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Basic Clin."},{"key":"10.1016\/j.neulet.2023.137315_b0335","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1023\/A:1026658826010","article-title":"Distribution and colocalization of nitric oxide synthase and calretinin in myenteric neurons of developing, aging, and Crohn\u2019s disease human small intestine","volume":"44","author":"Belai","year":"1999","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.neulet.2023.137315_b0340","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1136\/gut.48.4.468","article-title":"Neuronal COX-2 expression in human myenteric plexus in active inflammatory bowel disease","volume":"48","author":"Roberts","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.neulet.2023.137315_b0345","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1111\/j.1572-0241.2008.01930.x","article-title":"Crohn\u2019s disease but not chronic ulcerative colitis induces the expression of PAI-1 in enteric neurons","volume":"103","author":"Laerum","year":"2008","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.neulet.2023.137315_b0350","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/00001756-200302100-00006","article-title":"Decreased potassium channel IK1 and its regulator neurotrophin-3 (NT-3) in inflamed human bowel","volume":"14","author":"Arnold","year":"2003","journal-title":"Neuroreport"},{"key":"10.1016\/j.neulet.2023.137315_b0355","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/jgh.13973","article-title":"Increased enteric glial cells in proximal margin of resection is associated with postoperative recurrence of Crohn\u2019s disease","volume":"33","author":"Li","year":"2018","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.neulet.2023.137315_b0360","doi-asserted-by":"crossref","unstructured":"D.V. Boh\u00f3rquez, L.A. Samsa, A. Roholt, S. Medicetty, R. Chandra, R.A. 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