{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:14:23Z","timestamp":1782972863468,"version":"3.54.5"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.neulet.2024.137764","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T15:37:09Z","timestamp":1712245029000},"page":"137764","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Unraveling the molecular landscape of Ataxia Telangiectasia: Insights into Neuroinflammation, immune dysfunction, and potential therapeutic target"],"prefix":"10.1016","volume":"828","author":[{"given":"B.G.","family":"Sunila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Dhanushkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.R.","family":"Dasegowda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthick","family":"Vasudevan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2560-6394","authenticated-orcid":false,"given":"Majji","family":"Rambabu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.neulet.2024.137764_b0005","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1080\/1744666X.2020.1810570","article-title":"Ataxia-telangiectasia: epidemiology, pathogenesis, clinical phenotype, diagnosis, prognosis and management","volume":"16","author":"Amirifar","year":"2020","journal-title":"Expert Rev. Clin. Immunol."},{"key":"10.1016\/j.neulet.2024.137764_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.07.002","article-title":"ATM in DNA repair in cancer","volume":"203","author":"Jin","year":"2019","journal-title":"Pharmacol. Ther."},{"issue":"9","key":"10.1016\/j.neulet.2024.137764_b0015","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1136\/jcp.2007.051144","article-title":"T cell immunodeficiency","volume":"61","author":"Edgar","year":"2008","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.neulet.2024.137764_b0020","article-title":"Analysis of clinical and genetic characterization of three ataxia-telangiectasia pedigrees with novel ATM gene mutations","volume":"10","author":"Huang","year":"2022","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.neulet.2024.137764_b0025","doi-asserted-by":"crossref","unstructured":"Shiloh, Y., & Kastan, M. B. (2001). ATM: genome stability, neuronal development, and cancer cross paths.","DOI":"10.1016\/S0065-230X(01)83007-4"},{"issue":"1","key":"10.1016\/j.neulet.2024.137764_b0030","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1080\/22221751.2020.1746199","article-title":"Hypothesis for potential pathogenesis of SARS-CoV-2 infection\u2013a review of immune changes in patients with viral pneumonia","volume":"9","author":"Lin","year":"2020","journal-title":"Emerging Microbes Infect."},{"issue":"1","key":"10.1016\/j.neulet.2024.137764_b0035","first-page":"S1","article-title":"Allied healthcare professionals","volume":"35","author":"Akkunje","year":"2020","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neulet.2024.137764_b0040","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.neulet.2018.07.005","article-title":"The cerebellum and cognition","volume":"688","author":"Schmahmann","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2024.137764_b0045","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s12311-013-0531-6","article-title":"Consensus paper: management of degenerative cerebellar disorders","volume":"13","author":"Ilg","year":"2014","journal-title":"Cerebellum"},{"key":"10.1016\/j.neulet.2024.137764_b0050","doi-asserted-by":"crossref","unstructured":"Leinonen, R., Sugawara, H., Shumway, M., & International Nucleotide Sequence Database Collaboration. (2010). The sequence read archive.Nucleic acids research,39(suppl_1), D19-D21.","DOI":"10.1093\/nar\/gkq1019"},{"issue":"suppl_1","key":"10.1016\/j.neulet.2024.137764_b0055","first-page":"D28","article-title":"The European nucleotide archive","volume":"39","author":"Leinonen","year":"2010","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.neulet.2024.137764_b0060","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/gix120","article-title":"SOAPnuke: a MapReduce acceleration-supported software for integrated quality control and preprocessing of high-throughput sequencing data","volume":"7","author":"Chen","year":"2018","journal-title":"GigaScience"},{"issue":"15","key":"10.1016\/j.neulet.2024.137764_b0065","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neulet.2024.137764_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2164-16-S8-S2","article-title":"Comparison of GENCODE and RefSeq gene annotation and the impact of reference geneset on variant effect prediction","volume":"16","author":"Frankish","year":"2015","journal-title":"BMC Genomics"},{"issue":"8","key":"10.1016\/j.neulet.2024.137764_b0075","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.neulet.2024.137764_b0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1751-0473-6-2","article-title":"SAMMate: a GUI tool for processing short read alignments in SAM\/BAM format","volume":"6","author":"Xu","year":"2011","journal-title":"Source Code Biol. Med."},{"issue":"8","key":"10.1016\/j.neulet.2024.137764_b0085","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkz114","article-title":"The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads","volume":"47","author":"Liao","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"550","key":"10.1016\/j.neulet.2024.137764_b0090","first-page":"10","article-title":"Differential analysis of count data\u2013the DESeq2 package","volume":"15","author":"Love","year":"2014","journal-title":"GenomeBiol"},{"key":"10.1016\/j.neulet.2024.137764_b0095","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.talanta.2017.09.056","article-title":"Identification of coffee leaves using FT-NIR spectroscopy and SIMCA","volume":"177","author":"Mees","year":"2018","journal-title":"Talanta"},{"issue":"2","key":"10.1016\/j.neulet.2024.137764_b0100","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1198\/tas.2009.0033","article-title":"The history of the cluster heat map","volume":"63","author":"Wilkinson","year":"2009","journal-title":"Am. Stat."},{"key":"10.1016\/j.neulet.2024.137764_b0105","first-page":"111","article-title":"Statistical methods for identifying differentially expressed genes in replicated cDNA microarray experiments","author":"Dudoit","year":"2002","journal-title":"Statistica (Bologna) Sinica"},{"issue":"6","key":"10.1016\/j.neulet.2024.137764_b0110","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1093\/bib\/bby067","article-title":"Interpretation of differential gene expression results of RNA-seq data: review and integration","volume":"20","author":"McDermaid","year":"2019","journal-title":"Brief. Bioinform."},{"issue":"8","key":"10.1016\/j.neulet.2024.137764_b0115","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1093\/bioinformatics\/btz931","article-title":"ShinyGO: a graphical gene-set enrichment tool for animals and plants","volume":"36","author":"Ge","year":"2020","journal-title":"Bioinformatics"},{"issue":"suppl_1","key":"10.1016\/j.neulet.2024.137764_b0120","doi-asserted-by":"crossref","first-page":"D258","DOI":"10.1093\/nar\/gkh036","article-title":"The gene ontology (GO) database and informatics resource","volume":"32","author":"Gene Ontology Consortium","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neulet.2024.137764_b0125","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12859-018-2073-x","article-title":"MEGADOCK-Web: an integrated database of high-throughput structure-based protein-protein interaction predictions","volume":"19","author":"Hayashi","year":"2018","journal-title":"BMC Bioinf."},{"issue":"2","key":"10.1016\/j.neulet.2024.137764_b0130","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41596-018-0103-9","article-title":"Pathway enrichment analysis and visualization of omics data using g: profiler, GSEA, Cytoscape and EnrichmentMap","volume":"14","author":"Reimand","year":"2019","journal-title":"Nature Protocols"},{"key":"10.1016\/j.neulet.2024.137764_b0135","first-page":"7","article-title":"FastQ Screen: A tool for multi-genome mapping and quality control","author":"Wingett","year":"2018","journal-title":"F1000Res."},{"key":"10.1016\/j.neulet.2024.137764_b0140","article-title":"Three differential expression analysis methods for RNA sequencing: limma, EdgeR, DESeq2","volume":"175","author":"Liu","year":"2021","journal-title":"JoVE (journal of Visualized Experiments)"},{"issue":"suppl_2","key":"10.1016\/j.neulet.2024.137764_b0145","doi-asserted-by":"crossref","first-page":"W358","DOI":"10.1093\/nar\/gkn276","article-title":"GOEAST: a web-based software toolkit for gene ontology enrichment analysis","volume":"36","author":"Zheng","year":"2008","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.neulet.2024.137764_b0150","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gku1003","article-title":"STRING v10: protein\u2013protein interaction networks, integrated over the tree of life","volume":"43","author":"Szklarczyk","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"1\u20132","key":"10.1016\/j.neulet.2024.137764_b0155","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.mrfmmm.2004.04.020","article-title":"ATM signaling and genomic stability in response to DNA damage","volume":"569","author":"Lavin","year":"2005","journal-title":"Mutat. Res."},{"issue":"11","key":"10.1016\/j.neulet.2024.137764_b0160","doi-asserted-by":"crossref","first-page":"E656","DOI":"10.1073\/pnas.1110470109","article-title":"ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila","volume":"109","author":"Petersen","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.neulet.2024.137764_b0165","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40035-020-00221-2","article-title":"Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes","volume":"9","author":"Kwon","year":"2020","journal-title":"Transl. Neurodegen."},{"key":"10.1016\/j.neulet.2024.137764_b0170","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1007\/s12035-014-8811-9","article-title":"TYROBP in Alzheimer\u2019s disease","volume":"51","author":"Ma","year":"2015","journal-title":"Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.neulet.2024.137764_b0175","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1042\/BJ20042102","article-title":"Purkinje cell protein-2 (Pcp2) stimulates differentiation in PC12 cells by G\u03b2\u03b3-mediated activation of Ras and p38 MAPK","volume":"392","author":"Guan","year":"2005","journal-title":"Biochem. J"},{"key":"10.1016\/j.neulet.2024.137764_b0180","article-title":"AT neurodegeneration and DNA damage-induced transcriptional stress","volume":"103647","author":"Paull","year":"2024","journal-title":"DNA Repair"},{"key":"10.1016\/j.neulet.2024.137764_b0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-018-1338-7","article-title":"Ibuprofen prevents progression of ataxia telangiectasia symptoms in ATM-deficient mice","volume":"15","author":"Hui","year":"2018","journal-title":"J. Neuroinflammation"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394024001411?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394024001411?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T08:07:23Z","timestamp":1713168443000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394024001411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":37,"alternative-id":["S0304394024001411"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2024.137764","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unraveling the molecular landscape of Ataxia Telangiectasia: Insights into Neuroinflammation, immune dysfunction, and potential therapeutic target","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2024.137764","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"137764"}}