{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:21:12Z","timestamp":1793503272823,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471179"],"award-info":[{"award-number":["81471179"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.neulet.2022.137032","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T02:14:12Z","timestamp":1672020852000},"page":"137032","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["NLRP3 inflammasome inhibitor MCC950 reduces cerebral ischemia\/reperfusion induced neuronal ferroptosis"],"prefix":"10.1016","volume":"795","author":[{"given":"Xiang","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongbo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangchao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyan","family":"Kou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0620-8983","authenticated-orcid":false,"given":"Jinning","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2022.137032_b0005","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1001\/jama.2013.842","article-title":"Long-term mortality after stroke among adults aged 18 to 50 years","volume":"309","author":"Rutten-Jacobs","year":"2013","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.neulet.2022.137032_b0010","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1161\/CIRCULATIONAHA.116.025250","article-title":"Prevalence, Incidence, and Mortality of Stroke in China: Results from a Nationwide Population-Based Survey of 480 687 Adults","volume":"135","author":"Wang","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.neulet.2022.137032_b0015","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/s41418-018-0116-5","article-title":"A novel cell-penetrating peptide protects against neuron apoptosis after cerebral ischemia by inhibiting the nuclear translocation of annexin A1","volume":"26","author":"Li","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.neulet.2022.137032_b0020","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1186\/s12974-020-01988-x","article-title":"Low-density lipoprotein receptor (LDLR) regulates NLRP3-mediated neuronal pyroptosis following cerebral ischemia\/reperfusion injury","volume":"17","author":"Sun","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neulet.2022.137032_b0025","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41392-022-00917-z","article-title":"Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia\/reperfusion","volume":"7","author":"Tuo","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.neulet.2022.137032_b0030","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12974-021-02141-y","article-title":"Inhibition of MLKL-dependent necroptosis via downregulating interleukin-1R1 contributes to neuroprotection of hypoxic preconditioning in transient global cerebral ischemic rats","volume":"18","author":"Zhan","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neulet.2022.137032_b0035","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nrd.2018.97","article-title":"Targeting the NLRP3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.neulet.2022.137032_b0040","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.neulet.2022.137032_b0045","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/cr.2015.139","article-title":"Gasdermin D is an executor of pyroptosis and required for interleukin-1\u03b2 secretion","volume":"25","author":"He","year":"2015","journal-title":"Cell Res."},{"issue":"2022","key":"10.1016\/j.neulet.2022.137032_b0050","first-page":"273","article-title":"Buformin alleviates sepsis-induced acute lung injury via inhibiting NLRP3-mediated pyroptosis through an AMPK-dependent pathway","volume":"136","author":"Liu","year":"1979","journal-title":"Clin. Sci. (London England)"},{"key":"10.1016\/j.neulet.2022.137032_b0055","article-title":"MCC950 attenuates doxorubicin-induced myocardial injury in vivo and in vitro by inhibiting NLRP3-mediated pyroptosis","volume":"143","author":"Zhang","year":"2021","journal-title":"Biomed. Pharmacother. = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.neulet.2022.137032_b0060","doi-asserted-by":"crossref","first-page":"e12941","DOI":"10.1111\/cpr.12941","article-title":"Acid-sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration","volume":"54","author":"Zhao","year":"2021","journal-title":"Cell Prolif."},{"key":"10.1016\/j.neulet.2022.137032_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2022.136576","article-title":"Inhibition of PRMT5 attenuates cerebral ischemia\/reperfusion-Induced inflammation and pyroptosis through suppression of NF-\u03baB\/NLRP3 axis","volume":"776","author":"Wu","year":"2022","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2022.137032_b0070","doi-asserted-by":"crossref","first-page":"4810","DOI":"10.1080\/21655979.2022.2033381","article-title":"Crosstalk of pyroptosis, ferroptosis, and mitochondrial aldehyde dehydrogenase 2-related mechanisms in sepsis-induced lung injury in a mouse model","volume":"13","author":"Cao","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.neulet.2022.137032_b0075","first-page":"980","article-title":"[Inhibition of mitochondrial reactive oxygen species reduces high glucose-induced pyroptosis and ferroptosis in H9C2 cardiac myocytes]","volume":"41","author":"Wang","year":"2021","journal-title":"Nan fang yi ke da xue xue bao = J.of Southern Med. Univ."},{"key":"10.1016\/j.neulet.2022.137032_b0080","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1038\/s41598-022-06848-7","article-title":"Endothelial cell ferroptosis mediates monocrotaline-induced pulmonary hypertension in rats by modulating NLRP3 inflammasome activation","volume":"12","author":"Xie","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neulet.2022.137032_b0085","doi-asserted-by":"crossref","first-page":"e0136421","DOI":"10.1128\/Spectrum.01364-21","article-title":"In VitroAntifungal Activity of a Neodymium-Doped Yttrium Aluminum Garnet 1,064-Nanometer Laser against Sporothrix globosa by Inducing Apoptosis and Pyroptosis via the NLRP3\/Caspase-1 Signaling Pathway: and Study","volume":"9","author":"Yan","year":"2021","journal-title":"Microbiol. spectrum"},{"key":"10.1016\/j.neulet.2022.137032_b0090","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nri2725","article-title":"NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?","volume":"10","author":"Tschopp","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.neulet.2022.137032_b0095","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jhep.2016.12.018","article-title":"HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1\u03b2 production via suppressing the NF-\u03baB pathway and ROS production","volume":"66","author":"Yu","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.neulet.2022.137032_b0100","doi-asserted-by":"crossref","first-page":"4139048","DOI":"10.1155\/2021\/4139048","article-title":"MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis","volume":"2021","author":"Ni","year":"2021","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"10.1016\/j.neulet.2022.137032_b0105","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.neulet.2022.137032_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117638","article-title":"Inhibition of the NLRP3 inflammasome reduces brain edema and regulates the distribution of aquaporin-4 after cerebral ischaemia-reperfusion","volume":"251","author":"Wang","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.neulet.2022.137032_b0115","doi-asserted-by":"crossref","first-page":"19305","DOI":"10.1038\/s41598-021-98437-3","article-title":"The selective NLRP3 inhibitor MCC950 hinders atherosclerosis development by attenuating inflammation and pyroptosis in macrophages","volume":"11","author":"Zeng","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neulet.2022.137032_b0120","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nm.3806","article-title":"A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases","volume":"21","author":"Coll","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.neulet.2022.137032_b0125","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aah4066","article-title":"Inflammasome inhibition prevents \u03b1-synuclein pathology and dopaminergic neurodegeneration in mice","volume":"10","author":"Gordon","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neulet.2022.137032_b0130","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s00401-018-01957-y","article-title":"Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo","volume":"137","author":"Stancu","year":"2019","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neulet.2022.137032_b0135","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41589-019-0278-6","article-title":"MCC950 closes the active conformation of NLRP3 to an inactive state","volume":"15","author":"Tapia-Abell\u00e1n","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.neulet.2022.137032_b0140","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41419-021-04379-z","article-title":"NLPR3 inflammasome inhibition alleviates hypoxic endothelial cell death in vitro and protects blood-brain barrier integrity in murine stroke","volume":"13","author":"Bellut","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.neulet.2022.137032_b0145","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s00395-022-00948-1","article-title":"Mitochondrial calpain-1 activates NLRP3 inflammasome by cleaving ATP5A1 and inducing mitochondrial ROS in CVB3-induced myocarditis","volume":"117","author":"Liu","year":"2022","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.neulet.2022.137032_b0150","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.bbi.2021.01.003","article-title":"ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation","volume":"93","author":"Cui","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neulet.2022.137032_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105933","article-title":"Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke","volume":"174","author":"Li","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.neulet.2022.137032_b0160","doi-asserted-by":"crossref","first-page":"e2200330","DOI":"10.1002\/smll.202200330","article-title":"Cyclodextrin-Derived ROS-Generating Nanomedicine with pH-Modulated Degradability to Enhance Tumor Ferroptosis Therapy and Chemotherapy","volume":"18","author":"Xu","year":"2022","journal-title":"Small"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394022005936?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394022005936?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T10:00:33Z","timestamp":1736330433000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394022005936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":32,"alternative-id":["S0304394022005936"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2022.137032","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NLRP3 inflammasome inhibitor MCC950 reduces cerebral ischemia\/reperfusion induced neuronal ferroptosis","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2022.137032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"137032"}}