{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:55:37Z","timestamp":1792036537024,"version":"4.4.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"am","delay-in-days":359,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AG010129"],"award-info":[{"award-number":["P30 AG010129"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 ES023513"],"award-info":[{"award-number":["P30 ES023513"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 ES025570"],"award-info":[{"award-number":["R21 ES025570"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 ES026515"],"award-info":[{"award-number":["R21 ES026515"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["2018-AARGD-591676"],"award-info":[{"award-number":["2018-AARGD-591676"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007707","name":"University of California, Davis","doi-asserted-by":"publisher","award":["T32 ES007059"],"award-info":[{"award-number":["T32 ES007059"]}],"id":[{"id":"10.13039\/100007707","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007707","name":"University of California, Davis","doi-asserted-by":"publisher","award":["T32 MH112507"],"award-info":[{"award-number":["T32 MH112507"]}],"id":[{"id":"10.13039\/100007707","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.neulet.2022.136921","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T12:41:01Z","timestamp":1666096861000},"page":"136921","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Probing changes in brain esterified oxylipin concentrations during the early stages of pathogenesis in Alzheimer\u2019s Disease transgenic rats"],"prefix":"10.1016","volume":"791","author":[{"given":"Qing","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelley T.","family":"Patten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Valenzuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela J.","family":"Lein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameer Y.","family":"Taha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2022.136921_b0005","doi-asserted-by":"crossref","unstructured":"2021 Alzheimer's disease facts and figures, Alzheimer's Dementia 17 (2021) 327-406.","DOI":"10.1002\/alz.12328"},{"key":"10.1016\/j.neulet.2022.136921_b0010","first-page":"632","article-title":"Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures","volume":"117","author":"Abdu","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2022.136921_b0015","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1212\/WNL.53.9.1992","article-title":"Gender differences in the incidence of AD and vascular dementia: The EURODEM Studies. EURODEM Incidence Research Group","volume":"53","author":"Andersen","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2022.136921_b0020","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc.: Ser. B (Methodol.)"},{"key":"10.1016\/j.neulet.2022.136921_b0025","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s10571-015-0206-6","article-title":"The Docosanoid Neuroprotectin D1 Induces TH-Positive Neuronal Survival in a Cellular Model of Parkinson\u2019s Disease","volume":"35","author":"Calandria","year":"2015","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.neulet.2022.136921_b0030","doi-asserted-by":"crossref","first-page":"8188","DOI":"10.1523\/JNEUROSCI.1246-20.2020","article-title":"14,15-Epoxyeicosatrienoic Acid Alleviates Pathology in a Mouse Model of Alzheimer's Disease","volume":"40","author":"Chen","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2022.136921_b0035","doi-asserted-by":"crossref","first-page":"6245","DOI":"10.1523\/JNEUROSCI.3672-12.2013","article-title":"A Transgenic Alzheimer Rat with Plaques, Tau Pathology, Behavioral Impairment, Oligomeric A\u03b2, and Frank Neuronal Loss","volume":"33","author":"Cohen","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2022.136921_b0040","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1136\/jnnp.2005.063131","article-title":"Levels of CSF prostaglandin E2, cognitive decline, and survival in Alzheimer\u2019s disease","volume":"77","author":"Combrinck","year":"2006","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neulet.2022.136921_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2022.101165","article-title":"Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions","volume":"86","author":"Dyall","year":"2022","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.neulet.2022.136921_b0050","doi-asserted-by":"crossref","DOI":"10.1289\/EHP7045","article-title":"Pathological Cardiopulmonary Evaluation of Rats Chronically Exposed to Traffic-Related Air Pollution","volume":"128","author":"Edwards","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.neulet.2022.136921_b0055","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb1206","article-title":"An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer\u2019s disease","volume":"12","author":"Ghosh","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neulet.2022.136921_b0060","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1194\/jlr.D084228","article-title":"Brain oxylipin concentrations following hypercapnia\/ischemia: effects of brain dissection and dissection time","volume":"60","author":"Hennebelle","year":"2019","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.neulet.2022.136921_b0065","doi-asserted-by":"crossref","unstructured":"B. Inceoglu, S.L. Jinks, A. Ulu, C.M. Hegedus, K. Georgi, K.R. Schmelzer, K. Wagner, P.D. Jones, C. Morisseau, B.D. Hammock, Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways, Proc. Natl. Acad. Sci. 105 (2008) 18901\u201318906.","DOI":"10.1073\/pnas.0809765105"},{"key":"10.1016\/j.neulet.2022.136921_b0070","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.trci.2018.06.014","article-title":"Inflammation as a central mechanism in Alzheimer's disease","volume":"4","author":"Kinney","year":"2018","journal-title":"Alzheimers Dement (N Y)"},{"key":"10.1016\/j.neulet.2022.136921_b0075","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1194\/jlr.M072512","article-title":"Long-chain acyl-CoA synthetase isoforms differ in preferences for eicosanoid species and long-chain fatty acids","volume":"58","author":"Klett","year":"2017","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.neulet.2022.136921_b0080","doi-asserted-by":"crossref","unstructured":"J.L. Lahvic, M. Ammerman, P. Li, M.C. Blair, E.R. Stillman, E.M. Fast, A.L. Robertson, C. Christodoulou, J.R. Perlin, S. Yang, N. Chiang, P.C. Norris, M.L. Daily, S.E. Redfield, I.T. Chan, M. Chatrizeh, M.E. Chase, O. Weis, Y. Zhou, C.N. Serhan, L.I. Zon, Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132, Proc. Natl. Acad. Sci. 115 (2018) 9252\u20139257.","DOI":"10.1073\/pnas.1806077115"},{"key":"10.1016\/j.neulet.2022.136921_b0085","doi-asserted-by":"crossref","first-page":"10146","DOI":"10.1074\/jbc.RA119.008766","article-title":"Synthesis of oxidized phospholipids by sn-1 acyltransferase using 2\u201315-HETE lysophospholipids","volume":"294","author":"Liu","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2022.136921_b0090","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.prostaglandins.2016.09.002","article-title":"Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid","volume":"132","author":"Liu","year":"2017","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.neulet.2022.136921_b0095","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1172\/JCI25420","article-title":"A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease","volume":"115","author":"Lukiw","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neulet.2022.136921_b0100","doi-asserted-by":"crossref","unstructured":"T. Montine, K. Sidell, B. Crews, W. Markesbery, L. Marnett, L. Roberts, J. Morrow, Elevated CSF prostaglandin E2 levels in patients with probable AD, Neurology 53 (1999) 1495\u20131495.","DOI":"10.1212\/WNL.53.7.1495"},{"key":"10.1016\/j.neulet.2022.136921_b0105","doi-asserted-by":"crossref","first-page":"40676","DOI":"10.1074\/jbc.M507787200","article-title":"Identification of 9-Hydroxyoctadecadienoic Acid and Other Oxidized Free Fatty Acids as Ligands of the G Protein-coupled Receptor G2A *","volume":"280","author":"Obinata","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2022.136921_b0110","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/jnc.12392","article-title":"Unesterified docosahexaenoic acid is protective in neuroinflammation","volume":"127","author":"Orr","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2022.136921_b0115","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/lipd.12197","article-title":"Acute Hypercapnia\/Ischemia Alters the Esterification of Arachidonic Acid and Docosahexaenoic Acid Epoxide Metabolites in Rat Brain Neutral Lipids","volume":"55","author":"Otoki","year":"2020","journal-title":"Lipids"},{"key":"10.1016\/j.neulet.2022.136921_b0120","doi-asserted-by":"crossref","unstructured":"A. Ott, M.M.B. Breteler, F.v. Harskamp, T. Stijnen, A. Hofman, Incidence and Risk of Dementia: The Rotterdam study, Am. J. Epidemiol. 147 (1998) 574\u2013580.","DOI":"10.1093\/oxfordjournals.aje.a009489"},{"key":"10.1016\/j.neulet.2022.136921_b0125","doi-asserted-by":"crossref","DOI":"10.1289\/EHP8905","article-title":"The Effects of Chronic Exposure to Ambient Traffic-Related Air Pollution on Alzheimer\u2019s Disease Phenotypes in Wildtype and Genetically Predisposed Male and Female Rats","volume":"129","author":"Patten","year":"2021","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.neulet.2022.136921_b0130","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S0002-9440(10)63724-8","article-title":"12\/15-Lipoxygenase Is Increased in Alzheimer's Disease: Possible Involvement in Brain Oxidative Stress","volume":"164","author":"Pratic\u00f2","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.neulet.2022.136921_b0135","doi-asserted-by":"crossref","first-page":"H1605","DOI":"10.1152\/ajpheart.00471.2013","article-title":"Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke","volume":"305","author":"Shaik","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.neulet.2022.136921_b0140","doi-asserted-by":"crossref","unstructured":"Q. Shen, N. Liang, K.T. Patten, Y. Otoki, A.E. Valenzuela, C. Wallis, K.J. Bein, A.S. Wexler, P.J. Lein, A.Y. Taha, Pro-resolving Lipid Mediators Within Brain Esterified Lipid Pools are Reduced in Female Rats Chronically Exposed to Traffic-Related Air Pollution or Genetically Susceptible to Alzheimer\u2019s Disease Phenotype, bioRxiv (2022) 2022.2002.2016.480656.","DOI":"10.1101\/2022.02.16.480656"},{"key":"10.1016\/j.neulet.2022.136921_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112516","article-title":"Inhibition of sEH via stabilizing the level of EETs alleviated Alzheimer's disease through GSK3\u03b2 signaling pathway","volume":"156","author":"Sun","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.neulet.2022.136921_b0150","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.plefa.2016.05.004","article-title":"Regulation of rat plasma and cerebral cortex oxylipin concentrations with increasing levels of dietary linoleic acid","volume":"138","author":"Taha","year":"2018","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.neulet.2022.136921_b0155","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1476-511X-12-68","article-title":"Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein\/tau for Alzheimer\u2019s disease","volume":"12","author":"Tajima","year":"2013","journal-title":"Lipids Health Dis."},{"issue":"40","key":"10.1016\/j.neulet.2022.136921_b0160","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jalz.2013.12.024","article-title":"Resolution of inflammation is altered in Alzheimer\u2019s disease","volume":"11","author":"Wang","year":"2015","journal-title":"Alzheimer\u2019s & dementia: the journal of the Alzheimer\u2019s Association"},{"key":"10.1016\/j.neulet.2022.136921_b0165","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/ana.20558","article-title":"Elevation of 12\/15 lipoxygenase products in AD and mild cognitive impairment","volume":"58","author":"Yao","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neulet.2022.136921_b0170","doi-asserted-by":"crossref","first-page":"e15816","DOI":"10.1371\/journal.pone.0015816","article-title":"Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPAR\u03b3-Mediated Mechanisms in Alzheimer's Disease Models","volume":"6","author":"Zhao","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.neulet.2022.136921_b0175","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1007\/s12035-015-9544-0","article-title":"Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase A\u03b242 Phagocytosis","volume":"53","author":"Zhu","year":"2016","journal-title":"Mol. Neurobiol."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394022004827?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394022004827?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:47:24Z","timestamp":1759625244000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394022004827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":35,"alternative-id":["S0304394022004827"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2022.136921","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Probing changes in brain esterified oxylipin concentrations during the early stages of pathogenesis in Alzheimer\u2019s Disease transgenic rats","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2022.136921","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"136921"}}