{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:31:58Z","timestamp":1780669918010,"version":"3.54.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.neulet.2024.137831","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T17:14:51Z","timestamp":1716484491000},"page":"137831","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Subcutaneous administration of Stattic alleviates neuropathic pain by relieving inflammation in a mouse model of postherpetic neuralgia"],"prefix":"10.1016","volume":"834","author":[{"given":"Dan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6107-2306","authenticated-orcid":false,"given":"Hong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2024.137831_b0005","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1096\/fba.2019-00070","article-title":"Pharmacological inhibition of STAT3 pathway ameliorates acute liver injury in vivo via inactivation of inflammatory macrophages and hepatic stellate cells","volume":"2","author":"Akcora","year":"2020","journal-title":"FASEB bioAdv."},{"key":"10.1016\/j.neulet.2024.137831_b0010","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1093\/brain\/116.6.1477","article-title":"Postherpetic neuralgia: are C-nociceptors involved in signalling and maintenance of tactile allodynia?","volume":"116","author":"Baron","year":"1993","journal-title":"Brain"},{"key":"10.1016\/j.neulet.2024.137831_b0015","doi-asserted-by":"crossref","first-page":"4930","DOI":"10.1523\/JNEUROSCI.5480-05.2006","article-title":"Induction of glial fibrillary acidic protein expression in astrocytes by nitric oxide","volume":"26","author":"Brahmachari","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2024.137831_b0020","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s12264-017-0145-y","article-title":"Sex-dependent glial signaling in pathological pain: distinct roles of spinal microglia and astrocytes","volume":"34","author":"Chen","year":"2018","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.neulet.2024.137831_b0025","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.brainres.2005.02.024","article-title":"Effect of systemic and intrathecal gabapentin on allodynia in a new rat model of postherpetic neuralgia","volume":"1042","author":"Chen","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2024.137831_b0030","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.brainresrev.2004.07.008","article-title":"Allodynia in rats infected with varicella zoster virus\u2014a small animal model for post-herpetic neuralgia","volume":"46","author":"Dalziel","year":"2004","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.neulet.2024.137831_b0035","first-page":"5229","article-title":"Effects of metformin on the expression of AMPK and STAT3 in the spinal dorsal horn of rats with neuropathic pain","volume":"17","author":"Ge","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.neulet.2024.137831_b0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100352","article-title":"Molecular hydrogen attenuates neuropathic pain in mice","volume":"9","author":"Kawaguchi","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2024.137831_b0045","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0306-4522(02)00372-X","article-title":"Role of primary afferent nerves in allodynia caused by diabetic neuropathy in rats","volume":"114","author":"Khan","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2024.137831_b0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s10020-020-00232-9","article-title":"LncRNA KCNA2-AS regulates spinal astrocyte activation through STAT3 to affect postherpetic neuralgia","volume":"26","author":"Kong","year":"2020","journal-title":"Mol. Med."},{"key":"10.1016\/j.neulet.2024.137831_b0055","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.03029","article-title":"Recent developments on the crosstalk between STAT3 and inflammation in heart function and disease","volume":"9","author":"Kurdi","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.neulet.2024.137831_b0060","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1016\/j.pain.2012.07.020","article-title":"Mechanical allodynia but not thermal hyperalgesia is impaired in mice deficient for ERK2 in the central nervous system","volume":"153","author":"Otsubo","year":"2012","journal-title":"Pain\u00ae"},{"key":"10.1016\/j.neulet.2024.137831_b0065","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11122002","article-title":"JAK-STAT signaling: a double-edged sword of immune regulation and cancer progression","volume":"11","author":"Owen","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.neulet.2024.137831_b0070","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1523\/JNEUROSCI.23-07-02911.2003","article-title":"Resiniferatoxin induces paradoxical changes in thermal and mechanical sensitivities in rats: mechanism of action","volume":"23","author":"Pan","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2024.137831_b0075","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/brain\/119.2.347","article-title":"The relationship of pain, allodynia and thermal sensation in post-herpetic neuralgia","volume":"119","author":"Rowbotham","year":"1996","journal-title":"Brain"},{"key":"10.1016\/j.neulet.2024.137831_b0080","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.chembiol.2006.09.018","article-title":"Stattic: a small-molecule inhibitor of STAT3 activation and dimerization","volume":"13","author":"Schust","year":"2006","journal-title":"Chem. Biol."},{"key":"10.1016\/j.neulet.2024.137831_b0085","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nm.2710","article-title":"Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity","volume":"18","author":"Sorge","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.neulet.2024.137831_b0090","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0304-3959(00)00240-2","article-title":"Allodynia and hyperalgesia induced by herpes simplex virus type-1 infection in mice","volume":"86","author":"Takasaki","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.neulet.2024.137831_b0095","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1213\/ANE.0b013e3181e9f62f","article-title":"The effect of pulsed radiofrequency current on mechanical allodynia induced with resiniferatoxin in rats","volume":"111","author":"Tanaka","year":"2010","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.neulet.2024.137831_b0100","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neuroscience.2017.06.055","article-title":"Deep hypothermia therapy attenuates LPS-induced microglia neuroinflammation via the STAT3 pathway","volume":"358","author":"Tong","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2024.137831_b0105","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1093\/brain\/awr025","article-title":"JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats","volume":"134","author":"Tsuda","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.neulet.2024.137831_b0110","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0003-2697(78)90342-1","article-title":"Determination of malonaldehyde precursor in tissues by thiobarbituric acid test","volume":"86","author":"Uchiyama","year":"1978","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.neulet.2024.137831_b0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s10194-018-0836-4","article-title":"PKM2 is involved in neuropathic pain by regulating ERK and STAT3 activation in rat spinal cord","volume":"19","author":"Wang","year":"2018","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.neulet.2024.137831_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.172987","article-title":"\u03ba-opioid receptor activation promotes mitochondrial fusion and enhances myocardial resistance to ischemia and reperfusion injury via STAT3-OPA1 pathway","volume":"874","author":"Wang","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neulet.2024.137831_b0125","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/toxsci\/kfs106","article-title":"JAK\/STAT pathway plays a critical role in the proinflammatory gene expression and apoptosis of RAW264. 7 cells induced by trichothecenes as DON and T-2 toxin","volume":"127","author":"Wang","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.neulet.2024.137831_b0130","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neuroscience.2014.04.052","article-title":"Aspirin-triggered Lipoxin A4 attenuates mechanical allodynia in association with inhibiting spinal JAK2\/STAT3 signaling in neuropathic pain in rats","volume":"273","author":"Wang","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2024.137831_b0135","doi-asserted-by":"crossref","unstructured":"C.-h. Wu, Z.-t. Lv, Y. Zhao, Y. Gao, J.-q. Li, F. Gao, X.-f. Meng, B. Tian, J. Shi, H.-l. Pan, Electroacupuncture improves thermal and mechanical sensitivities in a rat model of postherpetic neuralgia, Mol. Pain 9 (2013) 1744-8069-1749-1718.","DOI":"10.1186\/1744-8069-9-18"},{"key":"10.1016\/j.neulet.2024.137831_b0140","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s11064-019-02936-9","article-title":"Resveratrol downregulates STAT3 expression and astrocyte activation in primary astrocyte cultures of rat","volume":"45","author":"Wu","year":"2020","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neulet.2024.137831_b0145","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.16917","article-title":"Treatments of traumatic neuropathic pain: a systematic review","volume":"8","author":"Yao","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.neulet.2024.137831_b0150","first-page":"1","article-title":"Long non-coding RNA MEG3 inhibits cervical cancer cell growth by promoting degradation of P-STAT3 protein via ubiquitination","volume":"19","author":"Zhang","year":"2019","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.neulet.2024.137831_b0155","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neulet.2016.11.041","article-title":"Changes in neurotrophic and inflammatory factors in the cerebrospinal fluid of patients with postherpetic neuralgia","volume":"637","author":"Zhao","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2024.137831_b0160","first-page":"1","article-title":"Electroacupuncture inhibits autophagy of glial cells in postherpetic neuralgia by increasing the expression of miR-223-3p","volume":"2021","author":"Zou","year":"2021","journal-title":"Biomed. Res. Int."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030439402400209X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030439402400209X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T23:44:44Z","timestamp":1717803884000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030439402400209X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":32,"alternative-id":["S030439402400209X"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2024.137831","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Subcutaneous administration of Stattic alleviates neuropathic pain by relieving inflammation in a mouse model of postherpetic neuralgia","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2024.137831","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"137831"}}