{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:38:33Z","timestamp":1788151113508,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.neulet.2021.136395","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T11:51:44Z","timestamp":1639482704000},"page":"136395","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Association of 5-HTR2A T102C and A-1438G polymorphisms with clinical response to atypical antipsychotic treatment in schizophrenia: A meta-analysis"],"prefix":"10.1016","volume":"770","author":[{"given":"Pan","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengdong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfen","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2021.136395_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2020.113470","article-title":"Association of the genetic polymorphisms of metabolizing enzymes, transporters, target receptors and their interactions with treatment response to olanzapine in chinese han schizophrenia patients","volume":"293","author":"Yan","year":"2020","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.neulet.2021.136395_b0010","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0140-6736(09)60072-6","article-title":"Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study","volume":"373","author":"Lichtenstein","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.neulet.2021.136395_b0015","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1001\/archpsyc.60.12.1187","article-title":"Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies","volume":"60","author":"Sullivan","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neulet.2021.136395_b0020","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1517\/17425255.2011.532787","article-title":"Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction","volume":"7","author":"Jian-Ping","year":"2011","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.neulet.2021.136395_b0025","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1515\/prilozi-2015-0030","article-title":"Pharmacogenetics and antipsychotic treatment response","volume":"36","author":"Naumovska","year":"2015","journal-title":"Pril"},{"key":"10.1016\/j.neulet.2021.136395_b0030","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/fcp.12424","article-title":"Dopamine (DRD2) and Serotonin (HTR2A, 2C) Receptor Gene Polymorphisms do not influence early response to Risperidone in South Indian Patients with Schizophrenia","volume":"33","author":"Alladi","year":"2019","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.neulet.2021.136395_b0035","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jad.2014.06.012","article-title":"Influence of 5-HTR2A genetic polymorphisms on the efficacy of antidepressants in the treatment of major depressive disorder: A meta-analysis","volume":"168","author":"Lin","year":"2014","journal-title":"J. Affect. Disord."},{"issue":"1","key":"10.1016\/j.neulet.2021.136395_b0040","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1001\/archgenpsychiatry.2009.176","article-title":"Decreased frontal serotonin2A receptor binding in antipsychotic-naive patients with first-episode schizophrenia","volume":"67","author":"Rasmussen","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neulet.2021.136395_b0045","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ajp.2017.07.026","article-title":"Identification of genetic correlates of response to Risperidone: Findings of a multicentric schizophrenia study from India","volume":"29","author":"Kaur","year":"2017","journal-title":"Asian J Psychiatr"},{"key":"10.1016\/j.neulet.2021.136395_b0050","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jad.2020.06.016","article-title":"The association of HTR2A polymorphisms with obsessive-compulsive disorder and its subtypes: A meta-analysis","volume":"275","author":"Mattina","year":"2020","journal-title":"J. Affect. Disord."},{"issue":"6","key":"10.1016\/j.neulet.2021.136395_b0055","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.biopsych.2004.06.020","article-title":"The -1438A\/G polymorphism in the 5-hydroxytryptamine type 2A receptor gene affects promoter activity","volume":"56","author":"Parsons","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2021.136395_b0060","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1176\/ajp.156.9.1456","article-title":"Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide","volume":"156","author":"Turecki","year":"1999","journal-title":"Am. J. Psychiatry"},{"issue":"2","key":"10.1016\/j.neulet.2021.136395_b0065","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0920-9964(98)00032-2","article-title":"Meta-analysis of studies on genetic variation in 5-HT2A receptors and clozapine response","volume":"32","author":"Arranz","year":"1998","journal-title":"Schizophr. Res."},{"issue":"9","key":"10.1016\/j.neulet.2021.136395_b0070","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur. J. Epidemiol."},{"issue":"8970","key":"10.1016\/j.neulet.2021.136395_b0075","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0140-6736(95)92168-0","article-title":"Association between clozapine response and allelic variation in 5-HT2A receptor gene","volume":"346","author":"Arranz","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.neulet.2021.136395_b0080","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/S0140-6736(95)91785-3","article-title":"Genetic variation of 5-HT2A receptor and response to clozapine","volume":"346","author":"Masellis","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.neulet.2021.136395_b0085","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1176\/ajp.153.8.1092","article-title":"Lack of association between polymorphisms in the 5-HT2A receptor gene and the antipsychotic response to clozapine","volume":"153","author":"Malhotra","year":"1996","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neulet.2021.136395_b0090","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0893-133X(98)00007-4","article-title":"Serotonin subtype 2 receptor genes and clinical response to clozapine in schizophrenia patients","volume":"19","author":"Masellis","year":"1998","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.neulet.2021.136395_b0095","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/sj.mp.4000348","article-title":"Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine","volume":"3","author":"Arranz","year":"1998","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neulet.2021.136395_b0100","first-page":"141","article-title":"A study on the relationship between the responses to clozapine and the 5-hydroxytryptamine type-2A receptor gene in chronic refractory schizophrenia","volume":"33","author":"Luo","year":"2000","journal-title":"Chin J Psvchiatry"},{"key":"10.1016\/j.neulet.2021.136395_b0105","first-page":"353","article-title":"The Association between 5-HT2A Receptor Gene Polymorphism and the Therapeutic Response of Risperidone., Chin","volume":"16","author":"Wang","year":"2000","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.neulet.2021.136395_b0110","first-page":"265","article-title":"Influence of serotonergic transmission on response to olanzapine","volume":"30","author":"Mata-Pastor","year":"2002","journal-title":"Actas Esp Psiquiatr."},{"key":"10.1016\/j.neulet.2021.136395_b0115","first-page":"7","article-title":"Association between the responses to olanzapine and six functional genes in schizophrenia","volume":"36","author":"Yuan","year":"2003","journal-title":"Chin. J Psychiatry"},{"key":"10.1016\/j.neulet.2021.136395_b0120","article-title":"The Relationship Between the Response to Risperidone Treatment and 5-HT2A Receptor Gene (T102C and 1438G\/A) Polymorphism in Schizophrenia","volume":"13","author":"Herken","year":"2003","journal-title":"Klinik Psikofarmakoloji Bulteni"},{"key":"10.1016\/j.neulet.2021.136395_b0125","first-page":"270","article-title":"Analysis the relationship between polymorphism in the serotonin 2A receptor gene and variability among individuals in their response to clozapine, Chin","volume":"20","author":"Zhao","year":"2004","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.neulet.2021.136395_b0130","first-page":"294","article-title":"Association between 5-HT2A receptor gene polymorphism and risperidone treatment response in the first episode (drug-naive) Chinese patients with schizophrenia","volume":"32","author":"Wang","year":"2006","journal-title":"Chin. J. Nerv. Mental Dis."},{"key":"10.1016\/j.neulet.2021.136395_b0135","article-title":"Association of 5-HT2A receptor gene polymorphisms with the response to olanzapine in Chinese patients with schizophrenia","volume":"16","author":"Guan","year":"2007","journal-title":"Chin J Behav. Med. Sci."},{"issue":"1","key":"10.1016\/j.neulet.2021.136395_b0140","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/hup.897","article-title":"Could HTR2A T102C and DRD3 Ser9Gly predict clinical improvement in patients with acutely exacerbated schizophrenia? Results from treatment responses to risperidone in a naturalistic setting","volume":"23","author":"Kim","year":"2008","journal-title":"Hum. Psychopharmacol."},{"issue":"3","key":"10.1016\/j.neulet.2021.136395_b0145","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.psychres.2007.09.010","article-title":"Correlates of response to Olanzapine in a North Indian Schizophrenia sample","volume":"161","author":"Thomas","year":"2008","journal-title":"Psychiatry Res."},{"issue":"4","key":"10.1016\/j.neulet.2021.136395_b0150","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000327602","article-title":"Polymorphisms of the 5-HT2A receptor gene and clinical response to olanzapine in paranoid schizophrenia","volume":"64","author":"Olajossy-Hilkesberger","year":"2011","journal-title":"Neuropsychobiology"},{"issue":"1","key":"10.1016\/j.neulet.2021.136395_b0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/08039488.2016.1217350","article-title":"Meta-analysis of polymorphism rs6311 and rs6313 in the 5-HT2AR gene and schizophrenia","volume":"71","author":"Sun","year":"2017","journal-title":"Nord. J. Psychiatry"},{"issue":"1-2","key":"10.1016\/j.neulet.2021.136395_b0160","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S1566-2772(03)00021-5","article-title":"Atypical antipsychotic drug actions: unitary or multiple mechanisms for \u2018atypicality\u2019?, Clin","volume":"3","author":"Roth","year":"2003","journal-title":"Neurosci. Res."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394021007746?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394021007746?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:41:20Z","timestamp":1759624880000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394021007746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":32,"alternative-id":["S0304394021007746"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2021.136395","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of 5-HTR2A T102C and A-1438G polymorphisms with clinical response to atypical antipsychotic treatment in schizophrenia: A meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2021.136395","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"136395"}}