{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:16:07Z","timestamp":1792444567749,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.neulet.2022.136995","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T13:44:22Z","timestamp":1669902262000},"page":"136995","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Inhibiting specificity protein 1 attenuated sevoflurane-induced mitochondrial stress and promoted autophagy in hippocampal neurons through PI3K\/Akt\/mTOR and \u03b17-nAChR signaling"],"prefix":"10.1016","volume":"794","author":[{"given":"Guoying","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manyi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonglei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuangang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.neulet.2022.136995_b0005","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/ALN.0b013e318195b569","article-title":"Long-term consequences of postoperative cognitive dysfunction","volume":"110","author":"Steinmetz","year":"2009","journal-title":"Anesthesiology"},{"issue":"8","key":"10.1016\/j.neulet.2022.136995_b0010","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1111\/aas.12724","article-title":"Post-operative cognitive dysfunction at 3 months in adults after non-cardiac surgery: a qualitative systematic review","volume":"60","author":"Paredes","year":"2016","journal-title":"Acta Anaesthesiol. Scand."},{"key":"10.1016\/j.neulet.2022.136995_b0015","doi-asserted-by":"crossref","first-page":"6215350","DOI":"10.1155\/2018\/6215350","article-title":"Emerging Roles of Immune Cells in Postoperative Cognitive Dysfunction","volume":"2018","author":"Liu","year":"2018","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.neulet.2022.136995_b0020","doi-asserted-by":"crossref","unstructured":"X. Feng, M. Valdearcos, Y. Uchida, D. Lutrin, M. Maze, S.K. Koliwad, Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice, JCI Insight 2 (2017) e91229.","DOI":"10.1172\/jci.insight.91229"},{"key":"10.1016\/j.neulet.2022.136995_b0025","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0074-7742(07)82016-2","article-title":"Oxidative stress and the pathogenesis of neurodegenerative disorders","volume":"82","author":"Reynolds","year":"2007","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.neulet.2022.136995_b0030","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.bbi.2018.07.016","article-title":"Oxidative stress and mitochondrial dysfunction contributes to postoperative cognitive dysfunction in elderly rats","volume":"73","author":"Netto","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neulet.2022.136995_b0035","doi-asserted-by":"crossref","first-page":"26797","DOI":"10.3390\/ijms161125990","article-title":"The Function of Autophagy in Neurodegenerative Diseases","volume":"16","author":"Kiriyama","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neulet.2022.136995_b0040","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.lfs.2017.11.008","article-title":"Dihydroartemisinin induced caspase-dependent apoptosis through inhibiting the specificity protein 1 pathway in hepatocellular carcinoma SK-Hep-1 cells","volume":"192","author":"Im","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.neulet.2022.136995_b0045","doi-asserted-by":"crossref","unstructured":"S. Safe, J. Abbruzzese, M. Abdelrahim, E. Hedrick, Specificity Protein Transcription Factors and Cancer: Opportunities for Drug Development, Cancer Prev. Res. (Phila) 11 (2018) 371-382.","DOI":"10.1158\/1940-6207.CAPR-17-0407"},{"key":"10.1016\/j.neulet.2022.136995_b0050","doi-asserted-by":"crossref","first-page":"5412","DOI":"10.1093\/nar\/gkr161","article-title":"Translational and transcriptional control of Sp1 against ischaemia through a hydrogen peroxide-activated internal ribosomal entry site pathway","volume":"39","author":"Yeh","year":"2011","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.neulet.2022.136995_b0055","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3233\/JAD-122263","article-title":"Expression of the transcription factor Sp1 and its regulatory hsa-miR-29b in peripheral blood mononuclear cells from patients with Alzheimer's disease","volume":"35","author":"Villa","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neulet.2022.136995_b0060","first-page":"1","article-title":"Silencing SP1 Alleviated Sevoflurane-Induced POCD Development via Cholinergic Anti-inflammatory Pathway","author":"Lv","year":"2020","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neulet.2022.136995_b0065","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1007\/s00018-004-4102-3","article-title":"Neural regulators of innate immune responses and inflammation","volume":"61","author":"Pavlov","year":"2004","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neulet.2022.136995_b0070","doi-asserted-by":"crossref","first-page":"6471984","DOI":"10.1155\/2017\/6471984","article-title":"Role of Cholinergic Anti-Inflammatory Pathway in Treatment of Intestinal Ischemia-Reperfusion Injury by Electroacupuncture at Zusanli","volume":"2017","author":"Geng","year":"2017","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.neulet.2022.136995_b0075","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/s12974-016-0725-1","article-title":"Immunomodulatory effects of nicotine on interleukin 1beta activated human astrocytes and the role of cyclooxygenase 2 in the underlying mechanism","volume":"13","author":"Revathikumar","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neulet.2022.136995_b0080","doi-asserted-by":"crossref","first-page":"112538","DOI":"10.1016\/j.bbr.2020.112538","article-title":"Dysfunction of Inflammation-Resolving Pathways Is Associated with Postoperative Cognitive Decline in Elderly Mice","volume":"386","author":"Gong","year":"2020","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neulet.2022.136995_b0085","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1097\/FBP.0000000000000507","article-title":"Sevoflurane-induced inflammation development: involvement of cholinergic anti-inflammatory pathway","volume":"30","author":"Yin","year":"2019","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.neulet.2022.136995_b0090","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.2147\/JPR.S164106","article-title":"Recovery characteristics of total intravenous anesthesia with propofol versus sevoflurane anesthesia: a prospective randomized clinical trial","volume":"11","author":"Kocaturk","year":"2018","journal-title":"J. Pain Res."},{"key":"10.1016\/j.neulet.2022.136995_b0095","doi-asserted-by":"crossref","unstructured":"X. Zhang, Y. Zhou, M. Xu, G. Chen, Autophagy is involved in the sevoflurane anesthesia-induced cognitive dysfunction of aged rats, PLoS One 11 (2016) e0153505.","DOI":"10.1371\/journal.pone.0153505"},{"key":"10.1016\/j.neulet.2022.136995_b0100","doi-asserted-by":"crossref","first-page":"158","DOI":"10.5152\/TJAR.2017.98624","article-title":"Short-Term and Long-Term Effects of Dexamethasone on Cognitive Dysfunction Induced by Sevoflurane in Adult Rats, Turk","volume":"45","author":"Karaman","year":"2017","journal-title":"J. Anaesthesiol. Reanim."},{"issue":"1","key":"10.1016\/j.neulet.2022.136995_b0105","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00181-17","article-title":"Protein Kinase A\/CREB Signaling Prevents Adriamycin-Induced Podocyte Apoptosis via Upregulation of Mitochondrial Respiratory Chain Complexes","volume":"38","author":"Xie","year":"2018","journal-title":"Mol. Cell Biol."},{"issue":"7","key":"10.1016\/j.neulet.2022.136995_b0110","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1177\/0960327121989416","article-title":"Nrf2 mediates the neuroprotective effect of isoflurane preconditioning in cortical neuron injury induced by oxygen-glucose deprivation","volume":"40","author":"Liu","year":"2021","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.neulet.2022.136995_b0115","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.nbd.2015.03.014","article-title":"mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy","volume":"84","author":"Perluigi","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neulet.2022.136995_b0120","doi-asserted-by":"crossref","first-page":"409","DOI":"10.33549\/physiolres.932684","article-title":"Important role of autophagy in regulation of metabolic processes in health, disease and aging","volume":"63","author":"Papackova","year":"2014","journal-title":"Physiol. Res."},{"key":"10.1016\/j.neulet.2022.136995_b0125","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/2045-3701-4-28","article-title":"Autophagy protects against palmitate-induced apoptosis in hepatocytes","volume":"4","author":"Cai","year":"2014","journal-title":"Cell Biosci."},{"key":"10.1016\/j.neulet.2022.136995_b0130","doi-asserted-by":"crossref","first-page":"11633","DOI":"10.1002\/jcb.28443","article-title":"AMPK\u03b11 overexpression improves postoperative cognitive dysfunction in aged rats through AMPK-Sirt1 and autophagy signaling","volume":"120","author":"Yan","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.neulet.2022.136995_b0135","first-page":"2037","article-title":"An investigation of the mechanism of dexmedetomidine in improving postoperative cognitive dysfunction from the perspectives of alleviating neuronal mitochondrial membrane oxidative stress and electrophysiological dysfunction","volume":"15","author":"Chen","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.neulet.2022.136995_b0140","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1007\/s11064-019-02799-0","article-title":"Lidocaine Attenuates Cognitive Impairment After Isoflurane Anesthesia by Reducing Mitochondrial Damage","volume":"44","author":"Li","year":"2019","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neulet.2022.136995_b0145","doi-asserted-by":"crossref","first-page":"13573","DOI":"10.1093\/nar\/gku1145","article-title":"Pin1-mediated Sp1 phosphorylation by CDK1 increases Sp1 stability and decreases its DNA-binding activity during mitosis","volume":"42","author":"Yang","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neulet.2022.136995_b0150","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.3892\/or.2016.5294","article-title":"miR-204 regulates epithelial-mesenchymal transition by targeting SP1 in the tubular epithelial cells after acute kidney injury induced by ischemia-reperfusion","volume":"37","author":"Chen","year":"2017","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.neulet.2022.136995_b0155","doi-asserted-by":"crossref","first-page":"775","DOI":"10.3727\/096504017X15132494420120","article-title":"MicroRNA-296 Targets Specificity Protein 1 to Suppress Cell Proliferation and Invasion in Cervical Cancer","volume":"26","author":"Lv","year":"2018","journal-title":"Oncol. Res."},{"key":"10.1016\/j.neulet.2022.136995_b0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13277-016-5244-2","article-title":"miR-326 reverses chemoresistance in human lung adenocarcinoma cells by targeting specificity protein 1","volume":"37","author":"Li","year":"2016","journal-title":"Tumor Biol."},{"key":"10.1016\/j.neulet.2022.136995_b0165","doi-asserted-by":"crossref","first-page":"672","DOI":"10.18632\/aging.102649","article-title":"Up-regulation of microRNA-375 ameliorates the damage of dopaminergic neurons, reduces oxidative stress and inflammation in Parkinson's disease by inhibiting SP1","volume":"12","author":"Cai","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.neulet.2022.136995_b0170","first-page":"40","article-title":"Transcription factor Sp1 inhibition, memory, and cytokines in a mouse model of Alzheimer's disease","volume":"4","author":"Citron","year":"2015","journal-title":"Am. J. Neurodegener. Dis."},{"key":"10.1016\/j.neulet.2022.136995_b0175","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.brainres.2018.11.018","article-title":"Bone marrow mesenchymal stem cell transplantation exerts neuroprotective effects following cerebral ischemia\/reperfusion injury by inhibiting autophagy via the PI3K\/Akt pathway","volume":"1707","author":"He","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2022.136995_b0180","doi-asserted-by":"crossref","DOI":"10.1007\/s10616-019-00313-6","article-title":"Cubeben induces autophagy via PI3K-AKT-mTOR pathway to protect primary neurons against amyloid beta in Alzheimer's disease","author":"Li","year":"2019","journal-title":"Cytotechnology"},{"issue":"2","key":"10.1016\/j.neulet.2022.136995_b0185","first-page":"218","article-title":"Effects of silencing FUNDC1 gene on proliferation and invasion of ovarian cancer cell SKOV3","volume":"36","author":"Long","year":"2016","journal-title":"J. Shanghai Jiaotong Univers. (Med. Sci.)"},{"key":"10.1016\/j.neulet.2022.136995_b0190","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1159\/000489068","article-title":"Activated Alpha7nachr Improves Postoperative Cognitive Dysfunction and Intestinal Injury Induced by Cardiopulmonary Bypass in Rats: Inhibition of the Proinflammatory Response Through the Th17 Immune Response","volume":"46","author":"Chen","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.neulet.2022.136995_b0195","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jss.2014.09.043","article-title":"Alpha 7 nicotinic acetylcholine receptor agonist GTS-21 mitigates isoflurane-induced cognitive impairment in aged rats","volume":"194","author":"Kong","year":"2015","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.neulet.2022.136995_b0200","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1007\/s10753-019-00979-2","article-title":"\u03b17nAChR deletion aggravates myocardial infarction and enhances systemic inflammatory reaction via mTOR-signaling-related autophagy","volume":"42","author":"Fang","year":"2019","journal-title":"Inflammation"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394022005560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394022005560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:46:50Z","timestamp":1759625210000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394022005560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":40,"alternative-id":["S0304394022005560"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2022.136995","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibiting specificity protein 1 attenuated sevoflurane-induced mitochondrial stress and promoted autophagy in hippocampal neurons through PI3K\/Akt\/mTOR and \u03b17-nAChR signaling","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2022.136995","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"136995"}}