{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T20:45:09Z","timestamp":1793738709073,"version":"4.6.1"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["118S519"],"award-info":[{"award-number":["118S519"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.neulet.2023.137245","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T10:26:29Z","timestamp":1681381589000},"page":"137245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Effects of chronic irisin treatment on brain monoamine levels in the hypothalamic and subcortical nuclei of adult male and female rats: An HPLC-ECD study"],"prefix":"10.1016","volume":"806","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5740-9518","authenticated-orcid":false,"given":"Ahmet","family":"Yardimci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazife Ulker","family":"Ertugrul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aslisah","family":"Ozgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulendam","family":"Ozbeg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Ridvan","family":"Ozdede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eda Coban","family":"Ercan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinan","family":"Canpolat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2023.137245_b0005","first-page":"563","article-title":"HPLC electrochemical detection and quantification of monoamines and their metabolites in rat brain tissue samples","volume":"73","author":"Viljoen","year":"2018","journal-title":"Pharm"},{"key":"10.1016\/j.neulet.2023.137245_b0010","series-title":"Adv. Neurotoxicology","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/bs.ant.2017.07.002","article-title":"The catecholaminergic neurotransmitter system in methylmercury-induced neurotoxicity","author":"Farina","year":"2017"},{"key":"10.1016\/j.neulet.2023.137245_b0015","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cmet.2019.11.016","article-title":"NTS catecholamine neurons mediate hypoglycemic hunger via medial hypothalamic feeding pathways","volume":"31","author":"Aklan","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.neulet.2023.137245_b0020","doi-asserted-by":"crossref","DOI":"10.3389\/fnana.2021.728720","article-title":"Organization of the catecholaminergic system in the short-lived fish Nothobranchius furzeri","volume":"15","author":"Borgonovo","year":"2021","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.neulet.2023.137245_b0025","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev.med.60.042307.110802","article-title":"The expanded biology of serotonin","volume":"60","author":"Berger","year":"2009","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.neulet.2023.137245_b0030","doi-asserted-by":"crossref","unstructured":"G. Aghajanian, R.-J. Liu, Serotonin (5-hydroxytryptamine; 5-HT): CNS pathways and neurophysiology, in: L.R. Squire (Ed.), Encycl. Neurosci., Academic Press, Oxford, 2009: pp. 715\u2013722. https:\/\/doi.org\/10.1016\/B978-008045046-9.01159-1.","DOI":"10.1016\/B978-008045046-9.01159-1"},{"key":"10.1016\/j.neulet.2023.137245_b0035","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1515\/tnsci-2016-0007","article-title":"The serotonergic system and cognitive function","volume":"7","author":"\u0160vob \u0160trac","year":"2016","journal-title":"Transl. Neurosci."},{"key":"10.1016\/j.neulet.2023.137245_b0040","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3389\/fnins.2016.00541","article-title":"Monoaminergic and histaminergic strategies and treatments in brain diseases","volume":"10","author":"Di Giovanni","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neulet.2023.137245_b0045","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev-med-060619-022943","article-title":"The role of exercise in management of mental health disorders: an integrative review","volume":"72","author":"Smith","year":"2021","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.neulet.2023.137245_b0050","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1007\/s12035-017-0516-4","article-title":"Exercise as a positive modulator of brain function","volume":"55","author":"Alkadhi","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neulet.2023.137245_b0055","first-page":"61","article-title":"Physical exercise ameliorates anxiety, depression and sleep quality in college students: experimental evidence from exercise intensity and frequency","volume":"12","author":"Ji","year":"2022","journal-title":"Behav. Sci. Basel Switz."},{"key":"10.1016\/j.neulet.2023.137245_b0060","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1113\/EP085672","article-title":"Brain train to combat brain drain; focus on exercise strategies that optimize neuroprotection","volume":"101","author":"Burley","year":"2016","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.neulet.2023.137245_b0065","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbrc.2016.04.047","article-title":"Irisin ameliorates depressive-like behaviors in rats by regulating energy metabolism","volume":"474","author":"Wang","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neulet.2023.137245_b0070","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.pnpbp.2018.03.004","article-title":"Central irisin administration affords antidepressant-like effect and modulates neuroplasticity-related genes in the hippocampus and prefrontal cortex of mice","volume":"84","author":"Siteneski","year":"2018","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry."},{"key":"10.1016\/j.neulet.2023.137245_b0075","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.ejphar.2016.09.011","article-title":"Central inhibitory effects on feeding induced by the adipo-myokine irisin","volume":"791","author":"Ferrante","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neulet.2023.137245_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2021.105597","article-title":"Irisin ameliorates male sexual dysfunction in paroxetine-treated male rats","volume":"136","author":"Canpolat","year":"2022","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neulet.2023.137245_b0085","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1159\/000523689","article-title":"Irisin improves high-fat diet-induced sexual dysfunction in obese male rats","volume":"112","author":"Yardimci","year":"2022","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.neulet.2023.137245_b0090","doi-asserted-by":"crossref","unstructured":"M.M. Herting, M.F. Keenan, Exercise and the developing brain in children and adolescents, in: R.R. Watson (Ed.), Phys. Act. Aging Brain, Academic Press, 2017: pp. 13\u201319. https:\/\/doi.org\/10.1016\/B978-0-12-805094-1.00002-2.","DOI":"10.1016\/B978-0-12-805094-1.00002-2"},{"key":"10.1016\/j.neulet.2023.137245_b0095","doi-asserted-by":"crossref","first-page":"e12031","DOI":"10.1002\/jcv2.12031","article-title":"Exercise interventions in child and adolescent mental health care: An overview of the evidence and recommendations for implementation","volume":"1","author":"Carney","year":"2021","journal-title":"JCPP Adv."},{"key":"10.1016\/j.neulet.2023.137245_b0100","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1248\/bpb.b12-00689","article-title":"Simultaneous measurement of serotonin, dopamine and their metabolites in mouse brain extracts by high-performance liquid chromatography with mass spectrometry following derivatization with ethyl chloroformate","volume":"36","author":"Park","year":"2013","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.neulet.2023.137245_b0105","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1530\/REP-20-0072","article-title":"Irisin may have a role in pubertal development and regulation of reproductive function in rats","volume":"160","author":"Ulker","year":"2020","journal-title":"Reprod. Camb. Engl."},{"key":"10.1016\/j.neulet.2023.137245_b0110","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/s42255-021-00438-z","article-title":"Exercise hormone irisin is a critical regulator of cognitive function","volume":"3","author":"Islam","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.neulet.2023.137245_b0115","doi-asserted-by":"crossref","first-page":"H1022","DOI":"10.1152\/ajpheart.2000.279.3.H1022","article-title":"Comparison of blood-brain barrier permeability in mice and rats using in situ brain perfusion technique","volume":"279","author":"Murakami","year":"2000","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.neulet.2023.137245_b0120","first-page":"423","article-title":"Inhibition of the pre-ovulatory LH surge in the rat by central noradrenergic mediation : Involvement of an anaesthetic (urethane) and opioid receptor agonists","volume":"12","author":"Yilmaz","year":"1996","journal-title":"Inhib. Pre-Ovulatory LH Surge Rat Cent. Noradrenergic Mediat. Involv. Anaesth. Urethane Opioid Recept. Agonists"},{"key":"10.1016\/j.neulet.2023.137245_b0125","doi-asserted-by":"crossref","unstructured":"M. Palkovits, [23] Punch sampling biopsy technique, in: Methods Enzymol., Academic Press, 1983: pp. 368\u2013376. https:\/\/doi.org\/10.1016\/S0076-6879(83)03025-6.","DOI":"10.1016\/S0076-6879(83)03025-6"},{"key":"10.1016\/j.neulet.2023.137245_b0130","series-title":"The Rat Brain In Stereotaxic Coordinates, The fourth edition","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.neulet.2023.137245_b0135","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1248\/bpb.24.163","article-title":"Effects of paint thinner exposure on serum LH, FSH and testosterone levels and hypothalamic catecholamine contents in the male rat","volume":"24","author":"Yilmaz","year":"2001","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.neulet.2023.137245_b0140","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/0361-9230(89)90106-8","article-title":"Effects of food intake and body weight on a serotonergic turnover index in rat hypothalamus","volume":"22","author":"Gardier","year":"1989","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neulet.2023.137245_b0145","series-title":"Neurotransmitters and Drugs","author":"Kruk","year":"1993"},{"key":"10.1016\/j.neulet.2023.137245_b0150","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0361-9230(99)00020-9","article-title":"Effects of mu, kappa, and delta opioid receptor agonists and antagonists on rat hypothalamic noradrenergic neurotransmission","volume":"48","author":"Yilmaz","year":"1999","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neulet.2023.137245_b0155","first-page":"371","article-title":"Opioid Modulation of the Pre-ovulatory LH Surge in the Conscious Rat: Involvement of Indolamines","volume":"29","author":"Yilmaz","year":"1999","journal-title":"Turk. J. Med. Sci."},{"issue":"1","key":"10.1016\/j.neulet.2023.137245_b0160","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2023.137245_b0165","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ejphar.2015.10.041","article-title":"Fucosterol, a sterol extracted from Sargassum fusiforme, shows antidepressant and anticonvulsant effects","volume":"768","author":"Zhen","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neulet.2023.137245_b0170","series-title":"The Role of Endogenous Opioids and Brain Neurotransmitters in the Generation of the LH Surge in the Rat, PhD","author":"Yilmaz","year":"1997"},{"key":"10.1016\/j.neulet.2023.137245_b0175","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1159\/000078101","article-title":"Mu opioid modulation of oxytocin secretion in late pregnant and parturient rats. Involvement of noradrenergic neurotransmission","volume":"79","author":"Kutlu","year":"2004","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.neulet.2023.137245_b0180","unstructured":"M.G. Pop, C. Crivii, I. Opincariu, Anatomy and function of the hypothalamus, in: Hypothal. Health Dis., IntechOpen, 2018."},{"key":"10.1016\/j.neulet.2023.137245_b0185","doi-asserted-by":"crossref","unstructured":"C.B. Saper, R.L. Stornetta, Chapter 23 - Central autonomic system, in: G. Paxinos (Ed.), Rat Nerv. Syst. Fourth Ed., Academic Press, San Diego, 2015: pp. 629\u2013673. https:\/\/doi.org\/10.1016\/B978-0-12-374245-2.00023-1.","DOI":"10.1016\/B978-0-12-374245-2.00023-1"},{"key":"10.1016\/j.neulet.2023.137245_b0190","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1210\/en.2011-1975","article-title":"Assessment of epigenetic contributions to sexually-dimorphic Kiss1 expression in the anteroventral periventricular nucleus of mice","volume":"153","author":"Semaan","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.neulet.2023.137245_b0195","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.exger.2016.04.015","article-title":"The transition to reproductive senescence is characterized by increase in A6 and AVPV neuron activity with attenuation of noradrenaline content","volume":"81","author":"Nicola","year":"2016","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.neulet.2023.137245_b0200","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0006-8993(85)90007-1","article-title":"The distribution of monoaminergic cells and fibers in a periventricular preoptic nucleus involved in the control of gonadotropin release: immunohistochemical evidence for a dopaminergic sexual dimorphism","volume":"330","author":"Simerly","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2023.137245_b0205","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0150-17.2017","article-title":"Effects of selective deletion of tyrosine hydroxylase from kisspeptin cells on puberty and reproduction in male and female mice","volume":"4","author":"Stephens","year":"2017","journal-title":"ENeuro."},{"key":"10.1016\/j.neulet.2023.137245_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2021.113341","article-title":"Chronic irisin exposure decreases sexual incentive motivation in female rats","volume":"232","author":"Ulker","year":"2021","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neulet.2023.137245_b0215","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.brainres.2005.06.082","article-title":"Estrogen and progesterone do not activate Fos in AVPV or LHRH neurons in male rats","volume":"1054","author":"Hoffman","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2023.137245_b0220","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.yfrne.2007.05.003","article-title":"Topography in the preoptic region: differential regulation of appetitive and consummatory male sexual behaviors","volume":"28","author":"Balthazart","year":"2007","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.neulet.2023.137245_b0225","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1365-2826.2007.01542.x","article-title":"Noradrenaline release in the medial preoptic area during the rat oestrous cycle: temporal relationship with plasma secretory surges of prolactin and luteinising hormone","volume":"19","author":"Szawka","year":"2007","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.neulet.2023.137245_b0230","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.pbb.2010.08.012","article-title":"Differential regulation of female sexual behaviour by dopamine agonists in the medial preoptic area","volume":"97","author":"Graham","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neulet.2023.137245_b0235","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1037\/0735-7044.114.4.772","article-title":"Dopamine release in the medial preoptic area of female rats in response to hormonal manipulation and sexual activity","volume":"114","author":"Matuszewich","year":"2000","journal-title":"Behav. Neurosci."},{"issue":"6778","key":"10.1016\/j.neulet.2023.137245_b0240","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35007534","article-title":"Central nervous system control of food intake","volume":"404","author":"Schwartz","year":"2000","journal-title":"Nature."},{"key":"10.1016\/j.neulet.2023.137245_b0245","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1007\/s00429-015-1038-3","article-title":"A premammillary lateral hypothalamic nuclear complex responds to hedonic but not aversive tastes in the male rat","volume":"221","author":"Chometton","year":"2016","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.neulet.2023.137245_b0250","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1159\/000501234","article-title":"MCH neuron activity is sufficient for reward and reinforces feeding","volume":"110","author":"Dilsiz","year":"2020","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.neulet.2023.137245_b0255","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nn1455","article-title":"Anatomy and regulation of the central melanocortin system","volume":"8","author":"Cone","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neulet.2023.137245_b0260","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.psyneuen.2015.02.020","article-title":"Dopamine release in the lateral hypothalamus is stimulated by \u03b1-MSH in both the anticipatory and consummatory phases of feeding","volume":"56","author":"Legrand","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neulet.2023.137245_b0265","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13578-022-00799-2","article-title":"The ventromedial hypothalamic nucleus: watchdog of whole-body glucose homeostasis","volume":"12","author":"Tu","year":"2022","journal-title":"Cell Biosci."},{"key":"10.1016\/j.neulet.2023.137245_b0270","first-page":"R1925","article-title":"Meal size and number: relationship to dopamine levels in the ventromedial hypothalamic nucleus","volume":"272","author":"Meguid","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.neulet.2023.137245_b0275","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0361-9230(85)90041-3","article-title":"Actions of feeding-relevant agents on hypothalamic glucose-responsive neurons in vitro","volume":"15","author":"Kow","year":"1985","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neulet.2023.137245_b0280","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0006-8993(86)90530-5","article-title":"Chronic infusion of norepinephrine into the ventromedial hypothalamus induces obesity in rats","volume":"369","author":"Shimazu","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2023.137245_b0285","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0361-9230(94)00173-X","article-title":"Decrease of norepinephrine and preservation of acetylcholine in the hypothalamus of VMH obese rats","volume":"36","author":"Takahashi","year":"1995","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neulet.2023.137245_b0290","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/BF00230938","article-title":"Brain cortical tissue levels of noradrenaline and its glycol metabolites: effects of ischemia and postischemic administration of idazoxan","volume":"90","author":"Gustafson","year":"1992","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.neulet.2023.137245_b0295","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/0024-3205(81)90672-X","article-title":"Brain noradrenergic neuronal activity affects 3,4-dihydroxyphenylethyleneglycol (DHPG) levels","volume":"29","author":"Warsh","year":"1981","journal-title":"Life Sci."},{"key":"10.1016\/j.neulet.2023.137245_b0300","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1172\/JCI117771","article-title":"Decreased stress responsivity of central and peripheral catecholaminergic systems in aged 344\/N Fischer rats","volume":"95","author":"Cizza","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neulet.2023.137245_b0305","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.peptides.2017.02.003","article-title":"Irisin in goldfish (Carassius auratus): Effects of irisin injections on feeding behavior and expression of appetite regulators, uncoupling proteins and lipoprotein lipase, and fasting-induced changes in FNDC5 expression","volume":"90","author":"Butt","year":"2017","journal-title":"Peptides"},{"key":"10.1016\/j.neulet.2023.137245_b0310","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neulet.2017.02.066","article-title":"The effects of intracerebroventricular infusion of irisin on feeding behaviour in rats","volume":"645","author":"Tekin","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2023.137245_b0315","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000368279","article-title":"The nucleus accumbens: A comprehensive review","volume":"93","author":"Salgado","year":"2015","journal-title":"Stereotact. Funct. Neurosurg."},{"key":"10.1016\/j.neulet.2023.137245_b0320","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fncir.2020.00037","article-title":"The nucleus accumbens: A common target in the comorbidity of depression and addiction","volume":"14","author":"Xu","year":"2020","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.neulet.2023.137245_b0325","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bbr.2015.02.012","article-title":"Tipepidine increases dopamine level in the nucleus accumbens without methamphetamine-like behavioral sensitization","volume":"284","author":"Hamao","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neulet.2023.137245_b0330","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.bbr.2014.12.009","article-title":"Involvement of dopamine in the differences in sexual behaviour between Roman high and low avoidance rats: an intracerebral microdialysis study","volume":"281","author":"Sanna","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neulet.2023.137245_b0335","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fnbeh.2019.00072","article-title":"Low daytime light intensity disrupts male copulatory behavior, and upregulates medial preoptic area steroid hormone and dopamine receptor expression, in a diurnal rodent model of seasonal affective disorder","volume":"13","author":"Lonstein","year":"2019","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neulet.2023.137245_b0340","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.neubiorev.2007.07.013","article-title":"Central neurophysiology and dopaminergic control of ejaculation","volume":"32","author":"Peeters","year":"2008","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neulet.2023.137245_b0345","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.bbr.2009.06.025","article-title":"Different subregions of the medial preoptic area are separately involved in the regulation of copulation and sexual incentive motivation in male rats: a behavioral and morphological study","volume":"205","author":"Yeh","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neulet.2023.137245_b0350","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41586-018-0416-4","article-title":"5-HT release in nucleus accumbens rescues social deficits in mouse autism model","volume":"560","author":"Walsh","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2023.137245_b0355","doi-asserted-by":"crossref","unstructured":"D.L. Christensen, J. Baio, K. Van Naarden Braun, D. Bilder, J. Charles, J.N. Constantino, J. Daniels, M.S. Durkin, R.T. Fitzgerald, M. Kurzius-Spencer, L.-C. Lee, S. Pettygrove, C. Robinson, E. Schulz, C. Wells, M.S. Wingate, W. Zahorodny, M. Yeargin-Allsopp, Centers for Disease Control and Prevention (CDC), Prevalence and characteristics of autism spectrum disorder among children aged 8 years--autism and developmental disabilities monitoring network, 11 Sites, United States, 2012, Morb. Mortal. Wkly. Rep. Surveill. Summ. Wash. DC 2002. 65 (2016) 1\u201323. https:\/\/doi.org\/10.15585\/mmwr.ss6503a1.","DOI":"10.15585\/mmwr.ss6503a1"},{"key":"10.1016\/j.neulet.2023.137245_b0360","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.tics.2012.02.007","article-title":"The social motivation theory of autism","volume":"16","author":"Chevallier","year":"2012","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.neulet.2023.137245_b0365","first-page":"42","article-title":"Serum relaxin-3 and irisin levels in children with autism spectrum disorder: comparison with healthy controls","volume":"59","author":"Kara","year":"2022","journal-title":"Isr. J. PSYCHIATRY Relat. Sci."},{"key":"10.1016\/j.neulet.2023.137245_b0370","series-title":"Handb. Behav. Neurosci.","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/B978-0-12-815134-1.00002-7","article-title":"Chapter 2 - Structure and function of the medial amygdala","author":"Petrulis","year":"2020"},{"key":"10.1016\/j.neulet.2023.137245_b0375","doi-asserted-by":"crossref","first-page":"8699","DOI":"10.1523\/JNEUROSCI.1176-14.2014","article-title":"Functional properties and projections of neurons in the medial amygdala","volume":"34","author":"Keshavarzi","year":"2014","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.neulet.2023.137245_b0380","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.yebeh.2005.06.014","article-title":"The role of serotonin in impulsive and aggressive behaviors associated with epilepsy-like neuronal hyperexcitability in the amygdala","volume":"7","author":"Keele","year":"2005","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.neulet.2023.137245_b0385","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1365-2826.2005.01279.x","article-title":"Norepinephrine release in medial amygdala facilitates activation of the hypothalamic-pituitary-adrenal axis in response to acute immobilisation stress","volume":"17","author":"Ma","year":"2005","journal-title":"J. Neuroendocrinol."},{"issue":"4","key":"10.1016\/j.neulet.2023.137245_b0390","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.neuroscience.2008.09.053","article-title":"Histamine in the posterodorsal medial amygdala modulates cardiovascular reflex responses in awake rats","volume":"157","author":"Quagliotto","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2023.137245_b0395","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neuroscience.2012.05.051","article-title":"Paraventricular and supraoptic nuclei of the hypothalamus mediate cardiovascular responses evoked by the microinjection of noradrenaline into the medial amygdaloid nucleus of the rat brain","volume":"219","author":"Fortaleza","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2023.137245_b0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.114953","article-title":"Irisin lowers blood pressure by activating the Nrf2 signaling pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats","volume":"394","author":"Huo","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.neulet.2023.137245_b0405","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.joim.2021.11.007","article-title":"Metabolomic characteristics of spontaneously hypertensive rats under chronic stress and the treatment effect of Danzhi Xiaoyao Powder, a traditional Chinese medicine formula","volume":"20","author":"Chen","year":"2022","journal-title":"J. Integr. Med."},{"key":"10.1016\/j.neulet.2023.137245_b0410","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/j.cell.2018.10.025","article-title":"Irisin mediates effects on bone and fat via \u03b1V integrin receptors","volume":"175","author":"Kim","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2023.137245_b0415","doi-asserted-by":"crossref","first-page":"514","DOI":"10.2337\/db13-1106","article-title":"Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling","volume":"63","author":"Zhang","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.neulet.2023.137245_b0420","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/s41418-019-0372-z","article-title":"FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT","volume":"27","author":"Zhang","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.neulet.2023.137245_b0425","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.yjmcc.2021.06.013","article-title":"FNDC5\/Irisin attenuates diabetic cardiomyopathy in a type 2 diabetes mouse model by activation of integrin \u03b1V\/\u03b25-AKT signaling and reduction of oxidative\/nitrosative stress","volume":"160","author":"Lin","year":"2021","journal-title":"J. Mol. Cell. Cardiol."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394023002033?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394023002033?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T15:01:58Z","timestamp":1736348518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394023002033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":85,"alternative-id":["S0304394023002033"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2023.137245","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of chronic irisin treatment on brain monoamine levels in the hypothalamic and subcortical nuclei of adult male and female rats: An HPLC-ECD study","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2023.137245","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"137245"}}