{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T18:37:48Z","timestamp":1787251068267,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.neulet.2023.137594","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T21:33:49Z","timestamp":1702416829000},"page":"137594","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Effects of the uremic toxin indoxyl sulfate on seizure activity, learning and brain oxidative stress parameters in mice"],"prefix":"10.1016","volume":"820","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9610-2532","authenticated-orcid":false,"given":"Krzysztof","family":"\u0141ukawski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Raszewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanis\u0142aw J.","family":"Czuczwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9888","key":"10.1016\/j.neulet.2023.137594_b0005","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0140-6736(13)60687-X","article-title":"Chronic kidney disease: global dimension and perspectives","volume":"382","author":"Jha","year":"2013","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.neulet.2023.137594_b0010","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.kint.2019.06.010","article-title":"The impact of epilepsy and its treatment in patients with end-stage renal disease","volume":"96","author":"Leon","year":"2019","journal-title":"Kidney Int."},{"issue":"9971","key":"10.1016\/j.neulet.2023.137594_b0015","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/S0140-6736(14)60456-6","article-title":"Epilepsy: new advances","volume":"385","author":"Mosh\u00e9","year":"2015","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.neulet.2023.137594_b0020","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.kint.2019.04.033","article-title":"Epilepsy and antiseizure medications increase all-cause mortality in dialysis patients in the United States","volume":"96","author":"Waddy","year":"2019","journal-title":"Kidney Int."},{"key":"10.1016\/j.neulet.2023.137594_b0025","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.1046\/j.1523-1755.2001.59780077.x","article-title":"Endogenous guanidino compounds as uremic neurotoxins","volume":"78","author":"De Deyn","year":"2001","journal-title":"Kidney Int. Suppl."},{"issue":"5","key":"10.1016\/j.neulet.2023.137594_b0030","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1046\/j.1523-1755.2003.00912.x","article-title":"Involvement of voltage- and ligand-gated Ca2+ channels in the neuroexcitatory and synergistic effects of putative uremic neurotoxins","volume":"63","author":"D'Hooge","year":"2003","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.neulet.2023.137594_b0035","doi-asserted-by":"crossref","first-page":"221","DOI":"10.5935\/0101-2800.20140033","article-title":"The quest for a better understanding of chronic kidney disease complications: an update on uremic toxins","volume":"36","author":"Barreto","year":"2014","journal-title":"J. Bras. Nefrol."},{"key":"10.1016\/j.neulet.2023.137594_b0040","doi-asserted-by":"crossref","first-page":"624","DOI":"10.5604\/01.3001.0010.3843","article-title":"Aryl hydrocarbon receptor (AhR) and its endogenous agonist - indoxyl sulfate in chronic kidney disease","volume":"71","author":"Kami\u0144ski","year":"2017","journal-title":"Postepy Hig. Med. Dosw."},{"issue":"12","key":"10.1016\/j.neulet.2023.137594_b0045","doi-asserted-by":"crossref","first-page":"358","DOI":"10.3390\/toxins8120358","article-title":"Indoxyl sulfate-review of toxicity and therapeutic strategies","volume":"8","author":"Leong","year":"2016","journal-title":"Toxins (Basel)"},{"issue":"1","key":"10.1016\/j.neulet.2023.137594_b0050","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1046\/j.1471-4159.2002.01108.x","article-title":"Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain","volume":"83","author":"Ohtsuki","year":"2002","journal-title":"J. Neurochem."},{"issue":"1\u20132","key":"10.1016\/j.neulet.2023.137594_b0055","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/0022-510X(92)90138-B","article-title":"Convulsive action and toxicity of uremic guanidino compounds: behavioral assessment and relation to brain concentration in adult mice","volume":"112","author":"D'Hooge","year":"1992","journal-title":"J. Neurol. Sci."},{"issue":"1","key":"10.1016\/j.neulet.2023.137594_b0060","first-page":"36","article-title":"Some pharmacological properties of the polyamines spermine and spermidine- a re-appraisal","volume":"198","author":"Shaw","year":"1972","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"issue":"1\u20132","key":"10.1016\/j.neulet.2023.137594_b0065","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0014-2999(94)90387-5","article-title":"Essential fatty acid preparation (SR-3) raises the seizure threshold in rats","volume":"254","author":"Yehuda","year":"1994","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.neulet.2023.137594_b0070","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0920-1211(91)90075-Q","article-title":"The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. II. Maximal electroshock seizure models","volume":"8","author":"L\u00f6scher","year":"1991","journal-title":"Epilepsy Res."},{"issue":"3","key":"10.1016\/j.neulet.2023.137594_b0075","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0920-1211(91)90062-K","article-title":"The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazole seizure models","volume":"8","author":"L\u00f6scher","year":"1991","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.neulet.2023.137594_b0080","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.neuro.2014.06.014","article-title":"Cerebro-renal interactions: impact of uremic toxins on cognitive function","volume":"44","author":"Watanabe","year":"2014","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neulet.2023.137594_b0085","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.3389\/fphar.2018.01153","article-title":"Genistein Ameliorates Scopolamine-Induced Amnesia in Mice Through the Regulation of the Cholinergic Neurotransmission, Antioxidant System and the ERK\/CREB\/BDNF Signaling","volume":"9","author":"Lu","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neulet.2023.137594_b0090","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3389\/fphar.2017.00370","article-title":"Indoxyl Sulfate Affects Glial Function Increasing Oxidative Stress and Neuroinflammation in Chronic Kidney Disease: Interaction between Astrocytes and Microglia","volume":"8","author":"Adesso","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neulet.2023.137594_b0095","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.neulet.2023.137594_b0100","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0022-3565(25)03549-9","article-title":"A simplified method of evaluating dose-effect experiments","volume":"96","author":"Litchfield","year":"1949","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neulet.2023.137594_b0105","doi-asserted-by":"crossref","first-page":"795259","DOI":"10.1155\/2012\/795259","article-title":"Oxidative stress and epilepsy: Literature review","volume":"2012","author":"Aguiar","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.neulet.2023.137594_b0110","doi-asserted-by":"crossref","first-page":"9483","DOI":"10.1038\/s41598-020-66421-y","article-title":"Neurobehavioral effects of uremic toxin-indoxyl sulfate in the rat model","volume":"10","author":"Karbowska","year":"2020","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.neulet.2023.137594_b0115","doi-asserted-by":"crossref","first-page":"6681","DOI":"10.18632\/aging.202523","article-title":"Indoxyl sulfate caused behavioral abnormality and neurodegeneration in mice with unilateral nephrectomy","volume":"13","author":"Sun","year":"2021","journal-title":"Aging (Albany NY)"},{"issue":"5","key":"10.1016\/j.neulet.2023.137594_b0120","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3390\/antiox12051049","article-title":"Oxidative stress and neurodegeneration in animal models of seizures and epilepsy","volume":"12","author":"\u0141ukawski","year":"2023","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"10.1016\/j.neulet.2023.137594_b0125","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jep.2012.04.006","article-title":"Anticonvulsant and antioxidative activity of hydroalcoholic extract of tuber of Orchis mascula in pentylenetetrazole and maximal electroshock induced seizures in rats","volume":"142","author":"Pahuja","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.neulet.2023.137594_b0130","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-3-030-78787-5_3","article-title":"Regulation of Antioxidant Enzyme Levels in Rat Brain","volume":"1339","author":"Guggilla","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"issue":"8","key":"10.1016\/j.neulet.2023.137594_b0135","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.fitote.2009.06.011","article-title":"Effects of isopulegol on pentylenetetrazol-induced convulsions in mice: Possible involvementof GABAergic system and antioxidant activity","volume":"80","author":"Silva","year":"2009","journal-title":"Fitoterapia"},{"issue":"7","key":"10.1016\/j.neulet.2023.137594_b0140","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.3390\/antiox12071397","article-title":"Antioxidant therapy reduces oxidative stress, restores Na, K-ATPase function and induces neuroprotection in rodent models of seizure and epilepsy: A systematic review and meta-analysis","volume":"12","author":"de Melo","year":"2023","journal-title":"Antioxidants (Basel)"},{"issue":"4","key":"10.1016\/j.neulet.2023.137594_b0145","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1007\/s11095-006-9183-2","article-title":"Involvement of indoxyl sulfate in renal and central nervous system toxicities during cisplatin-induced acute renal failure","volume":"24","author":"Iwata","year":"2007","journal-title":"Pharm. Res."},{"issue":"1","key":"10.1016\/j.neulet.2023.137594_b0150","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.taap.2011.05.015","article-title":"Metabolomics analysis reveals elevation of 3-indoxyl sulfate in plasma and brain during chemically-induced acute kidney injury in mice: investigation of nicotinic acid receptor agonists","volume":"255","author":"Zgoda-Pols","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.neulet.2023.137594_b0155","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1038\/s41598-018-37935-3","article-title":"Neurological sequel of chronic kidney disease: From diminished Acetylcholinesterase activity to mitochondrial dysfunctions, oxidative stress and inflammation in mice brain","volume":"9","author":"Mazumder","year":"2019","journal-title":"Sci. Rep."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394023005530?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394023005530?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:50:50Z","timestamp":1759625450000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394023005530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":31,"alternative-id":["S0304394023005530"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2023.137594","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of the uremic toxin indoxyl sulfate on seizure activity, learning and brain oxidative stress parameters in mice","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2023.137594","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"137594"}}