{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:52:47Z","timestamp":1787064767861,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000},"content-version":"am","delay-in-days":361,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS116828-01"],"award-info":[{"award-number":["NS116828-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.neulet.2022.137033","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T21:45:27Z","timestamp":1671918327000},"page":"137033","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Neuroprotective effect of lipopolysaccharides in a dual-hit rat pup model of preterm hypoxia\u2013ischemia"],"prefix":"10.1016","volume":"795","author":[{"given":"Da","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina V.","family":"Evangelou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krithika","family":"Shankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemah Iman","family":"Dewji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1264-7309","authenticated-orcid":false,"given":"Steven W.","family":"Levison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2022.137033_b0005","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0084-3954(08)70485-8","article-title":"The contribution of preterm birth to infant mortality rates in the United States","volume":"2008","author":"Stockman","year":"2008","journal-title":"Yearbook of Pediatrics"},{"key":"10.1016\/j.neulet.2022.137033_b0010","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13052-020-00852-1","article-title":"Ventilation, oxidative stress and risk of brain injury in preterm newborn","volume":"46","author":"Cannavo","year":"2020","journal-title":"Ital. J. Pediatr."},{"key":"10.1016\/j.neulet.2022.137033_b0015","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.3390\/cells9081871","article-title":"Preterm brain injury, antenatal triggers, and therapeutics: Timing is key","volume":"9","author":"Ophelders","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.neulet.2022.137033_b0020","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nrneurol.2015.13","article-title":"The role of inflammation in perinatal brain injury","volume":"11","author":"Hagberg","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neulet.2022.137033_b0025","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/glia.23216","article-title":"Combined fetal inflammation and postnatal hypoxia causes myelin deficits and autism-like behavior in a rat model of diffuse white matter injury","volume":"66","author":"van Tilborg","year":"2018","journal-title":"Glia"},{"key":"10.1016\/j.neulet.2022.137033_b0030","doi-asserted-by":"crossref","first-page":"7471","DOI":"10.4049\/jimmunol.0900762","article-title":"Lipopolysaccharide sensitizes neonatal hypoxic-ischemic brain injury in a MyD88-dependent manner","volume":"183","author":"Wang","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.neulet.2022.137033_b0035","doi-asserted-by":"crossref","unstructured":"R.C. Turner, Z.J. Naser, B.P. Lucke-Wold, A.F. Logsdon, R.L. Vangilder, R.R. Matsumoto, J.D. Huber, C.L. Rosen, Single low-dose lipopolysaccharide preconditioning: neuroprotective against axonal injury and modulates glial cells, Neuroimmunol. Neuroinflamm. 4 (2017) 6\u201315. 10.20517\/2347-8659.2016.40.","DOI":"10.20517\/2347-8659.2016.40"},{"key":"10.1016\/j.neulet.2022.137033_b0040","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1146\/annurev.biochem.71.110601.135414","article-title":"Lipopolysaccharide endotoxins","volume":"71","author":"Raetz","year":"2002","journal-title":"Annu. Rev. Biochem"},{"key":"10.1016\/j.neulet.2022.137033_b0045","doi-asserted-by":"crossref","unstructured":"M. Guardia Clausi, S.W. Levison, Delayed ALK5 inhibition improves functional recovery in neonatal brain injury, J. Cereb. Blood Flow Metab. 37 (2017) 787\u2013800. 10.1177\/0271678X16638669.","DOI":"10.1177\/0271678X16638669"},{"key":"10.1016\/j.neulet.2022.137033_b0050","doi-asserted-by":"crossref","unstructured":"J.M. Bain, A. Ziegler, Z. Yang, S.W. Levison, E. Sen, TGFSS1 stimulates the over-production of white matter astrocytes from precursors of the \u201cBrain Marrow\u201d in a rodent model of neonatal encephalopathy, PLoS ONE 5 (2010). https:\/\/doi:10.1371\/journal.pone.0009567.","DOI":"10.1371\/journal.pone.0009567"},{"key":"10.1016\/j.neulet.2022.137033_b0055","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1177\/42.5.8157933","article-title":"In situ nick-translation detects focal apoptosis in thymuses of glucocorticoid- and lipopolysaccharide-treated mice","volume":"42","author":"Fehsel","year":"1994","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.neulet.2022.137033_b0060","article-title":"Moderately inducing autophagy reduces tertiary brain injury after perinatal hypoxia-ischemia","volume":"10","author":"Kim","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.neulet.2022.137033_b0065","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12974-021-02119-w","article-title":"Fetal inflammation induces acute immune tolerance in the neonatal rat hippocampus","volume":"18","author":"Singh","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neulet.2022.137033_b0070","doi-asserted-by":"crossref","unstructured":"J.E. Simpson, M.S. Fernando, L. Clark, P.G. Ince, F. Matthews, G. Forster, J.T. O'Brien, R. Barber, R.N. Kalaria, C. Brayne, P.J. Shaw, C.E. Lewis, S.B. Wharton, M.R.C.C. Function, G. Ageing Neuropathology Study, White matter lesions in an unselected cohort of the elderly: astrocytic, microglial and oligodendrocyte precursor cell responses, Neuropathol. Appl. Neurobiol. 33 (2007) 410-419. 10.1111\/j.1365-2990.2007.00828.x.","DOI":"10.1111\/j.1365-2990.2007.00828.x"},{"key":"10.1016\/j.neulet.2022.137033_b0075","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13195-015-0139-9","article-title":"Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains","volume":"7","author":"Walker","year":"2015","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.neulet.2022.137033_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113324","article-title":"Neuroregenerative and protective functions of Leukemia Inhibitory Factor in perinatal hypoxic-ischemic brain injury","volume":"330","author":"Lin","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neulet.2022.137033_b0085","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1096-6374(02)00017-5","article-title":"Control of cell survival by IGF signaling pathways","volume":"12","author":"Vincent","year":"2002","journal-title":"Growth Horm. IGF Res."},{"key":"10.1016\/j.neulet.2022.137033_b0090","doi-asserted-by":"crossref","unstructured":"J. Zhang, L.D. Tucker, DongYan, Y. Lu, L. Yang, C. Wu, Y. Li, Q. Zhang, Tert-butylhydroquinone post-treatment attenuates neonatal hypoxic-ischemic brain damage in rats, Neurochem. Int. 116 (2018) 1-12. 10.1016\/j.neuint.2018.03.004.","DOI":"10.1016\/j.neuint.2018.03.004"},{"key":"10.1016\/j.neulet.2022.137033_b0095","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1203\/01.PDR.0000072517.01207.87","article-title":"Selective cortical alteration after hypoxic-ischemic injury in the very immature rat brain","volume":"54","author":"Sizonenko","year":"2003","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.neulet.2022.137033_b0100","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/1742-2094-9-175","article-title":"JNK signaling is the shared pathway linking neuroinflammation, blood-brain barrier disruption, and oligodendroglial apoptosis in the white matter injury of the immature brain","volume":"9","author":"Wang","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.neulet.2022.137033_b0105","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.647822","article-title":"Mice and rats display different ventilatory, hematological, and metabolic features of acclimatization to hypoxia","volume":"12","author":"Arias-Reyes","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.neulet.2022.137033_b0110","unstructured":"W. D., O.W. Schalm, Schalm's veterinary hematology, Wiley-Blackwell, Hoboken, NJ, 2010."},{"key":"10.1016\/j.neulet.2022.137033_b0115","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.imbio.2018.09.002","article-title":"Are rats more human than mice?","volume":"224","author":"Wildner","year":"2019","journal-title":"Immunobiology"},{"key":"10.1016\/j.neulet.2022.137033_b0120","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1161\/STROKEAHA.109.574004","article-title":"The Akt-endothelial nitric oxide synthase pathway in lipopolysaccharide preconditioning-induced hypoxic-ischemic tolerance in the neonatal rat brain","volume":"41","author":"Lin","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.neulet.2022.137033_b0125","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/377239a0","article-title":"Hypertension in mice lacking the gene for endothelial nitric oxide synthase","volume":"377","author":"Huang","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2022.137033_b0130","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.tins.2004.03.009","article-title":"Targeting eNOS for stroke protection","volume":"27","author":"Endres","year":"2004","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neulet.2022.137033_b0135","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2019.00270","article-title":"Early post-stroke activation of vascular endothelial growth factor receptor 2 hinders the receptor 1-dependent neuroprotection afforded by the endogenous ligand","volume":"13","author":"C\u00e1rdenas-Rivera","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neulet.2022.137033_b0140","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1159\/000105471","article-title":"Delayed IGF-1 administration rescues oligodendrocyte progenitors from glutamate-induced cell death and hypoxic-ischemic brain damage","volume":"29","author":"Wood","year":"2007","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.neulet.2022.137033_b0145","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/jcbfm.1993.79","article-title":"The effects of IGF-1 treatment after hypoxic-ischemic brain injury in adult rats","volume":"13","author":"Guan","year":"1993","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neulet.2022.137033_b0150","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1111\/j.1460-9568.2005.03982.x","article-title":"IGF-I neuroprotection in the immature brain after hypoxia-ischemia, involvement of Akt and GSK3beta?","volume":"21","author":"Brywe","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neulet.2022.137033_b0155","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.brainres.2005.09.042","article-title":"IGF-1 protects oligodendrocyte progenitor cells and improves neurological functions following cerebral hypoxia-ischemia in the neonatal rat","volume":"1063","author":"Lin","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2022.137033_b0160","doi-asserted-by":"crossref","unstructured":"S. Lin, L.W. Fan, P.G. Rhodes, Z. Cai, Intranasal administration of IGF-1 attenuates hypoxic-ischemic brain injury in neonatal rats, Exp. Neurol. 217 (2009) 361-370. S0014-4886(09)00096-X [pii].","DOI":"10.1016\/j.expneurol.2009.03.021"},{"key":"10.1016\/j.neulet.2022.137033_b0165","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1203\/01.PDR.0000163513.03619.8D","article-title":"Lipopolysaccharide induces both a primary and a secondary phase of sensitization in the developing rat brain","volume":"58","author":"Eklind","year":"2005","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.neulet.2022.137033_b0170","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1203\/PDR.0b013e31821d02aa","article-title":"Lipopolysaccharide-induced preconditioning against ischemic injury is associated with changes in toll-like receptor 4 expression in the rat developing brain","volume":"70","author":"Hickey","year":"2011","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.neulet.2022.137033_b0175","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1523\/JNEUROSCI.22-02-00455.2002","article-title":"Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia","volume":"22","author":"Back","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2022.137033_b0180","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1523\/JNEUROSCI.23-08-03308.2003","article-title":"Selective vulnerability of subplate neurons after early neonatal hypoxia-ischemia","volume":"23","author":"McQuillen","year":"2003","journal-title":"J. Neurosci."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394022005948?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394022005948?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T10:00:45Z","timestamp":1736330445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394022005948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":36,"alternative-id":["S0304394022005948"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2022.137033","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroprotective effect of lipopolysaccharides in a dual-hit rat pup model of preterm hypoxia\u2013ischemia","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2022.137033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"137033"}}