{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T08:36:02Z","timestamp":1783586162920,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T00:00:00Z","timestamp":1657324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["JCYJ20210324121800002"],"award-info":[{"award-number":["JCYJ20210324121800002"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.neulet.2022.136787","type":"journal-article","created":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T11:28:05Z","timestamp":1657366085000},"page":"136787","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Anti-depressant effects of acupuncture: The insights from NLRP3 mediated pyroptosis and inflammation"],"prefix":"10.1016","volume":"785","author":[{"given":"Yiping","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongyao","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junliang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqiong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianwei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4609-9248","authenticated-orcid":false,"given":"Xianjun","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2022.136787_b0005","unstructured":"Association, A.P. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Washington. 2013: DC: American Psychiatric Association."},{"issue":"1","key":"10.1016\/j.neulet.2022.136787_b0010","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-72677-1","article-title":"Work functioning impairment in the course of pharmacotherapy treatment for depression","volume":"10","author":"Nagata","year":"2020","journal-title":"Sci Rep"},{"issue":"7526","key":"10.1016\/j.neulet.2022.136787_b0015","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/515180a","article-title":"Mental health: a world of depression","volume":"515","author":"Smith","year":"2014","journal-title":"Nature"},{"issue":"10100","key":"10.1016\/j.neulet.2022.136787_b0020","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0140-6736(17)32154-2","article-title":"Global, regional, and national incidence, prevalence","volume":"390","author":"Vos","year":"2017","journal-title":"The Lancet"},{"issue":"1","key":"10.1016\/j.neulet.2022.136787_b0025","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-21243-x","article-title":"Prevalence of Depression in the Community from 30 Countries between 1994 and 2014","volume":"8","author":"Lim","year":"2018","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.neulet.2022.136787_b0030","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/j.1440-1614.2004.01377.x","article-title":"New Zealand College of Psychiatrists Clinical Practice Guidelines Team for, Australian and New Zealand clinical practice guidelines for the treatment of depression","volume":"38","author":"Ellis","year":"2004","journal-title":"Aust N Z J Psychiatry"},{"issue":"13","key":"10.1016\/j.neulet.2022.136787_b0035","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.3390\/ijerph16132255","article-title":"Indices of Change, Expectations, and Popularity of Biological Treatments for Major Depressive Disorder between 1988 and 2017: A Scientometric Analysis","volume":"16","author":"Tran","year":"2019","journal-title":"Int J Environ Res Public Health"},{"issue":"2","key":"10.1016\/j.neulet.2022.136787_b0040","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41380-019-0474-5","article-title":"Peripheral cytokine levels and response to antidepressant treatment in depression: a systematic review and meta-analysis","volume":"25","author":"Liu","year":"2020","journal-title":"Molecular psychiatry"},{"key":"10.1016\/j.neulet.2022.136787_b0045","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyg.2021.721872","article-title":"Trends of Acupuncture Therapy on Depression From 2011 to 2020: A Bibliometric Analysis","volume":"12","author":"Xiang","year":"2021","journal-title":"Front Psychol"},{"issue":"3","key":"10.1016\/j.neulet.2022.136787_b0050","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.bbrc.2020.02.149","article-title":"Minocycline alleviates NLRP3 inflammasome-dependent pyroptosis in monosodium glutamate-induced depressive rats","volume":"526","author":"Yang","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"10.1016\/j.neulet.2022.136787_b0055","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41573-021-00154-z","article-title":"Channelling inflammation: gasdermins in physiology and disease","volume":"20","author":"Liu","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.neulet.2022.136787_b0060","article-title":"High Mobility Group Box 1 Contributes to the Acute Rejection of Liver Allografts by Activating Dendritic Cells","volume":"12","author":"Chen","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.neulet.2022.136787_b0065","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3389\/fphys.2018.00313","article-title":"HMGB1 Increases IL-1beta Production in Vascular Smooth Muscle Cells via NLRP3 Inflammasome","volume":"9","author":"Kim","year":"2018","journal-title":"Front Physiol"},{"issue":"1","key":"10.1016\/j.neulet.2022.136787_b0070","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bbr.2011.07.006","article-title":"Pro- and anti-inflammatory cytokines expression in rat's brain and spleen exposed to chronic mild stress: involvement in depression","volume":"225","author":"You","year":"2011","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neulet.2022.136787_b0075","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3389\/fnmol.2018.00056","article-title":"Clinical Findings Documenting Cellular and Molecular Abnormalities of Glia in Depressive Disorders","volume":"11","author":"Czeh","year":"2018","journal-title":"Front Mol Neurosci"},{"issue":"3","key":"10.1016\/j.neulet.2022.136787_b0080","article-title":"Acupuncture for depression","volume":"2018","author":"Smith","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"issue":"11","key":"10.1016\/j.neulet.2022.136787_b0085","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1002\/ar.24783","article-title":"Efficacy and safety of acupuncture in the treatment of depression: A systematic review of clinical research","volume":"304","author":"Zhang","year":"2021","journal-title":"Anat Rec (Hoboken)"},{"issue":"8","key":"10.1016\/j.neulet.2022.136787_b0090","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.3390\/jcm8081140","article-title":"Acupuncture for Depression: A Systematic Review and Meta-Analysis","volume":"8","author":"Armour","year":"2019","journal-title":"J Clin Med"},{"key":"10.1016\/j.neulet.2022.136787_b0095","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2018.00149","article-title":"Electro-Acupuncture Alleviates Chronic Unpredictable Stress-Induced Depressive- and Anxiety-Like Behavior and Hippocampal Neuroinflammation in Rat Model of Depression","volume":"11","author":"Yue","year":"2018","journal-title":"Front Mol Neurosci"},{"issue":"11","key":"10.1016\/j.neulet.2022.136787_b0100","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1002\/ar.24778","article-title":"Acupuncture inhibits NLRP3 inflammasome activation in the prefrontal cortex of a chronic stress rat model of depression","volume":"304","author":"Li","year":"2021","journal-title":"Anat Rec (Hoboken)"},{"issue":"3","key":"10.1016\/j.neulet.2022.136787_b0105","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s12035-014-9012-2","article-title":"Bee Venom Acupuncture Alleviates Experimental Autoimmune Encephalomyelitis by Upregulating Regulatory T Cells and Suppressing Th1 and Th17 Responses","volume":"53","author":"Lee","year":"2016","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.neulet.2022.136787_b0110","first-page":"1","article-title":"Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1\/M2 Polarization in Mice with Alzheimer's Disease","volume":"2020","author":"Li","year":"2020","journal-title":"Neural Plast"},{"key":"10.1016\/j.neulet.2022.136787_b0115","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.brainresbull.2021.01.005","article-title":"Electroacupuncture alleviated the depression-like behavior by regulating FGF2 and astrocytes in the hippocampus of rats with chronic unpredictable mild stress","volume":"169","author":"Yao","year":"2021","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.neulet.2022.136787_b0120","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.freeradbiomed.2015.10.426","article-title":"Acupuncture ameliorates cognitive impairment and hippocampus neuronal loss in experimental vascular dementia through Nrf2-mediated antioxidant response","volume":"89","author":"Wang","year":"2015","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.neulet.2022.136787_b0125","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.lfs.2018.09.003","article-title":"Agomelatine-induced modulation of brain-derived neurotrophic factor (BDNF) in the rat hippocampus","volume":"210","author":"Lu","year":"2018","journal-title":"Life sciences"},{"key":"10.1016\/j.neulet.2022.136787_b0130","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2018.00102","article-title":"Antidepressant-Like Effects of Acupuncture-Insights From DNA Methylation and Histone Modifications of Brain-Derived Neurotrophic Factor","volume":"9","author":"Jiang","year":"2018","journal-title":"Front Psychiatry"},{"key":"10.1016\/j.neulet.2022.136787_b0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresbull.2018.06.007","article-title":"Effects of vortioxetine and fluoxetine on the level of Brain Derived Neurotrophic Factors (BDNF) in the hippocampus of chronic unpredictable mild stress-induced depressive rats","volume":"142","author":"Lu","year":"2018","journal-title":"Brain Res Bull"},{"issue":"23","key":"10.1016\/j.neulet.2022.136787_b0140","article-title":"NLRP3\/caspase-1\/GSDMD-mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression. JCI","volume":"6","author":"Li","year":"2021","journal-title":"Insight"},{"issue":"3","key":"10.1016\/j.neulet.2022.136787_b0145","doi-asserted-by":"crossref","DOI":"10.1007\/BF00187257","article-title":"Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant","volume":"93","author":"Willner","year":"1987","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neulet.2022.136787_b0150","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuroscience.2021.11.015","article-title":"Effects of High-fat Diet and Chronic Mild Stress on Depression-like Behaviors and Levels of Inflammatory Cytokines in the Hippocampus and Prefrontal Cortex of Rats","volume":"480","author":"Wang","year":"2022","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2022.136787_b0155","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2019.00012","article-title":"Bumetanide Prevents Brain Trauma-Induced Depressive-Like Behavior","volume":"12","author":"Goubert","year":"2019","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.neulet.2022.136787_b0160","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.neubiorev.2018.12.002","article-title":"Chronic unpredictable mild stress for modeling depression in rodents: Meta-analysis of model reliability","volume":"99","author":"Antoniuk","year":"2019","journal-title":"Neurosci Biobehav Rev"},{"issue":"2","key":"10.1016\/j.neulet.2022.136787_b0165","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s12035-020-02144-5","article-title":"Antidepressant Effect of Paeoniflorin Is Through Inhibiting Pyroptosis CASP-11\/GSDMD Pathway","volume":"58","author":"Tian","year":"2021","journal-title":"Mol Neurobiol"},{"issue":"1","key":"10.1016\/j.neulet.2022.136787_b0170","doi-asserted-by":"crossref","DOI":"10.1186\/s12929-021-00724-8","article-title":"NLRP3 inflammasome-mediated cytokine production and pyroptosis cell death in breast cancer","volume":"28","author":"Faria","year":"2021","journal-title":"J Biomed Sci"},{"issue":"10","key":"10.1016\/j.neulet.2022.136787_b0175","doi-asserted-by":"crossref","first-page":"e0186700","DOI":"10.1371\/journal.pone.0186700","article-title":"Chronic administration of fluoxetine and pro-inflammatory cytokine change in a rat model of depression","volume":"12","author":"Lu","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.neulet.2022.136787_b0180","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s11064-021-03440-9","article-title":"Young Plasma Induces Antidepressant-Like Effects in Aged Rats Subjected to Chronic Mild Stress by Suppressing Indoleamine 2,3-Dioxygenase Enzyme and Kynurenine Pathway in the Prefrontal Cortex","volume":"47","author":"Ghaffari-Nasab","year":"2022","journal-title":"Neurochem Res"},{"issue":"11","key":"10.1016\/j.neulet.2022.136787_b0185","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.biopsych.2008.11.011","article-title":"Interleukin-1 receptor antagonist and incident depressive symptoms over 6 years in older persons: the InCHIANTI study","volume":"65","author":"Milaneschi","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neulet.2022.136787_b0190","doi-asserted-by":"crossref","first-page":"114202","DOI":"10.1016\/j.psychres.2021.114202","article-title":"Inflammatory cytokines, cognition, and response to antidepressant treatment in patients with major depressive disorder","volume":"305","author":"Zhou","year":"2021","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.neulet.2022.136787_b0195","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.448262","article-title":"Cleavage of HMGB1 by Proteolytic Enzymes Associated with Inflammatory Conditions","volume":"11","author":"Sowinska","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.neulet.2022.136787_b0200","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.neuroscience.2021.11.023","article-title":"Exposure to X-rays Causes Depression-like Behaviors in Mice via HMGB1-mediated Pyroptosis","volume":"481","author":"Xu","year":"2022","journal-title":"Neuroscience"},{"issue":"7","key":"10.1016\/j.neulet.2022.136787_b0205","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.3390\/molecules24071247","article-title":"Neuroprotective Effect of Dioscin on the Aging Brain","volume":"24","author":"Qi","year":"2019","journal-title":"Molecules"},{"issue":"17","key":"10.1016\/j.neulet.2022.136787_b0210","article-title":"Electroconvulsive stimulation attenuates chronic neuroinflammation. JCI","volume":"5","author":"Goldfarb","year":"2020","journal-title":"Insight"},{"issue":"1","key":"10.1016\/j.neulet.2022.136787_b0215","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-021-01423-6","article-title":"Increased GFAP concentrations in the cerebrospinal fluid of patients with unipolar depression","volume":"11","author":"Michel","year":"2021","journal-title":"Transl Psychiatry"},{"issue":"1","key":"10.1016\/j.neulet.2022.136787_b0220","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1186\/1745-6215-14-344","article-title":"Electro-acupuncture with different current intensities to treat functional constipation: a study protocol for a randomized controlled trial","volume":"14","author":"Zheng","year":"2013","journal-title":"Trials"},{"issue":"5","key":"10.1016\/j.neulet.2022.136787_b0225","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/qjmed\/hct196","article-title":"Acupuncture modulates the neuro-endocrine-immune network","volume":"107","author":"Ding","year":"2014","journal-title":"QJM"},{"key":"10.1016\/j.neulet.2022.136787_b0230","first-page":"e929027","article-title":"Acupuncture Can Play an Antidepressant Role by Regulating the Intestinal Microbes and Neurotransmitters in a Rat Model of Depression","volume":"27","author":"Li","year":"2021","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.neulet.2022.136787_b0235","doi-asserted-by":"crossref","first-page":"109787","DOI":"10.1016\/j.biopha.2019.109787","article-title":"SiNiSan ameliorates depression-like behavior in rats by enhancing synaptic plasticity via the CaSR-PKC-ERK signaling pathway","volume":"124","author":"Shen","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.neulet.2022.136787_b0240","article-title":"Acupuncture Relieves Stress-Induced Depressive Behavior by Reducing Oxidative Stress and Neuroapoptosis in Rats","volume":"15","author":"Cheng","year":"2021","journal-title":"Front Behav Neurosci"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394022003482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394022003482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:16:33Z","timestamp":1778541393000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394022003482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":48,"alternative-id":["S0304394022003482"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2022.136787","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-depressant effects of acupuncture: The insights from NLRP3 mediated pyroptosis and inflammation","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2022.136787","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"136787"}}