{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T17:10:05Z","timestamp":1749489005754,"version":"3.41.0"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007337","name":"Universidade Federal de Santa Maria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.neulet.2025.138256","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T14:56:29Z","timestamp":1747234589000},"page":"138256","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Ultra-high dilution medicines can modulate dopaminergic molecular targets and \u0394FosB in the Nucleus accumbens preventing morphine reacquisition in rats"],"prefix":"10.1016","volume":"859-861","author":[{"given":"Murilo Barboza","family":"Fontoura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica Leandra","family":"Oliveira da Rosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenika Rubert","family":"Rossato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leana Eduarda","family":"Mezzomo de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa Munir","family":"Mustafa Dahleh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Prigol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Petri","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hecson Jesser","family":"Segat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilise Escobar","family":"Burger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2025.138256_b0005","unstructured":"National Institute on Drug Abuse, Advancing Addiction Science, \u2018Drug Overdose Death Rates\u2019. National Institute on Drug Abuse, 2023. Available in: <https:\/\/nida.nih.gov\/research-topics\/trends-statistics\/overdose-death-rates>."},{"key":"10.1016\/j.neulet.2025.138256_b0010","unstructured":"United Nations Office on Drugs and Crime (UNODC), World Drug Report 2023, booklet 2, Contemporary Issues On Drugs (United Nations publication, 2023). Available in: <https:\/\/www.unodc.org\/unodc\/en\/data-and-analysis\/wdr-2023_booklet-2.html>."},{"issue":"5","key":"10.1016\/j.neulet.2025.138256_b0015","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/OGX.0000000000000677","article-title":"The opioid epidemic in the United States\u2014overview, origins, and potential solutions","volume":"74","author":"Jones","year":"2019","journal-title":"Obstet. Gynecol. Surv."},{"issue":"9\u201310","key":"10.1016\/j.neulet.2025.138256_b0020","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/milmed\/usab485","article-title":"The public health approach to the worsening opioid crisis in the United States calls for harm reduction strategies to mitigate the harm from opioid addiction and overdose deaths","volume":"187","author":"Yeo","year":"2022","journal-title":"Mil. Med."},{"key":"10.1016\/j.neulet.2025.138256_b0025","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.drugalcdep.2018.03.021","article-title":"The role of the vasopressin system and dopamine D1 receptors in the effects of social housing condition on morphine reward","volume":"188","author":"Bates","year":"2018","journal-title":"Drug Alcohol Depend."},{"issue":"5","key":"10.1016\/j.neulet.2025.138256_b0030","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.neuron.2005.02.005","article-title":"Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission","volume":"45","author":"Kalivas","year":"2005","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.neulet.2025.138256_b0035","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4238\/2015.January.16.1","article-title":"Dopamine receptor D1 but not D3 essential for morphine-induced conditioned responses","volume":"14","author":"Wang","year":"2015","journal-title":"Genet. Mol. Res."},{"key":"10.1016\/j.neulet.2025.138256_b0040","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.neuroscience.2009.02.007","article-title":"Deficits of mesolimbic dopamine neurotransmission in rat dietary obesity","volume":"159","author":"Geiger","year":"2009","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.neulet.2025.138256_b0045","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1111\/j.1471-4159.1990.tb04599.x","article-title":"Blockade of the noradrenaline carrier increases extracellular dopamine concentrations in the prefrontal cortex: evidence that dopamine is taken up in vivo by noradrenergic terminals","volume":"55","author":"Carboni","year":"1990","journal-title":"J. Neurochem."},{"issue":"14","key":"10.1016\/j.neulet.2025.138256_b0050","doi-asserted-by":"crossref","first-page":"5274","DOI":"10.1073\/pnas.85.14.5274","article-title":"Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats","volume":"85","author":"Di Chiara","year":"1988","journal-title":"PNAS"},{"key":"10.1016\/j.neulet.2025.138256_b0055","article-title":"Management of opioid addiction with opioid substitution treatments: beyond methadone and buprenorphine","volume":"9","author":"Noble","year":"2019","journal-title":"Front. Psych."},{"key":"10.1016\/j.neulet.2025.138256_b0060","article-title":"Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence","volume":"2","author":"Mattick","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.neulet.2025.138256_b0065","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.pbb.2014.07.001","article-title":"Influence of neonatal tactile stimulation on amphetamine preference in young rats: parameters of addiction and oxidative stress","volume":"124","author":"Antoniazzi","year":"2014","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neulet.2025.138256_b0070","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.neuroscience.2025.03.011","article-title":"Beneficial effects of esketamine on morphine preference reacquisition in male rats","volume":"573","author":"Fontoura","year":"2025","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2025.138256_b0075","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.toxlet.2019.03.009","article-title":"Mediterranean X Western based diets: opposite influences on opioid reinstatement","volume":"308","author":"Milanesi","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.neulet.2025.138256_b0080","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.euroneuro.2019.12.111","article-title":"Physical exercise modifies behavioral and molecular parameters related to opioid addiction regardless of training time","volume":"32","author":"Rosa","year":"2020","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"9","key":"10.1016\/j.neulet.2025.138256_b0085","doi-asserted-by":"crossref","first-page":"5564","DOI":"10.1007\/s12035-022-02927-y","article-title":"Tactile stimulation in adult rats modulates dopaminergic molecular parameters in the nucleus accumbens preventing amphetamine relapse","volume":"59","author":"Rossato","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neulet.2025.138256_b0090","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neulet.2018.10.007","article-title":"Substitution therapy with amphetamine-isotherapic attenuates amphetamine toxicological aspects of addiction","volume":"690","author":"Segat","year":"2019","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.neulet.2025.138256_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-017-1807-z","article-title":"A bacosides-containing Bacopa monnieri extract alleviates allodynia and hyperalgesia in the chronic constriction injury model of neuropathic pain in rats","volume":"17","author":"Shahid","year":"2017","journal-title":"BMC Complement. Altern. Med."},{"issue":"5","key":"10.1016\/j.neulet.2025.138256_b0100","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.meegid.2011.02.010","article-title":"Virus-driven evolution: a probable explanation for \u201cSimilia Similibus Curantur\u201d philosophy","volume":"11","author":"Carlucci","year":"2011","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.neulet.2025.138256_b0105","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s12682-014-0197-y","article-title":"Homeopathy: from tradition to science?","volume":"13","author":"Vigan\u00f2","year":"2015","journal-title":"J Med Person"},{"key":"10.1016\/j.neulet.2025.138256_b0110","unstructured":"Horta DOI, Cunha PS. (2021) Parkinson disease treated with constitutional medicine and brains organotherapics: a forty-one (41) patients report. Int J Innov Sci Res Technol 6. DOI: ."},{"key":"10.1016\/j.neulet.2025.138256_b0115","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1590\/1981-7746-sol00130","article-title":"Forma\u00e7\u00e3o em pr\u00e1ticas integrativas e complementares em sa\u00fade: desafios para as universidades p\u00fablicas","volume":"16","author":"Nascimento","year":"2018","journal-title":"Trab Educ Sa\u00fade"},{"key":"10.1016\/j.neulet.2025.138256_b0120","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s11064-017-2444-0","article-title":"Effects of fish and grape seed oils as core of haloperidol-loaded nanocapsules on oral dyskinesia in rats","volume":"43","author":"Benvegn\u00fa","year":"2018","journal-title":"Neurochem. Res."},{"issue":"3","key":"10.1016\/j.neulet.2025.138256_b0125","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1023\/B:JTAN.0000027178.11665.8f","article-title":"New physico-chemical properties of extremely diluted aqueous solutions","volume":"75","author":"Elia","year":"2004","journal-title":"J. Therm. Anal. Calorim."},{"key":"10.1016\/j.neulet.2025.138256_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2019.105031","article-title":"Combining biorelevant in vitro and in silico tools to simulate and better understand the in vivo performance of a nano-sized formulation of aprepitant in the fasted and fed states","volume":"138","author":"Litou","year":"2019","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.neulet.2025.138256_b0135","article-title":"Albumin-bound formulation of paclitaxel (Abraxane\u00ae ABI-007) in the treatment of breast cancer","volume":"99\u2013105","author":"Miele","year":"2009","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.neulet.2025.138256_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctcp.2022.101602","article-title":"Efficacy of individualized homeopathy as an adjunct to standard of care of COVID-19: A randomized, single-blind, placebo-controlled study","volume":"48","author":"Nayak","year":"2022","journal-title":"Complement. Ther. Clin. Pract."},{"issue":"4","key":"10.1016\/j.neulet.2025.138256_b0145","first-page":"292","volume":"16","author":"Rompicherla","year":"2022","journal-title":"Homeopathy in Plantar Psoriasis: an Evidence-Based Case Report."},{"issue":"22","key":"10.1016\/j.neulet.2025.138256_b0150","doi-asserted-by":"crossref","first-page":"33872","DOI":"10.1007\/s11356-022-18633-0","article-title":"Zincum metallicum, a homeopathic drug, alleviates Zn-induced toxic effects and promotes plant growth and antioxidant capacity in Lepidium sativum L","volume":"29","author":"Boudali","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"1","key":"10.1016\/j.neulet.2025.138256_b0155","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4103\/ijrh.ijrh_74_16","article-title":"Homeopathic medicine Mercurius solubilis treatment improves cerebral blood flow and memory in experimentally induced dementia in rats","volume":"11","author":"Hanif","year":"2017","journal-title":"Indian J Res Homoeopathy"},{"issue":"1","key":"10.1016\/j.neulet.2025.138256_b0160","doi-asserted-by":"crossref","first-page":"13562","DOI":"10.1038\/s41598-018-31971-9","article-title":"RETRACTED ARTICLE: Ultra-diluted Toxicodendron pubescens attenuates pro-inflammatory cytokines and ROS-mediated neuropathic pain in rats","volume":"8","author":"Magar","year":"2018","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.neulet.2025.138256_b0165","doi-asserted-by":"crossref","first-page":"597","DOI":"10.17236\/sat00273","article-title":"Evidence-based homeopathy and veterinary homeopathy, and its potential to help overcome the anti-microbial resistance problem\u2014an overview","volume":"162","author":"Weiermayer","year":"2020","journal-title":"Schweizer Arch Tierheilkd"},{"key":"10.1016\/j.neulet.2025.138256_b0170","doi-asserted-by":"crossref","unstructured":"Milanesi LH, et al. (2023) Ferulic acid-loaded nanostructure prevents morphine reinstatement: the involvement of dopamine system, NRF2, and \u0394FosB in the striatum brain area of rats. Naunyn Schmiedebergs Arch Pharmacol:1-11. DOI: doi: 10.1007\/s00210-023-02420-w.","DOI":"10.1007\/s00210-023-02420-w"},{"key":"10.1016\/j.neulet.2025.138256_b0175","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ejphar.2016.06.031","article-title":"Trans fat intake across gestation and lactation increases morphine preference in females but not in male rats: Behavioral and biochemical parameters","volume":"788","author":"Roversi","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neulet.2025.138256_b0180","unstructured":"Farmacopeia Homeop\u00e1tica Brasileira. Bioter\u00e1picos e Isoter\u00e1picos. 3\u00aa ed., v. 1, p. 93, 2011. Available in: <https:\/\/www.gov.br\/anvisa\/pt-br\/ass\/farmacopeia\/farmacopeia-homeopatica\/arquivos\/8048json-file-1>."},{"key":"10.1016\/j.neulet.2025.138256_b0185","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3389\/fnbeh.2020.00075","article-title":"Ketamine blocks morphine-induced conditioned place preference and anxiety-like behaviors in mice","volume":"14","author":"McKendrick","year":"2020","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neulet.2025.138256_b0190","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s002130000569","article-title":"Conditioned place preference: What does it add to our preclinical understanding of drug reward?","volume":"153","author":"Bardo","year":"2000","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neulet.2025.138256_b0195","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.bbr.2014.04.019","article-title":"Influence of cholinesterase inhibitors, donepezil and rivastigmine, on the acquisition, expression, and reinstatement of morphine-induced conditioned place preference in rats","volume":"268","author":"Gawel","year":"2014","journal-title":"Behav. Brain Res."},{"issue":"6","key":"10.1016\/j.neulet.2025.138256_b0200","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1177\/0269881109102613","article-title":"Conditioned place preference and locomotor activity in response to methylphenidate, amphetamine, and cocaine in mice lacking dopamine D4 receptors","volume":"24","author":"Thanos","year":"2010","journal-title":"J. Psychopharmacol."},{"issue":"1\u20132","key":"10.1016\/j.neulet.2025.138256_b0205","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0166-4328(01)00164-4","article-title":"Effects of dopamine antagonists with different receptor blockade profiles on morphine-induced place preference in male mice","volume":"121","author":"Manzanedo","year":"2001","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neulet.2025.138256_b0210","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1750-1326-7-1","article-title":"Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice","volume":"7","author":"Chu","year":"2012","journal-title":"Mol. Neurodegener."},{"issue":"5","key":"10.1016\/j.neulet.2025.138256_b0215","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.physbeh.2007.03.028","article-title":"Brain serotonin depletion impairs short-term memory, but not long-term memory, in rats","volume":"91","author":"Hritcu","year":"2007","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neulet.2025.138256_b0220","first-page":"254","article-title":"The relation between fear induced by novel stimulation and exploratory behavior","volume":"48","author":"Montgomery","year":"1955","journal-title":"J. Comp. Physiol."},{"issue":"8","key":"10.1016\/j.neulet.2025.138256_b0225","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.biopsych.2008.05.025","article-title":"Early post-stressor intervention with high-dose corticosterone attenuates posttraumatic stress response in an animal model of posttraumatic stress disorder","volume":"64","author":"Cohen","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2025.138256_b0230","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s12640-015-9549-5","article-title":"Cross-generational trans fat consumption favors self-administration of amphetamine and changes molecular expressions of BDNF, DAT, and D1\/D2 receptors in the cortex and hippocampus of rats","volume":"28","author":"Kuhn","year":"2015","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.neulet.2025.138256_b0235","doi-asserted-by":"crossref","unstructured":"Watson C, Paxinos G. (2013) Chemoarchitectonic Atlas of the Mouse Brain. Academic Press, 1st ed. DOI: 10.1007\/s12682-014-0197-y.","DOI":"10.1007\/s12682-014-0197-y"},{"issue":"1","key":"10.1016\/j.neulet.2025.138256_b0240","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00213-018-5076-4","article-title":"Extinction of instrumental (operant) learning: Interference, varieties of context, and mechanisms of contextual control","volume":"236","author":"Bouton","year":"2019","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.neulet.2025.138256_b0245","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.neuroscience.2018.05.043","article-title":"Extinction and reinstatement of cocaine-seeking in self-administering mice is associated with bidirectional AMPAR-mediated plasticity in the nucleus accumbens shell","volume":"384","author":"Ebner","year":"2018","journal-title":"Neuroscience"},{"issue":"11","key":"10.1016\/j.neulet.2025.138256_b0250","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1038\/nn1105-1437","article-title":"The role of neuroadaptations in relapse to drug seeking","volume":"8","author":"Shaham","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neulet.2025.138256_b0255","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.bbr.2017.12.010","article-title":"Antagonism of the D1-and D2-like dopamine receptors in the nucleus accumbens attenuates forced swim stress-and morphine priming-induced reinstatement of extinguished rats","volume":"341","author":"Farzinpour","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neulet.2025.138256_b0260","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bbr.2014.01.005","article-title":"Exercise modifies amphetamine relapse: Behavioral and oxidative markers in rats","volume":"262","author":"Segat","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neulet.2025.138256_b0265","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.neuropharm.2004.06.032","article-title":"Dopamine and drug addiction: the nucleus accumbens shell connection","volume":"47","author":"Di Chiara","year":"2004","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.neulet.2025.138256_b0270","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.nrleng.2014.08.001","article-title":"Effects of morphine on brain plasticity","volume":"30","author":"Beltran-Campos","year":"2015","journal-title":"Neurolog\u00eda (engl Ed)"},{"issue":"12","key":"10.1016\/j.neulet.2025.138256_b0275","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1038\/s41380-019-0484-3","article-title":"Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion","volume":"25","author":"Soares-Cunha","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neulet.2025.138256_b0280","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1146\/annurev-psych-010418-103337","article-title":"Dopamine and addiction","volume":"71","author":"Wise","year":"2020","journal-title":"Annu. Rev. Psychol."},{"issue":"8","key":"10.1016\/j.neulet.2025.138256_b0285","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S2215-0366(16)00104-8","article-title":"Neurobiology of addiction: a neurocircuitry analysis","volume":"3","author":"Koob","year":"2016","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.neulet.2025.138256_b0290","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neubiorev.2018.03.020","article-title":"Dopamine D1 and D3 receptor polypharmacology as a potential treatment approach for substance use disorder","volume":"89","author":"Galaj","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.neulet.2025.138256_b0295","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/ejn.13357","article-title":"Membrane transporters as mediators of synaptic dopamine dynamics: implications for disease","volume":"45","author":"Lohr","year":"2017","journal-title":"Eur. J. Neurosci."},{"issue":"2\u20133","key":"10.1016\/j.neulet.2025.138256_b0300","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/FBP.0000000000000546","article-title":"D1-but not D2-like dopamine receptor antagonist in the CA1 region of the hippocampus reduced stress-induced reinstatement in extinguished morphine-conditioning place preference in the food-deprived rats","volume":"31","author":"Nazari-Serenjeh","year":"2020","journal-title":"Behav. Pharmacol."},{"issue":"8","key":"10.1016\/j.neulet.2025.138256_b0305","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/s41386-018-0284-5","article-title":"Dopamine D3R antagonist VK4-116 attenuates oxycodone self-administration and reinstatement without compromising its antinociceptive effects","volume":"44","author":"You","year":"2019","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.neulet.2025.138256_b0310","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1124\/jpet.105.083410","article-title":"D1 dopamine receptors modulate \u0394FosB induction in rat striatum after intermittent morphine administration","volume":"314","author":"Muller","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neulet.2025.138256_b0315","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.drugalcdep.2015.01.030","article-title":"The dopamine transporter gene may not contribute to susceptibility and the specific personality traits of amphetamine dependence","volume":"149","author":"Tzeng","year":"2015","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.neulet.2025.138256_b0320","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ejphar.2014.10.034","article-title":"\u0394FosB: a transcriptional regulator of stress and antidepressant responses","volume":"753","author":"Nestler","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"26","key":"10.1016\/j.neulet.2025.138256_b0325","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.1523\/JNEUROSCI.0296-18.2018","article-title":"Cell-type-specific role of \u0394FosB in nucleus accumbens in modulating intermale aggression","volume":"38","author":"Aleyasin","year":"2018","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.neulet.2025.138256_b0330","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1073\/pnas.1221742110","article-title":"\u0394FosB differentially modulates nucleus accumbens direct and indirect pathway function","volume":"110","author":"Grueter","year":"2013","journal-title":"PNAS"},{"issue":"1","key":"10.1016\/j.neulet.2025.138256_b0335","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biopsych.2011.08.011","article-title":"\u0394FosB enhances the rewarding effects of cocaine while reducing the pro-depressive effects of the kappa-opioid receptor agonist U50488","volume":"71","author":"Muschamp","year":"2012","journal-title":"Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.neulet.2025.138256_b0340","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1046\/j.0953-816x.2000.01443.x","article-title":"Dopamine D2 receptors regulate tyrosine hydroxylase activity and phosphorylation at Ser40 in rat striatum","volume":"13","author":"Lindgren","year":"2001","journal-title":"Eur J Neurosci"},{"issue":"1","key":"10.1016\/j.neulet.2025.138256_b0345","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12840","article-title":"Behavioral sensitization and cellular responses to psychostimulants are reduced in D2R knockout mice","volume":"26","author":"Solis","year":"2021","journal-title":"Addict. Biol."},{"issue":"8","key":"10.1016\/j.neulet.2025.138256_b0350","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1017\/S1461145713000205","article-title":"Innately low D2 receptor availability is associated with high novelty-seeking and enhanced behavioural sensitization to amphetamine","volume":"16","author":"Tournier","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neulet.2025.138256_b0355","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neuroscience.2014.01.025","article-title":"The role of D2-autoreceptors in regulating dopamine neuron activity and transmission","volume":"282","author":"Ford","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2025.138256_b0360","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.pbb.2016.08.009","article-title":"Modafinil decreases cocaine choice in human cocaine smokers only when the response requirement and the alternative reinforcer magnitude are large","volume":"150","author":"Foltin","year":"2016","journal-title":"Pharmacol. Biochem. Behav"},{"key":"10.1016\/j.neulet.2025.138256_b0365","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.drugalcdep.2016.09.005","article-title":"Use of and reasons for using multiple other tobacco products in daily and nondaily smokers: Associations with cigarette consumption and nicotine dependence","volume":"168","author":"Dunbar","year":"2016","journal-title":"Drug Alcohol Depend."},{"issue":"9358","key":"10.1016\/j.neulet.2025.138256_b0370","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0140-6736(03)12600-1","article-title":"1-year retention and social function after buprenorphine-assisted relapse prevention treatment for heroin dependence in Sweden: a randomised, placebo-controlled trial","volume":"361","author":"Kakko","year":"2003","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.neulet.2025.138256_b0375","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1177\/1060028016629161","article-title":"Treatment of severe alcohol withdrawal","volume":"50","author":"Schmidt","year":"2016","journal-title":"Ann. Pharmacother."},{"issue":"2","key":"10.1016\/j.neulet.2025.138256_b0380","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/JCP.0b013e3181d21967","article-title":"Cocaine choice in humans during D-amphetamine maintenance","volume":"30","author":"Rush","year":"2010","journal-title":"J. Clin. Psychopharmacol."},{"issue":"12","key":"10.1016\/j.neulet.2025.138256_b0385","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1080\/10826080500260800","article-title":"Dual diagnosis and quality of life in patients in treatment for opioid dependence","volume":"40","author":"Bizzarri","year":"2005","journal-title":"Subst. Use Misuse"},{"key":"10.1016\/j.neulet.2025.138256_b0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugalcdep.2019.107616","article-title":"Characteristics and current clinical practices of opioid treatment programs in the United States","volume":"205","author":"Jones","year":"2019","journal-title":"Drug Alcohol Depend."},{"issue":"1","key":"10.1016\/j.neulet.2025.138256_b0395","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/ADM.0b013e3181d41ddb","article-title":"Adoption and implementation of medications in addiction treatment programs","volume":"5","author":"Knudsen","year":"2011","journal-title":"J. Addict. Med."},{"issue":"6","key":"10.1016\/j.neulet.2025.138256_b0400","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/alcalc\/33.6.563","article-title":"Benzodiazepine treatment for alcohol-dependent patients","volume":"33","author":"Lejoyeux","year":"1998","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.neulet.2025.138256_b0405","article-title":"Alcohol withdrawal syndrome: benzodiazepines and beyond","volume":"9(9):VE01","author":"Sachdeva","year":"2015","journal-title":"J. Clin. Diagn. Res."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394025001442?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394025001442?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T16:31:23Z","timestamp":1749486683000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394025001442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":81,"alternative-id":["S0304394025001442"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2025.138256","relation":{},"ISSN":["0304-3940"],"issn-type":[{"type":"print","value":"0304-3940"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ultra-high dilution medicines can modulate dopaminergic molecular targets and \u0394FosB in the Nucleus accumbens preventing morphine reacquisition in rats","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2025.138256","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"138256"}}