{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:05:30Z","timestamp":1792652730712,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.neulet.2022.136587","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T19:12:46Z","timestamp":1648062766000},"page":"136587","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Cognitive impairments in type 1 diabetes mellitus model mice are associated with synaptic protein disorders"],"prefix":"10.1016","volume":"777","author":[{"given":"Yiming","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angyang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1-3","key":"10.1016\/j.neulet.2022.136587_b0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejphar.2009.12.024","article-title":"Enhanced NMDAR1, NMDA2B and mGlu5 receptors gene expression in the cerebellum of insulin induced hypoglycaemic and streptozotocin induced diabetic rats","volume":"630","author":"Anu","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neulet.2022.136587_b0010","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/21622965.2018.1504218","article-title":"Object recognition and location: Which component of object location memory for landmarks is affected by gender? Evidence from four to ten year-old children","volume":"9","author":"Bocchi","year":"2020","journal-title":"Appl. Neuropsychol. Child."},{"key":"10.1016\/j.neulet.2022.136587_b0015","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.pnpbp.2019.01.005","article-title":"Dendritic spines: Revisiting the physiological role","volume":"92","author":"Chidambaram","year":"2019","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2022.136587_b0020","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cbi.2017.05.008","article-title":"N-acetylcysteine treatment attenuates the cognitive impairment and synaptic plasticity loss induced by streptozotocin","volume":"272","author":"da Costa","year":"2017","journal-title":"Chem. Biol. Interact."},{"issue":"6","key":"10.1016\/j.neulet.2022.136587_b0025","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1177\/193229680800200619","article-title":"Alzheimer's disease is type 3 diabetes-evidence reviewed","volume":"2","author":"de la Monte","year":"2008","journal-title":"J. Diabetes Sci. Technol."},{"issue":"4","key":"10.1016\/j.neulet.2022.136587_b0030","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.neuroscience.2010.06.021","article-title":"Diabetes differentially affects the content of exocytotic proteins in hippocampal and retinal nerve terminals","volume":"169","author":"Gaspar","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2022.136587_b0035","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cbi.2015.11.032","article-title":"Challenges and issues with streptozotocin-induced diabetes - A clinically relevant animal model to understand the diabetes pathogenesis and evaluate therapeutics","volume":"244","author":"Goyal","year":"2016","journal-title":"Chem. Biol. Interact."},{"issue":"6","key":"10.1016\/j.neulet.2022.136587_b0040","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1007\/s11011-016-9864-4","article-title":"Altered expression and localization of synaptophysin in developing cerebellar cortex of neonatal rats due to maternal diabetes mellitus","volume":"31","author":"Hami","year":"2016","journal-title":"Metab. Brain Dis."},{"issue":"2","key":"10.1016\/j.neulet.2022.136587_b0045","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1109\/TPAMI.2018.2844175","article-title":"Mask R-CNN","volume":"42","author":"He","year":"2020","journal-title":"IEEE Trans. Pattern Anal. Mach. Intell."},{"issue":"6","key":"10.1016\/j.neulet.2022.136587_b0050","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.medici.2018.02.001","article-title":"Alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies","volume":"53","author":"Ighodaro","year":"2017","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.neulet.2022.136587_b0055","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-1-62703-068-7_10","article-title":"Experimentally induced rodent models of type 2 diabetes","volume":"933","author":"Islam","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.neulet.2022.136587_b0060","doi-asserted-by":"crossref","first-page":"445","DOI":"10.31887\/DCNS.2013.15.4\/hjahn","article-title":"Memory loss in Alzheimer's disease","volume":"15","author":"Jahn","year":"2013","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.neulet.2022.136587_b0065","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4103\/0253-7613.75684","article-title":"Anomalies in alloxan-induced diabetic model: It is better to standardize it first","volume":"43","author":"Jain","year":"2011","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.neulet.2022.136587_b0070","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1172\/JCI106180","article-title":"Diabetogenic action of streptozotocin: relationship of dose to metabolic response","volume":"48","author":"Junod","year":"1969","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neulet.2022.136587_b0075","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.autrev.2015.05.002","article-title":"Associated autoimmune diseases in children and adolescents with type 1 diabetes mellitus (T1DM)","volume":"14","author":"Kakleas","year":"2015","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.neulet.2022.136587_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2019.104601","article-title":"Melatonin attenuates streptozotocin-induced Alzheimer-like features in hyperglycemic rats","volume":"132","author":"Kamsrijai","year":"2020","journal-title":"Neurochem. Int."},{"issue":"5","key":"10.1016\/j.neulet.2022.136587_b0085","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.bbadis.2016.08.018","article-title":"Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal","volume":"1863","author":"Kandimalla","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.neulet.2022.136587_b0090","doi-asserted-by":"crossref","first-page":"17016","DOI":"10.1038\/nrdp.2017.16","article-title":"Type 1 diabetes mellitus","volume":"3","author":"Katsarou","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"1","key":"10.1016\/j.neulet.2022.136587_b0095","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/pedi.12787","article-title":"Does obesity cause type 2 diabetes mellitus (T2DM)? Or is it the opposite?","volume":"20","author":"Malone","year":"2019","journal-title":"Pediatr. Diabetes"},{"issue":"2","key":"10.1016\/j.neulet.2022.136587_b0100","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.neuron.2014.02.031","article-title":"Balance and stability of synaptic structures during synaptic plasticity","volume":"82","author":"Meyer","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2022.136587_b0105","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.brainres.2016.05.013","article-title":"Effects of metformin on inflammation and short-term memory in streptozotocin-induced diabetic mice","volume":"1644","author":"Oliveira","year":"2016","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.neulet.2022.136587_b0110","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/aja.1001270402","article-title":"The small pyramidal neuron of the rat cerebral cortex. The perikaryon, dendrites and spines","volume":"127","author":"Peters","year":"1970","journal-title":"Am. J. Anat."},{"issue":"4","key":"10.1016\/j.neulet.2022.136587_b0115","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0736-5748(93)90021-5","article-title":"Action of the diabetogenic drug streptozotocin on glycolytic and glycogenolytic metabolism in adult rat brain cortex and hippocampus","volume":"11","author":"Plaschke","year":"1993","journal-title":"Int. J. Dev. Neurosci."},{"issue":"17","key":"10.1016\/j.neulet.2022.136587_b0120","doi-asserted-by":"crossref","first-page":"R764","DOI":"10.1016\/j.cub.2013.05.041","article-title":"Interplay of hippocampus and prefrontal cortex in memory","volume":"23","author":"Preston","year":"2013","journal-title":"Curr. Biol."},{"issue":"4","key":"10.1016\/j.neulet.2022.136587_b0125","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s002130050523","article-title":"Differential effects of diazepam on anxiety in streptozotocin induced diabetic and non-diabetic rats","volume":"135","author":"Ramanathan","year":"1998","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neulet.2022.136587_b0130","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1464-5491.2005.01499.x","article-title":"Animal models of diabetes mellitus","volume":"22","author":"Rees","year":"2005","journal-title":"Diabet. Med."},{"issue":"3","key":"10.1016\/j.neulet.2022.136587_b0135","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1007\/s12035-018-1195-5","article-title":"Hyperglycemia-Driven Neuroinflammation Compromises BBB Leading to Memory Loss in Both Diabetes Mellitus (DM) Type 1 and Type 2 Mouse Models","volume":"56","author":"Rom","year":"2019","journal-title":"Mol. Neurobiol."},{"issue":"6","key":"10.1016\/j.neulet.2022.136587_b0140","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1073\/pnas.74.6.2485","article-title":"Studies of streptozotocin-induced insulitis and diabetes","volume":"74","author":"Rossini","year":"1977","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neulet.2022.136587_b0145","first-page":"412","article-title":"Diabetes mellitus and cognitive impairments, World","volume":"7","author":"Saedi","year":"2016","journal-title":"J. Diabetes"},{"key":"10.1016\/j.neulet.2022.136587_b0150","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.neuroscience.2012.09.081","article-title":"Diabetes onset influences hippocampal synaptic plasticity in streptozotocin-treated rats","volume":"227","author":"Sasaki-Hamada","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2022.136587_b0155","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1210\/jc.2018-01315","article-title":"Cognitive Dysfunction in Type 1 Diabetes Mellitus","volume":"104","author":"Shalimova","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.neulet.2022.136587_b0160","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.phrs.2005.05.004","article-title":"Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening","volume":"52","author":"Srinivasan","year":"2005","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.neulet.2022.136587_b0165","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13369","article-title":"5-HT6R null mutatrion induces synaptic and cognitive defects","volume":"20","author":"Sun","year":"2021","journal-title":"Aging Cell"},{"issue":"1-2","key":"10.1016\/j.neulet.2022.136587_b0170","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.molbrainres.2005.02.003","article-title":"Upregulation of mRNAs coding for AMPA and NMDA receptor subunits and metabotropic glutamate receptors in the dorsal horn of the spinal cord in a rat model of diabetes mellitus","volume":"136","author":"Tomiyama","year":"2005","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"6","key":"10.1016\/j.neulet.2022.136587_b0175","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/ana.20101","article-title":"Progressive age-related development of Alzheimer-like pathology in APP\/PS1 mice","volume":"55","author":"Trinchese","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neulet.2022.136587_b0180","doi-asserted-by":"crossref","first-page":"8054073","DOI":"10.1155\/2018\/8054073","article-title":"Improving the Reliability and Utility of Streptozotocin-Induced Rat Diabetic Model","volume":"2018","author":"Wang-Fischer","year":"2018","journal-title":"J. Diabetes Res."},{"issue":"7","key":"10.1016\/j.neulet.2022.136587_b0185","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1007\/s10571-020-00801-w","article-title":"Neuroprotective Effects of Salidroside in a Mouse Model of Alzheimer's Disease","volume":"40","author":"Wang","year":"2020","journal-title":"Cell. Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.neulet.2022.136587_b0190","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00125-007-0904-9","article-title":"The effects of type 1 diabetes on cerebral white matter","volume":"51","author":"Weinger","year":"2008","journal-title":"Diabetologia"},{"issue":"8","key":"10.1016\/j.neulet.2022.136587_b0195","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1007\/s00125-007-0714-0","article-title":"Cognitive performance in type 1 diabetes patients is associated with cerebral white matter volume","volume":"50","author":"Wessels","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.neulet.2022.136587_b0200","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.brainres.2019.05.037","article-title":"Albiflorin ameliorates memory deficits in APP\/PS1 transgenic mice via ameliorating mitochondrial dysfunction","volume":"1719","author":"Xu","year":"2019","journal-title":"Brain Res."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394022001446?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394022001446?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:42:32Z","timestamp":1759624952000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394022001446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":40,"alternative-id":["S0304394022001446"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2022.136587","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cognitive impairments in type 1 diabetes mellitus model mice are associated with synaptic protein disorders","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2022.136587","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"136587"}}