{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:14:22Z","timestamp":1783401262530,"version":"3.54.6"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.neulet.2026.138635","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:50:00Z","timestamp":1779205800000},"page":"138635","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Indoleamine 2,3-dioxygenase 1 (IDO1) promoted the activation of inflammatory response in the brain tissue of Alzheimer\u2019s disease mice by regulating NF-\u03baB pathway"],"prefix":"10.1016","volume":"882","author":[{"given":"XinQun","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QuanLan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WenQiang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8253-6808","authenticated-orcid":false,"given":"Fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HuanBing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YuangBing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.neulet.2026.138635_b0005","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41572-021-00269-y","article-title":"Alzheimer disease","volume":"7","author":"Knopman","year":"2021","journal-title":"J. Nature Reviews Disease Primers."},{"key":"10.1016\/j.neulet.2026.138635_b0010","doi-asserted-by":"crossref","unstructured":"L.E. Hebert P.A. Scherr J.L. Bienias D.A. Bennett D.A. Evans Alzheimer disease in the US population: prevalence estimates using the 2000 census J Arch Neurol. 60 8 10.1001\/archneur.60.8.1119. 2003, pp. 1119\u201322 https:\/\/doi.org\/.","DOI":"10.1001\/archneur.60.8.1119"},{"key":"10.1016\/j.neulet.2026.138635_b0015","doi-asserted-by":"crossref","unstructured":"L.A. Johnson S.L. Macauley Alzheimer's and metabolism wed with IDO1 J Science. 385 6711 10.1126\/science.adr5836. 2024, pp. 826\u2013827 https:\/\/doi.org\/.","DOI":"10.1126\/science.adr5836"},{"key":"10.1016\/j.neulet.2026.138635_b0020","doi-asserted-by":"crossref","unstructured":"Dewanjee S, Chakraborty P, Bhattacharya H, Chacko L, Singh B, Chaudhary A, Javvaji K, Pradhan SR, Vallamkondu J, Dey A, Kalra RS, Jha NK, Jha SK, Reddy PH, Kandimalla R. Altered glucose metabolism in Alzheimer's disease: Role of mitochondrial dysfunction and oxidative stress.J.Free radical biology & medicine.193(Pt1)(2022)134-157. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.09.032.","DOI":"10.1016\/j.freeradbiomed.2022.09.032"},{"key":"10.1016\/j.neulet.2026.138635_b0025","doi-asserted-by":"crossref","unstructured":"Yu D, Tao BB, Yang YY, Du LS, Yang SS, He XJ, Zhu YW, Yan JK, Yang Q. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 43(1)(2015)291-302. https:\/\/doi.org\/ 10.3233\/JAD-140414.","DOI":"10.3233\/JAD-140414"},{"key":"10.1016\/j.neulet.2026.138635_b0030","doi-asserted-by":"crossref","unstructured":"Chatterjee P, Zetterberg H, Goozee K, Lim CK, Jacobs KR, Ashton NJ, Hye A, Pedrini S, Sohrabi HR, Shah T, Asih PR, Dave P, Shen K, Taddei K, Lovejoy DB, Guillemin GJ, Blennow K, Martins RN. Plasma neurofilament light chain and amyloid-\u03b2 are associated with the kynurenine pathway metabolites in preclinical Alzheimer's disease. J Neuroinflammation. 16(1)(2019)186. https:\/\/doi.org\/ 10.1186\/s12974-019-1567-4.","DOI":"10.1186\/s12974-019-1567-4"},{"issue":"6711","key":"10.1016\/j.neulet.2026.138635_b0035","doi-asserted-by":"crossref","DOI":"10.1126\/science.abm6131","article-title":"Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies.J","volume":"385","author":"Minhas","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.neulet.2026.138635_b0040","doi-asserted-by":"crossref","unstructured":"A. Webers M.T. Heneka P.A. Gleeson The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease J. Immunology and Cell Biology. 98 1 10.1111\/imcb.12301. 2020, pp. 28\u201341 https:\/\/doi.org\/.","DOI":"10.1111\/imcb.12301"},{"key":"10.1016\/j.neulet.2026.138635_b0045","doi-asserted-by":"crossref","unstructured":"Tan L, Yu JT, Tan L. The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations.J.Journal of the neurological sciences. 323(1-2)(2012)1-8. https:\/\/doi.org\/10.1016\/j.jns.2012.08.005.","DOI":"10.1016\/j.jns.2012.08.005"},{"issue":"PtB","key":"10.1016\/j.neulet.2026.138635_b0050","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.neuropharm.2016.03.024","article-title":"Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases.J","volume":"112","author":"Lovelace","year":"2017","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.neulet.2026.138635_b0055","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00109-023-02289-5","article-title":"Activation of aryl hydrocarbon receptor (AhR) in Alzheimer's disease: role of tryptophan metabolites generated by gut host-microbiota","volume":"101","author":"Salminen","year":"2023","journal-title":"J. Mol. Med. (Berl)"},{"key":"10.1016\/j.neulet.2026.138635_b0060","doi-asserted-by":"crossref","unstructured":"Duan Z, Shi L, He ZNT, Kuang C, Han T, Yang Q. The Protective Effect of IDO1 Inhibition in A\u03b2-Treated Neurons and APP\/PS1 Mice. American journal of Alzheimer's disease and other dementias.38(2023)15333175231214861. https:\/\/doi.org\/10.1177\/15333175231214861.","DOI":"10.1177\/15333175231214861"},{"issue":"5","key":"10.1016\/j.neulet.2026.138635_b0065","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41573-019-0016-5","article-title":"Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond","volume":"18","author":"Platten","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.neulet.2026.138635_b0070","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41392-020-0188-9","article-title":"Amyloid \u03b2 neurotoxicity is IDO1-Kyn-AhR dependent and blocked by IDO1 inhibitor","volume":"5","author":"Duan","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.neulet.2026.138635_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156944","article-title":"Arbutin ameliorated depression by inhibiting neuroinflammation and modulating intestinal flora","volume":"145","author":"Cao","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.neulet.2026.138635_b0080","doi-asserted-by":"crossref","unstructured":"Ren W, Yan XS, Fan JC, Huo DS, Wang XX, Jia JX, Yang ZJ. Effect of total flavonoids ofDracocephalum moldavica L. On neuroinflammation in Alzheimer's disease model amyloid-\u03b2 (A\u03b21-42)-peptide-induced astrocyte activation.J.Journal of toxicology and environmental health Part A.87(10)(2024)436-447. https:\/\/doi.org\/10.1080\/15287394.2024.2336570.","DOI":"10.1080\/15287394.2024.2336570"},{"key":"10.1016\/j.neulet.2026.138635_b0085","first-page":"852","article-title":"Indoleamine 2,3-Dioxygenase as a Therapeutic Target for Alzheimer's Disease and Geriatric Depression","author":"Savonije","year":"2023","journal-title":"J. Br Ain sciences.13(6)"},{"issue":"9","key":"10.1016\/j.neulet.2026.138635_b0090","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.3390\/cells12091309","article-title":"GFAP as a potential Biomarker for Alzheimer's Disease: a Systematic Review and Meta-Analysis","volume":"12","author":"Kim","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.neulet.2026.138635_b0095","doi-asserted-by":"crossref","unstructured":"Milos T, Rojo D, Nedic Erjavec G, Konjevod M, Tudor L, Vuic B, Svob Strac D, Uzun S, Mimica N, Kozumplik O, Barbas C, Zarkovic N, Pivac N, Nikolac Perkovic M.Metabolic profiling of Alzheimer's disease: Untargeted metabolomics analysis of plasma samples. J.Progress in neuro-psychopharmacology & biological psychiatry.127(2023)110830. https:\/\/doi.org\/10.1016\/j.pnpbp.2023.110830.","DOI":"10.1016\/j.pnpbp.2023.110830"},{"key":"10.1016\/j.neulet.2026.138635_b0100","doi-asserted-by":"crossref","unstructured":"Li H, Tan Y, Cheng X, Zhang Z, Huang J, Hui S, Zhu L, Liu Y, Zhao D, Liu Z, Peng W. Untargeted metabolomics analysis of the hippocampus and cerebral cortex identified the neuroprotective mechanisms of Bushen Tiansui formula in an a\u03b225-35-induced rat model of Alzheimer's disease.Frontiers in pharmacology.13(2022)990307. https:\/\/doi.org\/10.3389\/fphar.2022.990307.","DOI":"10.3389\/fphar.2022.990307"},{"issue":"2","key":"10.1016\/j.neulet.2026.138635_b0105","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3390\/biom6020016","article-title":"Central Role of Glutamate Metabolism in the Maintenance of Nitrogen Homeostasis in Normal and Hyperammonemic Brain","volume":"6","author":"Cooper","year":"2016","journal-title":"J Biomolecules."},{"key":"10.1016\/j.neulet.2026.138635_b0110","doi-asserted-by":"crossref","unstructured":"Revett TJ, Baker GB, Jhamandas J, Kar S. Glutamate system, amyloid \u00df peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology.Journal of psychiatry & neuroscience : JPN. 38(1)(2013)6-23. https:\/\/doi.org\/10.1503\/jpn.110190.","DOI":"10.1503\/jpn.110190"},{"issue":"1","key":"10.1016\/j.neulet.2026.138635_b0115","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/jnc.15044","article-title":"Role of sphingolipid metabolism in neurodegeneration","volume":"158","author":"Alaamery","year":"2021","journal-title":"J. Journal of Neurochemistry."},{"key":"10.1016\/j.neulet.2026.138635_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2023.109690","article-title":"The role of the indoles in microbiota-gut-brain axis and potential therapeutic targets: a focus on human neurological and neuropsychiatric diseases.J","volume":"239","author":"Zhou","year":"2023","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.neulet.2026.138635_b0125","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s11011-016-9824-z","article-title":"TDO as a therapeutic target in brain diseases","volume":"31","author":"Yu","year":"2016","journal-title":"Metab. Brain Dis."},{"issue":"1","key":"10.1016\/j.neulet.2026.138635_b0130","first-page":"12050","article-title":"IL-1\u03b2, IL-6, TNF- \u03b1 and CRP in elderly patients with Depression or Alzheimer's disease","volume":"8","author":"Ng","year":"2018","journal-title":"Systematic Review and Meta-Analysis. Sci Rep."},{"issue":"16","key":"10.1016\/j.neulet.2026.138635_b0135","doi-asserted-by":"crossref","first-page":"8972","DOI":"10.3390\/ijms23168972","article-title":"The Pivotal Role of NF-kB in the Pathogenesis and Therapeutics of Alzheimer's Disease","volume":"23","author":"Sun","year":"2022","journal-title":"J. International Journal of Molecular Sciences."},{"issue":"5","key":"10.1016\/j.neulet.2026.138635_b0140","first-page":"2527","volume":"22","author":"Nguyen","year":"2021","journal-title":"A Novel 1,8-Naphthyridine-2-Carboxamide Derivative Attenuates Inflammatory Responses and Cell Migration in LPS-Treated BV2 Cells via the Suppression of ROS Generation and TLR4\/Myd88\/NF-\u039ab Signaling Pathway J. International Journal of Molecular Sciences"},{"key":"10.1016\/j.neulet.2026.138635_b0145","doi-asserted-by":"crossref","unstructured":"Zusso M, Lunardi V, Franceschini D, Pagetta A, Lo R, Stifani S, Frigo AC, Giusti P, Moro S. Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4\/NF-kB pathway.Journal of neuroinflammation J.16(1)(2019)148. https:\/\/doi.org\/10.1186\/s12974-019-1538-9.","DOI":"10.1186\/s12974-019-1538-9"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394026001345?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394026001345?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:17:38Z","timestamp":1783397858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394026001345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":29,"alternative-id":["S0304394026001345"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2026.138635","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Indoleamine 2,3-dioxygenase 1 (IDO1) promoted the activation of inflammatory response in the brain tissue of Alzheimer\u2019s disease mice by regulating NF-\u03baB pathway","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2026.138635","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"138635"}}