{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:49:11Z","timestamp":1767707351961,"version":"3.40.2"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.neulet.2025.138184","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T16:41:44Z","timestamp":1741279304000},"page":"138184","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["1-Epilupinine enhances cognition and reduces inflammation in scopolamine-induced dementia model mice"],"prefix":"10.1016","volume":"852","author":[{"given":"Chenhui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4826-9848","authenticated-orcid":false,"given":"Jiyi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomeng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tengfei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3128-9997","authenticated-orcid":false,"given":"Jing","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2025.138184_b0005","unstructured":"Prince PM, Guerchet M, Prina M. Policy brief for heads of government: the global impact of dementia 2013\u20132050, Alzheimer\u2019s disease international; 2013."},{"key":"10.1016\/j.neulet.2025.138184_b0010","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41392-024-01911-3","article-title":"Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.neulet.2025.138184_b0015","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev-med-042915-103753","article-title":"Update on Alzheimer's Disease Therapy and Prevention Strategies","volume":"68","author":"Graham","year":"2017","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.neulet.2025.138184_b0020","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s13311-022-01308-6","article-title":"Lecanemab, Aducanumab, and Gantenerumab - Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer's Disease","volume":"20","author":"S\u00f6derberg","year":"2023","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.neulet.2025.138184_b0025","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1001\/jamaneurol.2020.4478","article-title":"Possible Consequences of the Approval of a Disease-Modifying Therapy for Alzheimer Disease","volume":"78","author":"Musiek","year":"2021","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.neulet.2025.138184_b0030","doi-asserted-by":"crossref","first-page":"5148","DOI":"10.1021\/acsomega.4c05527","article-title":"Newer Therapeutic Approaches in Treating Alzheimer's Disease: A Comprehensive Review","volume":"10","author":"Reddi Sree","year":"2025","journal-title":"ACS Omega"},{"key":"10.1016\/j.neulet.2025.138184_b0035","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.bcp.2017.07.002","article-title":"Chinese herbal medicine for Alzheimer's disease: Clinical evidence and possible mechanism of neurogenesis","volume":"141","author":"Yang","year":"2017","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.neulet.2025.138184_b0040","doi-asserted-by":"crossref","DOI":"10.3390\/nu14020327","article-title":"Lupins and Health Outcomes: A Systematic Literature Review","volume":"14","author":"Bryant","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.neulet.2025.138184_b0045","doi-asserted-by":"crossref","first-page":"95","DOI":"10.17221\/114\/2016-CJFS","article-title":"White lupin (Lupinus albus L.) - nutritional and health values in human nutrition - a review","volume":"35","author":"Prusinski","year":"2017","journal-title":"Czech J. Food Sci."},{"key":"10.1016\/j.neulet.2025.138184_b0050","doi-asserted-by":"crossref","first-page":"27862","DOI":"10.1021\/acsomega.3c02179","article-title":"Quinolizidine-Type Alkaloids: Chemodiversity, Occurrence, and Bioactivity","volume":"8","author":"Cely-Veloza","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.neulet.2025.138184_b0055","first-page":"8","article-title":"Derivatives of lupinin and epilupinin as ligands of various cholinesterases","volume":"48","author":"Basova","year":"2012","journal-title":"Zh Evol Biokhim Fiziol"},{"key":"10.1016\/j.neulet.2025.138184_b0060","article-title":"Apigenin Ameliorates Scopolamine-Induced Cognitive Dysfunction and Neuronal Damage in Mice","volume":"26","author":"Kim","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.neulet.2025.138184_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112843","article-title":"Casticin ameliorates scopolamine-induced cognitive dysfunction in mice","volume":"259","author":"Kim","year":"2020","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.neulet.2025.138184_b0070","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1021\/acschemneuro.9b00661","article-title":"QTC-4-MeOBnE Rescues Scopolamine-Induced Memory Deficits in Mice by Targeting Oxidative Stress","volume":"11","author":"Fronza","year":"2020","journal-title":"Neuronal Plasticity, and Apoptosis, ACS Chem Neurosci"},{"key":"10.1016\/j.neulet.2025.138184_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2019.104537","article-title":"Danshensu attenuates scopolamine and amyloid-\u03b2-induced cognitive impairments through the activation of PKA-CREB signaling in mice","volume":"131","author":"Bae","year":"2019","journal-title":"Neurochem Int"},{"key":"10.1016\/j.neulet.2025.138184_b0080","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/cns.13035","article-title":"A review of clinical treatment considerations of donepezil in severe Alzheimer's disease","volume":"24","author":"Adlimoghaddam","year":"2018","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.neulet.2025.138184_b0085","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1080\/13543776.2017.1272571","article-title":"Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature","volume":"27","author":"McHardy","year":"2017","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.neulet.2025.138184_b0090","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/gps.1325","article-title":"Efficacy and safety of donepezil in patients with more severe Alzheimer's disease: a subgroup analysis from a randomized, placebo-controlled trial","volume":"20","author":"Feldman","year":"2005","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1016\/j.neulet.2025.138184_b0095","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1212\/01.wnl.0000266627.96040.5a","article-title":"Donepezil preserves cognition and global function in patients with severe Alzheimer disease","volume":"69","author":"Black","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2025.138184_b0100","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3233\/ADR-210061","article-title":"Neuroprotective Effects of Cholinesterase Inhibitors: Current Scenario in Therapies for Alzheimer's Disease and Future Perspectives","volume":"6","author":"Moreira","year":"2022","journal-title":"J Alzheimers Dis Rep"},{"key":"10.1016\/j.neulet.2025.138184_b0105","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?","volume":"17","author":"Leng","year":"2021","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.neulet.2025.138184_b0110","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1034\/j.1600-0404.2001.103003166.x","article-title":"Local and systemic GM-CSF increase in Alzheimer's disease and vascular dementia","volume":"103","author":"Tarkowski","year":"2001","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.neulet.2025.138184_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2023.578058","article-title":"Effect of Huangdisan grain on improving cognitive impairment in VD rats and its mechanism in immune inflammatory response","volume":"377","author":"Wang","year":"2023","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.neulet.2025.138184_b0120","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.cyto.2008.03.007","article-title":"The granulocyte macrophage colony stimulating factor (GM-CSF) regulates amyloid beta (Abeta) production","volume":"42","author":"Volmar","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.neulet.2025.138184_b0125","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1021\/acschemneuro.9b00329","article-title":"Gracilin A Derivatives Target Early Events in Alzheimer's Disease: in Vitro Effects on Neuroinflammation and Oxidative Stress","volume":"10","author":"Alvari\u00f1o","year":"2019","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.neulet.2025.138184_b0130","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1038\/nm.2965","article-title":"Inhibition of IL-12\/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline","volume":"18","author":"Vom Berg","year":"2012","journal-title":"Nat Med"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394025000722?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394025000722?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T20:01:40Z","timestamp":1742760100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394025000722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":26,"alternative-id":["S0304394025000722"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2025.138184","relation":{},"ISSN":["0304-3940"],"issn-type":[{"type":"print","value":"0304-3940"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"1-Epilupinine enhances cognition and reduces inflammation in scopolamine-induced dementia model mice","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2025.138184","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"138184"}}