{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T12:42:04Z","timestamp":1794487324998,"version":"4.9.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31670421"],"award-info":[{"award-number":["31670421"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["GK202007008"],"award-info":[{"award-number":["GK202007008"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.neulet.2023.137241","type":"journal-article","created":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T00:09:09Z","timestamp":1680912549000},"page":"137241","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Voluntary wheel running ameliorates abnormalities in social behavior induced by social isolation: Involvement of neural and neurochemical responses"],"prefix":"10.1016","volume":"806","author":[{"given":"Lu","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6804-4179","authenticated-orcid":false,"given":"Fadao","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2023.137241_b0005","first-page":"47","article-title":"Correlates of physical activity with intrusive thoughts, worry and impulsivity in adults with attention deficit\/hyperactivity disorder: a cross-sectional pilot study","volume":"50","author":"Abramovitch","year":"2013","journal-title":"Isr. J. Psychiatry Relat. Sci."},{"key":"10.1016\/j.neulet.2023.137241_b0010","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.yfrne.2011.08.002","article-title":"The molecular physiology of CRH neurons","volume":"33","author":"Aguilera","year":"2012","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.neulet.2023.137241_b0015","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/S0140-6736(18)30142-9","article-title":"The growing problem of loneliness","volume":"391","author":"Cacioppo","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.neulet.2023.137241_b0020","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1146\/annurev-psych-010814-015240","article-title":"The neuroendocrinology of social isolation","volume":"66","author":"Cacioppo","year":"2015","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.neulet.2023.137241_b0025","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neuron.2018.02.026","article-title":"Neural circuit mechanisms of social behavior","volume":"98","author":"Chen","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2023.137241_b0030","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan8821","article-title":"Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model","volume":"361","author":"Choi","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.neulet.2023.137241_b0035","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev.neuro.051508.135607","article-title":"Serotonin in affective control","volume":"32","author":"Dayan","year":"2009","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2023.137241_b0040","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1210\/en.2003-0097","article-title":"Effects of long-term voluntary exercise on the mouse hypothalamic-pituitary-adrenocortical axis","volume":"144","author":"Droste","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.neulet.2023.137241_b0045","first-page":"R1271","article-title":"Modulation of exercise tachycardia by vasopressin in the nucleus tractus solitarii","volume":"273","author":"Dufloth","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.neulet.2023.137241_b0050","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/JES.0b013e31821f7e45","article-title":"Exercise, stress resistance, and central serotonergic systems","volume":"39","author":"Greenwood","year":"2011","journal-title":"Exerc. Sport. Sci. Rev."},{"key":"10.1016\/j.neulet.2023.137241_b0055","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1007\/s11055-022-01297-1","article-title":"Effects of social isolation on the development of anxiety and depression-like behavior in model experiments in animals","volume":"52","author":"Grigoryan","year":"2022","journal-title":"Neurosci. Behav. Physiol."},{"key":"10.1016\/j.neulet.2023.137241_b0060","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/PSY.0b013e31802f054b","article-title":"Depression-like behavior and stressor-induced neuroendocrine activation in female prairie voles exposed to chronic social isolation","volume":"69","author":"Grippo","year":"2007","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.neulet.2023.137241_b0065","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.psyneuen.2007.07.004","article-title":"Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles","volume":"32","author":"Grippo","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neulet.2023.137241_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yhbeh.2015.12.001","article-title":"Subcaste differences in neural activation suggest a prosocial role for oxytocin in eusocial naked mole-rats","volume":"79","author":"Hathaway","year":"2016","journal-title":"Horm. Behav."},{"key":"10.1016\/j.neulet.2023.137241_b0075","doi-asserted-by":"crossref","first-page":"e44026","DOI":"10.7554\/eLife.44026","article-title":"Increased anxiety and decreased sociability induced by paternal deprivation involve the PVN-PrL OTergic pathway","volume":"8","author":"He","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.neulet.2023.137241_b0080","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41586-020-2995-0","article-title":"Distinct hypothalamic control of same- and opposite-sex mounting behaviour in mice","volume":"589","author":"Karigo","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2023.137241_b0085","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.bbr.2015.09.028","article-title":"Voluntary exercise facilitates pair-bonding in male prairie voles","volume":"296","author":"Kenkel","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neulet.2023.137241_b0090","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3389\/fnbeh.2019.00143","article-title":"Early life adversity and adult social behavior: focus on arginine vasopressin and oxytocin as potential mediators","volume":"13","author":"Kompier","year":"2019","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neulet.2023.137241_b0095","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0149-7634(98)00018-9","article-title":"The hypothalamus: cross-roads of endocrine and behavioural regulation in grooming and aggression","volume":"23","author":"Kruk","year":"1998","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neulet.2023.137241_b0100","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00213-020-05652-3","article-title":"CRF-5-HT interactions in the dorsal raphe nucleus and motivation for stress-induced opioid reinstatement","volume":"238","author":"Li","year":"2021","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.neulet.2023.137241_b0105","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41586-021-03837-0","article-title":"Chronic social isolation signals starvation and reduces sleep in Drosophila","volume":"597","author":"Li","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2023.137241_b0110","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.celrep.2018.09.033","article-title":"Social Isolation Induces Rac1-Dependent Forgetting of Social Memory","volume":"25","author":"Liu","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.neulet.2023.137241_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.136301","article-title":"Sex-specific effects of social isolation stress and ketamine on hippocampal plasticity","volume":"766","author":"Logue","year":"2022","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2023.137241_b0120","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.brainresbull.2022.04.016","article-title":"Involvement of DR\u2013>mPFC 5-HTergic neural projections in changes of social exploration behaviors caused by adult chronic social isolation in mice","volume":"186","author":"Lv","year":"2022","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neulet.2023.137241_b0125","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neubiorev.2013.11.009","article-title":"Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects","volume":"38","author":"Mahar","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neulet.2023.137241_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135556","article-title":"Difference in the brain serotonin and its metabolite level and anxiety-like behavior between forced and voluntary exercise conditions in rats","volume":"744","author":"Matsunaga","year":"2021","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2023.137241_b0135","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S0306-4530(03)00090-8","article-title":"Genomic and non-genomic effects of glucocorticoids on aggressive behavior in male rats","volume":"29","author":"Mikics","year":"2004","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neulet.2023.137241_b0140","doi-asserted-by":"crossref","first-page":"e122","DOI":"10.1038\/tp.2012.44","article-title":"Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin","volume":"2","author":"Mosienko","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.neulet.2023.137241_b0145","doi-asserted-by":"crossref","first-page":"R77","DOI":"10.1530\/JME-17-0165","article-title":"Voluntary exercise and depression-like behavior in rodents: are we running in the right direction?","volume":"60","author":"Mul","year":"2018","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.neulet.2023.137241_b0150","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1038\/s41386-018-0103-z","article-title":"Voluntary wheel running promotes resilience to chronic social defeat stress in mice: a role for nucleus accumbens DeltaFosB","volume":"43","author":"Mul","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neulet.2023.137241_b0155","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/cz\/zow027","article-title":"Central monoaminergic systems are a site of convergence of signals conveying the experience of exercise to brain circuits involved in cognition and emotional behavior","volume":"62","author":"Nicastro","year":"2016","journal-title":"Curr. Zool."},{"key":"10.1016\/j.neulet.2023.137241_b0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2017.07.045","article-title":"Long-term voluntary exercise prevents post-weaning social isolation-induced cognitive impairment in rats","volume":"360","author":"Okudan","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2023.137241_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.01.019","article-title":"Post-weaning social isolation exacerbates aggression in both sexes and affects the vasopressin and oxytocin system in a sex-specific manner","volume":"156","author":"Oliveira","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neulet.2023.137241_b0170","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neulet.2009.02.064","article-title":"Post-weaning social isolation alters anxiety-related behavior and neurochemical gene expression in the brain of male prairie voles","volume":"454","author":"Pan","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2023.137241_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112276","article-title":"Aggressive behavior and brain neuronal activation in sexually naive male Mongolian gerbils","volume":"378","author":"Pan","year":"2020","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neulet.2023.137241_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109104","article-title":"Social isolation impairs the prefrontal-nucleus accumbens circuit subserving social recognition in mice","volume":"35","author":"Park","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.neulet.2023.137241_b0185","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1073\/pnas.1524187113","article-title":"Effects of serotonin 2A\/1A receptor stimulation on social exclusion processing","volume":"113","author":"Preller","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neulet.2023.137241_b0190","doi-asserted-by":"crossref","first-page":"e21416","DOI":"10.7554\/eLife.21416","article-title":"Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels","volume":"5","author":"Sargin","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.neulet.2023.137241_b0195","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.avb.2008.06.003","article-title":"Role of serotonin and dopamine system interactions in the neurobiology of impulsive aggression and its comorbidity with other clinical disorders","volume":"13","author":"Seo","year":"2008","journal-title":"Aggress Violent Behav."},{"key":"10.1016\/j.neulet.2023.137241_b0200","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.biopsych.2013.09.017","article-title":"Hypothalamic oxytocin mediates social buffering of the stress response","volume":"76","author":"Smith","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2023.137241_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108874","article-title":"Neural circuits and activity dynamics underlying sex-specific effects of chronic social isolation stress","volume":"34","author":"Tan","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.neulet.2023.137241_b0210","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.bbr.2012.04.025","article-title":"The neural background of hyper-emotional aggression induced by post-weaning social isolation","volume":"233","author":"Toth","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neulet.2023.137241_b0215","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3389\/fnbeh.2019.00066","article-title":"Long-Term Behavioral Effects of Post-weaning Social Isolation in Males and Females","volume":"13","author":"Walker","year":"2019","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neulet.2023.137241_b0220","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1080\/10253890.2019.1617691","article-title":"Protective neuroendocrine effects of environmental enrichment and voluntary exercise against social isolation: evidence for mediation by limbic structures","volume":"22","author":"Watanasriyakul","year":"2019","journal-title":"Stress"},{"key":"10.1016\/j.neulet.2023.137241_b0225","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/0301-0082(93)90035-Q","article-title":"Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system","volume":"40","author":"Whitnall","year":"1993","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neulet.2023.137241_b0230","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.cell.2018.03.037","article-title":"The neuropeptide Tac2 controls a distributed brain state induced by chronic social isolation stress","volume":"173","author":"Zelikowsky","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2023.137241_b0235","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3389\/fnins.2019.00256","article-title":"Voluntary wheel running reverses deficits in social behavior induced by chronic social defeat stress in mice: involvement of the dopamine system","volume":"13","author":"Zhang","year":"2019","journal-title":"Front. Neurosci."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394023001994?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394023001994?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T15:01:47Z","timestamp":1736348507000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394023001994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":47,"alternative-id":["S0304394023001994"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2023.137241","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Voluntary wheel running ameliorates abnormalities in social behavior induced by social isolation: Involvement of neural and neurochemical responses","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2023.137241","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"137241"}}