{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:26:25Z","timestamp":1788953185844,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:00:00Z","timestamp":1723248000000},"content-version":"vor","delay-in-days":344,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020570","name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020570","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["PROEX 646\/2014"],"award-info":[{"award-number":["PROEX 646\/2014"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.neulet.2023.137432","type":"journal-article","created":{"date-parts":[[2023,8,6]],"date-time":"2023-08-06T08:04:59Z","timestamp":1691309099000},"page":"137432","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Environmental enrichment affects behavioral and pharmacological response to antidepressants in CF1 mice"],"prefix":"10.1016","volume":"813","author":[{"given":"Marta Lorena","family":"Speck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Luiza Azevedo","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Schafer","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Biz","family":"Willig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo Andr\u00e9","family":"Pilger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stela Maris Kuze","family":"Rates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2023.137432_b0005","first-page":"619","article-title":"Neural plasticity","volume":"2","author":"Jon","year":"2015","journal-title":"Int. Encycl. Soc. Behav. Sci."},{"issue":"2","key":"10.1016\/j.neulet.2023.137432_b0010","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbr.2012.05.006","article-title":"Behavioral effects of environmental enrichment during gestation in WKY and Wistar rats","volume":"233","author":"Rosenfeld","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neulet.2023.137432_b0015","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2014.00195","article-title":"Pre-reproductive maternal enrichment influences offspring developmental trajectories: motor behavior and neurotrophin expression","volume":"8","author":"Caporali","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neulet.2023.137432_b0020","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cobeha.2015.02.005","article-title":"Environmental enrichment and neurogenesis","volume":"4","author":"Clemenson","year":"2015","journal-title":"Curr. Opin. Behav. Sci."},{"issue":"6624","key":"10.1016\/j.neulet.2023.137432_b0025","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/386493a0","article-title":"More hippocampal neurons in adult mice living in an enriched environment","volume":"386","author":"Kempermann","year":"1997","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.neulet.2023.137432_b0030","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.bbr.2011.04.002","article-title":"The impact of environmental enrichment in laboratory rats\u2014behavioural and neurochemical aspects","volume":"222","author":"Simpson","year":"2011","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.neulet.2023.137432_b0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hipo.22342","article-title":"BDNF contributes to the facilitation of hippocampal synaptic plasticity and learning enabled by environmental enrichment","volume":"25","author":"Novkovic","year":"2015","journal-title":"Hippocampus"},{"key":"10.1016\/j.neulet.2023.137432_b0040","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2010.00189","article-title":"Why and how physical activity promotes experience-induced brain plasticity","volume":"4","author":"Kempermann","year":"2010","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.neulet.2023.137432_b0045","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/1099800417730400","article-title":"Antidepressive effects of environmental enrichment in chronic stress-induced depression in rats","volume":"20","author":"Seong","year":"2018","journal-title":"Biol. Res. Nurs."},{"issue":"4","key":"10.1016\/j.neulet.2023.137432_b0050","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/PSY.0000000000000052","article-title":"The effects of environmental enrichment on depressive-and anxiety-relevant behaviors in socially isolated prairie voles","volume":"76","author":"Grippo","year":"2014","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.neulet.2023.137432_b0055","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.nlm.2016.08.017","article-title":"Enriched environment ameliorates depression-induced cognitive deficits and restores abnormal hippocampal synaptic plasticity","volume":"134","author":"Mahati","year":"2016","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.neulet.2023.137432_b0060","doi-asserted-by":"crossref","DOI":"10.1177\/0269881107082898","article-title":"Effects of acute or 3\u2013day treatments of Hypericum caprifoliatum Cham. & Schltdt. (Guttiferae) extract or of two established antidepressants on basal and stress\u2013induced increase in serum and brain corticosterone levels","author":"Viana","year":"2008","journal-title":"J. Psychopharmacol."},{"issue":"1","key":"10.1016\/j.neulet.2023.137432_b0065","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.pnpbp.2011.08.015","article-title":"Antidepressant-like effect of Valeriana glechomifolia Meyer (Valerianaceae) in mice","volume":"36","author":"M\u00fcller","year":"2012","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2023.137432_b0070","doi-asserted-by":"crossref","unstructured":"L.G. M\u00fcller, et al. Effects of diene valepotriates from Valeriana glechomifolia on Na+\/K+-ATPase activity in the cortex and hippocampus of Mice. Planta medica, 81(3) (2015) 200\u2013207. DOI http:\/\/dx.doi.org\/10.1055\/s-0034-1396200.","DOI":"10.1055\/s-0034-1396200"},{"key":"10.1016\/j.neulet.2023.137432_b0075","unstructured":"R.D. Porsolt, A. Bertin, M. Jalfre, Behavioral despair in mice: a primary screening test for antidepressants. Arch. Int. Pharmacodyn. Ther., 229(2) (1977) 327-336."},{"key":"10.1016\/j.neulet.2023.137432_b0080","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bbr.2017.06.035","article-title":"Environmental enrichment attenuates behavioral abnormalities in valproic acid-exposed autism model mice","volume":"333","author":"Yamaguchi","year":"2017","journal-title":"Behav. Brain Res."},{"issue":"4","key":"10.1016\/j.neulet.2023.137432_b0085","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","article-title":"Behavioural despair in rats: a new model sensitive to antidepressant treatments","volume":"47","author":"Porsolt","year":"1978","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neulet.2023.137432_b0090","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pbb.2014.11.012","article-title":"Repeated forced swimming impairs prepulse inhibition and alters brain-derived neurotrophic factor and astroglial parameters in rats","volume":"128","author":"Borsoi","year":"2015","journal-title":"Pharmacol. Biochem. Behav"},{"issue":"1-3","key":"10.1016\/j.neulet.2023.137432_b0095","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0014-2999(03)01272-X","article-title":"The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review","volume":"463","author":"Prut","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neulet.2023.137432_b0100","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.anbehav.2018.01.018","article-title":"Testing experience and environmental enrichment potentiated open-field habituation and grooming behaviour in rats","volume":"137","author":"Rojas-Carvajal","year":"2018","journal-title":"Anim. Behav."},{"key":"10.1016\/j.neulet.2023.137432_b0105","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.psyneuen.2014.10.021","article-title":"Environmental enrichment models a naturalistic form of maternal separation and shapes the anxiety response patterns of offspring","volume":"52","author":"Connors","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neulet.2023.137432_b0110","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.brainres.2014.12.034","article-title":"Effect of environmental enrichment on dopamine and serotonin transporters and glutamate neurotransmission in medial prefrontal and orbitofrontal cortex","volume":"1599","author":"Darna","year":"2015","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.neulet.2023.137432_b0115","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00702-006-0565-8","article-title":"Environmental enrichment reduces the function of D1 dopamine receptors in the prefrontal cortex of the rat","volume":"114","author":"Del Arco","year":"2007","journal-title":"J. Neural Transm."},{"issue":"4","key":"10.1016\/j.neulet.2023.137432_b0120","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.pharep.2017.03.010","article-title":"Bupropion induces social anxiety in adolescent mice: Influence of housing conditions","volume":"69","author":"G\u00f3mez","year":"2017","journal-title":"Pharmacol. Rep."},{"issue":"1","key":"10.1016\/j.neulet.2023.137432_b0125","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrn.2015.8","article-title":"Neurobiology of rodent self-grooming and its value for translational neuroscience","volume":"17","author":"Kalueff","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2023.137432_b0130","doi-asserted-by":"crossref","unstructured":"T. F\u00fczesi, et al. Hypothalamic CRH neurons orchestrate complex behaviours after stress. Nature Commun. 7 (2016) 11937. DOI: 10.1038\/ncomms11937.","DOI":"10.1038\/ncomms11937"},{"key":"10.1016\/j.neulet.2023.137432_b0135","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pnpbp.2014.10.017","article-title":"Influence of enrichment on behavioral and neurogenic effects of antidepressants in Wistar rats submitted to repeated forced swim test","volume":"58","author":"Possamai","year":"2015","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"4-5","key":"10.1016\/j.neulet.2023.137432_b0140","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.neubiorev.2005.03.008","article-title":"Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test","volume":"29","author":"Cryan","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neulet.2023.137432_b0145","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuroscience.2014.01.047","article-title":"Individual differences in the forced swimming test and the effect of environmental enrichment: Searching for an interaction","volume":"265","author":"Sequeira-Cordero","year":"2014","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.neulet.2023.137432_b0150","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.psyneuen.2010.08.011","article-title":"The double edged sword of neural plasticity: increasing serotonin levels leads to both greater vulnerability to depression and improved capacity to recover","volume":"36","author":"Branchi","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neulet.2023.137432_b0155","doi-asserted-by":"crossref","unstructured":"B.H. Brummett, et al. Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR). Behav. Genet. 38.1 (2008) 34-43. DOI 10.1007\/s10519-007-9172-1.","DOI":"10.1007\/s10519-007-9172-1"},{"issue":"5","key":"10.1016\/j.neulet.2023.137432_b0160","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.semcdb.2011.07.002","article-title":"Effects of environmental enrichment and voluntary exercise on neurogenesis, learning and memory, and pattern separation: BDNF as a critical variable?","volume":"22","author":"Bekinschtein","year":"2011","journal-title":"Semin. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.neulet.2023.137432_b0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hipo.22342","article-title":"BDNF contributes to the facilitation of hippocampal synaptic plasticity and learning enabled by environmental enrichment","volume":"25","author":"Novkovic","year":"2015","journal-title":"Hippocampus"},{"issue":"1","key":"10.1016\/j.neulet.2023.137432_b0170","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ijdevneu.2015.07.008","article-title":"Post\u2010weaning environmental enrichment improves BDNF response of adult male rats","volume":"46","author":"Mosaferi","year":"2015","journal-title":"Int. J. Dev. Neurosci."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394023003919?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394023003919?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:47:59Z","timestamp":1777553279000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394023003919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":34,"alternative-id":["S0304394023003919"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2023.137432","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Environmental enrichment affects behavioral and pharmacological response to antidepressants in CF1 mice","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2023.137432","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"137432"}}