{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:35:03Z","timestamp":1788518103390,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.neulet.2024.137741","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T23:13:49Z","timestamp":1711062829000},"page":"137741","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["The impact of Dimethyl itaconate on c-Fos expression in the spinal cord in experimental pain models"],"prefix":"10.1016","volume":"828","author":[{"given":"Mohammad","family":"Abbaszadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8674-3993","authenticated-orcid":false,"given":"Zohreh","family":"Ghotbeddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Tabandeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaveh","family":"Rahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7893","key":"10.1016\/j.neulet.2024.137741_b0005","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/d41586-021-03806-7","article-title":"Nanoparticle asymmetry shapes an immune response","volume":"601","author":"Hooftman","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2024.137741_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2020.07.016","article-title":"The immunomodulatory metabolite itaconate modifies NLRP3 and inhibits inflammasome activation","volume":"32","author":"Hooftman","year":"2020","journal-title":"Cell Metab."},{"issue":"7702","key":"10.1016\/j.neulet.2024.137741_b0015","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41586-018-0052-z","article-title":"Electrophilic properties of itaconate and derivatives regulate the I\u03baB\u03b6\u2013ATF3 inflammatory axis","volume":"556","author":"Bambouskova","year":"2018","journal-title":"Nature"},{"issue":"7699","key":"10.1016\/j.neulet.2024.137741_b0020","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature25986","article-title":"Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1","volume":"556","author":"Mills","year":"2018","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.neulet.2024.137741_b0025","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cmet.2016.06.004","article-title":"Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation","volume":"24","author":"Lampropoulou","year":"2016","journal-title":"Cell Metab"},{"issue":"4","key":"10.1016\/j.neulet.2024.137741_b0030","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1002\/hep.31147","article-title":"Immune-responsive gene 1\/Itaconate activates Nuclear factor erythroid 2-related factor 2 in hepatocytes to protect against liver ischemia-reperfusion injury","volume":"72","author":"Yi","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.neulet.2024.137741_b0035","doi-asserted-by":"crossref","unstructured":"J. Ren, L. Yu, J. Lin, L. Ma, D. Gao, N. Sun, Y. Liu, L. Fang, Z. Cheng, K. Sun, M. Yan, Itaconate as a Promising Therapy for Neuropathic Pain and Inflammatory Pain, 2021.","DOI":"10.21203\/rs.3.rs-404819\/v1"},{"key":"10.1016\/j.neulet.2024.137741_b0040","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0168-9525(86)90191-5","article-title":"Proto-oncogene fos: a multifaceted gene","volume":"2","author":"Verma","year":"1986","journal-title":"Trends Genet."},{"issue":"1","key":"10.1016\/j.neulet.2024.137741_b0045","first-page":"3","article-title":"c-fos and its consequences in pain","volume":"9","author":"Ahmad","year":"2002","journal-title":"Malays J Med Sci"},{"issue":"6131","key":"10.1016\/j.neulet.2024.137741_b0050","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/328632a0","article-title":"Induction of c-fos-like protein in spinal cord neurons following sensory stimulation","volume":"328","author":"Hunt","year":"1987","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.neulet.2024.137741_b0055","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0306-4522(90)90352-5","article-title":"Changing patterns of c-fos induction in spinal neurons following thermal cutaneous stimulation in the rat","volume":"36","author":"Williams","year":"1990","journal-title":"Neuroscience"},{"issue":"2\u20133","key":"10.1016\/j.neulet.2024.137741_b0060","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0304-3959(96)03194-6","article-title":"C-fos can be induced in the neonatal rat spinal cord by both noxious and innocuous peripheral stimulation","volume":"68","author":"Jennings","year":"1996","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.neulet.2024.137741_b0065","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/bja\/76.1.99","article-title":"Nitrous oxide or halothane, or both, fail to suppress c-fos expression in rat spinal cord dorsal horn neurones after subcutaneous formalin","volume":"76","author":"Sun","year":"1996","journal-title":"Br. J. Anaesth."},{"issue":"2","key":"10.1016\/j.neulet.2024.137741_b0070","first-page":"743","article-title":"Intrathecally administered gabapentin inhibits formalin-evoked nociception and the expression of fos-like immunoreactivity in the spinal cord of the rat","volume":"292","author":"Kaneko","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"10.1016\/j.neulet.2024.137741_b0075","first-page":"395","article-title":"The effect of intracerebroventricular injection of CGRP on pain behavioral responses and monoamines concentrations in the periaqueductal gray area in rat","volume":"21","author":"Rahimi","year":"2018","journal-title":"Iran. J. Basic Med. Sci."},{"issue":"5","key":"10.1016\/j.neulet.2024.137741_b0080","first-page":"263","article-title":"Effects of Salmon calcitonin on the concentrations of monoamines in periaqueductal gray in formalin test","volume":"36","author":"Rahimi","year":"2019","journal-title":"Balkan Med J"},{"issue":"4","key":"10.1016\/j.neulet.2024.137741_b0085","doi-asserted-by":"crossref","first-page":"348","DOI":"10.4103\/0976-500X.103699","article-title":"Acetic acid induced painful endogenous infliction in writhing test on mice","volume":"3","author":"Gawade","year":"2012","journal-title":"J Pharmacol Pharmacother"},{"issue":"9","key":"10.1016\/j.neulet.2024.137741_b0090","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1177\/0271678X20943823","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"40","author":"Percie du Sert","year":"2020","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.neulet.2024.137741_b0095","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0304-3959(77)90130-0","article-title":"The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats","volume":"4","author":"Dubuisson","year":"1977","journal-title":"Pain"},{"issue":"5","key":"10.1016\/j.neulet.2024.137741_b0100","first-page":"392","article-title":"Effects of crocin and safranal, saffron constituents, on the formalin-induced orofacial pain in rats","volume":"5","author":"Erfanparast","year":"2015","journal-title":"Avicenna Journal of Phytomedicine"},{"issue":"1","key":"10.1016\/j.neulet.2024.137741_b0105","doi-asserted-by":"crossref","DOI":"10.1177\/15593258231157563","article-title":"Esketamine anesthetizes mice with a Similar potency to racemic ketamine","volume":"21","author":"Ma","year":"2023","journal-title":"Dose Response"},{"issue":"4","key":"10.1016\/j.neulet.2024.137741_b0110","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.neuroscience.2009.11.063","article-title":"Amylin suppresses acetic acid-induced visceral pain and spinal c-fos expression in the mouse","volume":"165","author":"Huang","year":"2010","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.neulet.2024.137741_b0115","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/jnr.20274","article-title":"Alterations in spinal cord gene expression after hindpaw formalin injection","volume":"78","author":"Li","year":"2004","journal-title":"J. Neurosci. Res."},{"issue":"3","key":"10.1016\/j.neulet.2024.137741_b0120","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.cmet.2020.07.016","article-title":"The immunomodulatory metabolite itaconate modifies NLRP3 and inhibits inflammasome activation","volume":"32","author":"Hooftman","year":"2020","journal-title":"Cell Metab"},{"key":"10.1016\/j.neulet.2024.137741_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102553","article-title":"The signaling pathways and therapeutic potential of itaconate to alleviate inflammation and oxidative stress in inflammatory diseases","volume":"58","author":"Shi","year":"2022","journal-title":"Redox Biol"},{"key":"10.1016\/j.neulet.2024.137741_b0130","article-title":"Dimethyl itaconate attenuates CFA-induced inflammatory pain via the NLRP3\/ IL-1\u03b2 signaling pathway","volume":"13","author":"Lin","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.neulet.2024.137741_b0135","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.pbb.2012.01.018","article-title":"Acetic acid- and phenyl-p-benzoquinone-induced overt pain-like behavior depends on spinal activation of MAP kinases, PI(3)K and microglia in mice","volume":"101","author":"Pavao-de-Souza","year":"2012","journal-title":"Pharmacol Biochem Behav"},{"issue":"16","key":"10.1016\/j.neulet.2024.137741_b0140","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1523\/JNEUROSCI.5392-07.2008","article-title":"Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions","volume":"28","author":"Pezet","year":"2008","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.neulet.2024.137741_b0145","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.pharmthera.2006.04.001","article-title":"Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development?","volume":"112","author":"Verri","year":"2006","journal-title":"Pharmacol Ther"},{"issue":"9","key":"10.1016\/j.neulet.2024.137741_b0150","first-page":"1176","article-title":"Effect of pre-electroacupuncture on p38 and c-fos expression in the spinal dorsal horn of rats suffering from visceral pain","volume":"123","author":"Xu","year":"2010","journal-title":"Chin Med J (engl)"},{"issue":"35","key":"10.1016\/j.neulet.2024.137741_b0155","doi-asserted-by":"crossref","first-page":"11120","DOI":"10.1523\/JNEUROSCI.23-35-11120.2003","article-title":"Analgesia induced by dietary restriction is mediated by the \u03ba-opioid system","volume":"23","author":"de los Santos-Arteaga","year":"2003","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.neulet.2024.137741_b0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0361-9230(97)00277-3","article-title":"Using c-fos as a neural marker of pain","volume":"45","author":"Harris","year":"1998","journal-title":"Brain Res. Bull."},{"issue":"3","key":"10.1016\/j.neulet.2024.137741_b0165","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/0306-4522(96)00073-5","article-title":"The massive expression of c-fos protein in spinal dorsal horn neurons is not followed by long-term changes in spinal nociception","volume":"73","author":"Sandk\u00fchler","year":"1996","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.neulet.2024.137741_b0170","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1046\/j.0953-816x.2001.01656.x","article-title":"A role for protein kinase intracellular messengers in substance P-and nociceptor afferent-mediated excitation and expression of the transcription factor fos in rat dorsal horn neurons in vitro","volume":"14","author":"Badie-Mahdavi","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neulet.2024.137741_b0175","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0079-6123(08)61797-5","article-title":"Immediate early genes (IEGs) encoding for inducible transcription factors (ITFs) and neuropeptides in the nervous system: functional network for long-term plasticity and pain","volume":"104","author":"Herdegen","year":"1995","journal-title":"Prog. Brain Res."},{"issue":"1","key":"10.1016\/j.neulet.2024.137741_b0180","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/cne.902310106","article-title":"The somatotopic organization of primary afferent terminals in the superficial laminae of the dorsal horn of the rat spinal cord","volume":"231","author":"Swett","year":"1985","journal-title":"J Comp Neurol"},{"issue":"4774","key":"10.1016\/j.neulet.2024.137741_b0185","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1126\/science.3764416","article-title":"Central projections of identified, unmyelinated (C) afferent fibers innervating mammalian skin","volume":"234","author":"Sugiura","year":"1986","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.neulet.2024.137741_b0190","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0006-8993(92)90378-M","article-title":"Organization of cutaneous primary afferent fibers projecting to the dorsal horn in the rat: WGA-HRP versus B-HRP","volume":"569","author":"Maslany","year":"1992","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.neulet.2024.137741_b0195","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1152\/jn.1987.58.3.460","article-title":"Physiology and morphology of multireceptive neurons with C-afferent fiber inputs in the deep dorsal horn of the rat lumbar spinal cord","volume":"58","author":"Woolf","year":"1987","journal-title":"J. Neurophysiol."},{"issue":"2","key":"10.1016\/j.neulet.2024.137741_b0200","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.neuroscience.2009.03.066","article-title":"Activation of mu-opioid receptors in thalamic nucleus submedius depresses bee venom\u2013evoked spinal c-fos expression and flinching behavior","volume":"161","author":"Feng","year":"2009","journal-title":"Neuroscience"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394024001186?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394024001186?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T01:08:26Z","timestamp":1714093706000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394024001186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":40,"alternative-id":["S0304394024001186"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2024.137741","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of Dimethyl itaconate on c-Fos expression in the spinal cord in experimental pain models","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2024.137741","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"137741"}}