{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T21:09:22Z","timestamp":1766869762385,"version":"build-2065373602"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.neulet.2021.136184","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T11:40:03Z","timestamp":1629286803000},"page":"136184","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["The role of circulating blood microRNA-374 and microRNA-10 levels in the pathogenesis and therapeutic mechanisms of major depressive disorder"],"prefix":"10.1016","volume":"763","author":[{"given":"Wanying","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuxu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanqun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shen","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caiping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunying","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaida","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huafang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.neulet.2021.136184_b0005","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jchemneu.2011.04.002","article-title":"Evidence demonstrating role of microRNAs in the etiopathology of major depression","volume":"42","author":"Dwivedi","year":"2011","journal-title":"J Chem Neuroanat"},{"issue":"2","key":"10.1016\/j.neulet.2021.136184_b0010","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: Genomics, Biogenesis, Mechanism, and Function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2021.136184_b0015","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.pnpbp.2016.03.010","article-title":"Diagnostic and therapeutic potential of microRNAs in neuropsychiatric disorders: Past, present, and future","volume":"73","author":"Alural","year":"2017","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"1","key":"10.1016\/j.neulet.2021.136184_b0020","doi-asserted-by":"crossref","first-page":"43","DOI":"10.31887\/DCNS.2014.16.1\/ydwivedi","article-title":"Emerging role of microRNAs in major depressive disorder: diagnosis and therapeutic implications","volume":"16","author":"Dwivedi","year":"2014","journal-title":"Dialogues Clin Neurosci"},{"issue":"1","key":"10.1016\/j.neulet.2021.136184_b0025","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/YCO.0000000000000379","article-title":"Major depression and its treatment: microRNAs as peripheral biomarkers of diagnosis and treatment response","volume":"31","author":"Lopez","year":"2018","journal-title":"Curr Opin Psychiatry"},{"key":"10.1016\/j.neulet.2021.136184_b0030","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2012.112","article-title":"Responder and nonresponder patients exhibit different peripheral transcriptional signatures during major depressive episode","volume":"2","author":"Belzeaux","year":"2012","journal-title":"Transl Psychiatry"},{"issue":"7","key":"10.1016\/j.neulet.2021.136184_b0035","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.euroneuro.2012.06.013","article-title":"Blood microRNA changes in depressed patients during antidepressant treatment","volume":"23","author":"Bocchio-Chiavetto","year":"2013","journal-title":"Eur Neuropsychopharmacol"},{"issue":"5","key":"10.1016\/j.neulet.2021.136184_b0040","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4306\/pi.2016.13.5.549","article-title":"Circulating Plasma Micro RNAs in Patients with Major Depressive Disorder Treated with Antidepressants: A Pilot Study","volume":"13","author":"Enatescu","year":"2016","journal-title":"Psychiatry Investig"},{"key":"10.1016\/j.neulet.2021.136184_b0045","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jpsychires.2014.08.007","article-title":"Differential expression of microRNA in peripheral blood mononuclear cells as specific biomarker for major depressive disorder patients","volume":"59","author":"Fan","year":"2014","journal-title":"J Psychiatr Res"},{"issue":"8","key":"10.1016\/j.neulet.2021.136184_b0050","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2016.131","article-title":"MicroRNAs as biomarkers for major depression: a role for let-7b and let-7c","volume":"6","author":"Gururajan","year":"2016","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.neulet.2021.136184_b0055","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jad.2013.12.035","article-title":"Identification of suitable plasma-based reference genes for miRNAome analysis of major depressive disorder","volume":"163","author":"Liu","year":"2014","journal-title":"J Affect Disord"},{"key":"10.1016\/j.neulet.2021.136184_b0060","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jad.2016.04.021","article-title":"Peripheral whole blood microRNA alterations in major depression and bipolar disorder","volume":"200","author":"Maffioletti","year":"2016","journal-title":"J Affect Disord"},{"issue":"3","key":"10.1016\/j.neulet.2021.136184_b0065","doi-asserted-by":"crossref","first-page":"e0121975","DOI":"10.1371\/journal.pone.0121975","article-title":"Identification of differential microRNAs in cerebrospinal fluid and serum of patients with major depressive disorder","volume":"10","author":"Wan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2021.136184_b0070","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jad.2018.10.363","article-title":"Increased expression of a novel miRNA in peripheral blood is negatively correlated with hippocampal volume in patients with major depressive disorder","volume":"245","author":"Zhao","year":"2019","journal-title":"J Affect Disord"},{"key":"10.1016\/j.neulet.2021.136184_b0075","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.psychres.2018.09.025","article-title":"Antidepressant treatment increased serum miR-183 and miR-212 levels in patients with major depressive disorder","volume":"270","author":"Lin","year":"2018","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.neulet.2021.136184_b0080","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.jad.2017.11.090","article-title":"Changes in miRNA-132 and miR-124 levels in non-treated and citalopram-treated patients with depression","volume":"227","author":"Fang","year":"2018","journal-title":"J Affect Disord"},{"key":"10.1016\/j.neulet.2021.136184_b0085","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jpsychires.2016.03.015","article-title":"Alterations of microRNA-124 expression in peripheral blood mononuclear cells in pre- and post-treatment patients with major depressive disorder","volume":"78","author":"He","year":"2016","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.neulet.2021.136184_b0090","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jpsychires.2015.07.023","article-title":"Comparison of plasma MicroRNA levels in drug naive, first episode depressed patients and healthy controls","volume":"69","author":"Camkurt","year":"2015","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.neulet.2021.136184_b0095","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neulet.2015.08.038","article-title":"MiR-335 is involved in major depression disorder and antidepressant treatment through targeting GRM4","volume":"606","author":"Li","year":"2015","journal-title":"Neurosci Lett"},{"issue":"11","key":"10.1016\/j.neulet.2021.136184_b0100","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1373\/clinchem.2010.147405","article-title":"The microRNA spectrum in 12 body fluids","volume":"56","author":"Weber","year":"2010","journal-title":"Clin Chem"},{"issue":"1","key":"10.1016\/j.neulet.2021.136184_b0105","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2015.213","article-title":"Aberrant expression of microRNAs as biomarker for schizophrenia: from acute state to partial remission, and from peripheral blood to cortical tissue","volume":"6","author":"Lai","year":"2016","journal-title":"Transl Psychiatry"},{"issue":"4","key":"10.1016\/j.neulet.2021.136184_b0110","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/npp.2016.175","article-title":"Identification of MicroRNA-124-3p as a Putative Epigenetic Signature of Major Depressive Disorder","volume":"42","author":"Roy","year":"2017","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/j.neulet.2021.136184_b0115","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s40291-020-00464-9","article-title":"Exploiting Circulating MicroRNAs as Biomarkers in Psychiatric Disorders","volume":"24","author":"Roy","year":"2020","journal-title":"Mol Diagn Ther"},{"issue":"1","key":"10.1016\/j.neulet.2021.136184_b0120","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1155\/2013\/984845","article-title":"Biomarkers predicting antidepressant treatment response: how can we advance the field?","volume":"35","author":"Labermaier","year":"2013","journal-title":"Dis Markers"},{"key":"10.1016\/j.neulet.2021.136184_b0125","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.2147\/NDT.S237116","article-title":"MicroRNA-Based Biomarkers in the Diagnosis and Monitoring of Therapeutic Response in Patients with Depression","volume":"15","author":"Xu","year":"2019","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"11","key":"10.1016\/j.neulet.2021.136184_b0130","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1176\/ajp.2006.163.11.1905","article-title":"Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report","volume":"163","author":"Rush","year":"2006","journal-title":"Am J Psychiatry"},{"issue":"6","key":"10.1016\/j.neulet.2021.136184_b0135","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"key":"10.1016\/j.neulet.2021.136184_b0140","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/978-3-030-05542-4_9","article-title":"MicroRNAs in Major Depressive Disorder","volume":"1118","author":"Fries","year":"2019","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"10.1016\/j.neulet.2021.136184_b0145","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.nbd.2011.12.035","article-title":"MicroRNAs and depression","volume":"46","author":"Mouillet-Richard","year":"2012","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neulet.2021.136184_b0150","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jad.2016.01.017","article-title":"Preliminary comparison of plasma notch-associated microRNA-34b and -34c levels in drug naive, first episode depressed patients and healthy controls","volume":"194","author":"Sun","year":"2016","journal-title":"J Affect Disord"},{"issue":"5","key":"10.1016\/j.neulet.2021.136184_b0155","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1111\/jcmm.14219","article-title":"The latest progress on miR-374 and its functional implications in physiological and pathological processes","volume":"23","author":"Bian","year":"2019","journal-title":"J Cell Mol Med"},{"issue":"1","key":"10.1016\/j.neulet.2021.136184_b0160","article-title":"Diagnostic Value of Peripheral Blood miR-374b-5p in Patients with Prostate Cancer","volume":"66","author":"Pang","year":"2020","journal-title":"Clin Lab"},{"issue":"2","key":"10.1016\/j.neulet.2021.136184_b0165","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/cdd.2009.58","article-title":"miR-10 in development and cancer","volume":"17","author":"Lund","year":"2010","journal-title":"Cell Death Differ"},{"issue":"2","key":"10.1016\/j.neulet.2021.136184_b0170","first-page":"773","article-title":"Serum miR-10a-5p and miR-196a-5p as non-invasive biomarkers in non-small cell lung cancer","volume":"11","author":"Bao","year":"2018","journal-title":"Int J Clin Exp Pathol"},{"issue":"3","key":"10.1016\/j.neulet.2021.136184_b0175","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s12185-015-1829-6","article-title":"Serum level of miR-10-5p as a prognostic biomarker for acute myeloid leukemia","volume":"102","author":"Zhi","year":"2015","journal-title":"Int J Hematol"},{"issue":"11","key":"10.1016\/j.neulet.2021.136184_b0180","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1161\/CIRCRESAHA.112.279711","article-title":"MicroRNA-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting vascular endothelial growth factor signaling","volume":"111","author":"Hassel","year":"2012","journal-title":"Circ Res"},{"issue":"1-2","key":"10.1016\/j.neulet.2021.136184_b0185","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.psychres.2014.03.042","article-title":"Elevated serum levels of FGF-2, NGF and IGF-1 in patients with manic episode of bipolar disorder","volume":"218","author":"Liu","year":"2014","journal-title":"Psychiatry Res"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394021005620?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394021005620?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:41:42Z","timestamp":1759610502000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394021005620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":37,"alternative-id":["S0304394021005620"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2021.136184","relation":{},"ISSN":["0304-3940"],"issn-type":[{"type":"print","value":"0304-3940"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of circulating blood microRNA-374 and microRNA-10 levels in the pathogenesis and therapeutic mechanisms of major depressive disorder","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2021.136184","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"136184"}}