{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T07:13:10Z","timestamp":1783581190217,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012669","name":"Natural Science Foundation Project of Chongqing","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172542"],"award-info":[{"award-number":["82172542"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301569"],"award-info":[{"award-number":["82301569"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["CSTB2022NSCQ-MSX0164"],"award-info":[{"award-number":["CSTB2022NSCQ-MSX0164"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["CSTB2023NSCQ-MSX0010"],"award-info":[{"award-number":["CSTB2023NSCQ-MSX0010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.neulet.2025.138466","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:02:27Z","timestamp":1764172947000},"page":"138466","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Transcutaneous auricular vagus nerve stimulation promotes post-spinal cord injury remyelination via \u03b17nAChR-mediated activation of oligodendrocyte precursor cells"],"prefix":"10.1016","volume":"871","author":[{"given":"Lingxia","family":"Min","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingliang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubing","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingming","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.neulet.2025.138466_b0005","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12984-025-01557-4","article-title":"Non-invasive cerebral and spinal cord stimulation for motor and gait recovery in incomplete spinal cord injury: systematic review and meta-analysis","volume":"22","author":"Hernandez-Navarro","year":"2025","journal-title":"J. Neuroeng. Rehabil."},{"issue":"1","key":"10.1016\/j.neulet.2025.138466_b0010","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s11033-025-10785-9","article-title":"Pathophysiology of spinal cord injury and advanced therapeutic approaches","volume":"52","author":"Yadav","year":"2025","journal-title":"Mol. Biol. Rep."},{"issue":"11","key":"10.1016\/j.neulet.2025.138466_b0015","doi-asserted-by":"crossref","first-page":"6466","DOI":"10.1007\/s12035-023-03477-7","article-title":"Vagus nerve stimulation prevents endothelial necroptosis to alleviate blood-spinal cord barrier disruption after spinal cord injury","volume":"60","author":"Chen","year":"2023","journal-title":"Mol. Neurobiol."},{"issue":"5","key":"10.1016\/j.neulet.2025.138466_b0020","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2023-082906","article-title":"Efficacy and safety of transcutaneous auricular vagus nerve stimulation (ta-VNS) in the treatment of tinnitus: protocol for an updated systematic review and meta-analysis","volume":"14","author":"Lin","year":"2024","journal-title":"BMJ Open"},{"issue":"1","key":"10.1016\/j.neulet.2025.138466_b0025","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.brs.2014.09.009","article-title":"Electrical stimulation of the vagus nerve dermatome in the external ear is protective in rat cerebral ischemia","volume":"8","author":"Ay","year":"2015","journal-title":"Brain Stimul."},{"key":"10.1016\/j.neulet.2025.138466_b0030","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.clinph.2021.11.079","article-title":"Transcutaneous auricular vagus nerve stimulation cannot modulate the P3b event-related potential in healthy volunteers","volume":"135","author":"Gadeyne","year":"2022","journal-title":"Clin. Neurophysiol."},{"issue":"8","key":"10.1016\/j.neulet.2025.138466_b0035","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.4103\/1673-5374.332155","article-title":"Efficacy and safety of transcutaneous auricular vagus nerve stimulation combined with conventional rehabilitation training in acute stroke patients: a randomized controlled trial conducted for 1 year involving 60 patients","volume":"17","author":"Li","year":"2022","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.neulet.2025.138466_b0040","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2022.811419","article-title":"Transcutaneous auricular vagus nerve stimulation promotes white matter repair and improves dysphagia symptoms in cerebral ischemia model rats","volume":"16","author":"Long","year":"2022","journal-title":"Front. Behav. Neurosci."},{"issue":"1","key":"10.1016\/j.neulet.2025.138466_b0045","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.brs.2023.12.008","article-title":"Locus coeruleus tyrosine hydroxylase positive neurons mediated the peripheral and central therapeutic effects of transcutaneous auricular vagus nerve stimulation (taVNS) in MRL\/lpr mice","volume":"17","author":"Lv","year":"2023","journal-title":"Brain Stimul."},{"key":"10.1016\/j.neulet.2025.138466_b0050","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jns.2016.08.004","article-title":"Transcutaneous auricular vagus nerve stimulation regulates expression of growth differentiation factor 11 and activin-like kinase 5 in cerebral ischemia\/reperfusion rats","volume":"369","author":"Ma","year":"2016","journal-title":"J. Neurol. Sci."},{"issue":"2","key":"10.1016\/j.neulet.2025.138466_b0055","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s00415-022-11465-5","article-title":"Effect of transcutaneous auricular vagus nerve stimulation on post-stroke dysphagia","volume":"270","author":"Wang","year":"2023","journal-title":"J. Neurol."},{"key":"10.1016\/j.neulet.2025.138466_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107448","article-title":"Regulation of microglia inflammation and oligodendrocyte demyelination by Engeletin via the TLR4\/RRP9\/NF-\u03baB pathway after spinal cord injury","volume":"209","author":"Chen","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"12","key":"10.1016\/j.neulet.2025.138466_b0065","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1631\/jzus.B2300790","article-title":"Olig2(+) single-colony-derived cranial bone-marrow mesenchymal stem cells achieve improved regeneration in a cuprizone-induced demyelination mouse model","volume":"25","author":"Peng","year":"2024","journal-title":"J. Zhejiang Univ. Sci. B"},{"issue":"792","key":"10.1016\/j.neulet.2025.138466_b0070","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adn9980","article-title":"Oligodendroglial precursor cells modulate immune response and early demyelination in a murine model of multiple sclerosis","volume":"17","author":"Wang","year":"2025","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neulet.2025.138466_b0075","article-title":"Transcutaneous auricular vagus nerve stimulation ameliorates heart failure with preserved ejection fraction through regulating macrophage polarization mediated by Alpha7nAChR","author":"Huo","year":"2025","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"3","key":"10.1016\/j.neulet.2025.138466_b0080","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1007\/s12035-024-04438-4","article-title":"Transcutaneous auricular vagus stimulation attenuates LPS-induced depression-like behavior by regulating central \u03b17nAChR\/JAK2 signaling","volume":"62","author":"Wang","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.neulet.2025.138466_b0085","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1186\/s12974-021-02341-6","article-title":"Mechanisms underlying antidepressant effect of transcutaneous auricular vagus nerve stimulation on CUMS model rats based on hippocampal \u03b17nAchR\/NF-\u03baB signal pathway","volume":"18","author":"Wang","year":"2021","journal-title":"J. Neuroinflammation"},{"issue":"16","key":"10.1016\/j.neulet.2025.138466_b0090","doi-asserted-by":"crossref","first-page":"7932","DOI":"10.1073\/pnas.1821853116","article-title":"Uniquely human CHRFAM7A gene increases the hematopoietic stem cell reservoir in mice and amplifies their inflammatory response","volume":"116","author":"Costantini","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.neulet.2025.138466_b0095","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1053\/j.gastro.2018.05.041","article-title":"Cigarette smoke induces stem cell features of pancreatic cancer cells via PAF1","volume":"155","author":"Nimmakayala","year":"2018","journal-title":"Gastroenterology"},{"issue":"9","key":"10.1016\/j.neulet.2025.138466_b0100","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1002\/stem.2077","article-title":"Cholinergic enhancement of cell proliferation in the postnatal neurogenic niche of the mammalian spinal cord","volume":"33","author":"Corns","year":"2015","journal-title":"Stem Cells"},{"issue":"6","key":"10.1016\/j.neulet.2025.138466_b0105","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1111\/jnc.13294","article-title":"Nicotinic acetylcholine receptors mediate donepezil-induced oligodendrocyte differentiation","volume":"135","author":"Imamura","year":"2015","journal-title":"J. Neurochem."},{"issue":"8","key":"10.1016\/j.neulet.2025.138466_b0110","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.4103\/1673-5374.274332","article-title":"Multimodal treatment for spinal cord injury: a sword of neuroregeneration upon neuromodulation","volume":"15","author":"Zheng","year":"2020","journal-title":"Neural Regen. Res."},{"issue":"24","key":"10.1016\/j.neulet.2025.138466_b0115","doi-asserted-by":"crossref","DOI":"10.1242\/dev.193946","article-title":"Reactive oligodendrocyte progenitor cells (re-)myelinate the regenerating zebrafish spinal cord","volume":"147","author":"Tsata","year":"2020","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.neulet.2025.138466_b0120","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.3171\/2019.1.FOCUS18591","article-title":"The role of diffusion tensor imaging in the diagnosis, prognosis, and assessment of recovery and treatment of spinal cord injury: a systematic review","volume":"46","author":"Zaninovich","year":"2019","journal-title":"Neurosurg. Focus"},{"key":"10.1016\/j.neulet.2025.138466_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135031","article-title":"\u03b17nAchR mediates transcutaneous auricular vagus nerve stimulation-induced neuroprotection in a rat model of ischemic stroke by enhancing axonal plasticity","volume":"730","author":"Li","year":"2020","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2025.138466_b0130","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1320278","article-title":"Exploring the mechanism on the medullary visceral zone inhibiting the cholinergic anti-inflammatory pathway induced by sepsis","volume":"2020","author":"Li","year":"2020","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.neulet.2025.138466_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101984","article-title":"Iron overload in the motor cortex induces neuronal ferroptosis following spinal cord injury","volume":"43","author":"Feng","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.neulet.2025.138466_b0140","article-title":"Vagus nerve stimulation reduces neuroinflammation through microglia polarization regulation to improve functional recovery after spinal cord injury","volume":"16","author":"Chen","year":"2022","journal-title":"Front. Neurosci."},{"issue":"7","key":"10.1016\/j.neulet.2025.138466_b0145","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1007\/s00586-022-07207-w","article-title":"Assessment of acute traumatic cervical spinal cord injury using conventional magnetic resonance imaging in combination with diffusion tensor imaging-tractography: a retrospective comparative study","volume":"31","author":"Zhu","year":"2022","journal-title":"Eur. Spine J."},{"issue":"6","key":"10.1016\/j.neulet.2025.138466_b0150","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1523\/JNEUROSCI.20-06-02218.2000","article-title":"Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord","volume":"20","author":"Horner","year":"2000","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.neulet.2025.138466_b0155","doi-asserted-by":"crossref","first-page":"882","DOI":"10.17305\/bjbms.2022.7111","article-title":"The \u03b17 nicotinic acetylcholine receptor agonist PNU-282987 ameliorates sepsis-induced acute kidney injury through CD4+CD25+ regulatory T cells in rats","volume":"22","author":"Shi","year":"2022","journal-title":"Bosn. J. Basic Med. Sci."},{"issue":"10","key":"10.1016\/j.neulet.2025.138466_b0160","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1007\/s12264-024-01261-8","article-title":"A new acquaintance of oligodendrocyte precursor cells in the central nervous system","volume":"40","author":"Ma","year":"2024","journal-title":"Neurosci. Bull."},{"issue":"3","key":"10.1016\/j.neulet.2025.138466_b0165","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1007\/s13311-023-01353-9","article-title":"Transcutaneous auricular vagus nerve stimulation (ta-VNS) for treatment of drug-resistant epilepsy: a randomized, double-blind clinical trial","volume":"20","author":"Yang","year":"2023","journal-title":"Neurotherapeutics"},{"issue":"12","key":"10.1016\/j.neulet.2025.138466_b0170","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.51217","article-title":"Transcutaneous auricular vagus nerve stimulation for chronic insomnia disorder: a randomized clinical trial","volume":"7","author":"Zhang","year":"2024","journal-title":"JAMA Netw. Open"},{"issue":"1","key":"10.1016\/j.neulet.2025.138466_b0175","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12974-020-01732-5","article-title":"Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression","volume":"17","author":"Liu","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"4","key":"10.1016\/j.neulet.2025.138466_b0180","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/joa.13122","article-title":"The anatomical basis for transcutaneous auricular vagus nerve stimulation","volume":"236","author":"Butt","year":"2020","journal-title":"J. Anat."},{"key":"10.1016\/j.neulet.2025.138466_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106758","article-title":"Neuroimmune nexus in the pathophysiology and therapy of inflammatory disorders: role of \u03b17 nicotinic acetylcholine receptors","volume":"191","author":"Keever","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.neulet.2025.138466_b0190","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.202300384","article-title":"Proteome profile of the cerebellum from \u03b17 nicotinic acetylcholine receptor deficient mice","author":"Caban","year":"2024","journal-title":"Proteomics"},{"issue":"7","key":"10.1016\/j.neulet.2025.138466_b0195","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/glia.23116","article-title":"The logistics of myelin biogenesis in the central nervous system","volume":"65","author":"Snaidero","year":"2017","journal-title":"Glia"},{"issue":"1","key":"10.1016\/j.neulet.2025.138466_b0200","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/s41467-022-28844-1","article-title":"Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing","volume":"13","author":"Ma","year":"2022","journal-title":"Nat. Commun."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394025003556?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394025003556?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:51:34Z","timestamp":1778629894000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394025003556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":40,"alternative-id":["S0304394025003556"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2025.138466","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcutaneous auricular vagus nerve stimulation promotes post-spinal cord injury remyelination via \u03b17nAChR-mediated activation of oligodendrocyte precursor cells","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2025.138466","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"138466"}}