{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:26:18Z","timestamp":1768433178284,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515010379"],"award-info":[{"award-number":["2025A1515010379"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"publisher","award":["GMUCR2024-02020"],"award-info":[{"award-number":["GMUCR2024-02020"]}],"id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472598"],"award-info":[{"award-number":["82472598"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2024A03J01274"],"award-info":[{"award-number":["2024A03J01274"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.neulet.2025.138447","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T05:35:34Z","timestamp":1763616934000},"page":"138447","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Constraint-induced movement therapy combined with Nogo-A downregulation enhances corticospinal tract remodeling and motor function in hemiplegic cerebral palsy mice"],"prefix":"10.1016","volume":"870","author":[{"given":"Yuan","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunlan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liru","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danxia","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Le","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0639-3488","authenticated-orcid":false,"given":"Kaishou","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.neulet.2025.138447_b0005","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1001\/jamapediatrics.2022.4541","article-title":"Cerebral palsy and maternal injury during pregnancy","volume":"177","author":"Liew","year":"2023","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.neulet.2025.138447_b0010","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/bs.acc.2020.04.006","article-title":"Advances in cerebral palsy biomarkers","volume":"100","author":"Alpay Savasan","year":"2021","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.neulet.2025.138447_b0015","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.pediatrneurol.2021.09.019","article-title":"Somatosensory plasticity in hemiplegic cerebral palsy following constraint induced movement therapy","volume":"126","author":"Jobst","year":"2022","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.neulet.2025.138447_b0020","doi-asserted-by":"crossref","unstructured":"Novak I, Morgan C, Fahey M, et al. State of the Evidence Traffic Lights 2019: Systematic Review of Interventions for Preventing and Treating Children with Cerebral Palsy.Curr Neurol Neurosci Rep. 2020;20(2):3. Published 2020 Feb 21. doi:10.1007\/s11910-020-1022-z.","DOI":"10.1007\/s11910-020-1022-z"},{"key":"10.1016\/j.neulet.2025.138447_b0025","doi-asserted-by":"crossref","unstructured":"Rumajogee P, Altamentova S, Li J, et al. Constraint-Induced Movement Therapy (CIMT) and Neural Precursor Cell (NPC) Transplantation Synergistically Promote Anatomical and Functional Recovery in a Hypoxic-Ischemic Mouse Model.Int J Mol Sci. 2024;25(17):9403. Published 2024 Aug 29. doi:10.3390\/ijms25179403.","DOI":"10.3390\/ijms25179403"},{"issue":"2","key":"10.1016\/j.neulet.2025.138447_b0030","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/cvr\/cvac108","article-title":"Nogo-a reduces ceramide de novo biosynthesis to protect from heart failure","volume":"119","author":"Sasset","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.neulet.2025.138447_b0035","doi-asserted-by":"crossref","unstructured":"Wang J, Ni G, Liu Y, Han Y, Jia L, Wang Y. Tanshinone IIA Promotes Axonal Regeneration in Rats with Focal Cerebral Ischemia Through the Inhibition of Nogo-A\/NgR1\/RhoA\/ROCKII\/MLC Signaling.Drug Des Devel Ther. 2020;14:2775-2787. Published 2020 Jul 15. doi:10.2147\/DDDT.S253280.","DOI":"10.2147\/DDDT.S253280"},{"issue":"2","key":"10.1016\/j.neulet.2025.138447_b0040","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1177\/1545968320981962","article-title":"Constraint-induced movement therapy promotes neural remodeling and functional reorganization by overcoming Nogo-A\/NgR\/RhoA\/rock signals in hemiplegic cerebral palsy mice","volume":"35","author":"Liu","year":"2021","journal-title":"Neurorehabil. Neural Repair"},{"issue":"6","key":"10.1016\/j.neulet.2025.138447_b0045","doi-asserted-by":"crossref","first-page":"390","DOI":"10.21037\/atm.2020.03.144","article-title":"Effects of bone marrow mesenchymal stem cells transplantation on the recovery of neurological functions and the expression of Nogo-a, NgR, Rhoa, and ROCK in rats with experimentally-induced convalescent cerebral ischemia","volume":"8","author":"Zhang","year":"2020","journal-title":"Ann. Transl. Med."},{"issue":"1","key":"10.1016\/j.neulet.2025.138447_b0050","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/ana.22009","article-title":"Nogo-a antibodies and training reduce muscle spasms in spinal cord-injured rats","volume":"68","author":"Gonzenbach","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neulet.2025.138447_b0055","doi-asserted-by":"crossref","unstructured":"Nagaraj V, Theis T, Johal AS, et al. Application of Antibodies to Neuronally Expressed Nogo-A Increases Neuronal Survival and Neurite Outgrowth.Int J Mol Sci. 2020;21(15):5417. Published 2020 Jul 30. doi:10.3390\/ijms21155417.","DOI":"10.3390\/ijms21155417"},{"issue":"4","key":"10.1016\/j.neulet.2025.138447_b0060","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/uog.24935","article-title":"Diffusion tensor imaging of fetal brain: principles, potential and limitations of promising technique","volume":"60","author":"Corroenne","year":"2022","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.neulet.2025.138447_b0065","doi-asserted-by":"crossref","unstructured":"Behler A, M\u00fcller HP, Ludolph AC, Kassubek J. Diffusion Tensor Imaging in Amyotrophic Lateral Sclerosis: Machine Learning for Biomarker Development.Int J Mol Sci. 2023;24(3):1911. Published 2023 Jan 18. doi:10.3390\/ijms24031911.","DOI":"10.3390\/ijms24031911"},{"key":"10.1016\/j.neulet.2025.138447_b0070","doi-asserted-by":"crossref","unstructured":"Zhang B, Li Z, Zhang R, et al. PKC\u03b3 promotes axonal remodeling in the cortico-spinal tract via GSK3\u03b2\/\u03b2-catenin signaling after traumatic brain injury.Sci Rep. 2019;9(1):17078. Published 2019 Nov 19. doi:10.1038\/s41598-019-53225-y.","DOI":"10.1038\/s41598-019-53225-y"},{"key":"10.1016\/j.neulet.2025.138447_b0075","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.brainres.2018.11.011","article-title":"Constrained-induced movement therapy promotes motor function recovery by enhancing the remodeling of ipsilesional corticospinal tract in rats after stroke","volume":"1708","author":"Hu","year":"2019","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.neulet.2025.138447_b0080","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00401-017-1745-3","article-title":"Nogo-A antibodies enhance axonal repair and remyelination in neuro-inflammatory and demyelinating pathology","volume":"134","author":"Ineichen","year":"2017","journal-title":"Acta Neuropathol."},{"issue":"28","key":"10.1016\/j.neulet.2025.138447_b0085","doi-asserted-by":"crossref","first-page":"14270","DOI":"10.1073\/pnas.1905309116","article-title":"Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke","volume":"116","author":"Rust","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2025.138447_b0090","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fneur.2016.00057","article-title":"Rodent hypoxia-ischemia models for cerebral palsy research: a systematic review","volume":"7","author":"Rumajogee","year":"2016","journal-title":"Front. Neurol."},{"issue":"4","key":"10.1016\/j.neulet.2025.138447_b0095","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1089\/hgtb.2013.076","article-title":"Transduction of the central nervous system after intracerebroventricular injection of adeno-associated viral vectors in neonatal and juvenile mice","volume":"24","author":"Gholizadeh","year":"2013","journal-title":"Hum. Gene Ther. Methods"},{"issue":"6","key":"10.1016\/j.neulet.2025.138447_b0100","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1249\/MSS.0000000000003134","article-title":"Maladaptive neuroplasticity in corticospinal tract after ankle sprain: causal links established by mendelian randomization","volume":"55","author":"Xue","year":"2023","journal-title":"Med. Sci. Sports Exerc."},{"issue":"4","key":"10.1016\/j.neulet.2025.138447_b0105","doi-asserted-by":"crossref","first-page":"52","DOI":"10.20463\/jenb.2017.0034","article-title":"Effects of acute voluntary loaded wheel running on BDNF expression in the rat hippocampus","volume":"21","author":"Lee","year":"2017","journal-title":"J. Exer. Nutri. Biochem."},{"key":"10.1016\/j.neulet.2025.138447_b0110","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.bbr.2016.09.067","article-title":"Physical exercise induces hippocampal neurogenesis and prevents cognitive decline","volume":"317","author":"Ma","year":"2017","journal-title":"Behav. Brain Res."},{"issue":"8","key":"10.1016\/j.neulet.2025.138447_b0115","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1111\/cns.14322","article-title":"Multiparametric mapping of white matter reorganizations in patients with frontal glioma-related epilepsy","volume":"29","author":"Zhang","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.neulet.2025.138447_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2023.103521","article-title":"A preliminary study on corticospinal tract morphology in incidental and symptomatic insular low-grade glioma: implications for post-surgical motor outcomes","volume":"40","author":"Yang","year":"2023","journal-title":"Neuroimage Clin."},{"issue":"5","key":"10.1016\/j.neulet.2025.138447_b0125","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.neucli.2021.09.002","article-title":"Brain functional reorganization in children with hemiplegic cerebral palsy: Assessment with TMS and therapeutic perspectives","volume":"51","author":"Nardone","year":"2021","journal-title":"Neurophysiol. Clin."},{"key":"10.1016\/j.neulet.2025.138447_b0130","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.neuroscience.2018.12.028","article-title":"Altered white matter connectivity associated with intergyral brain disorganization in hemiplegic cerebral palsy","volume":"399","author":"Papadelis","year":"2019","journal-title":"Neuroscience"},{"issue":"6881","key":"10.1016\/j.neulet.2025.138447_b0135","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/416636a","article-title":"Chondroitinase ABC promotes functional recovery after spinal cord injury","volume":"416","author":"Bradbury","year":"2002","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.neulet.2025.138447_b0140","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1177\/15459683231203194","article-title":"Anti-Nogo-A antibody therapy improves functional outcome following traumatic brain injury","volume":"37","author":"Powers","year":"2023","journal-title":"Neurorehabil. Neural Repair"},{"issue":"10","key":"10.1016\/j.neulet.2025.138447_b0145","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1007\/s12031-021-01863-1","article-title":"Combination of electroacupuncture and constraint-induced movement therapy enhances functional recovery after ischemic stroke in rats","volume":"71","author":"Wang","year":"2021","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.neulet.2025.138447_b0150","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.expneurol.2018.04.006","article-title":"Constraint-induced movement therapy improves efficacy of task-specific training after severe cortical stroke depending on the ipsilesional corticospinal projections","volume":"305","author":"Okabe","year":"2018","journal-title":"Exp. Neurol."},{"issue":"12","key":"10.1016\/j.neulet.2025.138447_b0155","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/j.clinph.2014.02.025","article-title":"Changes in diffusion tensor tractographic findings associated with constraint-induced movement therapy in young children with cerebral palsy","volume":"125","author":"Kwon","year":"2014","journal-title":"Clin. Neurophysiol."},{"issue":"Pt 3","key":"10.1016\/j.neulet.2025.138447_b0160","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1093\/brain\/awt336","article-title":"Rewiring of the corticospinal tract in the adult rat after unilateral stroke and anti-Nogo-A therapy","volume":"137","author":"Lindau","year":"2014","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.neulet.2025.138447_b0165","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1161\/STROKEAHA.111.000361","article-title":"Constraint-induced movement therapy overcomes the intrinsic axonal growth-inhibitory signals in stroke rats","volume":"44","author":"Zhao","year":"2013","journal-title":"Stroke"},{"issue":"10","key":"10.1016\/j.neulet.2025.138447_b0170","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.4103\/1673-5374.257528","article-title":"Constraint-induced movement therapy enhances angiogenesis and neurogenesis after cerebral ischemia\/reperfusion","volume":"14","author":"Zhai","year":"2019","journal-title":"Neural Regen. Res."},{"issue":"6\u20137","key":"10.1016\/j.neulet.2025.138447_b0175","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1177\/1545968318776371","article-title":"First-in-man intrathecal application of neurite growth-promoting Anti-Nogo-A antibodies in acute spinal cord injury","volume":"32","author":"Kucher","year":"2018","journal-title":"Neurorehabil. Neural Repair"},{"issue":"3","key":"10.1016\/j.neulet.2025.138447_b0180","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s40263-017-0407-2","article-title":"Nogo-A antibodies for progressive multiple sclerosis","volume":"31","author":"Ineichen","year":"2017","journal-title":"CNS Drugs"},{"key":"10.1016\/j.neulet.2025.138447_b0185","doi-asserted-by":"crossref","unstructured":"Gao Z, Pang Z, Lei G, et al. Crossing nerve transfer drives sensory input-dependent plasticity for motor recovery after brain injury.Sci Adv. 2022;8(35):eabn5899. doi:10.1126\/sciadv.abn5899.","DOI":"10.1126\/sciadv.abn5899"},{"issue":"5","key":"10.1016\/j.neulet.2025.138447_b0190","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.cmet.2020.08.015","article-title":"Glial metabolic rewiring promotes axon regeneration and functional recovery in the central nervous system","volume":"32","author":"Li","year":"2020","journal-title":"Cell Metab."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394025003362?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394025003362?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:02:19Z","timestamp":1768395739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394025003362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":38,"alternative-id":["S0304394025003362"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2025.138447","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Constraint-induced movement therapy combined with Nogo-A downregulation enhances corticospinal tract remodeling and motor function in hemiplegic cerebral palsy mice","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2025.138447","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"138447"}}