{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:27:58Z","timestamp":1777868878288,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["1397-04-11-15704"],"award-info":[{"award-number":["1397-04-11-15704"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.neulet.2025.138149","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T11:24:26Z","timestamp":1738754666000},"page":"138149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Synergistic effects of neural stem cells and ibrutinib on neural tissue repair and functional recovery in a contusion mouse model of spinal cord injury"],"prefix":"10.1016","volume":"850","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5305-9773","authenticated-orcid":false,"given":"Somayyeh","family":"Torabi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Zeraatpisheh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Hadi","family":"Anjamrooz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Ghanbari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Shadab","family":"Raza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadi","family":"Aligholi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Azari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2025.138149_b0005","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3389\/fneur.2019.00282","article-title":"Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms","volume":"10","author":"Alizadeh","year":"2019","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.neulet.2025.138149_b0010","doi-asserted-by":"crossref","first-page":"49","DOI":"10.47102\/annals-acadmedsg.V36N1p49","article-title":"Recovery and regeneration after spinal cord injury: a review and summary of recent literature","volume":"36","author":"Lim","year":"2007","journal-title":"Ann.-Acad. Med. Singapore"},{"issue":"6","key":"10.1016\/j.neulet.2025.138149_b0015","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1097\/01.TA.0000034228.18541.D1","article-title":"Traumatic spinal cord injury in Ontario, Canada","volume":"55","author":"Pickett","year":"2003","journal-title":"J. Trauma Acute Care Surg."},{"issue":"12","key":"10.1016\/j.neulet.2025.138149_b0020","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1093\/brain\/awl296","article-title":"The cellular inflammatory response in human spinal cords after injury","volume":"129","author":"Fleming","year":"2006","journal-title":"Brain"},{"issue":"7","key":"10.1016\/j.neulet.2025.138149_b0025","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/sj.sc.3101483","article-title":"Post-traumatic inflammation following spinal cord injury","volume":"41","author":"Hausmann","year":"2003","journal-title":"Spinal Cord"},{"issue":"1","key":"10.1016\/j.neulet.2025.138149_b0030","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s12974-021-02337-2","article-title":"Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration","volume":"18","author":"Hellenbrand","year":"2021","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.neulet.2025.138149_b0035","doi-asserted-by":"crossref","first-page":"4877","DOI":"10.2147\/OTT.S249586","article-title":"Ibrutinib in chronic lymphocytic leukemia: clinical applications, drug resistance, and prospects","volume":"13","author":"Zhou","year":"2020","journal-title":"OncoTargets Therapy"},{"issue":"1","key":"10.1016\/j.neulet.2025.138149_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s10020-018-0069-7","article-title":"Btk inhibitor ibrutinib reduces inflammatory myeloid cell responses in the lung during murine pneumococcal pneumonia","volume":"25","author":"de Porto","year":"2019","journal-title":"Mol. Med."},{"issue":"2","key":"10.1016\/j.neulet.2025.138149_b0045","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3109\/08830185.2012.668982","article-title":"The role of the tec kinase Bruton's tyrosine kinase (Btk) in leukocyte recruitment","volume":"31","author":"Block","year":"2012","journal-title":"Int. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.neulet.2025.138149_b0050","first-page":"23","article-title":"Bruton\u2019s tyrosine kinase inhibitors in the treatment of multiple sclerosis","volume":"32","author":"Shulga","year":"2023","journal-title":"Adva. Psych. Neurol\/post\u0119py Psychiatrii i Neurologii"},{"issue":"3","key":"10.1016\/j.neulet.2025.138149_b0055","doi-asserted-by":"crossref","first-page":"350","DOI":"10.5115\/acb.20.299","article-title":"Ibrutinib reduces neutrophil infiltration, preserves neural tissue and enhances locomotor recovery in mouse contusion model of spinal cord injury","volume":"54","author":"Torabi","year":"2021","journal-title":"Anat Cell Biol"},{"issue":"7","key":"10.1016\/j.neulet.2025.138149_b0060","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nrneurol.2010.73","article-title":"Stem cell therapies for spinal cord injury","volume":"6","author":"Sahni","year":"2010","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.neulet.2025.138149_b0065","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.wneu.2012.08.014","article-title":"Mesenchymal stem cell transplantation reduces glial cyst and improves functional outcome after spinal cord compression","volume":"81","author":"Boido","year":"2014","journal-title":"World Neurosurg."},{"key":"10.1016\/j.neulet.2025.138149_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12929-020-0622-x","article-title":"Effects of neural stem cell transplantation in Alzheimer\u2019s disease models","volume":"27","author":"Hayashi","year":"2020","journal-title":"J. Biomed. Sci."},{"issue":"7","key":"10.1016\/j.neulet.2025.138149_b0075","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.ijdevneu.2013.07.004","article-title":"Review of transplantation of neural stem\/progenitor cells for spinal cord injury","volume":"31","author":"Mothe","year":"2013","journal-title":"Int. J. Dev. Neurosci."},{"issue":"1","key":"10.1016\/j.neulet.2025.138149_b0080","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/stem.253","article-title":"Challenges of stem cell therapy for spinal cord injury: human embryonic stem cells, endogenous neural stem cells, or induced pluripotent stem cells?","volume":"28","author":"Ronaghi","year":"2010","journal-title":"Stem Cells"},{"issue":"38","key":"10.1016\/j.neulet.2025.138149_b0085","doi-asserted-by":"crossref","first-page":"9269","DOI":"10.1523\/JNEUROSCI.2785-16.2017","article-title":"Systemic neutrophil depletion modulates the migration and fate of transplanted human neural stem cells to rescue functional repair","volume":"37","author":"Nguyen","year":"2017","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.neulet.2025.138149_b0090","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2302\/kjm.51.115","article-title":"Neural stem cells: progression of basic research and perspective for clinical application","volume":"51","author":"Okano","year":"2002","journal-title":"Keio J. Med."},{"issue":"4","key":"10.1016\/j.neulet.2025.138149_b0095","doi-asserted-by":"crossref","first-page":"5620","DOI":"10.1111\/ejn.15391","article-title":"Local delivery of fingolimod through PLGA nanoparticles and PuraMatrix\u2010embedded neural precursor cells promote motor function recovery and tissue repair in spinal cord injury","volume":"54","author":"Zeraatpisheh","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neulet.2025.138149_b0100","article-title":"Establishing embryonic mouse neural stem cell culture using the neurosphere assay","volume":"47","author":"Azari","year":"2011","journal-title":"J. Vis. Exp."},{"issue":"1","key":"10.1016\/j.neulet.2025.138149_b0105","doi-asserted-by":"crossref","first-page":"47","DOI":"10.32598\/bcn.2021.35.3","article-title":"A new and simple method for spinal cord injury induction in mice","volume":"13","author":"Zeraatpisheh","year":"2022","journal-title":"Basic Clin. Neurosci."},{"issue":"5","key":"10.1016\/j.neulet.2025.138149_b0110","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1089\/neu.2006.23.635","article-title":"Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains","volume":"23","author":"Basso","year":"2006","journal-title":"J. Neurotrauma"},{"issue":"2","key":"10.1016\/j.neulet.2025.138149_b0115","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neures.2010.02.009","article-title":"A combined scoring method to assess behavioral recovery after mouse spinal cord injury","volume":"67","author":"Pajoohesh-Ganji","year":"2010","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neulet.2025.138149_b0120","first-page":"e2376","article-title":"Assessment of motor balance and coordination in mice using the balance beam","volume":"49","author":"Luong","year":"2011","journal-title":"JoVE (journal of Visualized Experiments)"},{"key":"10.1016\/j.neulet.2025.138149_b0125","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jneumeth.2013.12.008","article-title":"A new and safe method for stereotactically harvesting neural stem\/progenitor cells from the adult rat subventricular zone","volume":"225","author":"Aligholi","year":"2014","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.neulet.2025.138149_b0130","series-title":"Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments","first-page":"417","article-title":"Assessment of lesion and tissue sparing volumes following spinal cord injury","author":"Jakeman","year":"2012"},{"issue":"6","key":"10.1016\/j.neulet.2025.138149_b0135","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1177\/0963689718755778","article-title":"Microenvironment imbalance of spinal cord injury","volume":"27","author":"Fan","year":"2018","journal-title":"Cell Transplant."},{"issue":"6","key":"10.1016\/j.neulet.2025.138149_b0140","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1634\/stemcells.2005-0393","article-title":"Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: effect of in vitro differentiation on graft survival and teratoma formation","volume":"24","author":"Brederlau","year":"2006","journal-title":"Stem Cells"},{"issue":"4","key":"10.1016\/j.neulet.2025.138149_b0145","first-page":"215","article-title":"Stem cell survival and functional outcome after traumatic brain injury is dependent on transplant timing and location","volume":"29","author":"Shear","year":"2011","journal-title":"Restor. Neurol. Neurosci."},{"issue":"11","key":"10.1016\/j.neulet.2025.138149_b0150","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1089\/wound.2019.1046","article-title":"Cell therapeutic strategies for spinal cord injury","volume":"8","author":"Zhou","year":"2019","journal-title":"Adv. Wound Care"},{"issue":"9","key":"10.1016\/j.neulet.2025.138149_b0155","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.3390\/ijms17091380","article-title":"Anti-inflammatory mechanism of neural stem cell transplantation in spinal cord injury","volume":"17","author":"Cheng","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.neulet.2025.138149_b0160","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1146\/annurev.cellbio.24.110707.175235","article-title":"Communication between the synapse and the nucleus in neuronal development, plasticity, and disease","volume":"24","author":"Cohen","year":"2008","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"38","key":"10.1016\/j.neulet.2025.138149_b0165","doi-asserted-by":"crossref","first-page":"16463","DOI":"10.1073\/pnas.0813265106","article-title":"Cooperative synapse formation in the neocortex","volume":"106","author":"Fares","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"13","key":"10.1016\/j.neulet.2025.138149_b0170","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1523\/JNEUROSCI.4184-05.2006","article-title":"Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury","volume":"26","author":"Karimi-Abdolrezaee","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2025.138149_b0175","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1221890","article-title":"Neuronal activity and remyelination: new insights into the molecular mechanisms and therapeutic advancements","volume":"11","author":"Zhou","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"issue":"19","key":"10.1016\/j.neulet.2025.138149_b0180","doi-asserted-by":"crossref","first-page":"4694","DOI":"10.1523\/JNEUROSCI.0311-05.2005","article-title":"Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury","volume":"25","author":"Keirstead","year":"2005","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.neulet.2025.138149_b0185","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/stem.245","article-title":"Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants improve recovery after cervical spinal cord injury","volume":"28","author":"Sharp","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.neulet.2025.138149_b0190","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.792764","article-title":"Reactive astrocytes in central nervous system injury: subgroup and potential therapy","volume":"15","author":"Yu","year":"2021","journal-title":"Front. Cell. Neurosci."},{"issue":"14","key":"10.1016\/j.neulet.2025.138149_b0195","doi-asserted-by":"crossref","first-page":"13742","DOI":"10.1074\/jbc.M411959200","article-title":"A novel role of lactosylceramide in the regulation of tumor necrosis factor \u03b1-mediated proliferation of rat primary astrocytes: implications for astrogliosis following neurotrauma","volume":"280","author":"Pannu","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neulet.2025.138149_b0200","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.brainres.2016.03.043","article-title":"Preparing neural stem\/progenitor cells in PuraMatrix hydrogel for transplantation after brain injury in rats: A comparative methodological study","volume":"1642","author":"Aligholi","year":"2016","journal-title":"Brain Res."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394025000370?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394025000370?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:48:48Z","timestamp":1777553328000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394025000370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":40,"alternative-id":["S0304394025000370"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2025.138149","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic effects of neural stem cells and ibrutinib on neural tissue repair and functional recovery in a contusion mouse model of spinal cord injury","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2025.138149","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"138149"}}