{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T12:07:52Z","timestamp":1782562072487,"version":"3.54.5"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["142509\/2018-3"],"award-info":[{"award-number":["142509\/2018-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordination of Higher Education Personnel Improvement","doi-asserted-by":"publisher","award":["88882.328263\/2019-01"],"award-info":[{"award-number":["88882.328263\/2019-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2017\/18437-7"],"award-info":[{"award-number":["2017\/18437-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2019\/05240-6"],"award-info":[{"award-number":["2019\/05240-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.neulet.2024.138078","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T22:35:19Z","timestamp":1733438119000},"page":"138078","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Anti-panic effect of fluoxetine during late diestrus in female rats is mediated through GABAergic mechanisms in the dorsal periaqueductal gray"],"prefix":"10.1016","volume":"845","author":[{"given":"Matheus F.","family":"Batistela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma M.","family":"Hernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alana T.","family":"Frias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thelma A.","family":"Lovick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Helio","family":"Zangrossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2024.138078_b0005","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association, Diagnostic and statistical manual of mental disorders. 5th edition, text revision, Washington, DC, 2013.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"10.1016\/j.neulet.2024.138078_b0010","first-page":"239","article-title":"The influence of the menstrual cycle on reactivity to a CO2 challenge among women with and without premenstrual symptoms","volume":"46","author":"Nillni","year":"2017","journal-title":"Cogn. Behav. Ther."},{"key":"10.1016\/j.neulet.2024.138078_b0015","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.euroneuro.2014.11.017","article-title":"Elevation of brain allopregnanolone rather than 5-HT release by short term, low dose fluoxetine treatment prevents the estrous cycle-linked increase in stress sensitivity in female rats","volume":"25","author":"Devall","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neulet.2024.138078_b0020","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1177\/02698811211058986","article-title":"Enhanced responsiveness to hypoxic panicogenic challenge in female rats in late diestrus is suppressed by short-term, low-dose fluoxetine: involvement of the dorsal raphe nucleus and the dorsal periaqueductal gray","volume":"35","author":"Batistela","year":"2021","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.neulet.2024.138078_b0025","doi-asserted-by":"crossref","DOI":"10.1177\/0269881119841833","article-title":"Short-term, low-dose fluoxetine prevents oestrous cycle-linked increase in anxiety-like behaviour in female rats","author":"Machado Figueiredo","year":"2019","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.neulet.2024.138078_b0030","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.tins.2019.03.004","article-title":"Periaqueductal gray sheds light on dark areas of psychopathology","volume":"42","author":"George","year":"2019","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neulet.2024.138078_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2023.109458","article-title":"Orchestration of innate and conditioned defensive actions by the periaqueductal gray","volume":"228","author":"Reis","year":"2023","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neulet.2024.138078_b0040","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1016\/j.cub.2024.05.068","article-title":"Tonically active GABAergic neurons in the dorsal periaqueductal gray control instinctive escape in mice","volume":"34","author":"Stempel","year":"2024","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neulet.2024.138078_b0045","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.coph.2008.12.006","article-title":"SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake","volume":"9","author":"Pinna","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.neulet.2024.138078_b0050","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.psyneuen.2009.08.009","article-title":"Neurosteroids: endogenous allosteric modulators of GABAA receptors","volume":"34","author":"Lambert","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neulet.2024.138078_b0055","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.neubiorev.2014.07.027","article-title":"Etiology, triggers and neurochemical circuits associated with unexpected, expected, and laboratory-induced panic attacks","volume":"46","author":"Johnson","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neulet.2024.138078_b0060","doi-asserted-by":"crossref","first-page":"559","DOI":"10.7205\/MILMED-D-13-00359","article-title":"Syndrome of acute anxiety among marines after recent arrival at high altitude","volume":"179","author":"Sracic","year":"2014","journal-title":"Mil. Med."},{"key":"10.1016\/j.neulet.2024.138078_b0065","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.pnpbp.2019.02.003","article-title":"Nitric oxide in the dorsal periaqueductal gray mediates the panic-like escape response evoked by exposure to hypoxia","volume":"92","author":"Fernandes","year":"2019","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2024.138078_b0070","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neuroscience.2015.08.045","article-title":"Serotonin in the dorsal periaqueductal gray inhibits panic-like defensive behaviors in rats exposed to acute hypoxia","volume":"307","author":"Spiacci","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2024.138078_b0075","author":"Paxinos","year":"1998","journal-title":"Coronal Sections Sagittal Sections Horizontal Sections Transverse Sections"},{"key":"10.1016\/j.neulet.2024.138078_b0080","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.neuroscience.2006.08.058","article-title":"Neuronal excitability in the periaqueductal grey matter during the estrous cycle in female Wistar rats","volume":"144","author":"Brack","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2024.138078_b0085","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.bbr.2019.02.016","article-title":"GABA A \/benzodiazepine receptors in the dorsal periaqueductal gray mediate the panicolytic but not the anxiolytic effect of alprazolam in rats","volume":"364","author":"Frias","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neulet.2024.138078_b0090","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.pbb.2007.12.014","article-title":"GABA in the female brain - Oestrous cycle-related changes in GABAergic function in the periaqueductal grey matter","volume":"90","author":"Lovick","year":"2008","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neulet.2024.138078_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-023-40800-1","article-title":"Structural insights into opposing actions of neurosteroids on GABAA receptors","volume":"14","author":"Legesse","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neulet.2024.138078_b0100","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s40263-023-01030-7","article-title":"GABA-ergic modulators: new therapeutic approaches to premenstrual dysphoric disorder","volume":"37","author":"Sikes-Keilp","year":"2023","journal-title":"CNS Drugs"},{"key":"10.1016\/j.neulet.2024.138078_b0105","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.brainres.2004.07.018","article-title":"Essentiality of central GABAergic neuroactive steroid allopregnanolone for anticonvulsant action of fluoxetine against pentylenetetrazole-induced seizures in mice","volume":"1023","author":"Ugale","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2024.138078_b0110","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1124\/mol.117.108563","article-title":"Rapid throughput analysis of GABAA receptor subtype modulators and blockers using DiSBAC1(3) membrane potential red dye","volume":"92","author":"Nik","year":"2017","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neulet.2024.138078_b0115","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0304-3959(90)90070-T","article-title":"The effect of GABA and its antagonists on midbrain periaqueductal gray neurons in the rat","volume":"40","author":"Behbehani","year":"1990","journal-title":"Pain"},{"key":"10.1016\/j.neulet.2024.138078_b0120","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0091-3057(82)90441-5","article-title":"GABA mediation of the anti-aversive action of minor tranquilizers","volume":"16","author":"Brand\u00e3o","year":"1982","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neulet.2024.138078_b0125","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0166-4328(86)90038-0","article-title":"Modulation of the brain aversive system by gabaregic and serotonergic mechanisms","volume":"22","author":"Graeff","year":"1986","journal-title":"Behav. Brain Res."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394024004579?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394024004579?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T13:11:56Z","timestamp":1734613916000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394024004579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":25,"alternative-id":["S0304394024004579"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2024.138078","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-panic effect of fluoxetine during late diestrus in female rats is mediated through GABAergic mechanisms in the dorsal periaqueductal gray","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2024.138078","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"138078"}}