_b0415","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2017.09.007","article-title":"Role of intra-accumbal orexin receptors in the acquisition of morphine-induced conditioned place preference in the rats","volume":"660","author":"Alizamini","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2021.136137_b0420","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.pbb.2015.12.005","article-title":"Differential effects of intra-accumbal orexin-1 and-2 receptor antagonists on the expression and extinction of morphine-induced conditioned place preference in rats","volume":"142","author":"Sadeghzadeh","year":"2016","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neulet.2021.136137_b0425","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3389\/fnins.2016.00400","article-title":"Nucleus accumbens shell and mPFC but not insula orexin-1 receptors promote excessive alcohol drinking","volume":"10","author":"Lei","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neulet.2021.136137_b0430","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.pnpbp.2018.09.006","article-title":"Orexin 1 receptors in the anterior cingulate and orbitofrontal cortex regulate cost and benefit decision-making","volume":"89","author":"Karimi","year":"2019","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"18","key":"10.1016\/j.neulet.2021.136137_b0435","doi-asserted-by":"crossref","first-page":"7295","DOI":"10.1523\/JNEUROSCI.4385-14.2015","article-title":"Orexin signaling in the VTA gates morphine-induced synaptic plasticity","volume":"35","author":"Baimel","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2021.136137_b0440","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.brainres.2013.06.034","article-title":"Central administration of an orexin receptor 1 antagonist prevents the stimulatory effect of Olanzapine on endogenous glucose production","volume":"1527","author":"Girault","year":"2013","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.neulet.2021.136137_b0445","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0022-3565(25)10792-1","article-title":"The behavioral pharmacology of olanzapine, a novel\u201c atypical\u201d antipsychotic agent","volume":"262","author":"Moore","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"2","key":"10.1016\/j.neulet.2021.136137_b0450","first-page":"510","article-title":"Disruption of orexin\/hypocretin signaling blocks the effects of clozapine on the prefrontal cortex","volume":"31","author":"Deutch","year":"2005","journal-title":"Schizophr. Bull."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394021005152?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394021005152?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:43:25Z","timestamp":1759610605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394021005152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":90,"alternative-id":["S0304394021005152"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2021.136137","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blockade of the orexin 1 receptors in the nucleus accumbens\u2019 shell reversed the reduction effect of olanzapine on motivation for positive reinforcers","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2021.136137","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"136137"}}